LOCUS       NM_133169               1356 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens osteoclast associated Ig-like receptor (OSCAR),
            transcript variant 4, mRNA.
ACCESSION   NM_133169
VERSION     NM_133169.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1356)
  AUTHORS   Park,D.R., Kim,J., Kim,G.M., Lee,H., Kim,M., Hwang,D., Lee,H.,
            Kim,H.S., Kim,W., Park,M.C., Shim,H. and Lee,S.Y.
  TITLE     Osteoclast-associated receptor blockade prevents articular
            cartilage destruction via chondrocyte apoptosis regulation
  JOURNAL   Nat Commun 11 (1), 4343 (2020)
   PUBMED   32859940
  REMARK    GeneRIF: Osteoclast-associated receptor blockade prevents articular
            cartilage destruction via chondrocyte apoptosis regulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1356)
  AUTHORS   Wang,D., Yang,N. and Xie,S.
  TITLE     Sex-biased ceRNA networks reveal that OSCAR can promote
            proliferation and migration of lung adenocarcinoma in women
  JOURNAL   Clin Exp Pharmacol Physiol 47 (8), 1350-1359 (2020)
   PUBMED   32246488
  REMARK    GeneRIF: Sex-biased ceRNA networks reveal that OSCAR can promote
            proliferation and migration of lung adenocarcinoma in women.
REFERENCE   3  (bases 1 to 1356)
  AUTHORS   Dharmapatni,A.A.S.S.K., Algate,K., Coleman,R., Lorimer,M.,
            Cantley,M.D., Smith,M.D., Wechalekar,M.D. and Crotti,T.N.
  TITLE     Osteoclast-Associated Receptor (OSCAR) Distribution in the Synovial
            Tissues of Patients with Active RA and TNF-alpha and RANKL
            Regulation of Expression by Osteoclasts In Vitro
  JOURNAL   Inflammation 40 (5), 1566-1575 (2017)
   PUBMED   28555364
  REMARK    GeneRIF: regulation of OSCAR by TNF-alpha and receptor activator of
            NF kappa beta ligand (RANKL) in pre-osteoclasts/osteoclasts
REFERENCE   4  (bases 1 to 1356)
  AUTHORS   Schultz,H.S., Guo,L., Keller,P., Fleetwood,A.J., Sun,M., Guo,W.,
            Ma,C., Hamilton,J.A., Bjorkdahl,O., Berchtold,M.W. and Panina,S.
  TITLE     OSCAR-collagen signaling in monocytes plays a proinflammatory role
            and may contribute to the pathogenesis of rheumatoid arthritis
  JOURNAL   Eur J Immunol 46 (4), 952-963 (2016)
   PUBMED   26786702
  REMARK    GeneRIF: OSCAR can play a proinflammatory role in monocyte-derived
            cells and may contribute crucially on multiple levels to rheumatoid
            arthritis pathogenesis.
REFERENCE   5  (bases 1 to 1356)
  AUTHORS   Zhou,L., Hinerman,J.M., Blaszczyk,M., Miller,J.L., Conrady,D.G.,
            Barrow,A.D., Chirgadze,D.Y., Bihan,D., Farndale,R.W. and Herr,A.B.
  TITLE     Structural basis for collagen recognition by the immune receptor
            OSCAR
  JOURNAL   Blood 127 (5), 529-537 (2016)
   PUBMED   26552697
  REMARK    GeneRIF: Each domain of OSCAR binds a collagen triple-helical
            peptide; the primary site is on the C-terminal domain in contrast
            to GPVI and LAIR-1.
REFERENCE   6  (bases 1 to 1356)
  AUTHORS   Kim,G.S., Koh,J.M., Chang,J.S., Park,B.L., Kim,L.H., Park,E.K.,
            Kim,S.Y. and Shin,H.D.
  TITLE     Association of the OSCAR promoter polymorphism with BMD in
            postmenopausal women
  JOURNAL   J Bone Miner Res 20 (8), 1342-1348 (2005)
   PUBMED   16007331
  REMARK    GeneRIF: Promoter variant in OSCAR gene (OSCAR-2322A>G) might be
            one of genetic determinants of bone density in postmenopausal
            women.
REFERENCE   7  (bases 1 to 1356)
  AUTHORS   Tenca,C., Merlo,A., Merck,E., Bates,E.E., Saverino,D., Simone,R.,
            Zarcone,D., Trinchieri,G., Grossi,C.E. and Ciccone,E.
  TITLE     CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits
            human osteoclast-associated receptor-mediated activation of human
            dendritic cells
  JOURNAL   J Immunol 174 (11), 6757-6763 (2005)
   PUBMED   15905516
  REMARK    GeneRIF: Human OSCAR mediates the rescue from apoptosis and the
            cooperation between dendritic cells and antigen-specific T cells
            that is prevented by CD85j receptor.
REFERENCE   8  (bases 1 to 1356)
  AUTHORS   Merck,E., de Saint-Vis,B., Scuiller,M., Gaillard,C., Caux,C.,
            Trinchieri,G. and Bates,E.E.
  TITLE     Fc receptor gamma-chain activation via hOSCAR induces survival and
            maturation of dendritic cells and modulates Toll-like receptor
            responses
  JOURNAL   Blood 105 (9), 3623-3632 (2005)
   PUBMED   15650060
  REMARK    GeneRIF: ligation of OSCAR promotes dendritic cell survival by an
            ERK- and PI3K-dependent pathway, linked to expression of the Bcl-2
            and Bcl-x(L) antiapoptotic molecules
REFERENCE   9  (bases 1 to 1356)
  AUTHORS   Merck,E., Gaillard,C., Gorman,D.M., Montero-Julian,F., Durand,I.,
            Zurawski,S.M., Menetrier-Caux,C., Carra,G., Lebecque,S.,
            Trinchieri,G. and Bates,E.E.
  TITLE     OSCAR is an FcRgamma-associated receptor that is expressed by
            myeloid cells and is involved in antigen presentation and
            activation of human dendritic cells
  JOURNAL   Blood 104 (5), 1386-1395 (2004)
   PUBMED   15155468
  REMARK    GeneRIF: hOSCAR thus represents a novel class of molecule expressed
            by dendritic cells involved in the initiation of the immune
            response.
REFERENCE   10 (bases 1 to 1356)
  AUTHORS   Kim,N., Takami,M., Rho,J., Josien,R. and Choi,Y.
  TITLE     A novel member of the leukocyte receptor complex regulates
            osteoclast differentiation
  JOURNAL   J Exp Med 195 (2), 201-209 (2002)
   PUBMED   11805147
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC245052.3.
            
            On Apr 30, 2021 this sequence version replaced NM_133169.5.
            
            Summary: Osteoclasts are multinucleated cells that resorb bone and
            are essential for bone homeostasis. This gene encodes an
            osteoclast-associated receptor (OSCAR), which is a member of the
            leukocyte receptor complex protein family that plays critical roles
            in the regulation of both innate and adaptive immune responses. The
            encoded protein may play a role in oxidative stress-mediated
            atherogenesis as well as monocyte adhesion. Multiple alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (4) lacks an in-frame exon in the
            central coding region and lacks an internal segment in its 3'
            coding region, compared to variant 1. The encoded isoform (4) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF391162.1, AF251702.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358375.9/ ENSP00000351145.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC245052.3         29296-29343         c
            49-81               AC245052.3         28288-28320         c
            82-384              AC245052.3         25402-25704         c
            385-666             AC245052.3         24412-24693         c
            667-1356            AC245052.3         23208-23897         c
FEATURES             Location/Qualifiers
     source          1..1356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1356
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /note="osteoclast associated Ig-like receptor"
                     /db_xref="GeneID:126014"
                     /db_xref="HGNC:HGNC:29960"
                     /db_xref="MIM:606862"
     exon            1..48
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..803
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; polymeric immunoglobulin receptor 3; osteoclast
                     associated receptor OSCAR-S1; osteoclast associated
                     receptor OSCAR-S2; poly-Ig receptor 3; osteoclast
                     associated, immunoglobulin-like receptor"
                     /codon_start=1
                     /product="osteoclast-associated immunoglobulin-like
                     receptor isoform 4 precursor"
                     /protein_id="NP_573399.2"
                     /db_xref="CCDS:CCDS12875.1"
                     /db_xref="GeneID:126014"
                     /db_xref="HGNC:HGNC:29960"
                     /db_xref="MIM:606862"
                     /translation="MALVLILQLLTLWPLCHTDITPSVPPASYHPKPWLGAQPATVVT
                     PGVNVTLRCRAPQPAWRFGLFKPGEIAPLLFRDVSSELAEFFLEEVTPAQGGSYRCCY
                     RRPDWGPGVWSQPSDVLELLVTEELPRPSLVALPGPVVGPGANVSLRCAGRLRNMSFV
                     LYREGVAAPLQYRHSAQPWADFTLLGARAPGTYSCYYHTPSAPYVLSQRSEVLVISWE
                     DSGSSDYTRGNLVRLGLAGLVLISLGALVTFDWRSQNRAPAGIRP"
     exon            49..81
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /inference="alignment:Splign:2.1.0"
     exon            82..384
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /inference="alignment:Splign:2.1.0"
     exon            385..666
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..1356
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /note="hexamer: AATAAA"
     polyA_site      1356
                     /gene="OSCAR"
                     /gene_synonym="PIgR-3; PIGR3"
                     /note="major polyA site"
ORIGIN      
        1 atctgcccac catggccctg gtgctgatcc tccagctgct gaccctctgg cctctgtgtc
       61 acacagacat cactccgtct gtccccccag cttcatacca ccctaagcca tggctgggag
      121 ctcagccggc tacagttgtg acccctgggg tcaacgtgac cttgagatgc cgggcacccc
      181 aacccgcttg gagatttgga cttttcaagc ctggagagat cgctcccctt ctcttccggg
      241 atgtgtcctc cgagctggca gaattctttc tggaggaggt gactccagcc caagggggaa
      301 gttaccgctg ctgctaccga aggccagact gggggccggg tgtctggtcc cagcccagcg
      361 atgtcctgga gctgctggtg acagaggagc tgccgcggcc gtcgctggtg gcgctgcccg
      421 ggccggtggt gggtcctggc gccaacgtga gcctgcgctg cgcgggccgc ctgcggaaca
      481 tgagcttcgt gctgtaccgc gagggcgtgg cggccccgct gcagtaccgc cactccgcgc
      541 agccctgggc cgacttcacg ctgctgggcg cccgcgcccc cggcacctac agctgctact
      601 atcacacgcc ctccgcgccc tacgtgctgt cgcagcgcag cgaggtgctg gtcatcagct
      661 gggaagactc tggctcctcc gactacaccc gggggaacct agtccgcctg gggctggccg
      721 ggctggtcct catctccctg ggcgcgctgg tcacttttga ctggcgcagt cagaaccgcg
      781 ctcctgctgg tatccgcccc tgagccccag gagcactgca gcccgagact tccaacctga
      841 gtggcggaga agctgggacc ctgggctgga ctgtcctttc ctgcagcccc acagtcctgc
      901 tggctgagct ccgcggaacg gtccttagac cccgctgtgc cctgtgctgt agcttctttc
      961 caggcctttc ccaaggagta gctgaaagga agacgcgatt agtggttaag acttccaagc
     1021 cagaagacag agggttcgaa tcccagcact gccgtctact cactgtagta gtagcagcta
     1081 cagaaaggta gtagtgagac gtgaagccag ctggacttcc tgggttgaat ggggacctgg
     1141 agaacttttc tgtcttacaa gaggattgta aaatggacca atcagcactc tgtaagatgg
     1201 accaatcagc gctctgtaaa atggaccaat cagcaggaca cgggcgggga caataaggga
     1261 ataaaagctg gcgagcgcgg caccccacca gagtctgctt ccacgttgtg ggagctttgt
     1321 tctcttgctc tacacaataa atcttgctgc tgctaa
//
