LOCUS       NM_145798               3664 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens oxysterol binding protein like 7 (OSBPL7), mRNA.
ACCESSION   NM_145798
VERSION     NM_145798.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3664)
  AUTHORS   Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
            Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M., Naj,A. and
            Green,R.C.
  CONSRTM   GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative;
            Alzheimer's Disease Genetics Consortium
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 10 (1), 45-52 (2014)
   PUBMED   23535033
REFERENCE   2  (bases 1 to 3664)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   3  (bases 1 to 3664)
  AUTHORS   Loilome,W., Wechagama,P., Namwat,N., Jusakul,A., Sripa,B., Miwa,M.,
            Kuver,R. and Yongvanit,P.
  TITLE     Expression of oxysterol binding protein isoforms in
            opisthorchiasis-associated cholangiocarcinoma: a potential
            molecular marker for tumor metastasis
  JOURNAL   Parasitol Int 61 (1), 136-139 (2012)
   PUBMED   21763455
  REMARK    GeneRIF: In preliminary results, significantly higher levels of
            OSBP2 and OSBPL-7 mRNA were seen in blood samples from
            cholangiocarcinoma patients than in healthy controls.
REFERENCE   4  (bases 1 to 3664)
  AUTHORS   Zhong,W., Zhou,Y., Li,S., Zhou,T., Ma,H., Wei,K., Li,H.,
            Olkkonen,V.M. and Yan,D.
  TITLE     OSBP-related protein 7 interacts with GATE-16 and negatively
            regulates GS28 protein stability
  JOURNAL   Exp Cell Res 317 (16), 2353-2363 (2011)
   PUBMED   21669198
  REMARK    GeneRIF: ORP7 negatively regulates GS28 protein stability via
            sequestration of GATE-16, and may mediate the effect of 25-OH on
            GS28 and Golgi function.
REFERENCE   5  (bases 1 to 3664)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   6  (bases 1 to 3664)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3664)
  AUTHORS   Suchanek,M., Hynynen,R., Wohlfahrt,G., Lehto,M., Johansson,M.,
            Saarinen,H., Radzikowska,A., Thiele,C. and Olkkonen,V.M.
  TITLE     The mammalian oxysterol-binding protein-related proteins (ORPs)
            bind 25-hydroxycholesterol in an evolutionarily conserved pocket
  JOURNAL   Biochem J 405 (3), 473-480 (2007)
   PUBMED   17428193
REFERENCE   8  (bases 1 to 3664)
  AUTHORS   Lehto,M., Tienari,J., Lehtonen,S., Lehtonen,E. and Olkkonen,V.M.
  TITLE     Subfamily III of mammalian oxysterol-binding protein (OSBP)
            homologues: the expression and intracellular localization of ORP3,
            ORP6, and ORP7
  JOURNAL   Cell Tissue Res 315 (1), 39-57 (2004)
   PUBMED   14593528
REFERENCE   9  (bases 1 to 3664)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   10 (bases 1 to 3664)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC003665.1, AF392446.1,
            BC065482.1 and BM674891.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145798.2.
            
            Summary: This gene encodes a member of the oxysterol-binding
            protein (OSBP) family, a group of intracellular lipid receptors.
            Like most members, the encoded protein contains an N-terminal
            pleckstrin homology domain and a highly conserved C-terminal
            OSBP-like sterol-binding domain. Two transcript variants encoding
            the same isoform have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065482.1, AF323729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000007414.8/ ENSP00000007414.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC003665.1         34013-34025
            14-385              AF392446.1         54-425
            386-2714            BC065482.1         345-2673
            2715-2842           AF392446.1         2755-2882
            2843-3555           BC065482.1         2802-3514
            3556-3663           AF392446.1         3242-3349
            3664-3664           BM674891.1         24-24               c
FEATURES             Location/Qualifiers
     source          1..3664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..3664
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /note="oxysterol binding protein like 7"
                     /db_xref="GeneID:114881"
                     /db_xref="HGNC:HGNC:16387"
                     /db_xref="MIM:606735"
     exon            1..129
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            130..291
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..2745
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /note="OSBP-related protein 7; ORP-7"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 7"
                     /protein_id="NP_665741.1"
                     /db_xref="CCDS:CCDS11515.1"
                     /db_xref="GeneID:114881"
                     /db_xref="HGNC:HGNC:16387"
                     /db_xref="MIM:606735"
                     /translation="MDFQERDPPFLPESAQSSKPSSAQQASELWEVVEEPRVRLGTEG
                     VMPERQEGHLLKKRKWPLKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVM
                     SINKKAQRIDLDTEDNIYHLKIKSQDLFQSWVAQLRAHRLAHRLDMPRGSLPSTAHRK
                     VPGAQLPTAATASALPGLGPREKVSSWLRDSDGLDRCSHELSECQGKLQELHRLLQSL
                     ESLHRIPSAPVIPTHQASVTTERPKKGKRTSRMWCTQSFAKDDTIGRVGRLHGSVPNL
                     SRYLESRDSSGTRGLPPTDYAHLQRSFWALAQKVHSSLSSVLAALTMERDQLRDMHQG
                     SELSRMGVSEASTGQRRLHSLSTSSDTTADSFSSLNPEEQEALYMKGRELTPQLSQTS
                     ILSLADSHTEFFDACEVLLSASSSENEGSEEEESCTSEITTSLSEEMLDLRGAERCQK
                     GGCVPGRPMGPPRRRCLPAASGPGADVSLWNILRNNIGKDLSKVSMPVQLNEPLNTLQ
                     RLCEELEYSSLLDQASRIADPCERMVYIAAFAVSAYSSTYHRAGCKPFNPVLGETYEC
                     ERPDRGFRFISEQVSHHPPISACHAESENFAFWQDMKWKNKFWGKSLEIVPVGTVNVS
                     LPRFGDHFEWNKVTSCIHNVLSGQRWIEHYGEVLIRNTQDSSCHCKITFCKAKYWSSN
                     VHEVQGAVLSRSGRVLHRLFGKWHEGLYRGPTPGGQCIWKPNSMPPDHERNFGFTQFA
                     LELNELTAELKRSLPSTDTRLRPDQRYLEEGNIQAAEAQKRRIEQLQRDRRKVMEENN
                     IVHQARFFRRQTDSSGKEWWVTNNTYWRLRAEPGYGNMDGAVLW"
     exon            292..417
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            418..471
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            472..585
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            586..696
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            697..814
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            815..918
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1011
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1144
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1239
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1335
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1473
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1567
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1815
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1953
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2017
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2096
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2241
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2386
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2513
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2636
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..3664
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3647..3652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /note="hexamer: AATAAA"
     polyA_site      3664
                     /gene="OSBPL7"
                     /gene_synonym="ORP7"
                     /note="major polyA site"
ORIGIN      
        1 cttcctggtt cctgcagcag ctgctgccac tgctcagcgc ggtgaggagg gagccggtga
       61 ctcggagacg gtgactcaga ggcagagcgg cgcaagggcc aaggagtact ggcgtccatg
      121 gaccctgggg accccgtcag gagcaggtga catccttccc cttccaccct gctccctgct
      181 ctacatcccc agcagggagt ggcctctccc ttctccatgg acttccaaga gagggacccg
      241 cccttcctgc ctgagagcgc tcagtcctca aagcccagca gtgctcagca ggcctctgag
      301 ctgtgggagg tggtggagga gcctcgggtc aggctgggga cagagggtgt catgcctgag
      361 aggcaggaag gtcacctgct caagaagagg aagtggcctc tgaagggctg gcacaagaga
      421 tactttgtgc tcgaggacgg gatccttcat tatgcaacaa cccggcaaga catcaccaag
      481 gggaagctcc atggctccat cgatgtccgg ctgtcggtca tgtccatcaa caaaaaggcc
      541 cagcgcattg accttgacac tgaagacaac atctaccacc tcaagatcaa atcccaggac
      601 ctattccaga gctgggtggc gcagctgcgt gcccaccgcc tagcccaccg cctggacatg
      661 ccccgtggct cactgcccag tactgctcac cggaaggttc ctggtgccca gcttccaaca
      721 gcagctactg cctcagccct acctgggctt ggaccgcggg agaaagtgtc ttcctggctg
      781 agggacagtg atgggctgga ccgctgctct catgagctct ctgagtgtca ggggaagctc
      841 caggaactac acaggctcct ccagagcctg gagtccctgc accgaatccc ctcagcccct
      901 gttatcccca cacaccaggc ctcagtgaca accgaaagac ccaagaaggg gaaacggaca
      961 agccgcatgt ggtgcaccca gagctttgcc aaggatgaca ccattggacg ggttggtcgt
     1021 ctccatggct ctgttcccaa cctgtctcgc tacctggagt ctcgggactc ctcgggcacc
     1081 cgtgggctgc cacccacaga ctatgcccac ctgcagcgca gcttctgggc cctggcccag
     1141 aaggtgcaca gctccctcag cagcgtcctg gccgccctca ccatggaacg ggaccaactg
     1201 agggacatgc accagggctc agagttgtca agaatggggg tctctgaggc ctccactggc
     1261 cagaggcgcc tccactcact gtccacctcc tccgacacca cggcggactc tttcagctcc
     1321 ctcaaccctg aggagcaaga agctctgtac atgaaggggc gcgagctcac cccccagcta
     1381 tcgcagacca gcatcctgtc ccttgctgat tcccacacgg agttcttcga tgcctgcgag
     1441 gttctcctct ccgccagctc ttctgagaat gagggctcag aggaggagga gtcctgtacc
     1501 agtgaaatca ccaccagcct gtctgaggag atgctggacc tcaggggagc tgagcgctgt
     1561 cagaaagggg ggtgtgttcc agggagaccc atggggccac cccgccgtcg ctgcctgccg
     1621 gcggccagcg ggcctggggc tgacgtgagc ctgtggaaca ttctgcgcaa caacatcggc
     1681 aaagacctgt ccaaggtgtc aatgcctgtg cagctcaacg agccgctcaa cactctgcag
     1741 cggctctgcg aggagctgga gtacagcagc ctcctggacc aggccagccg catcgccgac
     1801 ccctgcgagc gcatggtgta catcgcagcc tttgctgtct cggcctactc ctccacatac
     1861 caccgagccg gctgcaagcc cttcaaccct gtcctggggg agacctacga gtgtgagcgg
     1921 cctgaccgag gcttccgctt catcagtgag caggtctccc accacccccc tatctcggcc
     1981 tgccatgcag agtctgagaa cttcgccttc tggcaagata tgaagtggaa gaacaagttc
     2041 tggggcaaat ccctggagat tgtgcctgtg ggaacagtca acgtcagcct gcccaggttt
     2101 ggggaccact ttgagtggaa caaggtgaca tcctgcattc acaatgtcct gagtggtcag
     2161 cgctggatcg agcactatgg ggaggtgctc atccgaaaca cacaggacag ctcctgccac
     2221 tgcaagatca ccttctgcaa ggccaagtac tggagttcca atgtccacga ggtgcagggc
     2281 gctgtgctca gtcggagtgg ccgtgtcctc caccgactct ttgggaagtg gcacgagggg
     2341 ctgtaccggg gacccacgcc aggtggccag tgcatctgga aacccaactc aatgcccccc
     2401 gaccatgagc gaaacttcgg cttcacccag tttgccttgg agctgaatga gctgacagca
     2461 gagctgaaac ggtcgctgcc ttccaccgac acgagactcc ggccagacca gaggtacctg
     2521 gaggagggga acatacaggc cgctgaggcc cagaagagaa ggatcgagca gctgcagcga
     2581 gacaggcgca aagtcatgga ggaaaacaac atcgtacacc aggctcgctt cttcaggcgg
     2641 cagacggata gcagcgggaa agagtggtgg gtgaccaaca atacctactg gaggctgcgg
     2701 gccgagccag gctatgggaa catggatggg gccgtgctct ggtagccctg gccccggggg
     2761 caggaggctc tggttcctca ctcctcctgc ctccaccccc taccatggac acatgggtga
     2821 ggccgggctc cccgcctcac tgcccttgag accaaagggg cagccctggc cctccctccc
     2881 ctctgctggc cagagggtct gcatctcagc ccacccccaa ccccaccgtt tggggtgaga
     2941 agcagaatct gtgcttcccc agtctccttg ccccagacaa ccagcatgta agacccttcc
     3001 cgcttcacca ttccgattcc tgtccccttt ggggtacttg ggggagactc tggctcccag
     3061 gatctgttcc ctatttcagt gccttcctag gacacagggg actccttgac gctccccagg
     3121 ctttctgtgc ccaggcctct gtccccagcg gtgaggttgc agtgagtgaa ggagaggagg
     3181 tgatctgttc tccctcccct tctgcccatc tccagcatct tcttcccctt ccctggccct
     3241 gcagggcctt ctccagctcc ctttggttag tccctggcca tccctcctgt cctggatccc
     3301 ttctccctaa ctgcaaaatg cctgcagctt ccagctcctt cgtccctgat cctcaagcgg
     3361 ttccctcccg tctcagctca gcggatcccc cagagtggag gaggcctctc catgaggagg
     3421 ggagcagccc aaggcacctg tcctctgacc caccggcagc gagtgcgcag gtgtgagtgt
     3481 aagttcatgt aggagagtgt atgcgtgtgc gcctgtgccc tgcttgcagg caagcagggc
     3541 tccctcatgt agccccgcct tccccctgct gggggtccac cacatcgctg ctctttctca
     3601 cagtctgcct ctgatgaggg cgaattgcta tgacattcca agctccaata aagactgtcc
     3661 caga
//
