LOCUS       NM_032523              10652 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens oxysterol binding protein like 6 (OSBPL6), transcript
            variant 1, mRNA.
ACCESSION   NM_032523
VERSION     NM_032523.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10652)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 10652)
  AUTHORS   Herold,C., Hooli,B.V., Mullin,K., Liu,T., Roehr,J.T.,
            Mattheisen,M., Parrado,A.R., Bertram,L., Lange,C. and Tanzi,R.E.
  TITLE     Family-based association analyses of imputed genotypes reveal
            genome-wide significant association of Alzheimer's disease with
            OSBPL6, PTPRG, and PDCL3
  JOURNAL   Mol Psychiatry 21 (11), 1608-1612 (2016)
   PUBMED   26830138
  REMARK    GeneRIF: family-based GWAS of imputed SNPs revealed novel genomic
            variants in (or near) PTPRG, OSBPL6, and PDCL3 that influence risk
            for Alzheimer's Disease. rs7609954 in the gene PTPRG, rs1347297 in
            the gene OSBPL6, and rs1513625 near PDCL3.  In addition, rs72953347
            in OSBPL6 and two SNPs in the gene CDKAL1 showed marginally
            significant association with LOAD (rs10456232, P-value=4.76 x 10-7;
            rs62400067, P-value=3.54 x 10-7).
REFERENCE   3  (bases 1 to 10652)
  AUTHORS   Ouimet,M., Hennessy,E.J., van Solingen,C., Koelwyn,G.J.,
            Hussein,M.A., Ramkhelawon,B., Rayner,K.J., Temel,R.E., Perisic,L.,
            Hedin,U., Maegdefessel,L., Garabedian,M.J., Holdt,L.M., Teupser,D.
            and Moore,K.J.
  TITLE     miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates
            Cholesterol Trafficking and Efflux
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (5), 942-951 (2016)
   PUBMED   26941018
  REMARK    GeneRIF: Oxysterol-binding protein-like 6 is a novel regulator of
            cholesterol trafficking that is part of the miR-33 and miR-27b
            target gene networks contributing to the maintenance of cholesterol
            homeostasis.
REFERENCE   4  (bases 1 to 10652)
  AUTHORS   Smith,J.G., Avery,C.L., Evans,D.S., Nalls,M.A., Meng,Y.A.,
            Smith,E.N., Palmer,C., Tanaka,T., Mehra,R., Butler,A.M., Young,T.,
            Buxbaum,S.G., Kerr,K.F., Berenson,G.S., Schnabel,R.B., Li,G.,
            Ellinor,P.T., Magnani,J.W., Chen,W., Bis,J.C., Curb,J.D.,
            Hsueh,W.C., Rotter,J.I., Liu,Y., Newman,A.B., Limacher,M.C.,
            North,K.E., Reiner,A.P., Quibrera,P.M., Schork,N.J.,
            Singleton,A.B., Psaty,B.M., Soliman,E.Z., Solomon,A.J.,
            Srinivasan,S.R., Alonso,A., Wallace,R., Redline,S., Zhang,Z.M.,
            Post,W.S., Zonderman,A.B., Taylor,H.A., Murray,S.S., Ferrucci,L.,
            Arking,D.E., Evans,M.K., Fox,E.R., Sotoodehnia,N., Heckbert,S.R.,
            Whitsel,E.A. and Newton-Cheh,C.
  CONSRTM   CARe and COGENT consortia
  TITLE     Impact of ancestry and common genetic variants on QT interval in
            African Americans
  JOURNAL   Circ Cardiovasc Genet 5 (6), 647-655 (2012)
   PUBMED   23166209
REFERENCE   5  (bases 1 to 10652)
  AUTHORS   Eriksson,N., Benton,G.M., Do,C.B., Kiefer,A.K., Mountain,J.L.,
            Hinds,D.A., Francke,U. and Tung,J.Y.
  TITLE     Genetic variants associated with breast size also influence breast
            cancer risk
  JOURNAL   BMC Med Genet 13, 53 (2012)
   PUBMED   22747683
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10652)
  AUTHORS   Maestrini,E., Pagnamenta,A.T., Lamb,J.A., Bacchelli,E., Sykes,N.H.,
            Sousa,I., Toma,C., Barnby,G., Butler,H., Winchester,L.,
            Scerri,T.S., Minopoli,F., Reichert,J., Cai,G., Buxbaum,J.D.,
            Korvatska,O., Schellenberg,G.D., Dawson,G., de Bildt,A.,
            Minderaa,R.B., Mulder,E.J., Morris,A.P., Bailey,A.J. and
            Monaco,A.P.
  CONSRTM   IMGSAC
  TITLE     High-density SNP association study and copy number variation
            analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4
            gene region in autism susceptibility
  JOURNAL   Mol Psychiatry 15 (9), 954-968 (2010)
   PUBMED   19401682
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10652)
  AUTHORS   Lehto,M., Tienari,J., Lehtonen,S., Lehtonen,E. and Olkkonen,V.M.
  TITLE     Subfamily III of mammalian oxysterol-binding protein (OSBP)
            homologues: the expression and intracellular localization of ORP3,
            ORP6, and ORP7
  JOURNAL   Cell Tissue Res 315 (1), 39-57 (2004)
   PUBMED   14593528
REFERENCE   8  (bases 1 to 10652)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   9  (bases 1 to 10652)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
REFERENCE   10 (bases 1 to 10652)
  AUTHORS   Laitinen,S., Olkkonen,V.M., Ehnholm,C. and Ikonen,E.
  TITLE     Family of human oxysterol binding protein (OSBP) homologues. A
            novel member implicated in brain sterol metabolism
  JOURNAL   J Lipid Res 40 (12), 2204-2211 (1999)
   PUBMED   10588946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB208898.1, AC011743.9,
            AF323728.1, AC009948.3 and CA425863.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032523.3.
            
            Summary: This gene encodes a member of the oxysterol-binding
            protein (OSBP) family, a group of intracellular lipid receptors.
            Most members contain an N-terminal pleckstrin homology domain and a
            highly conserved C-terminal OSBP-like sterol-binding domain.
            Transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. It encodes isoform a which contains both a pleckstrin
            homology domain and a sterol-binding domain.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.103586.1,
                                           SRR1803612.4779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000190611.9/ ENSP00000190611.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1382              AB208898.1         32-1413
            1383-1407           AC011743.9         59955-59979
            1408-1979           AF323728.1         1273-1844
            1980-3531           AB208898.1         2086-3637
            3532-6535           AC009948.3         2363-5366
            6536-7192           CA425863.1         18-674              c
            7193-10652          AC009948.3         6024-9483
FEATURES             Location/Qualifiers
     source          1..10652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..10652
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /note="oxysterol binding protein like 6"
                     /db_xref="GeneID:114880"
                     /db_xref="HGNC:HGNC:16388"
                     /db_xref="MIM:606734"
     exon            1..163
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            164..358
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            359..615
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             514..3318
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /note="isoform a is encoded by transcript variant 1;
                     OSBP-related protein 6; oxysterol-binding protein-related
                     protein 6; ORP-6"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 6
                     isoform a"
                     /protein_id="NP_115912.1"
                     /db_xref="CCDS:CCDS2277.1"
                     /db_xref="GeneID:114880"
                     /db_xref="HGNC:HGNC:16388"
                     /db_xref="MIM:606734"
                     /translation="MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTAS
                     SSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLK
                     GWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYH
                     LKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDG
                     KMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELS
                     KLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQVPFSA
                     TMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSA
                     FNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESII
                     CDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSS
                     ENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDT
                     SNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYER
                     MVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACH
                     CESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGR
                     RWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWH
                     EGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPD
                     QRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSND
                     TYWELRKDPGFSKVDSPVLW"
     exon            616..708
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            709..831
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            832..885
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            886..999
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1170
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1303
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1407
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1500
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1666
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1800
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1908
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2046
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2134
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2388
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2526
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2590
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2669
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2814
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2815..2959
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3086
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3209
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..10652
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3360..3365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /note="hexamer: AATAAA"
     polyA_site      3381
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /note="major polyA site"
     regulatory      6924..6929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /note="hexamer: ATTAAA"
     polyA_site      6943
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /note="major polyA site"
     regulatory      10631..10636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
                     /note="hexamer: AATAAA"
     polyA_site      10652
                     /gene="OSBPL6"
                     /gene_synonym="ORP6"
ORIGIN      
        1 gtcggtgctg gagatcgcgg ctcggtgcag gcggcgccca tgcctcctct cctccactag
       61 cccgcgcgcc agtccgcctg ccggggccgg ctctccgcct cctgcctccc gtcgcagccg
      121 cgcagccgcc gcagagtccg cggcgccacc gctcgccctc caggttctgc cacttgctgg
      181 gaaaacagca acagaaggat attaaggagc cacccctata atttacccag atagccccag
      241 caaggtcaaa gacatatcat gtcccaagga gaaaagctgc aggcatctga ggataaatca
      301 ctgtgaaaca gctttgacca taaagctgac ttggaagact ttgactccaa ggtgcaaggt
      361 ggtttggaca ccctcaatat tgcctgctct tttctagtca aacctgattc atgaaatgga
      421 atgaagctga aaaatcatct acttctttgt ttgtggattt gagagaagat tgggatggtc
      481 ttaagtgcat aaaacgagac tctaactgca gcgatgagtt cagatgagaa gggcatttcc
      541 cctgctcata aaacatccac tccaacccat agaagtgcct cctcttcaac atcctcccaa
      601 agggacagta ggcagagtat tcacatactg gagaggactg cttcctctag caccgagccc
      661 tctgtaagtc ggcaattgct agaaccggag ccagtccccc tctccaagga agctgacagc
      721 tgggaaatta tagaagggct gaaaataggc caaaccaatg tccagaaacc agacaaacat
      781 gagggcttta tgctgaagaa aagaaaatgg cctttaaaag gctggcacaa gcgttttttt
      841 gtcctggata atggaatgtt aaagtattca aaggcaccac tcgatattca gaaaggaaag
      901 gtccatggga gcatagatgt gggactctca gtcatgtcaa ttaaaaagaa agctcgaaga
      961 atagaccttg acaccgaaga gcacatctat catttgaagg tgaaatccca ggactggttt
     1021 gatgcatggg tctccaaact gcgacatcat cggttgtatc gtcagaatga aattgtgaga
     1081 tcaccaagag atgctagttt tcacatattt ccttcaacgt ccacagctga atcctcacca
     1141 gctgctaatg tttctgtaat ggatggaaag atgcaaccaa acagctttcc gtggcagtcc
     1201 cctttaccat gcagcaatag cctccctgca acgtgcacaa ctggccagag taaagtggca
     1261 gcctggttac aggactcgga agagatggac aggtgtgcag aagatcttgc acattgccag
     1321 tcaaaccttg tggaacttag caaactcctg caaaatttgg aaatacttca gagaactcag
     1381 tcggcaccta actttactga catgcaggct aactgtgtag atatttcaaa gaaagacaag
     1441 cgggtcacaa gacgatggag aacaaaaagt gtcagcaaag atacaaaaat acaactgcag
     1501 gttcctttca gtgctaccat gtcaccagtt cgcttgcatt cctccaaccc caacctttgt
     1561 gcagatattg aatttcagac tccccctagc cacctcactg accctctgga aagttcaaca
     1621 gattatacaa agctgcaaga agaattttgt ctaatcgcac agaaagtgca ttctcttttg
     1681 aagtctgcat ttaatagcat agctatagag aaggagaagc tgaagcagat ggtttccgag
     1741 caggatcaca gtaaaggcca cagcacgcag atggcacggc tccgacagtc actgtctcag
     1801 gcactcaacc agaatgctga actaaggagt cggttgaaca gaatacattc agagtctatt
     1861 atttgtgatc aggttgtcag tgtaaatatt attcctagcc ctgatgaggc tggtgagcaa
     1921 atccatgtca gtctcccctt atcacagcaa gtagccaatg agagccgcct ctccatgtca
     1981 gagtctgttt ctgagttctt tgatgcccaa gaggtgctcc tctctgcaag ttcgtcagag
     2041 aatgaggctt cagatgatga gtcttacatc agtgatgtga gtgataatat atctgaagac
     2101 aacaccagtg ttgcagacaa tatttctcgg caaatcctga atggggagct tacaggaggg
     2161 gccttccgaa atgggcgtcg agcatgcctg ccagctcctt gtcctgacac cagtaacatt
     2221 aacctgtgga atatcttgag gaacaacatt ggtaaagacc tgtctaaagt ctctatgcct
     2281 gtggagctaa acgagccgct caacaccctg cagcacctct gtgaggaaat ggaatacagc
     2341 gagctcctgg acaaggcttc ggaaactgat gatccatatg agcgcatggt tctcgttgcc
     2401 gcatttgcag tttcaggata ctgctccacc tatttcagag caggaagtaa gccattcaac
     2461 ccagtccttg gggagactta tgaatgcatt agagaagaca agggattccg ctttttctca
     2521 gaacaggtta gccatcatcc acccatttct gcctgtcact gtgaatcaaa gaattttgtg
     2581 ttttggcaag atatcagatg gaaaaacaag ttctggggga agtcgatgga aatcctgcct
     2641 gttggaacac tgaatgtcat gcttccaaag tatggagatt actatgtgtg gaataaagtc
     2701 accacttgca tacacaacat cctcagtggg agaagatgga tagaacatta tggagaagta
     2761 accatcagaa ataccaaaag cagtgtttgc atttgcaaac tcacatttgt caaggtgaat
     2821 tattggaatt ctaacatgaa tgaagtccag ggggtggtga tagatcagga ggggaaggcg
     2881 gtgtaccggc tgtttggaaa gtggcatgaa ggactctact gtggtgtggc cccctctgca
     2941 aagtgcattt ggagaccagg ttccatgcca acaaactatg agctgtacta tggcttcaca
     3001 aggtttgcta ttgagctcaa tgagttagat ccagtactaa aagatctcct tccaccaaca
     3061 gacgcccggt tccggccaga tcaaagattt ttggaagaag gaaatttaga agctgcagca
     3121 tcagagaagc aaagagtaga ggaactccag agatctcgga gacgatatat ggaagaaaac
     3181 aatcttgaac atataccaaa attttttaaa aaagttattg atgccaatca aagagaagcc
     3241 tgggtttcta acgacaccta ctgggagctt cgaaaggacc ctgggtttag caaagtagac
     3301 agccctgttc tttggtagac tgggaatgta gagctagcca acatatcaca ttctgaatga
     3361 ataaataact atgcacaatt atgtttctta tagctatgtg tggtttctgg gtcaactgaa
     3421 aacctaccat ttgcttttct attcatcttt ataatggact ttcagaagtg cattagacaa
     3481 ggcccctaac cactttggga tcctttctgt tttgctgcaa ccatattcct taaaaaaaaa
     3541 aaaaaaaaaa aaaaaaaaat ccacaccgtc cttggaaagc agaataaaag gagcagaata
     3601 taaaatccaa agtctgacca gtttgtaaag aaaaacaaat ggtaactggt gcttaaagct
     3661 gatcaagaaa gttaacaaca acatagaaac cacacgattg ttccactgtc tggaagcacc
     3721 atcccctatc gcaggactcc tgggccacaa gcagtcggtc agtgcagact tcaagtgtgt
     3781 ctgtttgatg tggtgtgatt gtgctggcct tgtcgaaaaa gatgtgatgc ttctcagaac
     3841 ctgttccatc tgtatgccat tgttcatgcc ttaagaaatg caaagatgta caataaatca
     3901 tttttaaaat gtgtgctcat aggtttatgt gaagaacaga ttttttgaat catggcatga
     3961 ttcactttct caatcaggac aattatgaga ctaacttaaa tgggtttttt aaaagtgaac
     4021 aacacgtgct ttactctgat aagtcagtta ccatatggta tgtctgaagg gaaagaagga
     4081 aaagacgtgc taagtagatc tctgtattta cgtggctcgt taatttcctg tcctgcgtcc
     4141 agataataaa ccatccctct tccacctaac ctcacagtgt gccctattat ttggaaaaat
     4201 ctgtctttga tttggacatt tggtcatcag tgttaaaacc ttaaaaggaa ataacaaaaa
     4261 gcatatggaa ttcctgtgtg ggcttagtag tactataaat gtaattgttt ttgagtgaag
     4321 caccatgtaa tccatgtctc aatcccatgc ccgctccact gacactagtc gaattccact
     4381 gagaacagaa gcaagaataa tagtagttta tttgcattgt ttaaatgaat tctatgcaaa
     4441 atcatatttc aaattttcat caagtgattc catatggtac atggctacat attaagcatt
     4501 taccttgcta ttggcagaga tatgaaactt aagctaagga atgtatccat cccaaagcag
     4561 gaaagcagaa gtgtgttttg catacttcag gatttgtttt tcctccacta atatacagag
     4621 gcttttgcag aaaacttgca tcagtattcc tgtttctgca cgtaggtgac tatataaatg
     4681 cctgtatgtt ttttttaaaa tatctcctca gagattttcc tagggaatta taaaattaca
     4741 tatattttat tgttagttag atgtttattc ttggattctt accattagaa tttaagtgtt
     4801 atttaaaact ctgatacagt tacagacact ttacatttta ttatgaggtg ttgattttag
     4861 tggtatttct cctcagcaaa gcattcctaa taatggctaa tacaccatca aatgaaaaac
     4921 tgctgatgag agtgtaagag aaagcgctaa cgtttccact agatggcgca atattttatt
     4981 tatccaaaac tcctcccttg catctgagtt tttatgttat gtgtacagtc tgcattagct
     5041 tagaatggaa tttcattctc aggtaaattt tcgaatccat caccagatct aagcattctg
     5101 cttcaacaat accctctcta ttcctctcat tcccatttta aatccatagg tggcttgccc
     5161 tgcggcagta aaatcttccc cttgatattg attctttttc tgctcattca tcttgatgtt
     5221 ctttttctgc atcctgagat acatgtcgtt aattttaata agaatcctat tgacttcctc
     5281 acgggagtct gttctcctat ggttgataaa gctttaaata ctatttaaag tggttctggt
     5341 ctgtacttac tagcacttcc ctgaacagtc tcaaaatagc ctaaacataa gaaaacaatc
     5401 ctgcaaagta aaggttttta caagcagaga tgaaggaaag ggagcagcag ctgaccatca
     5461 gatgtggtat caggtagctg gaagaggatc caggacccat cagggaagca acgactgtac
     5521 ttagcaattt gggttataat tacaaaaaag aaaaaatagt agaaaggatc tttaccagac
     5581 agtaaggtca tggtacaaat caggtgagtg aatgttggtc agaggtagcc tgacactctg
     5641 atgaggactt caagatgaga atgagaaaaa tgtctattaa aatcactaca tttgataata
     5701 tctcagattt agaatctctt ttgggattca gatagtctga ttattccaat tcaagtgttc
     5761 agttaagttt tagttactat tcctataata cccaattcac taatatcata tctcctgtgg
     5821 aatattcatt ggtgcgatgg cctcatcccc ttttttactt tttattgaca tggtggttat
     5881 aaaatgaaga gacttactct attggaattt tcatctacgt agtatttggg ctgtcaagac
     5941 taaatagcaa aagggtagaa tattagatca ttctcttaat aagacctgat ttattcctta
     6001 ggatgttata caaacctttt tatttcaggc ctactttctt gttttttcct aaaaggatct
     6061 aggatagagg agaacataat atgcctgtat acttctccca tggtttattc ataagctgct
     6121 tcatctcatt ggagatggtc attgaggaga gcagtaataa gtgacgatga ttctgaggac
     6181 ttggctagac tgagcggatc aatggcacac accagcactg gtagaggctg accagaagct
     6241 catcgattcc atatgctgtc acccagggtg cagatttact ctcttttgct gttattttat
     6301 tgtttttctt aaattaagcc attgtttttc atggattatt tttaaaatac ctaccccata
     6361 attttcaggc aattgtaaaa ataaacctta tttaagataa cttttaatgg tacatatcaa
     6421 ctatatgtgg ggaaaaaatg caattttctg ggcaagagaa accaaaggat tttcaatata
     6481 tgagatgcca ggttgtcaat tttctaaacc ttttcctcta gattattctg gccctaggcc
     6541 tttcagcaac cccactaatc aattattaga tcctgcccca aggagcagtg gcttgggggc
     6601 tggatttagg gaggaaaacc tgattaaact gttttgctta gtactggtta cagctgtagc
     6661 tggagaagag tttataatca taaagtacat ttttgttatt accttgtgga ttttaattat
     6721 ccatcttgtc taatcttgtt ctctgtcatc ctagataatg aggtgtttgt gggagcagag
     6781 ctctgcacac accaggggat gtaataaatg tttgcacttg gcccagtata ttatgaatgt
     6841 ggcacagtaa ataaagtttg tgtacaaaat actagtttat ttctatggga gccattatgt
     6901 tcaggatata taaaatgtat ctaattaaac aattttgaat ctattttgtg ctctagaaat
     6961 gttcttttgg ggaaagatgg aaagaaatgt ataaatggag ttaagattaa agtatttggg
     7021 gttttttttc cccaaaagct tcccagttgt ttagaaataa tactatccaa agtaggattc
     7081 ggtcctgtaa gtcctaactg aatttctttt gtaaaactga tacgtttaaa ctgtacattg
     7141 cataatcatt ctgttaaact aaacctttgt ttaatacata attgtaagag catatatttg
     7201 ttattgaatt gaaagacttt ttttgtagct tttgctttta aagaagatgg caaattatct
     7261 aagaaagact tagctttatt acgtccaaaa tgagatctaa agaaggaggt ctttaaaaat
     7321 tgttgtgatg gaccaacatg tccaacatct taagcaaatg aagcttcatg attaaggcag
     7381 cttacagata agtggaaaag aacttacctg tcatatgcat ccttttgttt tccaaaacaa
     7441 catctgattt agttcatttt ctccagcctt gctcctaaca tagtgaaagg catagataca
     7501 catgtatgtt cttttacact gtgtcattgt ttgtaaaata tacagtattt atgtacagtt
     7561 tcagagacat tcaatattga aaaccacttc agttagcctc ctagtgaata ctattaattt
     7621 ttcatggatt acatattacc atatgacccc ataaatacat tttattagtt actttggtat
     7681 cttcaaattg gtaagaaaaa aacataaaac aaaaatgttc ttattttctg caattttttt
     7741 ttctagccat tccttcctcc caaatagaag tgagggcaat tgtagagaga ggaatattaa
     7801 gttttcataa agcaaagtat catcttattt gtgttccacc tgtttcttct aacacttaat
     7861 tcataaagtg agcaattgaa cttcttaata ctgttagaga atatgctaga actattactt
     7921 cttttatctt agacacccac tttcccttaa ttctcatcta tttagttttt taataaaatt
     7981 gttgctagaa tttttttgtc ttttcaagtt ctttttttgt taattttatt gatattgctg
     8041 tacttttttt tttttttttg agacagagtc ttgagtgctc tgtcacccag gctggagcgc
     8101 aatggcacaa tctcggctca ctgcagcctc cgcctcccag gttcaaggga ttcttgtgcc
     8161 tcagcctccc gagtagctgg gtttacaggc gtgtgccacc cacctagcta atttttgtat
     8221 tttagttaga gacgggggtt ttgccatgtt ggccaggctg gtctcgaact cctgacctca
     8281 agtgtttcac ccgcctcagc cccccaaagt gctgggatta caggtgtgag caaccgcgcc
     8341 tggactcaag ttctttttaa agcttgatta aggtataacc gacatataat acacttcgca
     8401 tatttgaaca gtacttgata cagtttgatg tatgtatata cccttgacat aatcaaaata
     8461 gtgaacatat ctatcatccc caaaagtttc ccctgcccct ttgtaatcct tccccatcct
     8521 ctatcctgag gcaaccattg atctgctttt attattttta aaagttagcg tattttctta
     8581 tatgtattgc atatgggatt tttctagaag gccacgtgca tatgcaccct ccccttccat
     8641 taccccagta tccgccatca agtagtaaca tgttgtaaca gaaagaatcc cattaagtcc
     8701 tagttctggt agcccggtac aaattttaga ttttccccca aaaatgaaaa aaaattattt
     8761 aaaaaattta gatttgaaat gcttagaaaa caatcattta tttttttatg tcaaaatgtc
     8821 caagtaaatt aatggattaa tttccatgct tctggtgatg taacaccact tggtggtggc
     8881 gctgaggaaa ccctgggaag tgtttttctc ttctgtgtaa tgaaagactc actgacaaag
     8941 ccgtcggtat ccagaatgac tgctcttgaa atgatatttt gatgatgatg atcagggaag
     9001 tagcctatgc tgatttattt atcatccccc caccccaacc ccacttttgt gtcacaaaca
     9061 tttgaaacac ccagtgctca agaatgctgc ttttccaatt ctgctaatat cctctctccc
     9121 catctggaaa caaagttact aaacctagtt ttgaaaaagc aatggaaatg aaagtgtcca
     9181 gtgaacttac tggcagttgt gcaagttgaa agcttattcc ttacatcctg agcctaaaag
     9241 ccttattcct tatatccgga gcctaaaagt ttgctcaaaa gtagaaaact ttccagacaa
     9301 gatcacatac aaaatggtta acatgaaatg ctaatgaaga aacaaggcaa gaatgaatac
     9361 aagagaaatg gaatctgggg aaaaaagtag gttctctaac tggggcaggg atcttgcttc
     9421 ttgggggcat atggttggat cccaggtggg ccacgaaaat catcttggat atttgtttac
     9481 aggctgattc ctgagtttcc ctccaaagat tctgagtcca cagatctagg gtgtggaccg
     9541 agaatcctca ttgtaacaag caccctctgc ccccgggaca ttttaaggta gatggagaac
     9601 taaggtgaga gtgtgccagc taaatactct ttcctttgtc cctgtgcctc agtctttttt
     9661 gtttgttttt tttcatgtga cactcagtag gaaagtctag ttcaagaacc ggaaactgag
     9721 ccgggcatgg tggtgcgcac ctgtagtccc agctactcag gaggctgagg caggaggatg
     9781 gcttgagcct gacgcccatg ccgctgtgag ctatgattgc accactgccc tgagcctgga
     9841 cgacagagca agttcctgtc ttaaaaaaaa aagtaataaa aaagacattt aaaaaaaaat
     9901 tagagctcag tgacctgtga ctcactttgc cactttgtca ttttcttgac ttctgtccca
     9961 acgccagccc tgtaatatgg agataaagag tggggaggac agaactctga aacctaaaag
    10021 gcaagatttt tgctaaaccg gagaacgtaa aaatacattc ctagaggcaa tctaaccagc
    10081 cagataacca gaagtttact cttcaaagcc aagaatcagt acccccacct caccttccat
    10141 tctctcttag gctttgtcta tgtctctaag gggagttttt cagttgactg atgaggtcct
    10201 gactggtagg gaaagcctgc agggaaatcc tgtggcaaag cacactcttg atcacctact
    10261 taacaagaag gtctagcagg acattcttga tccaggtcag cttcttccct gaaaataata
    10321 catattttta atttctgttt gaaaaaactc cactgtgaaa ttactctgct tatattagaa
    10381 ggtatgaaga cagtagttat gtactgttcg tttgcatacg gtcattttga gatagaaaaa
    10441 ttaaattttt ttaggaaaag aatttcaagc aactttctac gaaaatacag cttgtggtta
    10501 aatttcctaa tgaaagagga attattcact gaaaaatttg tctaatctgt gccacctcaa
    10561 aataagaatt gtgcctcttc aatgaatgtt gtatatgaga atgttacatt tgtaacagca
    10621 caggaaactc aataaattat aaatgaatta ca
//
