LOCUS       NM_020896               3854 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens oxysterol binding protein like 5 (OSBPL5), transcript
            variant 1, mRNA.
ACCESSION   NM_020896
VERSION     NM_020896.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3854)
  AUTHORS   Wu,Y., Min,L., Zhang,P., Zhang,L., Xu,Y., Li,D., Zheng,M., Pei,D.
            and Wang,Q.
  TITLE     ORP5 promotes migration and invasion of cervical cancer cells by
            inhibiting endoplasmic reticulum stress
  JOURNAL   Cell Stress Chaperones 28 (4), 395-407 (2023)
   PUBMED   37314629
  REMARK    GeneRIF: ORP5 promotes migration and invasion of cervical cancer
            cells by inhibiting endoplasmic reticulum stress.
REFERENCE   2  (bases 1 to 3854)
  AUTHORS   Santos,N.C., Girik,V. and Nunes-Hasler,P.
  TITLE     ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at
            Membrane Contact Sites?
  JOURNAL   Biomolecules 10 (6), 928 (2020)
   PUBMED   32570981
  REMARK    GeneRIF: ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer
            Proteins at Membrane Contact Sites?
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3854)
  AUTHORS   Sandhu,J., Li,S., Fairall,L., Pfisterer,S.G., Gurnett,J.E.,
            Xiao,X., Weston,T.A., Vashi,D., Ferrari,A., Orozco,J.L.,
            Hartman,C.L., Strugatsky,D., Lee,S.D., He,C., Hong,C., Jiang,H.,
            Bentolila,L.A., Gatta,A.T., Levine,T.P., Ferng,A., Lee,R.,
            Ford,D.A., Young,S.G., Ikonen,E., Schwabe,J.W.R. and Tontonoz,P.
  TITLE     Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER
            Cholesterol Transport in Mammalian Cells
  JOURNAL   Cell 175 (2), 514-529 (2018)
   PUBMED   30220461
REFERENCE   4  (bases 1 to 3854)
  AUTHORS   Pulli,I., Lassila,T., Pan,G., Yan,D., Olkkonen,V.M. and
            Tornquist,K.
  TITLE     Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate
            calcium signaling at specific cell compartments
  JOURNAL   Cell Calcium 72, 62-69 (2018)
   PUBMED   29748134
  REMARK    GeneRIF: ORP5/8 regulate Ca(2+) signaling at specific membrane
            contact sites foci.
REFERENCE   5  (bases 1 to 3854)
  AUTHORS   Sohn,M., Korzeniowski,M., Zewe,J.P., Wills,R.C., Hammond,G.R.V.,
            Humpolickova,J., Vrzal,L., Chalupska,D., Veverka,V., Fairn,G.D.,
            Boura,E. and Balla,T.
  TITLE     PI(4,5)P2 controls plasma membrane PI4P and PS levels via ORP5/8
            recruitment to ER-PM contact sites
  JOURNAL   J Cell Biol 217 (5), 1797-1813 (2018)
   PUBMED   29472386
  REMARK    GeneRIF: ORP5/8 recruitment to the plasma membrane occurs through
            interactions with the N-terminal Pleckstrin homology domains and
            adjacent basic residues of ORP5/8 with both phosphatidylinositol
            4-phosphate and Phosphatidylinositol 4,5-bisphosphate.
REFERENCE   6  (bases 1 to 3854)
  AUTHORS   Ma,J., Dempsey,A.A., Stamatiou,D., Marshall,K.W. and Liew,C.C.
  TITLE     Identifying leukocyte gene expression patterns associated with
            plasma lipid levels in human subjects
  JOURNAL   Atherosclerosis 191 (1), 63-72 (2007)
   PUBMED   16806233
REFERENCE   7  (bases 1 to 3854)
  AUTHORS   Higashimoto,K., Soejima,H., Yatsuki,H., Joh,K., Uchiyama,M.,
            Obata,Y., Ono,R., Wang,Y., Xin,Z., Zhu,X., Masuko,S., Ishino,F.,
            Hatada,I., Jinno,Y., Iwasaka,T., Katsuki,T. and Mukai,T.
  TITLE     Characterization and imprinting status of OBPH1/Obph1 gene:
            implications for an extended imprinting domain in human and mouse
  JOURNAL   Genomics 80 (6), 575-584 (2002)
   PUBMED   12504849
  REMARK    GeneRIF: OBPH1/Obph1 gene is imprinted, with preferential
            expression from the maternal allele in human and mouse.
REFERENCE   8  (bases 1 to 3854)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   9  (bases 1 to 3854)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
REFERENCE   10 (bases 1 to 3854)
  AUTHORS   Laitinen,S., Olkkonen,V.M., Ehnholm,C. and Ikonen,E.
  TITLE     Family of human oxysterol binding protein (OSBP) homologues. A
            novel member implicated in brain sterol metabolism
  JOURNAL   J Lipid Res 40 (12), 2204-2211 (1999)
   PUBMED   10588946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC400863.1, BC039579.1,
            AC108448.12 and AL136918.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020896.3.
            
            Summary: This gene encodes a member of the oxysterol-binding
            protein (OSBP) family, a group of intracellular lipid receptors
            that play a key role in the maintenance of cholesterol balance in
            the body. Most members contain an N-terminal pleckstrin homology
            domain and a highly conserved C-terminal OSBP-like sterol-binding
            domain. This gene has been shown to be imprinted, with preferential
            expression from the maternal allele only in placenta. Transcript
            variants encoding different isoforms have been identified.
            [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Isoform a has a pleckstrin homology domain and a
            sterol-binding domain.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056510.1, AB074006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 12504849
            MANE Ensembl match     :: ENST00000263650.12/ ENSP00000263650.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                DC400863.1         43-89
            48-2764             BC039579.1         1-2717
            2765-3832           AC108448.12        48195-49262         c
            3833-3845           AL136918.1         3799-3811
            3846-3854           AC108448.12        48173-48181         c
FEATURES             Location/Qualifiers
     source          1..3854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3854
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /note="oxysterol binding protein like 5"
                     /db_xref="GeneID:114879"
                     /db_xref="HGNC:HGNC:16392"
                     /db_xref="MIM:606733"
     exon            1..95
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            96..252
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..2756
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /note="isoform a is encoded by transcript variant 1;
                     oxysterol-binding protein-related protein 5; OSBP-related
                     protein 5; oxysterol-binding protein homologue 1; ORP-5;
                     oxysterol-binding protein homolog 1"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 5
                     isoform a"
                     /protein_id="NP_065947.1"
                     /db_xref="CCDS:CCDS31344.1"
                     /db_xref="GeneID:114879"
                     /db_xref="HGNC:HGNC:16392"
                     /db_xref="MIM:606733"
                     /translation="MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLS
                     PGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQ
                     KENYRQEKKRATRQLLSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTP
                     KVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPS
                     SYLIFRAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLP
                     ASATVHPDQDLFPLNGSSLENDAFSDKSERENPEESDTETQDHSRKTESGSDQSETPG
                     APVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTF
                     VLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNP
                     ILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYG
                     NSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQA
                     QLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPS
                     GEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRAR
                     ERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVAR
                     QTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFV
                     PGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQ
                     SPRSWFLLCVFLACQLFINHILK"
     exon            253..335
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            336..416
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            417..518
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            519..722
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            723..807
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            808..982
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1175
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1360
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1442
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1541
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1638
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1737
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1835
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1925
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2062
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2248
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2375
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2514
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2617
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..3854
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3555..3560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /note="hexamer: AATAAA"
     polyA_site      3578
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /note="major polyA site"
     polyA_site      3619
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /note="major polyA site"
     regulatory      3819..3824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
                     /note="hexamer: AATAAA"
     polyA_site      3854
                     /gene="OSBPL5"
                     /gene_synonym="OBPH1; ORP5"
ORIGIN      
        1 atctgctggc atttcctgca gccaggcccg cgccgccagt ggagcccccg cgcgcccggc
       61 cggcccggag caccgagctc gcggcacggt aggagaagcc cccgagcgcc cacagcatga
      121 aggaggaggc cttcctccgg cgccgcttct ccctgtgtcc accttcctcc acccctcaga
      181 aagtcgaccc ccggaagctc acccggaact tgctcctcag cggagacaat gagctctacc
      241 cactcagccc agggaaggac atggagccca acggcccgtc gctgcccagg gatgaagggc
      301 ccccgacccc aagctctgcc acgaaggtgc caccggcaga gtacaggctg tgcaacgggt
      361 cagacaagga atgtgtgtcc cccaccgcca gggtcaccaa gaaggagact ctcaaggcgc
      421 agaaggagaa ctaccggcag gagaagaagc gcgccacacg gcagctgctc agcgctctga
      481 cagaccccag cgtggtcatc atggctgaca gcctgaagat ccgcggcacc ctgaagagct
      541 ggaccaagct gtggtgcgtg ctgaagccgg gggtgctgct catctacaag acgcccaagg
      601 tgggccagtg ggtgggcacg gtgctgctgc actgctgcga gctcatcgag cggccctcca
      661 agaaggacgg cttctgcttc aagctcttcc acccgctgga tcagtccgtc tgggccgtga
      721 agggccccaa aggtgagagc gtgggctcca tcacacagcc cctgcccagc agctacctga
      781 tcttcagggc cgcctccgag tcagatggtc gctgctggct ggacgccctg gagctggccc
      841 tgcgctgctc tagcctactg agactgggca cctgcaagcc gggccgagac ggggagccag
      901 ggacctcgcc agacgcatca ccctcatcgc tctgtgggct gccagcctca gccaccgtcc
      961 acccagacca agacctgttc ccactgaacg ggtcttccct ggagaacgat gcattctcag
     1021 acaagtcgga gagagagaac cctgaggagt cagataccga gacccaggac catagccgga
     1081 agacggagag tggcagcgac cagtcagaga cccctggggc cccggtgcgg agagggacca
     1141 cctatgtgga gcaggtccag gaggagctgg gggagctggg cgaggcgtcc caggtggaga
     1201 cagtgtcaga ggagaacaag agtctgatgt ggaccctgct gaagcagcta cggccaggca
     1261 tggacctgtc ccgcgtggtg ctacccacgt tcgtactgga gccgcgctcc ttcctgaaca
     1321 agctctccga ctactactac cacgcagacc tgctctccag ggctgcggtg gaggaggatg
     1381 cctacagccg catgaagctg gtgctgcggt ggtacctgtc tggcttctac aagaagccca
     1441 agggaatcaa gaagccgtac aaccccatcc tgggggagac cttccgctgc tgctggttcc
     1501 acccgcagac tgacagccgc acattctaca tagcagagca ggtgtcccac cacccgcccg
     1561 tgtctgcctt ccacgtcagc aaccggaagg acggcttctg catcagtggc agcatcacag
     1621 ccaagtccag gttttatggg aactcgctgt cggcgctgct ggacggcaaa gccacgctca
     1681 ccttcctgaa ccgagccgag gattacaccc ttaccatgcc ctacgcccac tgcaaaggaa
     1741 tcctgtatgg cacgatgacc ctggagctgg gtgggaaggt caccatcgag tgtgcgaaga
     1801 acaacttcca ggcccagctg gaattcaaac tcaagccctt cttcgggggt agcaccagca
     1861 tcaaccagat ctcgggaaag atcacgtcgg gagaggaagt cctggcgagc ctcagtggcc
     1921 actgggacag ggacgtgttt atcaaggagg aagggagcgg aagcagtgcg cttttctgga
     1981 ccccgagcgg ggaggtccgc agacagaggc tgaggcagca cacggtgccg ctggaggagc
     2041 agacggagct ggagtccgag aggctctggc agcacgtcac cagggccatc agcaagggcg
     2101 accagcacag ggccacacag gagaagtttg cactggagga ggcacagcgg cagcgggccc
     2161 gtgagcggca ggagagcctc atgccctgga agccgcagct gttccacctg gaccccatca
     2221 cccaggagtg gcactaccga tacgaggacc acagcccctg ggaccccctg aaggacatcg
     2281 cccagtttga gcaagacggg atcctgcgga ccttgcagca ggaggccgtg gcccgccaga
     2341 ccaccttcct gggcagccca gggcccaggc acgagaggtc tggcccagac cagcggcttc
     2401 gcaaggccag cgaccagccc tccggccaca gccaggccac ggagagcagc ggatccacgc
     2461 ctgagtcctg cccagagctc tcagacgagg agcaggatgg tgactttgtc cctggcggtg
     2521 agagcccatg ccctcggtgc aggaaggagg cgcggcggct gcaggccctg cacgaggcca
     2581 tcctctccat ccgagaggcc cagcaggagc tgcacaggca cctctcggcc atgctgagct
     2641 ccacggcacg ggcagcacag gcaccgaccc caggcctcct gcagagcccc cgatcctggt
     2701 tcctgctctg cgtgttcctg gcgtgtcagc tgttcattaa ccacatcctc aaataggagc
     2761 cctgagggca gagctcctgg ccggtcctga gccctccctc ccaggcaccc agcactttaa
     2821 gcctgctcca tggaggcaga gaggcccggc aagcacagcc actgtgacgg ggagtccagg
     2881 cgcaggaggg acccggggcc acaaggcgct gcgggcccag gtgtgctggg cccctctcag
     2941 gggcactggc ctctctgcag ggccttccgc ccagcgctgg ccttaatgct aaagccaaat
     3001 gcagcttctg ctgtgcgacg cactcctggc catcttgccg tgtcaccccc tgtccggcct
     3061 ccacttgcca tgggggatgg atggatttag ggtgggaggg cctgtggggg ccctggacag
     3121 tcacacccca gcagcagtga gtgggcaggt ttggaggagc cccgagtggc ccaggagtcc
     3181 ccccacacac agatgcatag gcctgccttc cggagaccct gtccacattg ccgggaccac
     3241 cctggtgggg ccactggtgg gtgccaggga caggttaggg ccactctggg gaaggcattt
     3301 tggtttttta ttccacgctg tgctgtttgg atgggagccc cacagaggca ggtcctggaa
     3361 ccaccccacc cccacacctg gacgctcgct ctggtggggg cacacgcagg tggaggtggt
     3421 tgtgggtgca ggtgtgtgca ggggtgtggg gggcgcaggg gtgtggctta gctggccccg
     3481 cacccaggcc ggggaggctc aagttcgcca ctttactcag accgatgcac agtcttccca
     3541 ttttacactt ttttaataaa cataattgca atattttagg tgggctgcga gctgcagtca
     3601 gccttcacgt ctggcctcag tccccgtgtc agtgccgctc tgcgtgtgcg tgtgcgcgtg
     3661 tgtgagcctc tacacatata tatacgtaca gagccttaaa ccacatcgtg gcggtgccgt
     3721 ctgagctgta gcgggtggct ttgtttccag tttttgtacc cgtgtccttg tctcccctcc
     3781 tcccccatct ggggatgtgt ctgtgttcca caccttgaaa taaacagaca catacgtgtt
     3841 ctcttcttgc ggga
//
