LOCUS       NM_015550               6749 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens oxysterol binding protein like 3 (OSBPL3), transcript
            variant 1, mRNA.
ACCESSION   NM_015550
VERSION     NM_015550.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6749)
  AUTHORS   Wang,X., Liu,J., Azoitei,A., Eiseler,T., Meessen,S., Jiang,W.,
            Zheng,X., Makori,A.W., Eckstein,M., Hartmann,A., Stilgenbauer,S.,
            Elati,M., Hohwieler,M., Kleger,A., John,A., Zengerling,F.,
            Wezel,F., Bolenz,C. and Gunes,C.
  TITLE     Loss of ORP3 induces aneuploidy and promotes bladder cancer cell
            invasion through deregulated microtubule and actin dynamics
  JOURNAL   Cell Mol Life Sci 80 (10), 299 (2023)
   PUBMED   37740130
  REMARK    GeneRIF: Loss of ORP3 induces aneuploidy and promotes bladder
            cancer cell invasion through deregulated microtubule and actin
            dynamics.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6749)
  AUTHORS   Wang,C., He,Y., He,Y., Liang,W., Zhou,C., Wu,M., Meng,Z., Li,W. and
            Cao,J.
  TITLE     Prognostic and biological function value of OSBPL3 in colorectal
            cancer analyzed by multi-omic data analysis
  JOURNAL   BMC Gastroenterol 23 (1), 270 (2023)
   PUBMED   37550605
  REMARK    GeneRIF: Prognostic and biological function value of OSBPL3 in
            colorectal cancer analyzed by multi-omic data analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6749)
  AUTHORS   Aibara,D., Sakaguchi,A. and Matsusue,K.
  TITLE     Oxysterol-binding protein-like 3 is a novel target gene of
            peroxisome proliferator-activated receptor gamma in fatty liver
            disease
  JOURNAL   Mol Cell Endocrinol 565, 111887 (2023)
   PUBMED   36781118
  REMARK    GeneRIF: Oxysterol-binding protein-like 3 is a novel target gene of
            peroxisome proliferator-activated receptor gamma in fatty liver
            disease.
REFERENCE   4  (bases 1 to 6749)
  AUTHORS   Zhang,M., Meng,L., Zhang,Z., Wu,J., Chen,X., Wang,Y. and He,J.
  TITLE     The relationships of OSBPL3 expression with KI-67 expression and
            KRAS mutations in CRC: implications for diagnosis and prognosis
  JOURNAL   BMC Med Genomics 15 (1), 259 (2022)
   PUBMED   36517805
  REMARK    GeneRIF: The relationships of OSBPL3 expression with KI-67
            expression and KRAS mutations in CRC: implications for diagnosis
            and prognosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6749)
  AUTHORS   Hu,Q., Masuda,T., Koike,K., Sato,K., Tobo,T., Kuramitsu,S.,
            Kitagawa,A., Fujii,A., Noda,M., Tsuruda,Y., Otsu,H., Kuroda,Y.,
            Ito,S., Oki,E. and Mimori,K.
  TITLE     Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene
            that promotes tumor growth in part through R-Ras/Akt signaling in
            gastric cancer
  JOURNAL   Sci Rep 11 (1), 19178 (2021)
   PUBMED   34584127
  REMARK    GeneRIF: Oxysterol binding protein-like 3 (OSBPL3) is a novel
            driver gene that promotes tumor growth in part through R-Ras/Akt
            signaling in gastric cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6749)
  AUTHORS   Collier,F.M., Gregorio-King,C.C., Apostolopoulos,J., Walder,K. and
            Kirkland,M.A.
  TITLE     ORP3 splice variants and their expression in human tissues and
            hematopoietic cells
  JOURNAL   DNA Cell Biol 22 (1), 1-9 (2003)
   PUBMED   12590732
REFERENCE   7  (bases 1 to 6749)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   8  (bases 1 to 6749)
  AUTHORS   Gregorio-King,C.C., Collier,G.R., McMillan,J.S., Waugh,C.M.,
            McLeod,J.L., Collier,F.M. and Kirkland,M.A.
  TITLE     ORP-3, a human oxysterol-binding protein gene differentially
            expressed in hematopoietic cells
  JOURNAL   Blood 98 (7), 2279-2281 (2001)
   PUBMED   11568019
REFERENCE   9  (bases 1 to 6749)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
REFERENCE   10 (bases 1 to 6749)
  AUTHORS   Laitinen,S., Olkkonen,V.M., Ehnholm,C. and Ikonen,E.
  TITLE     Family of human oxysterol binding protein (OSBP) homologues. A
            novel member implicated in brain sterol metabolism
  JOURNAL   J Lipid Res 40 (12), 2204-2211 (1999)
   PUBMED   10588946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR003143.1, AB014604.2,
            AC003093.1 and AY008372.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015550.3.
            
            Summary: This gene encodes a member of the oxysterol-binding
            protein (OSBP) family, a group of intracellular lipid receptors.
            Most members contain an N-terminal pleckstrin homology domain and a
            highly conserved C-terminal OSBP-like sterol-binding domain. The
            encoded protein is involved in the regulation of cell adhesion and
            organization of the actin cytoskeleton. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). Isoform a contains a pleckstrin homology domain and a
            sterol-binding domain. It is also known as isoform 1a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY008372.1, AF392444.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313367.7/ ENSP00000315410.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                DR003143.1         66-94
            30-4349             AB014604.2         1-4320
            4350-4350           AC003093.1         105381-105381       c
            4351-6749           AY008372.1         4215-6613
FEATURES             Location/Qualifiers
     source          1..6749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.3"
     gene            1..6749
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /note="oxysterol binding protein like 3"
                     /db_xref="GeneID:26031"
                     /db_xref="HGNC:HGNC:16370"
                     /db_xref="MIM:606732"
     exon            1..293
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            294..538
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..3106
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /note="isoform a is encoded by transcript variant 1;
                     OSBP-related protein 3; oxysterol-binding protein-related
                     protein 3"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 3
                     isoform a"
                     /protein_id="NP_056365.1"
                     /db_xref="CCDS:CCDS5390.1"
                     /db_xref="GeneID:26031"
                     /db_xref="HGNC:HGNC:16370"
                     /db_xref="MIM:606732"
                     /translation="MMSDEKNLGVSQKLVSPSRSTSSCSSKQGSRQDSWEVVEGLRGE
                     MNYTQEPPVQKGFLLKKRKWPLKGWHKRFFYLDKGILKYAKSQTDIEREKLHGCIDVG
                     LSVMSVKKSSKCIDLDTEEHIYHLKVKSEEVFDEWVSKLRHHRMYRQNEIAMFPHEVN
                     HFFSGSTITDSSSGVFDSISSRKRSSISKQNLFQTGSNVSFSCGGETRVPLWLQSSED
                     MEKCSKDLAHCHAYLVEMSQLLQSMDVLHRTYSAPAINAIQGGSFESPKKEKRSHRRW
                     RSRAIGKDAKGTLQVPKPFSGPVRLHSSNPNLSTLDFGEEKNYSDGSETSSEFSKMQE
                     DLCHIAHKVYFTLRSAFNIMSAEREKLKQLMEQDASSSPSAQVIGLKNALSSALAQNT
                     DLKERLRRIHAESLLLDSPAVAKSGDNLAEENSRDENRALVHQLSNESRLSITDSLSE
                     FFDAQEVLLSPSSSENEISDDDSYVSDISDNLSLDNLSNDLDNERQTLGPVLDSGREA
                     KSRRRTCLPAPCPSSSNISLWNILRNNIGKDLSKVAMPVELNEPLNTLQRLCEELEYS
                     ELLDKAAQIPSPLERMVYVAAFAISAYASSYYRAGSKPFNPVLGETYECIREDKGFQF
                     FSEQVSHHPPISACHAESRNFVFWQDVRWKNKFWGKSMEIVPIGTTHVTLPVFGDHFE
                     WNKVTSCIHNILSGQRWIEHYGEIVIKNLHDDSCYCKVNFIKAKYWSTNAHEIEGTVF
                     DRSGKAVHRLFGKWHESIYCGGGSSSACVWRANPMPKGYEQYYSFTQFALELNEMDPS
                     SKSLLPPTDTRFRPDQRFLEEGNLEEAEIQKQRIEQLQRERRRVLEENHVEHQPRFFR
                     KSDDDSWVSNGTYLELRKDLGFSKLDHPVLW"
     exon            539..655
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            656..709
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..823
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            824..991
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1115
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1219
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1312
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1469
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1600
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1708
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1843
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1937
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2188
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2326
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2390
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2469
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2614
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2759
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2886
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..3009
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..6749
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6729..6734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /note="hexamer: AATAAA"
     polyA_site      6749
                     /gene="OSBPL3"
                     /gene_synonym="ORP-3; ORP3; OSBP3"
                     /note="major polyA site"
ORIGIN      
        1 gagaagttct gggcaaagta ctcagaactg gccgcgtgct ggtggcgccc gccagccggc
       61 ccgggagagg ggacttgagc gcttcgcggc cggtgcgcag cgcggctccg gccccgcagt
      121 ctgtctgcaa gtggccatcc ccgcccccga ctcctgcggc cggtgcggga gctgtcagct
      181 gcacgttgcg ggggtaccgg agaagccggg gttgccttct cccggttctg tgcgctaacc
      241 ccggagcccg gccccgggga actagggagc gtctccggct gcacagcgct caggttttag
      301 ggtttccttt gggccaccca aaatgttttt taaatacttt ggataagagc taaaccacct
      361 gccactgggg acttccatac tctcggctcc cttgtcatct gatggcattt tgattgtctc
      421 gaggccaagt gacttgctgt ccatgatgag tgatgagaag aaccttggtg tgtcccaaaa
      481 attggtatca ccttcaagga gcacaagtag ctgctcttcc aagcaaggaa gtcgacagga
      541 cagctgggaa gtggtggaag gactgagggg ggagatgaat tacacccagg agccaccagt
      601 tcagaaagga tttttgctga aaaagaggaa gtggccctta aaaggctggc ataagagatt
      661 cttctatctg gacaaaggaa tcttgaaata tgccaagagc caaaccgata tagagagaga
      721 gaagctgcat ggctgcattg atgtcgggct ctcagtgatg tctgtaaaga agtcatcaaa
      781 atgcatagac cttgacaccg aggagcacat ctaccatctg aaggtcaagt cagaagaagt
      841 ctttgatgag tgggtatcga aacttcgcca ccacagaatg tatcgtcaga atgaaattgc
      901 catgtttcca catgaagtta accacttttt ctcagggtcc accatcacag actcttcatc
      961 tggggtgttt gactccattt caagtaggaa gcgtagcagt atatcaaagc agaatttatt
     1021 tcaaactgga agcaatgtat cattttcttg tggtggtgag acacgagttc cattatggtt
     1081 acagtcttca gaggacatgg aaaaatgctc caaagacctg gcgcactgtc atgcctacct
     1141 ggtagaaatg agccagctcc tgcaaagcat ggacgtcctg catcggacat actcggcacc
     1201 agctatcaac gccatccagg gtggatcttt tgaaagtccc aaaaaggaaa aaagatcgca
     1261 caggaggtgg cggtccagag ctattggcaa agatgctaaa ggaacactgc aggtcccgaa
     1321 acctttttct ggcccagtaa gactacactc ctccaatcct aatttgtcaa cactagattt
     1381 tggagaagag aaaaattatt ctgatggctc tgaaacctca tcagagtttt ctaaaatgca
     1441 agaagatctg tgtcatattg cccataaagt ttacttcact ttaaggtcag cttttaatat
     1501 catgtcagcg gagagagaga aactgaagca gctgatggag caggatgcct cctcctcccc
     1561 gtctgctcag gtcattggtc tgaagaacgc cctgtcatcc gccctagcac aaaacacaga
     1621 tcttaaagaa cgcttacgca gaatccatgc cgagtctctg ctcctcgact cccccgctgt
     1681 cgccaagtcg ggtgacaatc tggcagagga aaactccaga gatgaaaacc gagctctagt
     1741 tcatcagctt tctaatgaaa gtagactctc catcactgac tccctttctg agttttttga
     1801 tgctcaggaa gttctgttat ctccaagctc ttcagaaaac gagatttctg atgatgactc
     1861 atatgtcagt gacataagtg ataatctttc cttagataat ctcagtaatg atttagataa
     1921 tgagagacag accttggggc ctgtccttga tagtggtcgg gaagcgaagt cccggagaag
     1981 aacgtgcctg ccggcgccct gcccgagcag cagtaacatc agcctgtgga acatcctgag
     2041 gaacaacatc gggaaggacc tgtccaaggt ggccatgccg gtggagctga acgagcccct
     2101 gaacacgctg cagaggctct gcgaggagct ggagtacagc gagctcctgg acaaggccgc
     2161 gcagattccc agccccctgg aaaggatggt atatgtggca gcctttgcca tatcagcgta
     2221 tgcatctagc tactaccgag ctggaagcaa gccatttaat ccggttcttg gagaaacata
     2281 tgaatgtatt cgggaggaca agggcttcca gtttttttca gaacaggtca gccaccatcc
     2341 gcctatctct gcgtgtcatg ctgagtctag aaattttgtt ttctggcaag atgtgagatg
     2401 gaaaaacaaa ttctggggca aatccatgga aattgttcca attggcacaa cccatgtgac
     2461 tctgccagtt tttggggatc attttgagtg gaacaaagtg acctcttgca tccataacat
     2521 cttaagcggg cagaggtgga ttgagcacta tggagagatt gtcatcaaga acctgcatga
     2581 tgattcctgc tactgcaaag tgaattttat aaaggcaaaa tactggagca ctaatgccca
     2641 tgagattgaa ggcacagtgt ttgacaggag tggaaaagcg gttcatcggc tgtttgggaa
     2701 atggcatgaa agcatctact gtggcggcgg ctcctcttct gcctgtgtat ggagagcaaa
     2761 tcctatgccg aaaggctacg agcaatacta tagcttcaca cagtttgcgc tggaattaaa
     2821 tgaaatggat ccatcatcaa agtctttatt gccacctact gacactcgat ttaggccaga
     2881 ccagaggttt ctagaggaag ggaacttaga agaagctgaa atacaaaagc agaggattga
     2941 acaactgcag agagaaaggc ggcgggtctt agaagaaaat catgtggagc accagcctcg
     3001 gtttttcagg aaatccgacg atgactcttg ggtgagcaac ggcacctatt tggaacttag
     3061 aaaagatctt ggtttttcca aactggacca tcctgtctta tggtgaaaaa gtaaagaaga
     3121 aagataacat tagtgtattt ctcctgtgct tgccttctga agtggcacaa acctgtgttt
     3181 atatatttaa aagatactct aggatgatca cttgtgctta gcttagcatt gtaactcttt
     3241 aagtctatat tttcctcagt gcgtttcttt acaatttcaa atgttaccct gattgtttat
     3301 atgaatgtag aacaccttga catttctttt tatatataaa ctatttaata aaaatgaaag
     3361 attgaatgtt catgtgtggg ttaaaaaaag aagctttaac actaattttc caaaggttag
     3421 ggaagattcc aattaaattt atgccttata aaattatgtt gtagaaaaaa aatcaacctc
     3481 tcccaggtgc attaagaaat aagaattccc agggttactc acccatgcgt aagctaccca
     3541 agtttaattt ggtagctgaa atatcttttt gcctcagaca gctcttgaat tgctcataca
     3601 gaacaattct gctggtgctg gagtctgaag aatattttca tttgcatttt agtggttagg
     3661 gagaggatat aagattaatg gaatgtatat ttttatataa gacgtatacg gcaccttctt
     3721 gaaaaggaag catttgaact tgttcctccc tatagttcta ttgccttata tgcaaaattg
     3781 taccctgttg ctcagagaaa ttattcataa gagaaaagaa ttccaattaa ttaaatatca
     3841 caatagcatc ccagagagac agtaggaaat ttctccttag tgagagctga gtccttgaga
     3901 agttaagaga ctgtttcctg cttcccaccc caccccgttt tttgtccctc cgtttgatca
     3961 cctccctgtt gagtatggaa tgtcccagtt taatataaaa catacagttt attccacaca
     4021 gcagtttgac tttgtaaaag tttagcaaaa taactgattg ttttggataa ctcaacatgt
     4081 ttttcttaaa tgctgtttta gtattttcta cctcttaata agcaccatat tttagatctt
     4141 gtataaaaag ttgccatctg ccttatagac aaatgtagag aattgatgtt cttgctttgt
     4201 gttgtgttct ggtaaagctt taagtgagtg tcttacccct ttcctatact ttcttgttat
     4261 ccatatcatt cttttgtgag ttttgcagca gtcttgaata atacagatta taactactga
     4321 aaggggaacc ttcgtctttt taaatgtgtt atttcacatt acaataatat gtgtagtagt
     4381 tgaattgtgt tatcaaagca tgtccaactt ctgtccagat gacattaaaa ccaaagccta
     4441 attgttaagc ctcttattct aaagtccata gcaatgctat ggaatatcaa gtataatgat
     4501 gtagtaaaaa gatttctcca gaaaacactt tgagatactt aaagaaattc agagcatatc
     4561 gaatgttatg aatgaagagt aaaataatta caggaaaaga atgcatgatt tttcattgtc
     4621 acaccaaata accagttgga caatattgca ttttcaaaat ggagagttat ttaaagtgga
     4681 tgtgtagcct tctggaatct gcacgtgact ggcattttaa aacaactcat taaatattgg
     4741 attcatttta tcgagatgcc aagatgaaca caatgtgaat atcatttcca tttctaagca
     4801 gttgaatgac acagtcagat tctttggtgt atgctttgtt ctttccatct caagcattta
     4861 tccaaattct gctcacagac atgaggaagc aggctgtaga tttaagggca ctcaagggga
     4921 aaacaaatgt agtttccaca gtgtgaggat aaatgtagaa tcgtggtaat attggctgtt
     4981 aaattggcct gctccagaga ctggctcaaa aaagaaagaa gcaacgaaaa caaaatgcac
     5041 agcctgaatg gacgtagcac tgtcatgtgg catttggaaa atctttaatt atcctaatgt
     5101 tatttcactt gcccttatgc tttattttag agtcccaggg acaactggat gaaacattac
     5161 gtctgtagtc atcttatttg agatgggggt gggaacgaat taaaatatga tagagaacta
     5221 tatgcagatt ttaaaatcta gtcagtacta gcatctataa agggcttttc tgaaatttaa
     5281 acagcttggt gatgcatcct gatattataa gcttaaaact atcttgaggg ggaaatgact
     5341 tcttttctcc ttctgtccct tttctcaaaa gcatctttcc cccaaatgta tgtctctagg
     5401 acattttata gttttaagag gaagaaaaca gaaacgtggc atcatttggg aagaaccaag
     5461 gtagaattta attttctgga ctttaaatct cctggttaaa taatgctaat cactgtacca
     5521 tttgagttac atgttttaac ctcttttttt tttctaatta ttccatccaa aatttctggt
     5581 gaattacaca gaaatttttg gaaatgggac tttgtgcagg taaccaccct gcacttcagg
     5641 taatgttcct gtcacagctg tcgactaccc cacgctgcag gaaatccatt cagaaatgag
     5701 ctaacagtct ccagtgtagc aggagagcca gtcacttccc tccccaggcc ccaaagcacc
     5761 ccaaggctgg tattccttga gtcataggta ttaataataa aagcctcaat gcagcttctc
     5821 catgtagttc ctctcctaca agccaggtgg attctggtcc taactaaaga gatgggagtt
     5881 cacctgaggg caagaagtac ccaggatgcc caaacagccg cacaggtgtc ctgtgcttcc
     5941 tgtgagactt cctgggggaa atatacaaac taatatattt tttaatgttt acgtcattta
     6001 cactgctgct tttctcatat tctgctttta attacttgta gtaaatcatt tgtttgggct
     6061 tcaagcactg tcttccatct gcatcttcca gatttatcat gagtgatctt gttctactgt
     6121 taaagatgtc aagcctaaaa agtaataaag tttttatttg gctgttgaac cttgatgtag
     6181 cccctactac atacactaca agttatgcct tctggctact acagaatctc cgcagacctt
     6241 ttagttatga gtagaagcaa taagaaggtg tccttatggt cttaggaata atagttccaa
     6301 tgtattggca taatttgttt gaatgtcttt attttgatat taacaccggc ataaatctat
     6361 ttttgctacc agatgatagc tattttcatt tgctctattt tcctctgcat tgtactaatc
     6421 tgttactcag tgttagtctt catttttctg tgttggaaac ctgcgtcatg taaatatctg
     6481 caaatcatga cagtctaaag tgcaaaccat tttcagagac tttggggaat gcagtgatca
     6541 gaagtggcta atttatttta tttctgatta ttttatccag agggtacttt tttaatggat
     6601 atttgtaaat cttccactta accactgaaa attattttgt tttaatccca cccttccatc
     6661 catacctctg cctccccaaa aagctcctat taatttgctt atccccctca tgtagctagt
     6721 tgaatgtgaa taaataacat ggaaaaaaa
//
