LOCUS       NM_080597               4152 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens oxysterol binding protein like 1A (OSBPL1A),
            transcript variant 2, mRNA.
ACCESSION   NM_080597
VERSION     NM_080597.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4152)
  AUTHORS   Schuler,B., Sladek,M. and Gilk,S.D.
  TITLE     Host Lipid Transport Protein ORP1 Is Necessary for Coxiella
            burnetii Growth and Vacuole Expansion in Macrophages
  JOURNAL   mSphere 8 (3), e0010423 (2023)
   PUBMED   37017523
  REMARK    GeneRIF: Host Lipid Transport Protein ORP1 Is Necessary for
            Coxiella burnetii Growth and Vacuole Expansion in Macrophages.
REFERENCE   2  (bases 1 to 4152)
  AUTHORS   Boutry,M. and Kim,P.K.
  TITLE     ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion
            three-way contact contributes to mitochondrial division
  JOURNAL   Nat Commun 12 (1), 5354 (2021)
   PUBMED   34504082
  REMARK    GeneRIF: ORP1L mediated PI(4)P signaling at
            ER-lysosome-mitochondrion three-way contact contributes to
            mitochondrial division.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4152)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4152)
  AUTHORS   Di Mattia,T., Martinet,A., Ikhlef,S., McEwen,A.G., Nomine,Y.,
            Wendling,C., Poussin-Courmontagne,P., Voilquin,L., Eberling,P.,
            Ruffenach,F., Cavarelli,J., Slee,J., Levine,T.P., Drin,G.,
            Tomasetto,C. and Alpy,F.
  TITLE     FFAT motif phosphorylation controls formation and lipid transfer
            function of inter-organelle contacts
  JOURNAL   EMBO J 39 (23), e104369 (2020)
   PUBMED   33124732
REFERENCE   5  (bases 1 to 4152)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4152)
  AUTHORS   Johansson,M., Bocher,V., Lehto,M., Chinetti,G., Kuismanen,E.,
            Ehnholm,C., Staels,B. and Olkkonen,V.M.
  TITLE     The two variants of oxysterol binding protein-related protein-1
            display different tissue expression patterns, have different
            intracellular localization, and are functionally distinct
  JOURNAL   Mol Biol Cell 14 (3), 903-915 (2003)
   PUBMED   12631712
  REMARK    GeneRIF: Results suggest that the two forms of oxysterol binding
            protein-related protein-1 (ORP1) are functionally distinct and that
            ORP1L is involved in control of cellular lipid metabolism
REFERENCE   7  (bases 1 to 4152)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   8  (bases 1 to 4152)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
REFERENCE   9  (bases 1 to 4152)
  AUTHORS   Xu,Y., Liu,Y., Ridgway,N.D. and McMaster,C.R.
  TITLE     Novel members of the human oxysterol-binding protein family bind
            phospholipids and regulate vesicle transport
  JOURNAL   J Biol Chem 276 (21), 18407-18414 (2001)
   PUBMED   11279184
REFERENCE   10 (bases 1 to 4152)
  AUTHORS   Laitinen,S., Olkkonen,V.M., Ehnholm,C. and Ikonen,E.
  TITLE     Family of human oxysterol binding protein (OSBP) homologues. A
            novel member implicated in brain sterol metabolism
  JOURNAL   J Lipid Res 40 (12), 2204-2211 (1999)
   PUBMED   10588946
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK096358.1, BC136452.1 and
            AF274714.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_080597.3.
            
            Summary: This gene encodes a member of the oxysterol-binding
            protein (OSBP) family, a group of intracellular lipid receptors.
            Most members contain an N-terminal pleckstrin homology domain and a
            highly conserved C-terminal OSBP-like sterol-binding domain,
            although some members contain only the sterol-binding domain.
            Transcript variants derived from alternative promoter usage and/or
            alternative splicing exist; they encode different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2, also known as ORP1L or
            OSBPL1B) encodes the longest isoform (2, also known as B). Isoform
            2 contains three ankyrin repeats, a pleckstrin homology domain and
            a sterol-binding domain. Unlike the tissue-specific expression of
            variant 1, this variant is widely expressed.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.113108.1,
                                           SRR1803617.51931.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319481.8/ ENSP00000320291.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AK096358.1         46-103
            59-4055             BC136452.1         1-3997
            4056-4152           AF274714.1         3214-3310
FEATURES             Location/Qualifiers
     source          1..4152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..4152
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /note="oxysterol binding protein like 1A"
                     /db_xref="GeneID:114876"
                     /db_xref="HGNC:HGNC:16398"
                     /db_xref="MIM:606730"
     exon            1..170
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            171..293
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..3025
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /note="isoform 2 is encoded by transcript variant 2;
                     oxysterol binding protein-like 1B; OSBP-related protein 1"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 1
                     isoform 2"
                     /protein_id="NP_542164.2"
                     /db_xref="CCDS:CCDS11884.1"
                     /db_xref="GeneID:114876"
                     /db_xref="HGNC:HGNC:16398"
                     /db_xref="MIM:606730"
                     /translation="MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSK
                     SNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLE
                     YNADTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTAL
                     LNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQG
                     AEMKHILVGNKVIYKALKRYEGPLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNI
                     YRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSA
                     YSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKE
                     MLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETL
                     ATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLG
                     SRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITM
                     PVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKP
                     FNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGK
                     SVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCV
                     LNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNT
                     EEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVL
                     NEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDW
                     KTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY"
     exon            294..379
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            380..454
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            455..566
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            567..652
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            653..797
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            798..859
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            860..904
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            905..978
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1042
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1141
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1264
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1346
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1453
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1616
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1773
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1849
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1984
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2082
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2265
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2373
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2463
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2464..2590
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2707
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2831
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2922
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2923..4152
                     /gene="OSBPL1A"
                     /gene_synonym="ORP-1; ORP1; OSBPL1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggtcccgg cgccgggtcc cggagacaga cgttacgcgg gctcgagcgt cctcggggag
       61 tgccagccag agttggtgac gaccacttcc tcgacgtggg gcgggcggac gggaagcctg
      121 gggtcgtggc caccgcctcg ggagctctgg gagcccgggt gaccgcgtag aaatgaacac
      181 agaagcggag caacagcttc tccatcacgc cagaaatggc aatgctgaag aagtaagaca
      241 actattagag accatggcga ggaatgaagt gattgctgac attaattgca aaggaagaag
      301 taagtctaac ttgggctgga cacctctaca tctggcatgc tattttggac acagacaagt
      361 ggtccaggat ctgttgaagg ctggtgcaga agtgaatgtg ttgaatgaca tgggagacac
      421 gccgcttcat cgagctgcct ttacaggacg aaaggagttg gtaatgcttc tcttagaata
      481 taatgctgat actactattg ttaatgggag tggacagaca gcaaaagaag ttactcatgc
      541 tgaagaaatc agaagcatgc ttgaagctgt agaaaggact caacaaagaa agcttgaaga
      601 attactttta gcagcagcaa gagaaggcaa aacaacagaa ctcacagctc tgctcaacag
      661 gcccaatcct cctgatgtta actgttcgga tcagttagga aatacaccct tgcattgtgc
      721 agcttaccgg gcccataaac aatgtgcctt aaagcttcta agaagtggag cagaccctaa
      781 tctgaagaac aaaaatgatc agaaacctct tgaccttgcc cagggtgctg aaatgaaaca
      841 cattcttgtt ggtaataagg tcatctacaa agcattgaaa cgatatgagg gccctctctg
      901 gaagagttca agattttttg gctggagatt attctgggta gtgttagagc atggagtcct
      961 ttcatggtat aggaaacagc ctgatgcagt tcataatatt tatcgccagg gatgcaaaca
     1021 cctgactcaa gcagtatgca cggtaaaatc cactgatagc tgcctcttct ttattaaatg
     1081 ctttgatgac accattcatg gcttccgggt tcctaagaat agccttcagc agtcaagaga
     1141 ggactggctg gaagcaatag aagaacattc tgcttacagc actcactact gttcccagga
     1201 ccagctgact gatgaggagg aggaagatac ggtttctgct gcagacctga agaaatcatt
     1261 agagaaagca cagtcatgcc aacagcgact agatagggaa atttccaact ttctcaaaat
     1321 gattaaggag tgtgacatgg ctaaagaaat gcttccatca tttcttcaga aagttgaagt
     1381 tgtctcagaa gcttctagag aaacttgtgt agctttgact gattgcctta atctcttcac
     1441 caaacaagaa ggggtgagga attttaaatt ggaacaagag caagaaaaaa acaaaatctt
     1501 gtcagaagca ctggagacgc tggccactga acatcatgaa ttagagcagt ctctggtgaa
     1561 aggctctcca cccgccagca tccttagcga ggacgagttc tatgatgcgc tgtcagattc
     1621 cgagtccgaa aggtccctga gtagattgga agcagtgaca gcacgctcct ttgaagagga
     1681 aggagagcat ttgggcagta gaaaacacag aatgtccgaa gaaaaagact gtggtggcgg
     1741 agatgctctc tccaatggca tcaagaaaca cagaacaagt ttgccttctc ctatgttttc
     1801 cagaaatgac ttcagtatct ggagcatcct cagaaaatgt attggaatgg aactatccaa
     1861 gatcacgatg ccagttatat ttaatgagcc tctgagcttc ctacagcgcc taactgaata
     1921 catggagcat acttacctca tccacaaggc cagttcactc tctgatcctg tggaaaggat
     1981 gcagtgtgta gctgcgtttg ctgtatctgc tgttgcttct cagtgggaac ggactggaaa
     2041 acctttcaac ccactgctgg gagagactta tgaattagtg cgagatgacc ttggatttag
     2101 actcatctcc gaacaggtca gccatcaccc accaatcagt gcatttcatg ctgaaggatt
     2161 aaacaatgac ttcatctttc atggctctat ctatcccaaa ctgaaattct gggggaagag
     2221 tgtagaagca gaacccaaag gaaccatcac cttggagctc cttgaacaca atgaggcata
     2281 tacatggaca aatcccacct gctgtgtgca taatatcatt gtgggtaaac tgtggatcga
     2341 acagtatggc aatgtggaaa ttataaacca caagactggg gacaaatgtg tgttgaattt
     2401 taagccatgt ggcctttttg gtaaggaatt acacaaagtt gaaggctaca ttcaagataa
     2461 aagcaaaaag aagctctgtg ccctctatgg gaagtggact gaatgtttat acagtgttga
     2521 ccctgccacg tttgacgctt acaaaaaaaa tgataagaaa aatacagaag agaagaagaa
     2581 cagcaaacag atgagcacct ctgaggagtt ggatgaaatg ccagtgccgg attctgaaag
     2641 tgtattcatt atccctggaa gcgttcttct atggcgaata gccccacggc ctccaaattc
     2701 tgcccagatg tataatttta ctagttttgc aatggttttg aatgaagtag acaaagacat
     2761 ggagagtgtg attcccaaga cagactgcag gttacggcct gacatcagag ccatggaaaa
     2821 tggagagata gatcaagcta gtgaagaaaa aaaacgactt gaggaaaaac aaagagcagc
     2881 ccgcaaaaac aggtccaagt cagaagagga ctggaagacg aggtggttcc atcaaggtcc
     2941 taatccctac aatggagcac aggactggat ttactctggc agctactggg acagaaatta
     3001 cttcaatttg cctgacattt attaaaatgc atacaagtca gggtgtttgg ctaatctaca
     3061 aataagtctt aaacctatgt ttttaaattt ttttcccttg gtttctactt atcttttaaa
     3121 aaaaaaaatg aaaaaacact catgagataa ctgcatttca cccaacaaaa gcagggtata
     3181 aggcgatatt ggtgatgaaa gtcttaggaa aaatgcataa ttttgctata aaatgtactt
     3241 atttggaata ctattttata tagaggtaag agaacactgc tggggaatat gctttttatg
     3301 gttgctgttg ccatatttac tgaaggttta tacctaaatg taactttagc tttatggaac
     3361 tatatagtaa tcccaaatca agttattttg aatattttta tgctgtcatg cttgaatgtt
     3421 ttagatgtaa cctttgacat atttagaact ctcctcctat acaatgttta ttctcagata
     3481 tagaggttat gtcattttat aaagacttca ttgataagat ggcttttatt catactaatc
     3541 ctcccaatgt taccccttcc atcttccaag aagaaaaaaa atgcctgaat attcagaata
     3601 gatatttctg atttgaaaat tctaaagaat taaactggaa aagtatttca tttacttagt
     3661 gctctgaatt tacttttaca gttttctgca gtcagtatca ttaaaatggt taagtttaca
     3721 tttgaactga aaatatgtat aaaatctagc aattcacaaa aatgccctag aaatatagat
     3781 tttaatcacc attacataat gacaaacctt gttaaatgct tccacttcca gtggcaaatg
     3841 ccactaggga aagtaagttg cactcatgta agtatcaaac tatataaaag gaggccttgt
     3901 gcatttcaag tttgcaaagt acctgtgtac ttaaaatatg tgtggagacc tactgtacag
     3961 tagttttgcc cctttaattg gggcacattc atcttaaatc ttatagtatt tatccaccca
     4021 aaccccagac tgagatactg ctcccagggg cctaggtagc tgccagtccg tgattttaat
     4081 tgctgtcttg aagttaacaa gtgttataat gaaataatct acctgatgct aaataaaggc
     4141 tttagaatgt tc
//
