LOCUS       NM_022776               4598 bp    mRNA    linear   PRI 25-JAN-2025
DEFINITION  Homo sapiens oxysterol binding protein like 11 (OSBPL11), mRNA.
ACCESSION   NM_022776
VERSION     NM_022776.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4598)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4598)
  AUTHORS   Peng,H., Yan,Z., Zeng,X., Zhang,S., Jiang,H., Huang,H. and Zhuo,H.
  TITLE     Serum and tissue proteomic signatures of patients with
            hepatocellular carcinoma using 2-D gel electrophoresis
  JOURNAL   Mol Med Rep 20 (2), 1025-1038 (2019)
   PUBMED   31173207
  REMARK    GeneRIF: OSBPL11 is down-regulated and may be a potential indicator
            for hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 4598)
  AUTHORS   Nissila,E., Ohsaki,Y., Weber-Boyvat,M., Perttila,J., Ikonen,E. and
            Olkkonen,V.M.
  TITLE     ORP10, a cholesterol binding protein associated with microtubules,
            regulates apolipoprotein B-100 secretion
  JOURNAL   Biochim Biophys Acta 1821 (12), 1472-1484 (2012)
   PUBMED   22906437
REFERENCE   4  (bases 1 to 4598)
  AUTHORS   Zhou,Y., Robciuc,M.R., Wabitsch,M., Juuti,A., Leivonen,M.,
            Ehnholm,C., Yki-Jarvinen,H. and Olkkonen,V.M.
  TITLE     OSBP-related proteins (ORPs) in human adipose depots and cultured
            adipocytes: evidence for impacts on the adipocyte phenotype
  JOURNAL   PLoS One 7 (9), e45352 (2012)
   PUBMED   23028956
  REMARK    GeneRIF: ORP8 overexpression resulted in reduced expression of the
            aP2 mRNA, while down-regulation of adiponectin and aP2 was observed
            in ORP11 silenced cells. ORP8 overexpression or silencing of ORP11
            markedly decreased cellular triglyceride storage.
REFERENCE   5  (bases 1 to 4598)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 4598)
  AUTHORS   Bouchard,L., Faucher,G., Tchernof,A., Deshaies,Y., Marceau,S.,
            Lescelleur,O., Biron,S., Bouchard,C., Perusse,L. and Vohl,M.C.
  TITLE     Association of OSBPL11 gene polymorphisms with cardiovascular
            disease risk factors in obesity
  JOURNAL   Obesity (Silver Spring) 17 (7), 1466-1472 (2009)
   PUBMED   19325544
  REMARK    GeneRIF: The OSBPL11 gene is involved in cholesterol and glucose
            metabolism in obese individuals.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4598)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 4598)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 4598)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   10 (bases 1 to 4598)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA722217.1, DA112146.1,
            BX506747.1 and BC065213.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022776.4.
            
            Summary: This gene encodes a member of the oxysterol-binding
            protein (OSBP) family, a group of intracellular lipid receptors.
            Like most members, the encoded protein contains an N-terminal
            pleckstrin homology domain and a highly conserved C-terminal
            OSBP-like sterol-binding domain. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065213.1, AF392454.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296220.6/ ENSP00000296220.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               DA722217.1         41-165
            126-553             DA112146.1         144-571
            554-610             BX506747.1         370-426
            611-4007            BC065213.1         1-3397
            4008-4598           BC065213.1         3399-3989
FEATURES             Location/Qualifiers
     source          1..4598
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.2"
     gene            1..4598
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /note="oxysterol binding protein like 11"
                     /db_xref="GeneID:114885"
                     /db_xref="HGNC:HGNC:16397"
                     /db_xref="MIM:606739"
     exon            1..861
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     CDS             698..2941
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /note="OSBP-related protein 11; testicular tissue protein
                     Li 132"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 11"
                     /protein_id="NP_073613.2"
                     /db_xref="CCDS:CCDS3033.1"
                     /db_xref="GeneID:114885"
                     /db_xref="HGNC:HGNC:16397"
                     /db_xref="MIM:606739"
                     /translation="MQGGEPVSTMKVSESEGKLEGQATAVTPNKNSSCGGGISSSSSS
                     RGGSAKGWQYSDHMENVYGYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKP
                     RGTLQLAGAVISPSDEDSHTFTVNAASGEQYKLRATDAKERQHWVSRLQICTQHHTEA
                     IGKNNPPLKSRSFSLASSSNSPISQRRPSQNAISFFNVGHSKLQSLSKRTNLPPDHLV
                     EVREMMSHAEGQQRDLIRRIECLPTSGHLSSLDQDLLMLKATSMATMNCLNDCFHILQ
                     LQHASHQKGSLPSGTTIEWLEPKISLSNHYKNGADQPFATDQSKPVAVPEEQPVAESG
                     LLAREPEEINADDEIEDTCDHKEDDLGAVEEQRSVILHLLSQLKLGMDLTRVVLPTFI
                     LEKRSLLEMYADFMSHPDLFIAITNGATAEDRMIRFVEYYLTSFHEGRKGAIAKKPYN
                     PIIGETFHCSWKMPKSEVASSVFSSSSTQGVTNHAPLSGESLTQVGSDCYTVRFVAEQ
                     VSHHPPVSGFYAECTERKMCVNAHVWTKSKFLGMSIGVTMVGEGILSLLEHGEEYTFS
                     LPCAYARSILTVPWVELGGKVSVNCAKTGYSASITFHTKPFYGGKLHRVTAEVKHNIT
                     NTVVCRVQGEWNSVLEFTYSNGETKYVDLTKLAVTKKRVRPLEKQDPFESRRLWKNVT
                     DSLRESEIDKATEHKHTLEERQRTEERHRTETGTPWKTKYFIKEGDGWVYHKPLWKII
                     PTTQPAE"
     exon            862..930
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1106
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1186
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1363
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1565
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1711
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1852
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2351
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2538
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2721
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2875
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..4598
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4577..4582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /note="hexamer: AATAAA"
     polyA_site      4598
                     /gene="OSBPL11"
                     /gene_synonym="ORP-11; ORP11; OSBP12; TCCCIA00292"
                     /note="major polyA site"
ORIGIN      
        1 attcgcgctt gggtctggag atagcgcgag agactcaccg gctcctggga acccagtcga
       61 gggcccgggc caggggcata agaggaagtt gtcccgagtg gctcgcctct ggccctggga
      121 gaggcggccc cgggagccgg cgtcccgccc ccggcggcct cattccccga ccctcctccc
      181 cggctgcgcg cgccggccct ggctgtatct cgggggctgc ggcgggaact gccgagcggg
      241 cttgactgga cgcactgcct gaggacctgc ggaggagacg agggagcgcg gcgggtcagc
      301 cccgaggtta ggccgcgggt cccctgtccg tggcgctccg tccttttccc agccgtcttg
      361 gctacagaat ctgcgacctc cccacactcc ttctcttttg agtatgtcac ttaagtcttc
      421 tcgccggatg ctttttcctc cttgcttttg ccggaaagga gagagataca tgtgaaggat
      481 atctgtcctc gttgcttccc ctgccctctc aaaagtttaa cttctgtggg aatgtgtatc
      541 ttccttttct ggaccatttg acagtcccgc cccagccgcc gtgtgattta gcaaccggta
      601 tcatattcag atcaaatctt aaaaaaaaaa agtcacctac agaactacag aattgttctc
      661 tcccgctcaa gaagggcaag tggactttgg cgttaagatg caggggggtg aaccagtgtc
      721 cacaatgaaa gtctcggaga gcgaaggaaa gctggagggc caggccacag cggtgacccc
      781 gaacaagaac agcagctgtg gaggtggaat cagtagcagc agcagcagcc gcggtggcag
      841 tgcaaaaggc tggcagtaca gtgatcacat ggaaaatgtg tatggctatt taatgaagta
      901 taccaacctt gtcactgggt ggcagtacag gttttttgtt ttaaacaatg aagctgggct
      961 gttggagtac tttgtgaatg aacagtctag aaatcagaaa cctagaggaa ctttgcagct
     1021 tgcaggagct gtaatatcac ccagtgatga ggattctcac accttcactg taaacgctgc
     1081 cagtggggaa caatataaac tcagagctac agatgcaaaa gagcgacagc actgggttag
     1141 cagacttcag atatgtacac agcatcatac tgaagctatt ggaaagaata atcctcctct
     1201 gaagtcacgg agcttctcac ttgcatctag tagtaattct cctatatcgc agaggagacc
     1261 aagtcaaaat gccatttctt tttttaatgt tggacattcc aaactgcaat cactgagcaa
     1321 aagaactaat ttacctccag accatcttgt ggaagtcaga gaaatgatgt ctcatgctga
     1381 aggacaacaa agagacttaa ttagacgaat tgaatgcctt cctacttctg gccatcttag
     1441 ttccttggac caggatctct taatgctcaa agctacttcc atggcaacta tgaactgctt
     1501 aaatgactgc tttcatattc tccagttaca gcatgcatca catcagaagg gctcattgcc
     1561 ttcaggaacg acaatcgagt ggttagaacc aaagatatct ttatcaaacc actataaaaa
     1621 tggagctgac cagccctttg caactgatca gagtaagccg gtggcagtcc cagaagagca
     1681 gcctgttgca gaatctggac tattagcgag ggagcctgaa gaaataaatg cagatgatga
     1741 gatagaggat acatgtgacc acaaagagga tgacctggga gctgtagaag aacaacgtag
     1801 tgtcatccta catctcttgt cacagcttaa gctgggcatg gatttaacaa gagtggtgct
     1861 tcctacattt atcctagaga agcgttcctt gctggaaatg tatgcagact ttatgtctca
     1921 tccagaccta tttatagcca tcactaatgg agccacagct gaggacagaa tgattcgctt
     1981 tgttgagtac taccttacct catttcatga aggccgtaag ggagccattg ctaaaaaacc
     2041 atacaatcct atcattggag aaacatttca ctgttcctgg aagatgccaa aaagcgaggt
     2101 agcatccagt gtttttagca gttcttccac ccagggagtc acaaatcatg ctcctttatc
     2161 gggggagtct ttgacccagg tgggatcaga ctgttacaca gtcagatttg ttgctgagca
     2221 ggtttctcat catcctccag tctcaggatt ttatgcagaa tgtacagaga ggaagatgtg
     2281 tgtaaatgcg catgtctgga ctaagagcaa gttcttaggc atgtcaatag gcgtgacaat
     2341 ggttggagaa ggtatcctta gtctgttgga gcatggagaa gagtacacat tttctctacc
     2401 ctgtgcatat gctcggtcaa ttttgactgt tccttgggta gaactgggtg gcaaagtcag
     2461 tgtcaactgt gcaaaaactg gatattcagc cagcatcact tttcatacca agccatttta
     2521 tggtggcaaa ctgcatcggg ttacagctga agtaaagcac aacatcacca acactgtggt
     2581 atgcagagtg caaggggaat ggaatagtgt tcttgagttc acatatagca atggagagac
     2641 aaagtatgtg gacttgacta aattggcagt gacgaagaaa agagtgagac ctctggagaa
     2701 gcaggatcca tttgaatcca ggcgattgtg gaaaaatgtg acagactcgc tgagagaatc
     2761 tgaaattgat aaggccacag agcataagca taccctggaa gaacgtcaga ggactgaaga
     2821 aaggcatcgt actgaaacag gcacaccttg gaaaaccaaa tattttatta aagagggaga
     2881 tggctgggtt tatcataaac cactttggaa aataattcca acaacacaac cagcagagtg
     2941 acacatacta tctaaaactc gaccaaatga ggttcttctc tgtttaccct aaatcctccc
     3001 agaatggagt cattgcactg agtgacctgc ttcctgattg cgcagactga aactagctaa
     3061 acctgaatgt acctactagg gcaccataat actgcagcaa gaccaaagtg gtaaagaaac
     3121 acagtggacc ttttaccaac ctgttcatgt gatgtgagca ataccatctt aaaacttgtt
     3181 acctgaatca gtagatgaat cttttatcca gttcttgctc ctaaagttaa gtttgaatcc
     3241 cctatttttg cacaggggca gcagatacac acaacaatga gaactcagtg actttgattt
     3301 ctttgtagtg aaaagtgaag tctccgtttc agagtttgtg tctttctttc tgtccataac
     3361 tgaagtattc actactcttg taaaccaacc aagaggagga gaaagatgac ccagaagtgg
     3421 attcagccat tgtgcctgaa atcagtgttt aaaaaaaaaa atcaaccagg ttgtggtaac
     3481 aaggcattct atttcttcaa aaagactgta tgcctgtgtc tgaggaactt acctattatc
     3541 cacctctgtt ggaactctct tttaaaaagt acatttatag attgatcaga attataacca
     3601 tggagaattt tttcttctga gcattttaat atacttgaaa acaacattga cttgaaaaat
     3661 ttcagaacat ttttcagtac ctagttttat taaatattac acttgagaga cactttttaa
     3721 aaatgtgtta atgtcaatat gatgagattt tagcctttct ccagaactaa ggcattaaag
     3781 aaaatagcaa atattaaaaa ataaaactgt tacttttttc cttctttctt ttcaccttta
     3841 ggttaatatc cagtattatg tgttatccct ttggataagt atgctttatt ttacctctgt
     3901 taaaaattaa aataaatgat tctattcata tttgtcagta attcaaaact tatatgtgta
     3961 actgaacgcg catgtaaggt atggttttat ttattttttt tttttttgag gaaatttaaa
     4021 tgctaaagaa acaacgaaat gaaaaggtat caggaaaaaa agatcaggaa gttgtattca
     4081 ggtacaaatc tttttttaaa taagtatttt gttgaggttg aagaattgct ggcaattaaa
     4141 agaatagagc taattatggc tttcatcatt cattcatgta tttattgagc acctacttat
     4201 tatggtgctc aacacttgtt actgcaagct accttaattt cccaagagtg gtgccttact
     4261 ctgttttttc tgatatggtc ttccaatcag tgtgtgtaac atacctgttg tttatcagcc
     4321 attgtaggtg gctgtgtctg ttgcatcatc ataagaagtt taagctttgt gctctgataa
     4381 attgtgttct gttaaagagg ttagtaggat gaaaacagca aaacaataat tttttcaaca
     4441 aattgtaaat tataagaaaa agagttggtt tgtgtacaac aattttaatg attcccttgt
     4501 tcatttttgc tgtgaaatgc actgaaaaaa atcctcaaaa tgagttatag ttcctgtgtt
     4561 gggaaaattg acaaataata aaactagaga acaaacaa
//
