LOCUS       NM_017784               3625 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens oxysterol binding protein like 10 (OSBPL10),
            transcript variant 1, mRNA.
ACCESSION   NM_017784
VERSION     NM_017784.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3625)
  AUTHORS   Kawasaki,A., Sakai,A., Nakanishi,H., Hasegawa,J., Taguchi,T.,
            Sasaki,J., Arai,H., Sasaki,T., Igarashi,M. and Nakatsu,F.
  TITLE     PI4P/PS countertransport by ORP10 at ER-endosome membrane contact
            sites regulates endosome fission
  JOURNAL   J Cell Biol 221 (1) (2022)
   PUBMED   34817532
  REMARK    GeneRIF: PI4P/PS countertransport by ORP10 at ER-endosome membrane
            contact sites regulates endosome fission.
REFERENCE   2  (bases 1 to 3625)
  AUTHORS   Wang,S., Zhang,X., Li,Z., Wang,W., Li,B., Huang,X., Sun,G., Xu,J.,
            Li,Q., Xu,Z., Xia,Y., Wang,L., Zhang,Q., Li,Q., Zhang,L., Chen,J.,
            Wu,Y., Cao,J., Xu,P., Zhang,D., Xu,H. and Xu,Z.
  TITLE     Circular RNA profile identifies circOSBPL10 as an oncogenic factor
            and prognostic marker in gastric cancer
  JOURNAL   Oncogene 38 (44), 6985-7001 (2019)
   PUBMED   31409903
  REMARK    GeneRIF: findings reveal that circOSBPL10 may serve as a new
            proliferation factor and prognostic marker in gastric cancer
REFERENCE   3  (bases 1 to 3625)
  AUTHORS   Shaffer,J.R., Polk,D.E., Wang,X., Feingold,E., Weeks,D.E.,
            Lee,M.K., Cuenco,K.T., Weyant,R.J., Crout,R.J., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association study of periodontal health measured by
            probing depth in adults ages 18-49 years
  JOURNAL   G3 (Bethesda) 4 (2), 307-314 (2014)
   PUBMED   24347629
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3625)
  AUTHORS   Boardman,J.D., Domingue,B.W., Blalock,C.L., Haberstick,B.C.,
            Harris,K.M. and McQueen,M.B.
  TITLE     Is the gene-environment interaction paradigm relevant to
            genome-wide studies? The case of education and body mass index
  JOURNAL   Demography 51 (1), 119-139 (2014)
   PUBMED   24281739
REFERENCE   5  (bases 1 to 3625)
  AUTHORS   Maeda,K., Anand,K., Chiapparino,A., Kumar,A., Poletto,M.,
            Kaksonen,M. and Gavin,A.C.
  TITLE     Interactome map uncovers phosphatidylserine transport by
            oxysterol-binding proteins
  JOURNAL   Nature 501 (7466), 257-261 (2013)
   PUBMED   23934110
REFERENCE   6  (bases 1 to 3625)
  AUTHORS   Perttila,J., Merikanto,K., Naukkarinen,J., Surakka,I., Martin,N.W.,
            Tanhuanpaa,K., Grimard,V., Taskinen,M.R., Thiele,C., Salomaa,V.,
            Jula,A., Perola,M., Virtanen,I., Peltonen,L. and Olkkonen,V.M.
  TITLE     OSBPL10, a novel candidate gene for high triglyceride trait in
            dyslipidemic Finnish subjects, regulates cellular lipid metabolism
  JOURNAL   J Mol Med (Berl) 87 (8), 825-835 (2009)
   PUBMED   19554302
  REMARK    GeneRIF: Analysis of variants in three genes encoding OSBP
            homologues in families with familial low high-density lipoprotein
            levels or familial combined hyperlipidemia revealed linkage of
            OSBPL10 single-nucleotide polymorphisms with high triglyceride
            trait.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3625)
  AUTHORS   Suchanek,M., Hynynen,R., Wohlfahrt,G., Lehto,M., Johansson,M.,
            Saarinen,H., Radzikowska,A., Thiele,C. and Olkkonen,V.M.
  TITLE     The mammalian oxysterol-binding protein-related proteins (ORPs)
            bind 25-hydroxycholesterol in an evolutionarily conserved pocket
  JOURNAL   Biochem J 405 (3), 473-480 (2007)
   PUBMED   17428193
REFERENCE   8  (bases 1 to 3625)
  AUTHORS   Ma,J., Dempsey,A.A., Stamatiou,D., Marshall,K.W. and Liew,C.C.
  TITLE     Identifying leukocyte gene expression patterns associated with
            plasma lipid levels in human subjects
  JOURNAL   Atherosclerosis 191 (1), 63-72 (2007)
   PUBMED   16806233
REFERENCE   9  (bases 1 to 3625)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   10 (bases 1 to 3625)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC377079.1, BC003168.1 and
            AK000370.1.
            
            On Aug 11, 2020 this sequence version replaced NM_017784.4.
            
            Summary: This gene encodes a member of the oxysterol-binding
            protein (OSBP) family, a group of intracellular lipid receptors.
            Like most members, the encoded protein contains an N-terminal
            pleckstrin homology domain and a highly conserved C-terminal
            OSBP-like sterol-binding domain. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003168.1, SRR11853563.22302.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396556.7/ ENSP00000379804.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               DC377079.1         290-500
            212-1613            BC003168.1         204-1605
            1614-2295           AK000370.1         1078-1759
            2296-3625           BC003168.1         2288-3617
FEATURES             Location/Qualifiers
     source          1..3625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p23-p22.3"
     gene            1..3625
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /note="oxysterol binding protein like 10"
                     /db_xref="GeneID:114884"
                     /db_xref="HGNC:HGNC:16395"
                     /db_xref="MIM:606738"
     exon            1..364
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2378
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oxysterol-binding protein-related protein 10; OSBP-related
                     protein 10; ORP-10"
                     /codon_start=1
                     /product="oxysterol-binding protein-related protein 10
                     isoform 1"
                     /protein_id="NP_060254.2"
                     /db_xref="CCDS:CCDS2651.1"
                     /db_xref="GeneID:114884"
                     /db_xref="HGNC:HGNC:16395"
                     /db_xref="MIM:606738"
                     /translation="MERAVQGTDGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRS
                     AAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEA
                     GILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQ
                     FWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPHGTPNSASPCSQRHLSVGAPGVVTI
                     THHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLL
                     LLKATSAATLSCLGECLNLLQQSVHQAGQPSQKPGASENILGWHGSKSHSTEQLKNGT
                     LGSLPSASANITWAILPNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGV
                     MEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGAT
                     PEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSP
                     ASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGM
                     SVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATV
                     IFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPV
                     YPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRT
                     PWKPKYFIQEGDGWVYFNPLWKAH"
     exon            365..540
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            541..620
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            621..812
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1023
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1178
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1328
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1809
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1996
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2179
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2333
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..3625
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3605..3610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /note="hexamer: AATATA"
     polyA_site      3625
                     /gene="OSBPL10"
                     /gene_synonym="ORP10; OSBP9"
                     /note="major polyA site"
ORIGIN      
        1 gtccggagct gtagcagcag cagcagccgc cgtgccgggg ccgccaccgc ggcgggcacc
       61 cgcgtcccgg gcgcccacgg accatggaga gggcagtcca gggcacagac ggcggcgggg
      121 gtagcaacag cagcagccgc agcagcagcc gtgctacctc ggcgggctcc tcgccctcct
      181 gctctctggc gggccggggg gtctccagcc ggtcggcggc ggccgggctc ggcggcgggg
      241 gaagccgcag cagcccgggc tctgtggccg ctagcccgtc cgggggaggc ggccgcagga
      301 gggagccggc gctcgagggc gtgctcagca aatacaccaa cctcctccag ggctggcaga
      361 acaggtactt cgtactggat ttcgaggctg gcatcctgca gtattttgtg aatgagcaaa
      421 gcaaacacca gaagcctcga ggagtcctgt ctttatctgg agccatagtg tccctgagcg
      481 atgaagctcc ccacatgctg gtggtgtact ctgctaatgg agagatgttt aaactgagag
      541 ctgctgatgc aaaagagaaa caattctggg tgactcagct tcgagcttgt gccaaatacc
      601 acatggaaat gaattctaag agtgctccaa gctcccgaag ccgaagtctc actttgctcc
      661 cacatggaac acccaattct gcgtctccct gtagccagag acacctcagt gtgggggccc
      721 ccggtgttgt cacaatcacg catcacaagt cgcctgcagc cgcccgaaga gccaagagtc
      781 agtattccgg ccagcttcac gaagtcagag agatgatgaa ccaggtggaa gggcagcaga
      841 agaaccttgt gcacgccatt gagtccctgc cagggtccgg ccccctcact gccttggacc
      901 aggacctgct gctcctgaaa gctacctctg ctgccaccct cagctgcctt ggggagtgcc
      961 tcaacttgtt acagcagagt gtgcaccagg cgggccagcc cagccagaag ccaggagcct
     1021 cggaaaacat cctgggatgg cacgggtcca agtcacattc cacagagcag ctgaaaaatg
     1081 ggacacttgg ctctttgcca tcagccagtg ccaacataac ctgggcaatt ttaccaaact
     1141 ctgctgaaga cgaacaaacc tcacagccag agccagagcc aaactcaggc tctgaattgg
     1201 ttttgtctga agatgaaaaa agtgacaatg aagataagga agagacggaa ttgggcgtca
     1261 tggaggatca gcgtagtata attcttcatc tcatttcaca actcaaactt ggaatggatt
     1321 tgaccaaggt ggtgcttccc acctttatcc tggagaagcg atctttgctg gagatgtatg
     1381 cagatttcat ggcgcaccca gacctactgc tggccatcac cgctggggcc acaccagagg
     1441 agagagtcat ttgcttcgtt gagtattatc tcacagcctt tcacgagggc cgcaagggcg
     1501 ctttagccaa gaagccctac aaccccatca taggcgagac atttcactgc tcctgggaag
     1561 ttcccaagga cagggtcaag cctaagagga ctgcttcccg ctctcctgcc agctgtcacg
     1621 aacacccaat ggccgatgac ccttccaaaa gctacaaact aaggtttgtg gctgagcaag
     1681 tgtcccatca cccacccatc tcctgcttct actgtgagtg cgaggagaag agactgtgcg
     1741 tcaacactca tgtatggacc aaaagcaagt tcatgggcat gtccgtgggg gtctctatga
     1801 taggggaagg tgtgttgagg ctcctggaac acggggagga gtacgtattc accctgccta
     1861 gtgcctacgc ccggtccatt ctcaccatcc cgtgggtgga gctcggagga aaagtcagca
     1921 tcaactgtgc caagactggg tactcagcga cagtgatatt ccacacgaag cctttctatg
     1981 gagggaaagt ccacagggtt accgcagaag tgaagcacaa cccaaccaac accattgttt
     2041 gtaaagccca tggggaatgg aatggtactt tagagttcac ctacaacaat ggagaaacca
     2101 aagtcatcga cacaaccaca ctgccagtgt atcccaagaa gatcagacct cttgagaagc
     2161 agggacccat ggagtccagg aacctctggc gggaggtgac ccgatacctg cggctggggg
     2221 acattgacgc agccaccgag cagaagcggc acctggagga gaagcaacgg gtggaggaac
     2281 ggaagcgcga gaacctccgc acaccatgga agcccaaata ttttatccag gagggcgatg
     2341 gctgggtata cttcaatccc ctctggaaag cacactgatg gggtggaggt gcagagcttt
     2401 ccagtatagc cctgtttttg taggaatatt aaagtagtag agtatcaggg ttttgttggc
     2461 attcactgag accttgtatt agcatccaag aaatgatgag agagagagaa attatatact
     2521 atgaaaagtg cacccccaca ctctgctaga ggaatgaatt tattcaagag ccattcgggg
     2581 cacgtgtgtg tacacaccgt atacgttcac acacatgcac tatgtaaaca tctgagtatg
     2641 attacacatt taaatactgc actcaccaag gttaaagtgg gtaatcataa gctccttttt
     2701 atcaatgaag tttgaagttt ttctattttt cactttgcca aaaatgtttt acactcacaa
     2761 agatattctc acttagtcaa ctcctgtcaa aatgaaggtg aactggcatg gcccgatcac
     2821 tgtccataag ggagaaagtg gctcattcct ggtagaagta tgggtggtta tcatttcaaa
     2881 attattgtga ttctcacctc cctccccacc tcagtgtttt gtctgtccgc gcccaagaaa
     2941 gataagcaag tatttcctgc tggatggggg ttggcaggaa gctgttaaag atttatgcca
     3001 gagccttgca ggatggagca cctctgggac aactaagagc caaggcccac caaggagttt
     3061 tccacccgtc tctcatggtc acagcgctag tcattcattt ttgagaagtt gcttctttta
     3121 catcagaaaa ccagtcaatc atatggagac ttcttttgtg atgaaaaagg gctttagaag
     3181 ttaaatacat gcatgcacat gaaaacatgc acaaccacag cctcaatctt gtatttagtt
     3241 tggggaaaga gaagagaatt tcctgtggat tattttttcc tcaagtgcac ctctctggtt
     3301 aacccaaact ctgcaagaaa gcactgtgac taaaacatac ataacgcctg cataaatatt
     3361 ccatggtttc agttaaattt cagtttttag cctttacaca tgaggtcaaa ggagtgacga
     3421 aaatacaaag caaggaaaaa atgaaatatc tggtttttgc tgaatgctta atttattttt
     3481 tactgtgcca ctccaatatt tatcaaatcc aaatagcatg aatgcttctc tgtagtaata
     3541 ctaattttgt gccttttgtc tgctttctta agaccagttg ttcacacttt gtagatatta
     3601 gacaaatata tttcgattga ataca
//
