LOCUS       NM_030758               4261 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens oxysterol binding protein 2 (OSBP2), transcript
            variant 1, mRNA.
ACCESSION   NM_030758
VERSION     NM_030758.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4261)
  AUTHORS   Wu,Q., Li,X., Long,M., Xie,X. and Liu,Q.
  TITLE     Integrated analysis of histone lysine lactylation (Kla)-specific
            genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic
            targets for hepatocellular carcinoma
  JOURNAL   Sci Rep 13 (1), 18642 (2023)
   PUBMED   37903971
  REMARK    GeneRIF: Integrated analysis of histone lysine lactylation
            (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are
            novel therapeutic targets for hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4261)
  AUTHORS   Zhong,W., Cao,X., Pan,G., Niu,Q., Feng,X., Xu,M., Li,M., Huang,Y.,
            Yi,Q. and Yan,D.
  TITLE     ORP4L is a prerequisite for the induction of T-cell leukemogenesis
            associated with human T-cell leukemia virus 1
  JOURNAL   Blood 139 (7), 1052-1065 (2022)
   PUBMED   34797912
  REMARK    GeneRIF: ORP4L is a prerequisite for the induction of T-cell
            leukemogenesis associated with human T-cell leukemia virus 1.
REFERENCE   3  (bases 1 to 4261)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4261)
  AUTHORS   Cao,X., Chen,J., Li,D., Xie,P., Xu,M., Lin,W., Li,S., Pan,G.,
            Tang,Y., Xu,J., Olkkonen,V.M., Yan,D. and Zhong,W.
  TITLE     ORP4L couples IP3 to ITPR1 in control of endoplasmic reticulum
            calcium release
  JOURNAL   FASEB J 33 (12), 13852-13865 (2019)
   PUBMED   31648575
  REMARK    GeneRIF: ORP4L is a cofactor of ITPR1.
REFERENCE   5  (bases 1 to 4261)
  AUTHORS   Wang,C., JeBailey,L. and Ridgway,N.D.
  TITLE     Oxysterol-binding-protein (OSBP)-related protein 4 binds
            25-hydroxycholesterol and interacts with vimentin intermediate
            filaments
  JOURNAL   Biochem J 361 (Pt 3), 461-472 (2002)
   PUBMED   11802775
REFERENCE   6  (bases 1 to 4261)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   7  (bases 1 to 4261)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
REFERENCE   8  (bases 1 to 4261)
  AUTHORS   Moreira,E.F., Jaworski,C., Li,A. and Rodriguez,I.R.
  TITLE     Molecular and biochemical characterization of a novel
            oxysterol-binding protein (OSBP2) highly expressed in retina
  JOURNAL   J Biol Chem 276 (21), 18570-18578 (2001)
   PUBMED   11278871
REFERENCE   9  (bases 1 to 4261)
  AUTHORS   Silva,N.H., Pimenta,G., Pulcheri,W.A., Fournier,M.V., Spector,N.
            and da Costa Carvalho,M.G.
  TITLE     Detection of messenger RNA in leukocytes or plasma of patients with
            chronic myeloid leukemia
  JOURNAL   Oncol Rep 8 (3), 693-696 (2001)
   PUBMED   11295104
REFERENCE   10 (bases 1 to 4261)
  AUTHORS   Fournier,M.V., Guimaraes da Costa,F., Paschoal,M.E., Ronco,L.V.,
            Carvalho,M.G. and Pardee,A.B.
  TITLE     Identification of a gene encoding a human oxysterol-binding
            protein-homologue: a potential general molecular marker for blood
            dissemination of solid tumors
  JOURNAL   Cancer Res 59 (15), 3748-3753 (1999)
   PUBMED   10446991
  REMARK    Erratum:[Cancer Res 2001 Jan 15;61(2):792. Guimaraes, FC [corrected
            to Guimaraes da Costa, F]]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF323731.1 and AB051451.2.
            
            On Nov 22, 2018 this sequence version replaced NM_030758.3.
            
            Summary: The protein encoded by this gene contains a pleckstrin
            homology (PH) domain and an oxysterol-binding region. It binds
            oxysterols such as 7-ketocholesterol and may inhibit their
            cytotoxicity. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051451.2, AF288741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332585.11/ ENSP00000332576.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2818              AF323731.1         69-2886
            2819-4261           AB051451.2         2795-4237
FEATURES             Location/Qualifiers
     source          1..4261
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..4261
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /note="oxysterol binding protein 2"
                     /db_xref="GeneID:23762"
                     /db_xref="HGNC:HGNC:8504"
                     /db_xref="MIM:606729"
     exon            1..680
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..2787
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /note="isoform a is encoded by transcript variant 1;
                     oxysterol binding protein-like 1; OSBP-related protein 4;
                     oxysterol-binding protein-related protein 4"
                     /codon_start=1
                     /product="oxysterol-binding protein 2 isoform a"
                     /protein_id="NP_110385.1"
                     /db_xref="CCDS:CCDS43002.1"
                     /db_xref="GeneID:23762"
                     /db_xref="HGNC:HGNC:8504"
                     /db_xref="MIM:606729"
                     /translation="MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTS
                     GSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQ
                     GSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKT
                     PLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQG
                     EMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKA
                     VRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSL
                     TELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYE
                     QEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDT
                     EYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVK
                     RRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDK
                     AVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQV
                     SHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKS
                     TSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQG
                     KAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENM
                     YYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRL
                     EACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPN
                     IF"
     exon            681..889
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1143
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1336
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1454
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1512
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1659
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1905
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1906..2026
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2130
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2226
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2411
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2644
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..4261
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4240..4245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /note="hexamer: AATAAA"
     polyA_site      4261
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /note="major polyA site"
ORIGIN      
        1 actggccgct cggccgcgcg cgggtcggcc ggctctatgg ggaaagcggc ggctccgagc
       61 cgaggcggcg gctgtggcgg ccgctcccgc gggctctcgt cgctgttcac ggttgtcccc
      121 tgcctgtcgt gccacacggc ggcgccgggc atgagcgctt ccacgtccgg ctccgggccg
      181 gagcccaagc cccagcccca gcccgtgccc gaaccggagc ggggaccgct gtcagaacag
      241 gtgtcggagg cagtttcgga ggcagtgcca agatcggaac ctgtgtccga gacgacgtct
      301 gagccggagc caggggctgg gcagccatcg gaactgctgc aggggtcgcg gccggggtca
      361 gagtcaagct caggtgtagg ggctgggccc ttcactaagg ccgcatcgga gccgctctcc
      421 cgggcggtgg ggagcgcgac ctttctcaga cccgagtcag gatcgctgcc agcgttaaag
      481 cccctgcctc ttctgcgacc aggacaggcg aagactcctc ttggggttcc aatgtcgggg
      541 actggcacga cctccagtgc cccactggcc ttactgcctc tggacagctt cgagggctgg
      601 cttctcaagt ggaccaacta tctgaagggc taccagcgcc gctggttcgt gctgggcaat
      661 ggtttgctct cttactacag aaatcagggt gaaatggccc acacgtgccg tggaaccatc
      721 aacctgtcca ccgcgcacat tgacacggag gactcttgtg gtatcttgct gaccagtggg
      781 gccaggagct accacctcaa ggccagctca gaggtggacc ggcagcagtg gatcaccgcc
      841 ctggagctgg ccaaggccaa ggctgtccgc gtgatgaaca ctcattcaga tgactctggg
      901 gacgacgacg aggctaccac cccagccgac aagagcgagc tgcaccacac cctgaagaat
      961 ctttccctga agttagatga cctcagcacg tgcaatgacc tcatcgccaa gcacggcgct
     1021 gcactccagc gctccctgac agagctggac ggcctcaaga tcccatctga gagtggggag
     1081 aagctgaagg tggtgaatga gcgggccacc ctcttccgca tcacatccaa tgctatgatc
     1141 aacgcctgca gggacttctt ggaactagca gagatacaca gtcggaaatg gcagcgggca
     1201 ctgcagtatg agcaggagca gcgcgtgcac ttggaggaaa ccattgagca gctggcgaag
     1261 cagcacaaca gcctcgagcg ggccttccac agtgcccctg gccggccggc caacccctcc
     1321 aagagcttca ttgagggaag cctcttgact cccaaaggag aggacagtga ggaagatgaa
     1381 gataccgagt actttgatgc catggaagac tccacatcct tcatcaccgt gatcaccgag
     1441 gccaaggaag acagcagaaa agctgaaggt agcaccggga caagttccgt ggactggagc
     1501 tcagcagaca atgtactaga tggtgcctcg ctcgtgccca agggttcatc caaagtcaag
     1561 aggcgagtcc gcattcccaa caagcccaac tacagcctta acctctggag catcatgaag
     1621 aactgcatcg gccgggagct ctccaggatc cccatgccgg tgaacttcaa tgagcccctg
     1681 tccatgctcc agcggctgac agaggacctg gagtaccacc acctgctgga caaggcagtg
     1741 cactgcacca gctcagtgga gcagatgtgc ctggtggccg ccttctctgt gtcctcctac
     1801 tccaccacag tgcaccgcat cgccaagccc ttcaacccca tgctggggga gaccttcgag
     1861 ctggaccgcc tcgacgacat gggcctgcgc tccctctgtg agcaggtgag ccaccacccc
     1921 ccctcagctg cgcactacgt gttctccaag catggctgga gcctctggca ggagatcacc
     1981 atctccagca agttccgggg aaaatacatc tccatcatgc cgctaggtgc catccactta
     2041 gaattccagg ccagtgggaa tcactacgtg tggaggaaga gcacctcaac tgttcacaac
     2101 atcatcgtgg gcaagctctg gatcgaccag tcaggggaca tcgagattgt gaaccataag
     2161 accaatgacc ggtgccagct gaagttcctg ccctacagct acttctccaa agaggcagcc
     2221 cggaaggtga caggagtggt gagtgacagc cagggcaagg cccattacgt gctgtccggc
     2281 tcgtgggatg aacaaatgga gtgctccaag gtcatgcata gcagtcccag cagccccagc
     2341 tctgacggga agcagaagac agtgtaccag accctgtcag ccaagctgct gtggaagaag
     2401 tacccgctgc cggagaacgc ggagaacatg tactacttct cagagctggc cctgaccctc
     2461 aacgagcacg aggagggcgt agcgccaacc gacagccgcc tgcggcccga ccagcggctg
     2521 atggagaagg gccgttggga cgaggccaat accgagaagc agcggctgga ggagaagcag
     2581 cgcctgtcgc ggcgccggcg gctggaggcc tgcgggccgg gcagcagctg cagctcggag
     2641 gaagagaagg aggcggatgc ctacacgcca ctgtggtttg agaagaggct ggatccgctg
     2701 accggggaga tggcctgtgt gtacaagggc ggctactggg aggccaagga gaagcaagac
     2761 tggcatatgt gccccaacat cttctgagcg ccacccttgc aacaaataca ggcgcctgca
     2821 cagcctggcc cacctgttca ttaatgcact caatttagta ctgaatggtc tttctcccag
     2881 cccattccca gcccttccta tttcctttcc tatttttttt ttctccccac actttcttgg
     2941 gactcccacc ttggaaggag gaagggctga cctgggttct ctccagcccc caggtgcgcc
     3001 gggtcacccg tgccccttca ttatggacct gggccctacc ggaacccctg ccccagttac
     3061 cacaactcag gccggctggc ccgggccatg ggctgcgcaa atcaccagcc cccaacccag
     3121 ggaggaactg gcccctccta gggagcctct tcgacttttt tagaaaaatg atctccattt
     3181 ctttccagcc atgatgttta gtaaatattt ttagtaccgc acttagcaga cagctttcca
     3241 agtgtgcttt cttgccacaa aagtgtcctg gcaagagccc cttattttta agacatcagg
     3301 aagccagacc gctttgagtt gggagaattt tgtagctcaa catatcaagt cctcgatggt
     3361 atctgagctg cccacacccc cacctgccaa ggccccacag agcccaaaac agaagggggc
     3421 tgccccagcc cagcagagca cagagtttct ggagctccca tccacagatg caggaggggg
     3481 tactgatggt aacccccatg tggatttgag ggcagcagtc cctggcctca ccctagccag
     3541 cctgggtggc tccctagccc caagaggcca ggaagggctg gaaggcaggg cctgcaggtg
     3601 ctccccgccc tgagacccag gccccaaatc agcaataatg aacaaaccct tggcccagcc
     3661 tgggctggtg acctgggcac cagagacctt gcatccctcc tcatcctagg aggcccctag
     3721 gggtgcccca tctcagtgtc ccctgaactc tttatttgcc taatttatat atatatatat
     3781 gagatatata aatatatata aaatagctat tttgcttaaa tttctacagt atgtaaaagt
     3841 gaaaaaatga tgaagacggg tgcacctgtc tgagtttggc cctcatgtga gctgtgccct
     3901 tccctctcct catgccccct tccagcggct tctgccaacc atggggggct ggaccaccat
     3961 ggccactgac ccagcccctc agaatcccac actccaatcc tttccatttc agtttagtcc
     4021 taaaagttca tcacagggtc tttctttcta ctccaggact ggttttgttt ttatatatat
     4081 aaaaaaaaaa agtgaaaaca ccaatgtgtg aaatgcctta caatgcccac tggagaggcg
     4141 gggcggggtg gggcaggatg gccccactgg ggctcctaca gagctgtgga atgtacctct
     4201 ccccaacact gttttgttag cgagcacctt ttgaccagta ataaaaaacc ttggctttgg
     4261 a
//
