LOCUS       NM_001282739            4258 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens oxysterol binding protein 2 (OSBP2), transcript
            variant 4, mRNA.
ACCESSION   NM_001282739 XM_005261464
VERSION     NM_001282739.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4258)
  AUTHORS   Wu,Q., Li,X., Long,M., Xie,X. and Liu,Q.
  TITLE     Integrated analysis of histone lysine lactylation (Kla)-specific
            genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic
            targets for hepatocellular carcinoma
  JOURNAL   Sci Rep 13 (1), 18642 (2023)
   PUBMED   37903971
  REMARK    GeneRIF: Integrated analysis of histone lysine lactylation
            (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are
            novel therapeutic targets for hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4258)
  AUTHORS   Zhong,W., Cao,X., Pan,G., Niu,Q., Feng,X., Xu,M., Li,M., Huang,Y.,
            Yi,Q. and Yan,D.
  TITLE     ORP4L is a prerequisite for the induction of T-cell leukemogenesis
            associated with human T-cell leukemia virus 1
  JOURNAL   Blood 139 (7), 1052-1065 (2022)
   PUBMED   34797912
  REMARK    GeneRIF: ORP4L is a prerequisite for the induction of T-cell
            leukemogenesis associated with human T-cell leukemia virus 1.
REFERENCE   3  (bases 1 to 4258)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4258)
  AUTHORS   Cao,X., Chen,J., Li,D., Xie,P., Xu,M., Lin,W., Li,S., Pan,G.,
            Tang,Y., Xu,J., Olkkonen,V.M., Yan,D. and Zhong,W.
  TITLE     ORP4L couples IP3 to ITPR1 in control of endoplasmic reticulum
            calcium release
  JOURNAL   FASEB J 33 (12), 13852-13865 (2019)
   PUBMED   31648575
  REMARK    GeneRIF: ORP4L is a cofactor of ITPR1.
REFERENCE   5  (bases 1 to 4258)
  AUTHORS   Wang,C., JeBailey,L. and Ridgway,N.D.
  TITLE     Oxysterol-binding-protein (OSBP)-related protein 4 binds
            25-hydroxycholesterol and interacts with vimentin intermediate
            filaments
  JOURNAL   Biochem J 361 (Pt 3), 461-472 (2002)
   PUBMED   11802775
REFERENCE   6  (bases 1 to 4258)
  AUTHORS   Jaworski,C.J., Moreira,E., Li,A., Lee,R. and Rodriguez,I.R.
  TITLE     A family of 12 human genes containing oxysterol-binding domains
  JOURNAL   Genomics 78 (3), 185-196 (2001)
   PUBMED   11735225
REFERENCE   7  (bases 1 to 4258)
  AUTHORS   Lehto,M., Laitinen,S., Chinetti,G., Johansson,M., Ehnholm,C.,
            Staels,B., Ikonen,E. and Olkkonen,V.M.
  TITLE     The OSBP-related protein family in humans
  JOURNAL   J Lipid Res 42 (8), 1203-1213 (2001)
   PUBMED   11483621
REFERENCE   8  (bases 1 to 4258)
  AUTHORS   Moreira,E.F., Jaworski,C., Li,A. and Rodriguez,I.R.
  TITLE     Molecular and biochemical characterization of a novel
            oxysterol-binding protein (OSBP2) highly expressed in retina
  JOURNAL   J Biol Chem 276 (21), 18570-18578 (2001)
   PUBMED   11278871
REFERENCE   9  (bases 1 to 4258)
  AUTHORS   Silva,N.H., Pimenta,G., Pulcheri,W.A., Fournier,M.V., Spector,N.
            and da Costa Carvalho,M.G.
  TITLE     Detection of messenger RNA in leukocytes or plasma of patients with
            chronic myeloid leukemia
  JOURNAL   Oncol Rep 8 (3), 693-696 (2001)
   PUBMED   11295104
REFERENCE   10 (bases 1 to 4258)
  AUTHORS   Fournier,M.V., Guimaraes da Costa,F., Paschoal,M.E., Ronco,L.V.,
            Carvalho,M.G. and Pardee,A.B.
  TITLE     Identification of a gene encoding a human oxysterol-binding
            protein-homologue: a potential general molecular marker for blood
            dissemination of solid tumors
  JOURNAL   Cancer Res 59 (15), 3748-3753 (1999)
   PUBMED   10446991
  REMARK    Erratum:[Cancer Res 2001 Jan 15;61(2):792. Guimaraes, FC [corrected
            to Guimaraes da Costa, F]]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF323731.1, BC118914.2,
            AC004542.1 and AB051451.2.
            
            On May 31, 2019 this sequence version replaced NM_001282739.1.
            
            Summary: The protein encoded by this gene contains a pleckstrin
            homology (PH) domain and an oxysterol-binding region. It binds
            oxysterols such as 7-ketocholesterol and may inhibit their
            cytotoxicity. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Sep 2013].
            
            Transcript Variant: This variant (4) uses an alternate in-frame
            splice site, compared to variant 1. The encoded isoform (d) is
            shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.112826.1,
                                           SRR1803612.87527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AF323731.1         69-83
            16-1019             BC118914.2         1-1004
            1020-1020           AC004542.1         25218-25218
            1021-2851           BC118914.2         1006-2836
            2852-4258           AB051451.2         2831-4237
FEATURES             Location/Qualifiers
     source          1..4258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..4258
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /note="oxysterol binding protein 2"
                     /db_xref="GeneID:23762"
                     /db_xref="HGNC:HGNC:8504"
                     /db_xref="MIM:606729"
     exon            1..680
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..2784
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /note="isoform d is encoded by transcript variant 4;
                     oxysterol binding protein-like 1; OSBP-related protein 4;
                     oxysterol-binding protein-related protein 4"
                     /codon_start=1
                     /product="oxysterol-binding protein 2 isoform d"
                     /protein_id="NP_001269668.1"
                     /db_xref="CCDS:CCDS63448.1"
                     /db_xref="GeneID:23762"
                     /db_xref="HGNC:HGNC:8504"
                     /db_xref="MIM:606729"
                     /translation="MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTS
                     GSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQ
                     GSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKT
                     PLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQG
                     EMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKA
                     VRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSL
                     TELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYE
                     QEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDT
                     EYFDAMEDSTSFITVITEAKEDRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKR
                     RVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKA
                     VHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVS
                     HHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKST
                     STVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGK
                     AHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMY
                     YFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLE
                     ACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNI
                     F"
     exon            681..889
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1143
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1336
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1454
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1509
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1656
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1902
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2023
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2127
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2223
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2408
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2641
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..4258
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4237..4242
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /note="hexamer: AATAAA"
     polyA_site      4258
                     /gene="OSBP2"
                     /gene_synonym="HLM; ORP-4; ORP4; OSBPL1; OSBPL4"
                     /note="major polyA site"
ORIGIN      
        1 actggccgct cggccgcgcg cgggtcggcc ggctctatgg ggaaagcggc ggctccgagc
       61 cgaggcggcg gctgtggcgg ccgctcccgc gggctctcgt cgctgttcac ggttgtcccc
      121 tgcctgtcgt gccacacggc ggcgccgggc atgagcgctt ccacgtccgg ctccgggccg
      181 gagcccaagc cccagcccca gcccgtgccc gaaccggagc ggggaccgct gtcagaacag
      241 gtgtcggagg cagtttcgga ggcagtgcca agatcggaac ctgtgtccga gacgacgtct
      301 gagccggagc caggggctgg gcagccatcg gaactgctgc aggggtcgcg gccggggtca
      361 gagtcaagct caggtgtagg ggctgggccc ttcactaagg ccgcatcgga gccgctctcc
      421 cgggcggtgg ggagcgcgac ctttctcaga cccgagtcag gatcgctgcc agcgttaaag
      481 cccctgcctc ttctgcgacc aggacaggcg aagactcctc ttggggttcc aatgtcgggg
      541 actggcacga cctccagtgc cccactggcc ttactgcctc tggacagctt cgagggctgg
      601 cttctcaagt ggaccaacta tctgaagggc taccagcgcc gctggttcgt gctgggcaat
      661 ggtttgctct cttactacag aaatcagggt gaaatggccc acacgtgccg tggaaccatc
      721 aacctgtcca ccgcgcacat tgacacggag gactcttgtg gtatcttgct gaccagtggg
      781 gccaggagct accacctcaa ggccagctca gaggtggacc ggcagcagtg gatcaccgcc
      841 ctggagctgg ccaaggccaa ggctgtccgc gtgatgaaca ctcattcaga tgactctggg
      901 gacgacgacg aggctaccac cccagccgac aagagcgagc tgcaccacac cctgaagaat
      961 ctttccctga agttagatga cctcagcacg tgcaatgacc tcatcgccaa gcacggcgct
     1021 gcactccagc gctccctgac agagctggac ggcctcaaga tcccatctga gagtggggag
     1081 aagctgaagg tggtgaatga gcgggccacc ctcttccgca tcacatccaa tgctatgatc
     1141 aacgcctgca gggacttctt ggaactagca gagatacaca gtcggaaatg gcagcgggca
     1201 ctgcagtatg agcaggagca gcgcgtgcac ttggaggaaa ccattgagca gctggcgaag
     1261 cagcacaaca gcctcgagcg ggccttccac agtgcccctg gccggccggc caacccctcc
     1321 aagagcttca ttgagggaag cctcttgact cccaaaggag aggacagtga ggaagatgaa
     1381 gataccgagt actttgatgc catggaagac tccacatcct tcatcaccgt gatcaccgag
     1441 gccaaggaag acagaaaagc tgaaggtagc accgggacaa gttccgtgga ctggagctca
     1501 gcagacaatg tactagatgg tgcctcgctc gtgcccaagg gttcatccaa agtcaagagg
     1561 cgagtccgca ttcccaacaa gcccaactac agccttaacc tctggagcat catgaagaac
     1621 tgcatcggcc gggagctctc caggatcccc atgccggtga acttcaatga gcccctgtcc
     1681 atgctccagc ggctgacaga ggacctggag taccaccacc tgctggacaa ggcagtgcac
     1741 tgcaccagct cagtggagca gatgtgcctg gtggccgcct tctctgtgtc ctcctactcc
     1801 accacagtgc accgcatcgc caagcccttc aaccccatgc tgggggagac cttcgagctg
     1861 gaccgcctcg acgacatggg cctgcgctcc ctctgtgagc aggtgagcca ccaccccccc
     1921 tcagctgcgc actacgtgtt ctccaagcat ggctggagcc tctggcagga gatcaccatc
     1981 tccagcaagt tccggggaaa atacatctcc atcatgccgc taggtgccat ccacttagaa
     2041 ttccaggcca gtgggaatca ctacgtgtgg aggaagagca cctcaactgt tcacaacatc
     2101 atcgtgggca agctctggat cgaccagtca ggggacatcg agattgtgaa ccataagacc
     2161 aatgaccggt gccagctgaa gttcctgccc tacagctact tctccaaaga ggcagcccgg
     2221 aaggtgacag gagtggtgag tgacagccag ggcaaggccc attacgtgct gtccggctcg
     2281 tgggatgaac aaatggagtg ctccaaggtc atgcatagca gtcccagcag ccccagctct
     2341 gacgggaagc agaagacagt gtaccagacc ctgtcagcca agctgctgtg gaagaagtac
     2401 ccgctgccgg agaacgcgga gaacatgtac tacttctcag agctggccct gaccctcaac
     2461 gagcacgagg agggcgtagc gccaaccgac agccgcctgc ggcccgacca gcggctgatg
     2521 gagaagggcc gttgggacga ggccaatacc gagaagcagc ggctggagga gaagcagcgc
     2581 ctgtcgcggc gccggcggct ggaggcctgc gggccgggca gcagctgcag ctcggaggaa
     2641 gagaaggagg cggatgccta cacgccactg tggtttgaga agaggctgga tccgctgacc
     2701 ggggagatgg cctgtgtgta caagggcggc tactgggagg ccaaggagaa gcaagactgg
     2761 catatgtgcc ccaacatctt ctgagcgcca cccttgcaac aaatacaggc gcctgcacag
     2821 cctggcccac ctgttcatta atgcactcaa tttagtactg aatggtcttt ctcccagccc
     2881 attcccagcc cttcctattt cctttcctat tttttttttc tccccacact ttcttgggac
     2941 tcccaccttg gaaggaggaa gggctgacct gggttctctc cagcccccag gtgcgccggg
     3001 tcacccgtgc cccttcatta tggacctggg ccctaccgga acccctgccc cagttaccac
     3061 aactcaggcc ggctggcccg ggccatgggc tgcgcaaatc accagccccc aacccaggga
     3121 ggaactggcc cctcctaggg agcctcttcg acttttttag aaaaatgatc tccatttctt
     3181 tccagccatg atgtttagta aatattttta gtaccgcact tagcagacag ctttccaagt
     3241 gtgctttctt gccacaaaag tgtcctggca agagcccctt atttttaaga catcaggaag
     3301 ccagaccgct ttgagttggg agaattttgt agctcaacat atcaagtcct cgatggtatc
     3361 tgagctgccc acacccccac ctgccaaggc cccacagagc ccaaaacaga agggggctgc
     3421 cccagcccag cagagcacag agtttctgga gctcccatcc acagatgcag gagggggtac
     3481 tgatggtaac ccccatgtgg atttgagggc agcagtccct ggcctcaccc tagccagcct
     3541 gggtggctcc ctagccccaa gaggccagga agggctggaa ggcagggcct gcaggtgctc
     3601 cccgccctga gacccaggcc ccaaatcagc aataatgaac aaacccttgg cccagcctgg
     3661 gctggtgacc tgggcaccag agaccttgca tccctcctca tcctaggagg cccctagggg
     3721 tgccccatct cagtgtcccc tgaactcttt atttgcctaa tttatatata tatatatgag
     3781 atatataaat atatataaaa tagctatttt gcttaaattt ctacagtatg taaaagtgaa
     3841 aaaatgatga agacgggtgc acctgtctga gtttggccct catgtgagct gtgcccttcc
     3901 ctctcctcat gcccccttcc agcggcttct gccaaccatg gggggctgga ccaccatggc
     3961 cactgaccca gcccctcaga atcccacact ccaatccttt ccatttcagt ttagtcctaa
     4021 aagttcatca cagggtcttt ctttctactc caggactggt tttgttttta tatatataaa
     4081 aaaaaaaagt gaaaacacca atgtgtgaaa tgccttacaa tgcccactgg agaggcgggg
     4141 cggggtgggg caggatggcc ccactggggc tcctacagag ctgtggaatg tacctctccc
     4201 caacactgtt ttgttagcga gcaccttttg accagtaata aaaaaccttg gctttgga
//
