LOCUS       NM_006812               2682 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens OS9 endoplasmic reticulum lectin (OS9), transcript
            variant 1, mRNA.
ACCESSION   NM_006812
VERSION     NM_006812.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2682)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   2  (bases 1 to 2682)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   3  (bases 1 to 2682)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2682)
  AUTHORS   Li,W., Chung,C.Y.L., Wang,C.C., Chan,T.F., Leung,M.B.W., Chan,O.K.,
            Wu,L., Appiah,K., Chaemsaithong,P., Cheng,Y.K.Y., Poon,L.C.Y. and
            Leung,T.Y.
  TITLE     Monochorionic twins with selective fetal growth restriction:
            insight from placental whole-transcriptome analysis
  JOURNAL   Am J Obstet Gynecol 223 (5), 749 (2020)
   PUBMED   32437666
  REMARK    GeneRIF: Monochorionic twins with selective fetal growth
            restriction: insight from placental whole-transcriptome analysis.
REFERENCE   5  (bases 1 to 2682)
  AUTHORS   van der Goot,A.T., Pearce,M.M.P., Leto,D.E., Shaler,T.A. and
            Kopito,R.R.
  TITLE     Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding
            Glycan and Non-glycan Degrons in ER-Associated Degradation
  JOURNAL   Mol Cell 70 (3), 516-530 (2018)
   PUBMED   29706535
  REMARK    GeneRIF: The relative expression of OS9 and XTP3B and the
            distribution of glycan and non-glycan degrons within the same
            protein contribute to the fidelity.
REFERENCE   6  (bases 1 to 2682)
  AUTHORS   Kimura,Y., Nakazawa,M. and Yamada,M.
  TITLE     Cloning and characterization of three isoforms of OS-9 cDNA and
            expression of the OS-9 gene in various human tumor cell lines
  JOURNAL   J Biochem 123 (5), 876-882 (1998)
   PUBMED   9562620
REFERENCE   7  (bases 1 to 2682)
  AUTHORS   Kimura,Y., Nakazawa,M., Tsuchiya,N., Asakawa,S., Shimizu,N. and
            Yamada,M.
  TITLE     Genomic organization of the OS-9 gene amplified in human sarcomas
  JOURNAL   J Biochem 122 (6), 1190-1195 (1997)
   PUBMED   9498564
REFERENCE   8  (bases 1 to 2682)
  AUTHORS   Elkahloun,A.G., Krizman,D.B., Wang,Z., Hofmann,T.A., Roe,B. and
            Meltzer,P.S.
  TITLE     Transcript mapping in a 46-kb sequenced region at the core of
            12q13.3 amplification in human cancers
  JOURNAL   Genomics 42 (2), 295-301 (1997)
   PUBMED   9192850
REFERENCE   9  (bases 1 to 2682)
  AUTHORS   Su,Y.A., Hutter,C.M., Trent,J.M. and Meltzer,P.S.
  TITLE     Complete sequence analysis of a gene (OS-9) ubiquitously expressed
            in human tissues and amplified in sarcomas
  JOURNAL   Mol Carcinog 15 (4), 270-275 (1996)
   PUBMED   8634085
REFERENCE   10 (bases 1 to 2682)
  AUTHORS   Su,Y.A., Trent,J.M., Guan,X.Y. and Meltzer,P.S.
  TITLE     Direct isolation of genes encoded within a homogeneously staining
            region by chromosome microdissection
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 9121-9125 (1994)
   PUBMED   8090779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU132426.1, BC000532.2,
            U41635.1 and BC023513.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006812.3.
            
            Summary: This gene encodes a protein that is highly expressed in
            osteosarcomas. This protein binds to the hypoxia-inducible factor 1
            (HIF-1), a key regulator of the hypoxic response and angiogenesis,
            and promotes the degradation of one of its subunits. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also referred to as
            OS-9-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.837461.1,
                                           SRR1660809.22245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315970.12/ ENSP00000318165.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AU132426.1         30-47
            19-1576             BC000532.2         1-1558
            1577-2612           U41635.1           1632-2667
            2613-2682           BC023513.2         2420-2489
FEATURES             Location/Qualifiers
     source          1..2682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3-q14.1"
     gene            1..2682
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /note="OS9 endoplasmic reticulum lectin"
                     /db_xref="GeneID:10956"
                     /db_xref="HGNC:HGNC:16994"
                     /db_xref="MIM:609677"
     exon            1..192
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2034
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; erlectin 2; endoplasmic reticulum lectin 2;
                     osteosarcoma amplified 9, endoplasmic reticulum associated
                     protein; protein OS-9; amplified in osteosarcoma 9;
                     osteosarcoma amplified 9, endoplasmic reticulum lectin"
                     /codon_start=1
                     /product="protein OS-9 isoform 1 precursor"
                     /protein_id="NP_006803.1"
                     /db_xref="CCDS:CCDS31843.1"
                     /db_xref="GeneID:10956"
                     /db_xref="HGNC:HGNC:16994"
                     /db_xref="MIM:609677"
                     /translation="MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIE
                     ILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELL
                     SPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAK
                     ASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSY
                     VLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEEL
                     QDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQD
                     PSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDA
                     AEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDRD
                     RLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQ
                     SPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKREN
                     PQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFN
                     ILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF"
     exon            193..369
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            370..433
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            434..510
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            511..609
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            610..820
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            821..922
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1023
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1075
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1164
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1440
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1630
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1795
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1908
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2682
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2662..2667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /note="hexamer: AATAAA"
     polyA_site      2682
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /note="major polyA site"
ORIGIN      
        1 agattctctg cataagaagg ggaacgaaag atggcggcgg aaacgctgct gtccagtttg
       61 ttaggactgc tgcttctggg actcctgtta cccgcaagtc tgaccggcgg tgtcgggagc
      121 ctgaacctgg aggagctgag tgagatgcgt tatgggatcg agatcctgcc gttgcctgtc
      181 atgggagggc agagccaatc ttcggacgtg gtgattgtct cctctaagta caaacagcgc
      241 tatgagtgtc gcctgccagc tggagctatt cacttccagc gtgaaaggga ggaggaaaca
      301 cctgcttacc aagggcctgg gatccctgag ttgttgagcc caatgagaga tgctccctgc
      361 ttgctgaaga caaaggactg gtggacatat gaattctgtt atggacgcca catccagcaa
      421 taccacatgg aagattcaga gatcaaaggt gaagtcctct atctcggcta ctaccaatca
      481 gccttcgact gggatgatga aacagccaag gcctccaagc agcatcgtct taaacgctac
      541 cacagccaga cctatggcaa tgggtccaag tgcgacctta atgggaggcc ccgggaggcc
      601 gaggttcggt tcctctgtga cgagggtgca ggtatctctg gggactacat cgatcgcgtg
      661 gacgagccct tgtcctgctc ttatgtgctg accattcgca ctcctcggct ctgcccccac
      721 cctctcctcc ggcccccacc cagtgctgca ccgcaggcca tcctctgtca cccttcccta
      781 cagcctgagg agtacatggc ctacgttcag aggcaagccg actcaaagca gtatggagat
      841 aaaatcatag aggagctgca agatctaggc ccccaagtgt ggagtgagac caagtctggg
      901 gtggcacccc aaaagatggc aggtgcgagc ccgaccaagg atgacagtaa ggactcagat
      961 ttctggaaga tgcttaatga gccagaggac caggccccag gaggggagga ggtgccggct
     1021 gaggagcagg acccaagccc tgaggcagca gattcagctt ctggtgctcc caatgatttt
     1081 cagaacaacg tgcaggtcaa agtcattcga agccctgcgg atttgattcg attcatagag
     1141 gagctgaaag gtggaacaaa aaaggggaag ccaaatatag gccaagagca gcctgtggat
     1201 gatgctgcag aagtccctca gagggaacca gagaaggaaa ggggtgatcc agaacggcag
     1261 agagagatgg aagaagagga ggatgaggat gaggatgagg atgaagatga ggatgaacgg
     1321 cagttactgg gagaatttga gaaggaactg gaagggatcc tgcttccgtc agaccgagac
     1381 cggctccgtt cggaggtgaa ggctggcatg gagcgggaac tggaaaacat catccaggag
     1441 acagagaaag agctggaccc agatgggctg aagaaggagt cagagcggga tcgggcaatg
     1501 ctggctctca catccactct caacaaactc atcaaaagac tggaggaaaa acagagtcca
     1561 gagctggtga agaagcacaa gaaaaagagg gttgtcccca aaaagcctcc cccatcaccc
     1621 caacctacag aggaggatcc tgagcacaga gtccgggtcc gggtcaccaa gctccgtctc
     1681 ggaggcccta atcaggatct gactgtcctc gagatgaaac gggaaaaccc acagctgaaa
     1741 caaatcgagg ggctggtgaa ggagctgctg gagagggagg gactcacagc tgcagggaaa
     1801 attgagatca aaattgtccg cccatgggct gaagggactg aagagggtgc acgttggctg
     1861 actgatgagg acacgagaaa cctcaaggag atcttcttca atatcttggt gccgggagct
     1921 gaagaggccc agaaggaacg ccagcggcag aaagagctgg agagcaatta ccgccgggtg
     1981 tggggctctc caggtgggga gggcacaggg gacctggacg aatttgactt ctgagaccaa
     2041 cactacactt gacccttcac ggaatccaga ctcttcctgg actggcttgc ctcctcccca
     2101 cctccccacc ctggaacccc tgagggccaa acagcagagt ggagctgagc tgtggacctc
     2161 tcgggcaact ctgtgggtgt gggggccctg ggtgaatgct gctgcccctg ctggcagcca
     2221 ccttgagacc tcaccgggcc tgtgatattt gctctcctga actctcactc aatcctcttc
     2281 ctctcctctg tggcttttcc tgttattgtc ccctaatgat aggatattcc ctgctgccta
     2341 cctggagatt cagtaggatc ttttgagtgg aggtgggtag agagagcaag gagggcagga
     2401 cacttagcag gcactgagca agcaggcccc cacctgccct tagtgatgtt tggagtcgtt
     2461 ttaccctctt ctattgaatt gccttgggat ttccttctcc ctttccctgc ccaccctgtc
     2521 ccctacaatt tgtgcttctg agttgaggag ccttcacctc tgttgctgag gaaatggtag
     2581 aatgctgcct atcacctcca gcacaatccc agtgaaaaag gtgtgaagca cccaccatgt
     2641 tcttgaacaa tcaggtttct aaataaacaa ctggaccatc aa
//
