LOCUS       NM_001261421            2421 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens OS9 endoplasmic reticulum lectin (OS9), transcript
            variant 6, mRNA.
ACCESSION   NM_001261421
VERSION     NM_001261421.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Li,W., Chung,C.Y.L., Wang,C.C., Chan,T.F., Leung,M.B.W., Chan,O.K.,
            Wu,L., Appiah,K., Chaemsaithong,P., Cheng,Y.K.Y., Poon,L.C.Y. and
            Leung,T.Y.
  TITLE     Monochorionic twins with selective fetal growth restriction:
            insight from placental whole-transcriptome analysis
  JOURNAL   Am J Obstet Gynecol 223 (5), 749 (2020)
   PUBMED   32437666
  REMARK    GeneRIF: Monochorionic twins with selective fetal growth
            restriction: insight from placental whole-transcriptome analysis.
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   van der Goot,A.T., Pearce,M.M.P., Leto,D.E., Shaler,T.A. and
            Kopito,R.R.
  TITLE     Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding
            Glycan and Non-glycan Degrons in ER-Associated Degradation
  JOURNAL   Mol Cell 70 (3), 516-530 (2018)
   PUBMED   29706535
  REMARK    GeneRIF: The relative expression of OS9 and XTP3B and the
            distribution of glycan and non-glycan degrons within the same
            protein contribute to the fidelity.
REFERENCE   6  (bases 1 to 2421)
  AUTHORS   Kimura,Y., Nakazawa,M. and Yamada,M.
  TITLE     Cloning and characterization of three isoforms of OS-9 cDNA and
            expression of the OS-9 gene in various human tumor cell lines
  JOURNAL   J Biochem 123 (5), 876-882 (1998)
   PUBMED   9562620
REFERENCE   7  (bases 1 to 2421)
  AUTHORS   Kimura,Y., Nakazawa,M., Tsuchiya,N., Asakawa,S., Shimizu,N. and
            Yamada,M.
  TITLE     Genomic organization of the OS-9 gene amplified in human sarcomas
  JOURNAL   J Biochem 122 (6), 1190-1195 (1997)
   PUBMED   9498564
REFERENCE   8  (bases 1 to 2421)
  AUTHORS   Elkahloun,A.G., Krizman,D.B., Wang,Z., Hofmann,T.A., Roe,B. and
            Meltzer,P.S.
  TITLE     Transcript mapping in a 46-kb sequenced region at the core of
            12q13.3 amplification in human cancers
  JOURNAL   Genomics 42 (2), 295-301 (1997)
   PUBMED   9192850
REFERENCE   9  (bases 1 to 2421)
  AUTHORS   Su,Y.A., Hutter,C.M., Trent,J.M. and Meltzer,P.S.
  TITLE     Complete sequence analysis of a gene (OS-9) ubiquitously expressed
            in human tissues and amplified in sarcomas
  JOURNAL   Mol Carcinog 15 (4), 270-275 (1996)
   PUBMED   8634085
REFERENCE   10 (bases 1 to 2421)
  AUTHORS   Su,Y.A., Trent,J.M., Guan,X.Y. and Meltzer,P.S.
  TITLE     Direct isolation of genes encoded within a homogeneously staining
            region by chromosome microdissection
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 9121-9125 (1994)
   PUBMED   8090779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU132426.1, AK298532.1 and
            BC000532.2.
            
            On Aug 14, 2020 this sequence version replaced NM_001261421.1.
            
            Summary: This gene encodes a protein that is highly expressed in
            osteosarcomas. This protein binds to the hypoxia-inducible factor 1
            (HIF-1), a key regulator of the hypoxic response and angiogenesis,
            and promotes the degradation of one of its subunits. Alternate
            transcriptional splice variants, encoding different isoforms, have
            been characterized. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (6) has multiple differences in
            the coding region but maintains the reading frame, compared to
            variant 1. The resulting isoform (6) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298532.1, SRR14038195.1176408.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AU132426.1         30-42
            14-1328             AK298532.1         1-1315
            1329-2421           BC000532.2         1407-2499
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3-q14.1"
     gene            1..2421
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /note="OS9 endoplasmic reticulum lectin"
                     /db_xref="GeneID:10956"
                     /db_xref="HGNC:HGNC:16994"
                     /db_xref="MIM:609677"
     exon            1..192
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1773
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /note="isoform 6 precursor is encoded by transcript
                     variant 6; erlectin 2; endoplasmic reticulum lectin 2;
                     osteosarcoma amplified 9, endoplasmic reticulum associated
                     protein; protein OS-9; amplified in osteosarcoma 9;
                     osteosarcoma amplified 9, endoplasmic reticulum lectin"
                     /codon_start=1
                     /product="protein OS-9 isoform 6 precursor"
                     /protein_id="NP_001248350.1"
                     /db_xref="CCDS:CCDS58248.1"
                     /db_xref="GeneID:10956"
                     /db_xref="HGNC:HGNC:16994"
                     /db_xref="MIM:609677"
                     /translation="MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIE
                     ILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELL
                     SPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAK
                     FLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQ
                     PEEYMAYVQRQAVDSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKD
                     SDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLI
                     RFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDED
                     EDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKK
                     ESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTGKIEIKI
                     VRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGS
                     PGGEGTGDLDEFDF"
     exon            193..369
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            370..433
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            434..510
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            511..721
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            722..826
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            827..927
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            928..979
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1068
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1344
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1534
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1647
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..2421
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /note="hexamer: AATAAA"
     polyA_site      2421
                     /gene="OS9"
                     /gene_synonym="ERLEC2; OS-9"
                     /note="major polyA site"
ORIGIN      
        1 agattctctg cataagaagg ggaacgaaag atggcggcgg aaacgctgct gtccagtttg
       61 ttaggactgc tgcttctggg actcctgtta cccgcaagtc tgaccggcgg tgtcgggagc
      121 ctgaacctgg aggagctgag tgagatgcgt tatgggatcg agatcctgcc gttgcctgtc
      181 atgggagggc agagccaatc ttcggacgtg gtgattgtct cctctaagta caaacagcgc
      241 tatgagtgtc gcctgccagc tggagctatt cacttccagc gtgaaaggga ggaggaaaca
      301 cctgcttacc aagggcctgg gatccctgag ttgttgagcc caatgagaga tgctccctgc
      361 ttgctgaaga caaaggactg gtggacatat gaattctgtt atggacgcca catccagcaa
      421 taccacatgg aagattcaga gatcaaaggt gaagtcctct atctcggcta ctaccaatca
      481 gccttcgact gggatgatga aacagccaag ttcctctgtg acgagggtgc aggtatctct
      541 ggggactaca tcgatcgcgt ggacgagccc ttgtcctgct cttatgtgct gaccattcgc
      601 actcctcggc tctgccccca ccctctcctc cggcccccac ccagtgctgc accgcaggcc
      661 atcctctgtc acccttccct acagcctgag gagtacatgg cctacgttca gaggcaagcc
      721 gtagactcaa agcagtatgg agataaaatc atagaggagc tgcaagatct aggcccccaa
      781 gtgtggagtg agaccaagtc tggggtggca ccccaaaaga tggcaggtgc gagcccgacc
      841 aaggatgaca gtaaggactc agatttctgg aagatgctta atgagccaga ggaccaggcc
      901 ccaggagggg aggaggtgcc ggctgaggag caggacccaa gccctgaggc agcagattca
      961 gcttctggtg ctcccaatga ttttcagaac aacgtgcagg tcaaagtcat tcgaagccct
     1021 gcggatttga ttcgattcat agaggagctg aaaggtggaa caaaaaaggg gaagccaaat
     1081 ataggccaag agcagcctgt ggatgatgct gcagaagtcc ctcagaggga accagagaag
     1141 gaaaggggtg atccagaacg gcagagagag atggaagaag aggaggatga ggatgaggat
     1201 gaggatgaag atgaggatga acggcagtta ctgggagaat ttgagaagga actggaaggg
     1261 atcctgcttc cgtcagaccg agaccggctc cgttcggagg tgaaggctgg catggagcgg
     1321 gaactggaaa acatcatcca ggagacagag aaagagctgg acccagatgg gctgaagaag
     1381 gagtcagagc gggatcgggc aatgctggct ctcacatcca ctctcaacaa actcatcaaa
     1441 agactggagg aaaaacagag tccagagctg gtgaagaagc acaagaaaaa gagggttgtc
     1501 cccaaaaagc ctcccccatc accccaacct acagggaaaa ttgagatcaa aattgtccgc
     1561 ccatgggctg aagggactga agagggtgca cgttggctga ctgatgagga cacgagaaac
     1621 ctcaaggaga tcttcttcaa tatcttggtg ccgggagctg aagaggccca gaaggaacgc
     1681 cagcggcaga aagagctgga gagcaattac cgccgggtgt ggggctctcc aggtggggag
     1741 ggcacagggg acctggacga atttgacttc tgagaccaac actacacttg acccttcacg
     1801 gaatccagac tcttcctgga ctggcttgcc tcctccccac ctccccaccc tggaacccct
     1861 gagggccaaa cagcagagtg gagctgagct gtggacctct cgggcaactc tgtgggtgtg
     1921 ggggccctgg gtgaatgctg ctgcccctgc tggcagccac cttgagacct caccgggcct
     1981 gtgatatttg ctctcctgaa ctctcactca atcctcttcc tctcctctgt ggcttttcct
     2041 gttattgtcc cctaatgata ggatattccc tgctgcctac ctggagattc agtaggatct
     2101 tttgagtgga ggtgggtaga gagagcaagg agggcaggac acttagcagg cactgagcaa
     2161 gcaggccccc acctgccctt agtgatgttt ggagtcgttt taccctcttc tattgaattg
     2221 ccttgggatt tccttctccc tttccctgcc caccctgtcc cctacaattt gtgcttctga
     2281 gttgaggagc cttcacctct gttgctgagg aaatggtaga atgctgccta tcacctccag
     2341 cacaatccca gtgaaaaagg tgtgaagcac ccaccatgtt cttgaacaat caggtttcta
     2401 aataaacaac tggaccatca a
//
