LOCUS       NM_000608                759 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens orosomucoid 2 (ORM2), mRNA.
ACCESSION   NM_000608
VERSION     NM_000608.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Ge,Y., Xu,B., Cai,H., Jing,W., Ouyang,Q., Yuan,Q., Li,X., Fan,Y.,
            Shen,Y., Shi,Q., Wang,Q., Cui,L., Yin,X. and Ma,G.
  TITLE     Diagnostic role of plasma ORM2 in differentiating prostate cancer
            from benign prostatic hyperplasia
  JOURNAL   J Cancer Res Clin Oncol 149 (6), 2301-2310 (2023)
   PUBMED   36198834
  REMARK    GeneRIF: Diagnostic role of plasma ORM2 in differentiating prostate
            cancer from benign prostatic hyperplasia.
REFERENCE   2  (bases 1 to 759)
  AUTHORS   Nakamura,Y., Iwata,S., Yokoi,K., Mizutani,Y., Yoshikane,M.,
            Kawase,K., Kato,T., Kobayashi,S., Goto,H., Saitoh,S. and Iwata,O.
  TITLE     Influence of Intrauterine Inflammation, Delivery, and Postnatal
            Feeding on the Temporal Changes of Serum Alpha 1 Acid Glycoprotein
            Levels in Extremely-Low-Birth-Weight Infants
  JOURNAL   Nutrients 14 (23), 5162 (2022)
   PUBMED   36501194
  REMARK    GeneRIF: Influence of Intrauterine Inflammation, Delivery, and
            Postnatal Feeding on the Temporal Changes of Serum Alpha 1 Acid
            Glycoprotein Levels in Extremely-Low-Birth-Weight Infants.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Elpek,G.O.
  TITLE     Orosomucoid in liver diseases
  JOURNAL   World J Gastroenterol 27 (45), 7739-7747 (2021)
   PUBMED   34963738
  REMARK    GeneRIF: Orosomucoid in liver diseases.
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Sabry,R., El-Madbouly,A.A., Abozeid,H.E. and Hassan,M.M.
  TITLE     Urinary Orosomucoid - 2 and Soluble CD14 as Potential Biomarkers
            for Assessment of Disease Activity in Rheumatoid Arthritis
  JOURNAL   Egypt J Immunol 25 (2), 107-116 (2018)
   PUBMED   30600953
  REMARK    GeneRIF: Urinary ORM-2 and sCD14 levels were increased in patients
            with Rheumatoid Arthritis and were correlated with the disease
            activity.
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Treuheit,M.J., Costello,C.E. and Halsall,H.B.
  TITLE     Analysis of the five glycosylation sites of human alpha 1-acid
            glycoprotein
  JOURNAL   Biochem J 283 (Pt 1) (Pt 1), 105-112 (1992)
   PUBMED   1567356
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Merritt,C.M. and Board,P.G.
  TITLE     Structure and characterisation of a duplicated human alpha 1 acid
            glycoprotein gene
  JOURNAL   Gene 66 (1), 97-106 (1988)
   PUBMED   2970990
REFERENCE   8  (bases 1 to 759)
  AUTHORS   Yuasa,I., Suenaga,K., Umetsu,K., Ito,K. and Robinet-Levy,M.
  TITLE     Orosomucoid (ORM) typing by isoelectric focusing: evidence for gene
            duplication of ORM1 and genetic polymorphism of ORM2
  JOURNAL   Hum Genet 77 (3), 255-258 (1987)
   PUBMED   3679210
REFERENCE   9  (bases 1 to 759)
  AUTHORS   Escallon,M.H., Ferrell,R.E. and Kamboh,M.I.
  TITLE     Genetic studies of low-abundance human plasma proteins. V. Evidence
            for a second orosomucoid structural locus (ORM2) expressed in
            plasma
  JOURNAL   Am J Hum Genet 41 (3), 418-427 (1987)
   PUBMED   3631077
REFERENCE   10 (bases 1 to 759)
  AUTHORS   Dente,L., Pizza,M.G., Metspalu,A. and Cortese,R.
  TITLE     Structure and expression of the genes coding for human alpha 1-acid
            glycoprotein
  JOURNAL   EMBO J 6 (8), 2289-2296 (1987)
   PUBMED   2822385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356796.16.
            
            On Dec 11, 2019 this sequence version replaced NM_000608.3.
            
            Summary: This gene encodes a key acute phase plasma protein.
            Because of its increase due to acute inflammation, this protein is
            classified as an acute-phase reactant.  The specific function of
            this protein has not yet been determined; however, it may be
            involved in aspects of immunosuppression. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG618005.1, BC056239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431067.4/ ENSP00000394936.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL356796.16        60050-60199
            151-293             AL356796.16        60615-60757
            294-364             AL356796.16        60973-61043
            365-472             AL356796.16        61748-61855
            473-576             AL356796.16        62007-62110
            577-759             AL356796.16        63250-63432
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..759
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /note="orosomucoid 2"
                     /db_xref="GeneID:5005"
                     /db_xref="HGNC:HGNC:8499"
                     /db_xref="MIM:138610"
     exon            1..150
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..642
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /note="alpha-1-acid glycoprotein, type 2; alpha-1-acid
                     glycoprotein 2; AGP 2; OMD 2"
                     /codon_start=1
                     /product="alpha-1-acid glycoprotein 2 precursor"
                     /protein_id="NP_000599.1"
                     /db_xref="CCDS:CCDS6804.1"
                     /db_xref="GeneID:5005"
                     /db_xref="HGNC:HGNC:8499"
                     /db_xref="MIM:138610"
                     /translation="MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWF
                     YIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRE
                     NGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFY
                     EALDCLCIPRSDVMYTDWKKDKCEPLEKQHEKERKQEEGES"
     exon            151..293
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            294..364
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..472
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..576
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..759
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      736..741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /note="hexamer: AATAAA"
     polyA_site      759
                     /gene="ORM2"
                     /gene_synonym="AGP-B; AGP-B'; AGP2"
                     /note="major polyA site"
ORIGIN      
        1 agcactgcct ggctccacgt gcctcctggt ctcagtatgg cgctgtcctg ggttcttaca
       61 gtcctgagcc tcctacctct gctggaagcc cagatcccat tgtgtgccaa cctagtaccg
      121 gtgcccatca ccaacgccac cctggaccgg atcactggca agtggtttta tatcgcatcg
      181 gcctttcgaa acgaggagta caataagtcg gttcaggaga tccaagcaac cttcttttac
      241 tttaccccca acaagacaga ggacacgatc tttctcagag agtaccagac ccgccagaac
      301 cagtgcttct ataactccag ttacctgaat gtccagcggg agaatgggac cgtctccaga
      361 tacgagggag gccgagaaca tgttgctcac ctgctgttcc ttagggacac caagaccttg
      421 atgtttggtt cctacctgga cgatgagaag aactgggggc tgtctttcta tgctgacaag
      481 ccagagacga ccaaggagca actgggagag ttctacgaag ctctcgactg cttgtgcatt
      541 cccaggtcag atgtcatgta caccgactgg aaaaaggata agtgtgagcc actggagaag
      601 cagcacgaga aggagaggaa acaggaggag ggggaatcct agcaggacac agccttggat
      661 caggacagag acttgggggc catcctgccc ctccaacccg acatgtgtac ctcagctttt
      721 tccctcactt gcatcaataa agcttctgtg tttggaaca
//
