LOCUS       NM_000607                764 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens orosomucoid 1 (ORM1), mRNA.
ACCESSION   NM_000607
VERSION     NM_000607.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 764)
  AUTHORS   Yue,L., Xu,X., Dai,S., Xu,F., Zhao,W., Gu,J., Dai,X. and Qian,X.
  TITLE     Orosomucoid 1 promotes colorectal cancer progression and liver
            metastasis by affecting PI3K/AKT pathway and inducing macrophage M2
            polarization
  JOURNAL   Sci Rep 13 (1), 14092 (2023)
   PUBMED   37640741
  REMARK    GeneRIF: Orosomucoid 1 promotes colorectal cancer progression and
            liver metastasis by affecting PI3K/AKT pathway and inducing
            macrophage M2 polarization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 764)
  AUTHORS   Martin-Fernandez,L., Garcia-Martinez,I., Lopez,S.,
            Martinez-Perez,A., Vilalta,N., Plaza,M., Moret,C., Vinuela,A.,
            Brown,A.A., Panousis,N.I., Buil,A., Dermitzakis,E.T., Corrales,I.,
            Souto,J.C., Vidal,F. and Soria,J.M.
  TITLE     Multiallelic Copy Number Variation in ORM1 is Associated with
            Plasma Cell-Free DNA Levels as an Intermediate Phenotype for Venous
            Thromboembolism
  JOURNAL   Thromb Haemost 123 (4), 438-452 (2023)
   PUBMED   36696913
  REMARK    GeneRIF: Multiallelic Copy Number Variation in ORM1 is Associated
            with Plasma Cell-Free DNA Levels as an Intermediate Phenotype for
            Venous Thromboembolism.
REFERENCE   3  (bases 1 to 764)
  AUTHORS   Yang,B.F., Zhai,F., Yu,S., An,H.J., Cao,Z.H., Liu,Y.H., Wang,R. and
            Cheng,X.X.
  TITLE     Evaluation of IFIT3 and ORM1 as Biomarkers for Discriminating
            Active Tuberculosis from Latent Infection
  JOURNAL   Curr Med Sci 42 (6), 1201-1212 (2022)
   PUBMED   36462134
  REMARK    GeneRIF: Evaluation of IFIT3 and ORM1 as Biomarkers for
            Discriminating Active Tuberculosis from Latent Infection.
REFERENCE   4  (bases 1 to 764)
  AUTHORS   Gu,J., Xu,S., Chen,X., Luo,H., Tan,G., Qi,W., Ling,F., Wang,C.,
            Maimaiti,F., Chen,Y., Yang,L., Yin,M. and Chen,D.
  TITLE     ORM 1 as a biomarker of increased vascular invasion and decreased
            sorafenib sensitivity in hepatocellular carcinoma
  JOURNAL   Bosn J Basic Med Sci 22 (6), 949-958 (2022)
   PUBMED   35765957
  REMARK    GeneRIF: ORM 1 as a biomarker of increased vascular invasion and
            decreased sorafenib sensitivity in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 764)
  AUTHORS   Lopez,S., Martinez-Perez,A., Rodriguez-Rius,A., Vinuela,A.,
            Brown,A.A., Martin-Fernandez,L., Vilalta,N., Arus,M.,
            Panousis,N.I., Buil,A., Sabater-Lleal,M., Souto,J.C.,
            Dermitzakis,E.T. and Soria,J.M.
  TITLE     Integrated GWAS and Gene Expression Suggest ORM1 as a Potential
            Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk
  JOURNAL   Thromb Haemost 122 (6), 1027-1039 (2022)
   PUBMED   35272364
  REMARK    GeneRIF: Integrated GWAS and Gene Expression Suggest ORM1 as a
            Potential Regulator of Plasma Levels of Cell-Free DNA and
            Thrombosis Risk.
REFERENCE   6  (bases 1 to 764)
  AUTHORS   Treuheit,M.J., Costello,C.E. and Halsall,H.B.
  TITLE     Analysis of the five glycosylation sites of human alpha 1-acid
            glycoprotein
  JOURNAL   Biochem J 283 (Pt 1) (Pt 1), 105-112 (1992)
   PUBMED   1567356
REFERENCE   7  (bases 1 to 764)
  AUTHORS   Zuffardi,O., Caiulo,A., Maraschio,P., Tupler,R., Bianchi,E.,
            Amisano,P., Beluffi,G., Moratti,R. and Liguri,G.
  TITLE     Regional assignment of the loci for adenylate kinase to 9q32 and
            for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz
            syndrome in region 9q32-qter?
  JOURNAL   Hum Genet 82 (1), 17-19 (1989)
   PUBMED   2541064
REFERENCE   8  (bases 1 to 764)
  AUTHORS   Dube,J.Y., Paradis,G., Tetu,B. and Tremblay,R.R.
  TITLE     Synthesis of alpha 1-acid glycoprotein by the human prostate
  JOURNAL   Prostate 15 (3), 251-258 (1989)
   PUBMED   2479939
REFERENCE   9  (bases 1 to 764)
  AUTHORS   Dente,L., Pizza,M.G., Metspalu,A. and Cortese,R.
  TITLE     Structure and expression of the genes coding for human alpha 1-acid
            glycoprotein
  JOURNAL   EMBO J 6 (8), 2289-2296 (1987)
   PUBMED   2822385
REFERENCE   10 (bases 1 to 764)
  AUTHORS   Dente,L., Ciliberto,G. and Cortese,R.
  TITLE     Structure of the human alpha 1-acid glycoprotein gene: sequence
            homology with other human acute phase protein genes
  JOURNAL   Nucleic Acids Res 13 (11), 3941-3952 (1985)
   PUBMED   2409529
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356796.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 10, 2020 this sequence version replaced NM_000607.3.
            
            Summary: This gene encodes a key acute phase plasma protein.
            Because of its increase due to acute inflammation, this protein is
            classified as an acute-phase reactant.  The specific function of
            this protein has not yet been determined; however, it may be
            involved in aspects of immunosuppression. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU930416.1, BG616847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259396.9/ ENSP00000259396.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL356796.16        53279-53428
            151-293             AL356796.16        53844-53986
            294-364             AL356796.16        54199-54269
            365-472             AL356796.16        54971-55078
            473-576             AL356796.16        55230-55333
            577-764             AL356796.16        56473-56660
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q32"
     gene            1..764
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /note="orosomucoid 1"
                     /db_xref="GeneID:5004"
                     /db_xref="HGNC:HGNC:8498"
                     /db_xref="MIM:138600"
     exon            1..150
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..642
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /note="alpha-1-acid glycoprotein 1; AGP 1; OMD 1;
                     epididymis secretory sperm binding protein Li 153w"
                     /codon_start=1
                     /product="alpha-1-acid glycoprotein 1 precursor"
                     /protein_id="NP_000598.2"
                     /db_xref="CCDS:CCDS6803.1"
                     /db_xref="GeneID:5004"
                     /db_xref="HGNC:HGNC:8498"
                     /db_xref="MIM:138600"
                     /translation="MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWF
                     YIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRE
                     NGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFY
                     EALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES"
     exon            151..293
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            294..364
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            365..472
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            473..576
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /inference="alignment:Splign:2.1.0"
     exon            577..764
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      736..741
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /note="hexamer: AATAAA"
     polyA_site      764
                     /gene="ORM1"
                     /gene_synonym="A1AG1; AGP-A; AGP1; HEL-S-153w; ORM"
                     /note="major polyA site"
ORIGIN      
        1 agcactgcct ggctccacgt gcctcctggt ctcagtatgg cgctgtcctg ggttcttaca
       61 gtcctgagcc tcctacctct gctggaagcc cagatcccat tgtgtgccaa cctagtaccg
      121 gtgcccatca ccaacgccac cctggaccgg atcactggca agtggtttta tatcgcatcg
      181 gcctttcgaa acgaggagta caataagtcg gttcaggaga tccaagcaac cttcttttac
      241 ttcaccccca acaagacaga ggacacgatc tttctcagag agtaccagac ccgacaggac
      301 cagtgcatct ataacaccac ctacctgaat gtccagcggg aaaatgggac catctccaga
      361 tacgtgggag gccaagagca tttcgctcac ttgctgatcc tcagggacac caagacctac
      421 atgcttgctt ttgacgtgaa cgatgagaag aactgggggc tgtctgtcta tgctgacaag
      481 ccagagacga ccaaggagca actgggagag ttctacgaag ctctcgactg cttgcgcatt
      541 cccaagtcag atgtcgtgta caccgattgg aaaaaggata agtgtgagcc actggagaag
      601 cagcacgaga aggagaggaa acaggaggag ggggaatcct agcaggacac agccttggat
      661 caggacagag acttgggggc catcctgccc ctccaacccg acatgtgtac ctcagctttt
      721 tccctcactt gcatcaataa agcttctgtg tttggaacag ctaa
//
