LOCUS       NM_014321               1615 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens origin recognition complex subunit 6 (ORC6),
            transcript variant 1, mRNA.
ACCESSION   NM_014321
VERSION     NM_014321.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Yang,W.L., Zhang,W.F., Wang,Y., Lou,Y., Cai,Y. and Zhu,J.
  TITLE     Origin recognition complex 6 overexpression promotes growth of
            glioma cells
  JOURNAL   Cell Death Dis 15 (7), 485 (2024)
   PUBMED   38971772
  REMARK    GeneRIF: Origin recognition complex 6 overexpression promotes
            growth of glioma cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Liu,Z., Zhang,Y., Yu,L., Zhang,Z. and Li,G.
  TITLE     A miR-361-5p/ ORC6/ PLK1 axis regulates prostate cancer progression
  JOURNAL   Exp Cell Res 440 (1), 114130 (2024)
   PUBMED   38885805
  REMARK    GeneRIF: A miR-361-5p/ ORC6/ PLK1 axis regulates prostate cancer
            progression.
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Zhang,G., Tao,X., Ji,B.W. and Gong,J.
  TITLE     Long Non-coding RNA COX10-AS1 Promotes Glioma Progression by
            Competitively Binding miR-1-3p to Regulate ORC6 Expression
  JOURNAL   Neuroscience 540, 68-76 (2024)
   PUBMED   38244670
  REMARK    GeneRIF: Long Non-coding RNA COX10-AS1 Promotes Glioma Progression
            by Competitively Binding miR-1-3p to Regulate ORC6 Expression.
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Kurniawan,F., Chakraborty,A., Oishi,H.Z., Liu,M., Arif,M.K.,
            Chen,D., Prasanth,R., Lin,Y.C., Olalaye,G., Prasanth,K.V. and
            Prasanth,S.G.
  TITLE     Phosphorylation of Orc6 During Mitosis Regulates DNA Replication
            and Ribosome Biogenesis
  JOURNAL   Mol Cell Biol 44 (7), 289-301 (2024)
   PUBMED   38867464
  REMARK    GeneRIF: Phosphorylation of Orc6 During Mitosis Regulates DNA
            Replication and Ribosome Biogenesis.
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Zhu,J., Chen,Q., Zeng,L., Gao,H., Wu,T., He,Y., Xu,J., Pang,J.,
            Peng,J., Deng,Y., Han,Y. and Yi,W.
  TITLE     Multi-omics analysis reveals the involvement of origin recognition
            complex subunit 6 in tumor immune regulation and malignant
            progression
  JOURNAL   Front Immunol 14, 1236806 (2023)
   PUBMED   37901236
  REMARK    GeneRIF: Multi-omics analysis reveals the involvement of origin
            recognition complex subunit 6 in tumor immune regulation and
            malignant progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Mendez,J., Zou-Yang,X.H., Kim,S.Y., Hidaka,M., Tansey,W.P. and
            Stillman,B.
  TITLE     Human origin recognition complex large subunit is degraded by
            ubiquitin-mediated proteolysis after initiation of DNA replication
  JOURNAL   Mol Cell 9 (3), 481-491 (2002)
   PUBMED   11931757
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Chesnokov,I., Remus,D. and Botchan,M.
  TITLE     Functional analysis of mutant and wild-type Drosophila origin
            recognition complex
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 11997-12002 (2001)
   PUBMED   11593009
  REMARK    GeneRIF: Functional studies of the Drosophila homolog
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Vashee,S., Simancek,P., Challberg,M.D. and Kelly,T.J.
  TITLE     Assembly of the human origin recognition complex
  JOURNAL   J Biol Chem 276 (28), 26666-26673 (2001)
   PUBMED   11323433
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Dhar,S.K. and Dutta,A.
  TITLE     Identification and characterization of the human ORC6 homolog
  JOURNAL   J Biol Chem 275 (45), 34983-34988 (2000)
   PUBMED   10945994
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Li,J.J. and Herskowitz,I.
  TITLE     Isolation of ORC6, a component of the yeast origin recognition
            complex by a one-hybrid system
  JOURNAL   Science 262 (5141), 1870-1874 (1993)
   PUBMED   8266075
  REMARK    GeneRIF: Functional studies of the yeast homolog
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050725.1 and BC063565.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014321.3.
            
            Summary: The origin recognition complex (ORC) is a highly conserved
            six subunit protein complex essential for the initiation of the DNA
            replication in eukaryotic cells. Studies in yeast demonstrated that
            ORC binds specifically to origins of replication and serves as a
            platform for the assembly of additional initiation factors such as
            Cdc6 and Mcm proteins. The protein encoded by this gene is a
            subunit of the ORC complex. Gene silencing studies with small
            interfering RNA demonstrated that this protein plays an essential
            role in coordinating chromosome replication and segregation with
            cytokinesis. [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.196556.1, AK024019.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219097.7/ ENSP00000219097.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BC050725.1         14-41
            29-1615             BC063565.1         11-1597
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q11.2"
     gene            1..1615
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /note="origin recognition complex subunit 6"
                     /db_xref="GeneID:23594"
                     /db_xref="HGNC:HGNC:17151"
                     /db_xref="MIM:607213"
     exon            1..112
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..806
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /codon_start=1
                     /product="origin recognition complex subunit 6"
                     /protein_id="NP_055136.1"
                     /db_xref="CCDS:CCDS10722.1"
                     /db_xref="GeneID:23594"
                     /db_xref="HGNC:HGNC:17151"
                     /db_xref="MIM:607213"
                     /translation="MGSELIGRLAPRLGLAEPDMLRKAEEYLRLSRVKCVGLSARTTE
                     TSSAVMCLDLAASWMKCPLDRAYLIKLSGLNKETYQSCLKSFECLLGLNSNIGIRDLA
                     VQFSCIEAVNMASKILKSYESSLPQTQQVDLDLSRPLFTSAALLSACKILKLKVDKNK
                     MVATSGVKKAIFDRLCKQLEKIGQQVDREPGDVATPPRKRKKIVVEAPAKEMEKVEEM
                     PHKPQKDEDLTQDYEEWKRKILENAASAQKATAE"
     exon            113..242
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /inference="alignment:Splign:2.1.0"
     exon            243..406
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /inference="alignment:Splign:2.1.0"
     exon            407..496
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /inference="alignment:Splign:2.1.0"
     exon            497..609
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /inference="alignment:Splign:2.1.0"
     exon            610..678
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1615
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /note="hexamer: AATAAA"
     polyA_site      1615
                     /gene="ORC6"
                     /gene_synonym="ORC6L"
                     /note="major polyA site"
ORIGIN      
        1 gttgacccgc ggcgttcacg ggaattgttc gctttagtgc cggcgccatg gggtcggagc
       61 tgatcgggcg cctagccccg cgcctgggcc tcgccgagcc cgacatgctg aggaaagcag
      121 aggagtactt gcgcctgtcc cgggtgaagt gtgtcggcct ctccgcacgc accacggaga
      181 ccagcagtgc agtcatgtgc ctggaccttg cagcttcctg gatgaagtgc cccttggaca
      241 gggcttattt aattaaactt tctggtttga acaaggagac atatcagagc tgtcttaaat
      301 cttttgagtg tttactgggc ctgaattcaa atattggaat aagagaccta gctgtacagt
      361 ttagctgtat agaagcagtg aacatggctt caaagatact aaaaagctat gagtccagtc
      421 ttccccagac acagcaagtg gatcttgact tatccaggcc acttttcact tctgctgcac
      481 tgctttcagc atgcaagatt ctaaagctga aagtggataa aaacaaaatg gtagccacat
      541 ccggtgtaaa aaaagctata tttgatcgac tgtgtaaaca actagagaag attggacagc
      601 aggtcgacag agaacctgga gatgtagcta ctccaccacg gaagagaaag aagatagtgg
      661 ttgaagcccc agcaaaggaa atggagaagg tagaggagat gccacataaa ccacagaaag
      721 atgaagatct gacacaggat tatgaagaat ggaaaagaaa aattttggaa aatgctgcca
      781 gtgctcaaaa ggctacagca gagtgatttc agcttccaaa ctggtataca ttccaaactg
      841 atagtacatt gccatctcca ggaagacttg acggctttgg gattttgttt aaacttttat
      901 aataaggatc ctaagactgt tgcctttaaa tagcaaagca gcctacctgg aggctaagtc
      961 tgggcagtgg gctggcccct ggtgtgagca ttagaccagc cacagtgcct gattggtata
     1021 gccttatgtg ctttcctaca aaatggaatt ggaggccggg cgcagtggct cacgcctgta
     1081 atcccagcac tttgggaggc caaggtgggt ggatcacctg aggtcaggag ctcgagacca
     1141 gcctggccaa catggtgaaa ccccatctct actaaaaata caaaaattag ccaggtgtga
     1201 tggtgcatgc ctgtaatccc agctcctcag taggctgaga caggagcatc acttgaacgt
     1261 gggaggcaga ggttgcagtg agccgagatt gcaccaccgc actccagcct gggtgacaga
     1321 gcgagactta tctcataaat aaatagatag atactccagc ctgggtgaca gagcgagact
     1381 tatagataga tagatagata gatggataga tagatagata gatagataga tagataaacg
     1441 gaattggagc cattttgctt taagtgaatg gcagtccctt gtcttattca gaatataaaa
     1501 ttcagtctga atggcatctt acagatttta cttcaatttt tgtgtacggt attttttatt
     1561 tgactaaatc aatatattgt acagcctaag ttaataaatg ttatttatat atgca
//
