LOCUS       NM_004153               3121 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens origin recognition complex subunit 1 (ORC1),
            transcript variant 1, mRNA.
ACCESSION   NM_004153
VERSION     NM_004153.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3121)
  AUTHORS   Xia,L., Nie,T., Lu,F., Huang,L., Shi,X., Ren,D., Lu,J., Li,X.,
            Xu,T., Cui,B., Wang,Q., Gao,G. and Yang,Q.
  TITLE     Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1
            activation and tumor progression in pancreatic cancer
  JOURNAL   Autophagy 20 (3), 505-524 (2024)
   PUBMED   37772772
  REMARK    GeneRIF: Direct regulation of FNIP1 and FNIP2 by MEF2 sustains
            MTORC1 activation and tumor progression in pancreatic cancer.
REFERENCE   2  (bases 1 to 3121)
  AUTHORS   Wu,L., Chen,H. and Yang,C.
  TITLE     Origin recognition complex subunit 1(ORC1) is a potential biomarker
            and therapeutic target in cancer
  JOURNAL   BMC Med Genomics 16 (1), 243 (2023)
   PUBMED   37833711
  REMARK    GeneRIF: Origin recognition complex subunit 1(ORC1) is a potential
            biomarker and therapeutic target in cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3121)
  AUTHORS   Han,L. and Li,F.
  TITLE     Origin recognition complex subunit 1 (ORC1) augments malignant
            behaviors of lung adenocarcinoma cells via targeting Wnt signaling
  JOURNAL   Bioengineered 13 (5), 13520-13533 (2022)
   PUBMED   36700467
  REMARK    GeneRIF: Origin recognition complex subunit 1 (ORC1) augments
            malignant behaviors of lung adenocarcinoma cells via targeting Wnt
            signaling.
REFERENCE   4  (bases 1 to 3121)
  AUTHORS   Hossain,M., Bhalla,K. and Stillman,B.
  TITLE     Multiple, short protein binding motifs in ORC1 and CDC6 control the
            initiation of DNA replication
  JOURNAL   Mol Cell 81 (9), 1951-1969 (2021)
   PUBMED   33761311
  REMARK    GeneRIF: Multiple, short protein binding motifs in ORC1 and CDC6
            control the initiation of DNA replication.
REFERENCE   5  (bases 1 to 3121)
  AUTHORS   Jaremko,M.J., On,K.F., Thomas,D.R., Stillman,B. and Joshua-Tor,L.
  TITLE     The dynamic nature of the human origin recognition complex revealed
            through five cryoEM structures
  JOURNAL   Elife 9, e58622 (2020)
   PUBMED   32808929
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3121)
  AUTHORS   Herbig,U., Marlar,C.A. and Fanning,E.
  TITLE     The Cdc6 nucleotide-binding site regulates its activity in DNA
            replication in human cells
  JOURNAL   Mol Biol Cell 10 (8), 2631-2645 (1999)
   PUBMED   10436018
REFERENCE   7  (bases 1 to 3121)
  AUTHORS   Saha,P., Chen,J., Thome,K.C., Lawlis,S.J., Hou,Z.H., Hendricks,M.,
            Parvin,J.D. and Dutta,A.
  TITLE     Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is
            selectively eliminated from the nucleus at the onset of S phase
  JOURNAL   Mol Cell Biol 18 (5), 2758-2767 (1998)
   PUBMED   9566895
REFERENCE   8  (bases 1 to 3121)
  AUTHORS   Ohtani,K., DeGregori,J., Leone,G., Herendeen,D.R., Kelly,T.J. and
            Nevins,J.R.
  TITLE     Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated
            by cell proliferation via the E2F transcription factor
  JOURNAL   Mol Cell Biol 16 (12), 6977-6984 (1996)
   PUBMED   8943353
REFERENCE   9  (bases 1 to 3121)
  AUTHORS   Eki,T., Okumura,K., Amin,A., Ishiai,M., Abe,M., Nogami,M.,
            Taguchi,H., Hurwitz,J., Murakami,Y. and Hanaoka,F.
  TITLE     Mapping of the human homologue (ORC1L) of the yeast origin
            recognition complex subunit 1 gene to chromosome band 1p32
  JOURNAL   Genomics 36 (3), 559-561 (1996)
   PUBMED   8884289
REFERENCE   10 (bases 1 to 3121)
  AUTHORS   Gavin,K.A., Hidaka,M. and Stillman,B.
  TITLE     Conserved initiator proteins in eukaryotes
  JOURNAL   Science 270 (5242), 1667-1671 (1995)
   PUBMED   7502077
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U40152.1 and U43416.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004153.3.
            
            Summary: The origin recognition complex (ORC) is a highly conserved
            six subunits protein complex essential for the initiation of the
            DNA replication in eukaryotic cells. Studies in yeast demonstrated
            that ORC binds specifically to origins of replication and serves as
            a platform for the assembly of additional initiation factors such
            as Cdc6 and Mcm proteins. The protein encoded by this gene is the
            largest subunit of the ORC complex. While other ORC subunits are
            stable throughout the cell cycle, the levels of this protein vary
            during the cell cycle, which has been shown to be controlled by
            ubiquitin-mediated proteolysis after initiation of DNA replication.
            This protein is found to be selectively phosphorylated during
            mitosis. It is also reported to interact with MYST histone
            acetyltransferase 2 (MyST2/HBO1), a protein involved in control of
            transcription silencing. Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) is the longest transcript and
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U43416.1, SRR1803613.50543.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371568.8/ ENSP00000360623.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1928              U40152.1           37-1964
            1929-3121           U43416.1           1957-3149
FEATURES             Location/Qualifiers
     source          1..3121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..3121
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /note="origin recognition complex subunit 1"
                     /db_xref="GeneID:4998"
                     /db_xref="HGNC:HGNC:8487"
                     /db_xref="MIM:601902"
     exon            1..178
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..278
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2769
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     origin recognition complex, subunit 1 homolog; replication
                     control protein 1"
                     /codon_start=1
                     /product="origin recognition complex subunit 1 isoform 1"
                     /protein_id="NP_004144.2"
                     /db_xref="CCDS:CCDS566.1"
                     /db_xref="GeneID:4998"
                     /db_xref="HGNC:HGNC:8487"
                     /db_xref="MIM:601902"
                     /translation="MAHYPTRLKTRKTYSWVGRPLLDRKLHYQTYREMCVKTEGCSTE
                     IHIQIGQFVLIEGDDDENPYVAKLLELFEDDSDPPPKKRARVQWFVRFCEVPACKRHL
                     LGRKPGAQEIFWYDYPACDSNINAETIIGLVRVIPLAPKDVVPTNLKNEKTLFVKLSW
                     NEKKFRPLSSELFAELNKPQESAAKCQKPVRAKSKSAESPSWTPAEHVAKRIESRHSA
                     SKSRQTPTHPLTPRARKRLELGNLGNPQMSQQTSCASLDSPGRIKRKVAFSEITSPSK
                     RSQPDKLQTLSPALKAPEKTRETGLSYTEDDKKASPEHRIILRTRIAASKTIDIREER
                     TLTPISGGQRSSVVPSVILKPENIKKRDAKEAKAQNEATSTPHRIRRKSSVLTMNRIR
                     QQLRFLGNSKSDQEEKEILPAAEISDSSSDEEEASTPPLPRRAPRTVSRNLRSSLKSS
                     LHTLTKVPKKSLKPRTPRCAAPQIRSRSLAAQEPASVLEEARLRLHVSAVPESLPCRE
                     QEFQDIYNFVESKLLDHTGGCMYISGVPGTGKTATVHEVIRCLQQAAQANDVPPFQYI
                     EVNGMKLTEPHQVYVQILQKLTGQKATANHAAELLAKQFCTRGSPQETTVLLVDELDL
                     LWTHKQDIMYNLFDWPTHKEARLVVLAIANTMDLPERIMMNRVSSRLGLTRMCFQPYT
                     YSQLQQILRSRLKHLKAFEDDAIQLVARKVAALSGDARRCLDICRRATEICEFSQQKP
                     DSPGLVTIAHSMEAVDEMFSSSYITAIKNSSVLEQSFLRAILAEFRRSGLEEATFQQI
                     YSQHVALCRMEGLPYPTMSETMAVCSHLGSCRLLLVEPSRNDLLLRVRLNVSQDDVLY
                     ALKDE"
     exon            279..406
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..585
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..904
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1265
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1370
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1566
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1664
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1766
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1938
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2046
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2196
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2316
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2486
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2574
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..3121
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3098..3103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /note="hexamer: ATTAAA"
     polyA_site      3121
                     /gene="ORC1"
                     /gene_synonym="HSORC1; ORC1L; PARC1"
                     /note="major polyA site"
ORIGIN      
        1 ccttccacct tcttttcatt tctagtgaga cacacgcttt ggtcctggct ttcggcccgt
       61 agttgtagaa ggagccctgc tggtgcaggt tagaggtgcc gcatcccccg gagctctcga
      121 agtggaggcg gtaggaaacg gagggcttgc ggctagccgg aggaagcttt ggagccggaa
      181 gccatggcac actaccccac aaggctgaag accagaaaaa cttattcatg ggttggcagg
      241 cccttgttgg atcgaaaact gcactaccaa acctatagag aaatgtgtgt gaaaacagaa
      301 ggttgttcca ccgagattca catccagatt ggacagtttg tgttgattga aggggatgat
      361 gatgaaaacc cgtatgttgc taaattgctt gagttgttcg aagatgactc tgatcctcct
      421 cctaagaaac gtgctcgagt acagtggttt gtccgattct gtgaagtccc tgcctgtaaa
      481 cggcatttgt tgggccggaa gcctggtgca caggaaatat tctggtatga ttacccggcc
      541 tgtgacagca acattaatgc ggagaccatc attggccttg ttcgggtgat acctttagcc
      601 ccaaaggatg tggtaccgac gaatctgaaa aatgagaaga cactctttgt gaaactatcc
      661 tggaatgaga agaaattcag gccactttcc tcagaactat ttgcggagtt gaataaacca
      721 caagagagtg cagccaagtg ccagaaaccc gtgagagcca agagtaagag tgcagagagc
      781 ccttcttgga ccccagcaga acatgtggcc aaaaggattg aatcaaggca ctccgcctcc
      841 aaatctcgcc aaactcctac ccatcctctt accccaagag ccagaaagag gctggagctt
      901 ggcaacttag gtaaccctca gatgtcccag cagacttcat gtgcctcctt ggattctcca
      961 ggaagaataa aacggaaagt ggccttctcg gagatcacct caccttctaa gagatctcag
     1021 cctgataaac ttcaaacctt gtctccagct ctgaaagccc cagagaaaac cagagagact
     1081 ggactctctt atactgagga tgacaagaag gcttcacctg aacatcgcat aatcctgaga
     1141 acccgaattg cagcttcgaa aaccatagac attagagagg agagaacact tacccctatc
     1201 agtgggggac agagatcttc agtggtgcca tccgtgattc tgaaaccaga aaacatcaaa
     1261 aagagggatg caaaagaagc aaaagcccag aatgaagcga cctctactcc ccatcgtatc
     1321 cgcagaaaga gttctgtctt gactatgaat cggattaggc agcagcttcg gtttctaggt
     1381 aatagtaaaa gtgaccaaga agagaaagag attctgccag cagcagagat ttcagactct
     1441 agcagtgacg aagaagaggc ttccacaccg ccccttccaa ggagagcacc cagaactgtg
     1501 tccaggaacc tgcgatcttc cttgaagtca tccttacata ccctcacgaa ggtgccaaag
     1561 aagagtctca agcctagaac gccacgttgt gccgctcctc agatccgtag tcgaagcctg
     1621 gctgcccagg agccagccag tgtgctggag gaagcccgac tgaggctgca tgtttctgct
     1681 gtacctgagt ctcttccctg tcgggaacag gaattccaag acatctacaa ttttgtggaa
     1741 agcaaactcc ttgaccatac cggagggtgc atgtacatct ccggtgtccc tgggacaggg
     1801 aagactgcca ctgttcatga agtgatacgc tgcctgcagc aggcagccca agccaatgat
     1861 gttcctccct ttcaatacat tgaggtcaat ggcatgaagc tgacggagcc ccaccaagtc
     1921 tatgtgcaaa tcttgcagaa gctaacaggc caaaaagcaa cagccaacca tgcggcagaa
     1981 ctgctggcaa agcaattctg cacccgaggg tcacctcagg aaaccaccgt cctgcttgtg
     2041 gatgagctcg accttctgtg gactcacaaa caagacataa tgtacaatct ctttgactgg
     2101 cccactcata aggaggcccg gcttgtggtc ctggcaattg ccaacacaat ggacctgcca
     2161 gagcgaatca tgatgaaccg ggtgtccagc cgactgggtc ttaccaggat gtgcttccag
     2221 ccctatacat atagccagct gcagcagatc ctaaggtccc ggctcaagca tctaaaggcc
     2281 tttgaagatg atgccatcca gctggtagcc aggaaggtag cagcactgtc tggagatgca
     2341 cgacggtgcc tggacatctg caggcgtgcc acagagatct gtgagttctc ccagcagaag
     2401 cctgactccc ctggcctggt caccatagcc cactcaatgg aagctgtgga tgagatgttt
     2461 tcatcatcat acatcacggc catcaaaaat tcctctgttc tggaacagag cttcctgaga
     2521 gccatcctcg cagagttccg tcgatcagga ctggaggaag ccacgtttca acagatatat
     2581 agtcaacatg tggcactgtg cagaatggag ggactgccgt accccaccat gtcagagacc
     2641 atggccgtgt gttctcacct gggctcctgt cgcctcctgc ttgtggagcc cagcaggaac
     2701 gatctgctcc ttcgggtgcg gctcaacgtc agccaggatg atgtgctgta tgcgctgaaa
     2761 gacgagtaaa ggggcttcac aagttaaaag actggggtct tgctgggttt tgttttttga
     2821 gacagggtct tgctctgtcg cccaggctgg agtgcagtgg cacgatcatg gctcactgca
     2881 gccttgactt ctcaggctta ggtgaccccc caacctcatc ctcccaggtg gctgaaacta
     2941 caggcacatg ccaccatgcc cagctgattt tttgtagaga cagggcttca ccatgttgcc
     3001 aagctagtct acaaagcatc tgattttgga agtacatgga attgttgtaa caaagtatat
     3061 tgaatggaaa tggctctcat gtattttgga attttccatt aaataatttg ctttttcctg
     3121 a
//
