LOCUS       NM_001126340           10747 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ORAI calcium release-activated calcium modulator 2
            (ORAI2), transcript variant 1, mRNA.
ACCESSION   NM_001126340
VERSION     NM_001126340.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10747)
  AUTHORS   Ma,Y., Dammer,E.B., Felsky,D., Duong,D.M., Klein,H.U., White,C.C.,
            Zhou,M., Logsdon,B.A., McCabe,C., Xu,J., Wang,M., Wingo,T.S.,
            Lah,J.J., Zhang,B., Schneider,J., Allen,M., Wang,X.,
            Ertekin-Taner,N., Seyfried,N.T., Levey,A.I., Bennett,D.A. and De
            Jager,P.L.
  TITLE     Atlas of RNA editing events affecting protein expression in aged
            and Alzheimer's disease human brain tissue
  JOURNAL   Nat Commun 12 (1), 7035 (2021)
   PUBMED   34857756
  REMARK    GeneRIF: Atlas of RNA editing events affecting protein expression
            in aged and Alzheimer's disease human brain tissue.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10747)
  AUTHORS   Wu,S., Chen,M., Huang,J., Zhang,F., Lv,Z., Jia,Y., Cui,Y.Z.,
            Sun,L.Z., Wang,Y., Tang,Y., Verhoeft,K.R., Li,Y., Qin,Y., Lin,X.,
            Guan,X.Y. and Lam,K.O.
  TITLE     ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through
            PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly
  JOURNAL   Cancer Res 81 (4), 986-1000 (2021)
   PUBMED   33310726
  REMARK    GeneRIF: ORAI2 Promotes Gastric Cancer Tumorigenicity and
            Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal
            Adhesion Disassembly.
REFERENCE   3  (bases 1 to 10747)
  AUTHORS   Singh,A.K., Roy,N.K., Bordoloi,D., Padmavathi,G., Banik,K.,
            Khwairakpam,A.D., Kunnumakkara,A.B. and Sukumar,P.
  TITLE     Orai-1 and Orai-2 regulate oral cancer cell migration and
            colonisation by suppressing Akt/mTOR/NF-kappaB signalling
  JOURNAL   Life Sci 261, 118372 (2020)
   PUBMED   32882268
  REMARK    GeneRIF: Orai-1 and Orai-2 regulate oral cancer cell migration and
            colonisation by suppressing Akt/mTOR/NF-kappaB signalling.
REFERENCE   4  (bases 1 to 10747)
  AUTHORS   Zhang,X., Xin,P., Yoast,R.E., Emrich,S.M., Johnson,M.T., Pathak,T.,
            Benson,J.C., Azimi,I., Gill,D.L., Monteith,G.R. and Trebak,M.
  TITLE     Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3
            channels
  JOURNAL   Cell Calcium 91, 102281 (2020)
   PUBMED   32896813
  REMARK    GeneRIF: Distinct pharmacological profiles of ORAI1, ORAI2, and
            ORAI3 channels.
REFERENCE   5  (bases 1 to 10747)
  AUTHORS   Scremin,E., Agostini,M., Leparulo,A., Pozzan,T., Greotti,E. and
            Fasolato,C.
  TITLE     ORAI2 Down-Regulation Potentiates SOCE and Decreases Abeta42
            Accumulation in Human Neuroglioma Cells
  JOURNAL   Int J Mol Sci 21 (15), 5288 (2020)
   PUBMED   32722509
  REMARK    GeneRIF: ORAI2 Down-Regulation Potentiates SOCE and Decreases
            Abeta42 Accumulation in Human Neuroglioma Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10747)
  AUTHORS   DeHaven,W.I., Smyth,J.T., Boyles,R.R. and Putney,J.W. Jr.
  TITLE     Calcium inhibition and calcium potentiation of Orai1, Orai2, and
            Orai3 calcium release-activated calcium channels
  JOURNAL   J Biol Chem 282 (24), 17548-17556 (2007)
   PUBMED   17452328
  REMARK    GeneRIF: Results suggest that Orai1, -2, and -3 channels are
            similarly inhibited by extracellular calcium, indicating similar
            affinities for Ca(2+) within the selectivity filter.
REFERENCE   7  (bases 1 to 10747)
  AUTHORS   Lis,A., Peinelt,C., Beck,A., Parvez,S., Monteilh-Zoller,M.,
            Fleig,A. and Penner,R.
  TITLE     CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with
            distinct functional properties
  JOURNAL   Curr Biol 17 (9), 794-800 (2007)
   PUBMED   17442569
REFERENCE   8  (bases 1 to 10747)
  AUTHORS   Mercer,J.C., Dehaven,W.I., Smyth,J.T., Wedel,B., Boyles,R.R.,
            Bird,G.S. and Putney,J.W. Jr.
  TITLE     Large store-operated calcium selective currents due to
            co-expression of Orai1 or Orai2 with the intracellular calcium
            sensor, Stim1
  JOURNAL   J Biol Chem 281 (34), 24979-24990 (2006)
   PUBMED   16807233
REFERENCE   9  (bases 1 to 10747)
  AUTHORS   Feske,S., Gwack,Y., Prakriya,M., Srikanth,S., Puppel,S.H.,
            Tanasa,B., Hogan,P.G., Lewis,R.S., Daly,M. and Rao,A.
  TITLE     A mutation in Orai1 causes immune deficiency by abrogating CRAC
            channel function
  JOURNAL   Nature 441 (7090), 179-185 (2006)
   PUBMED   16582901
REFERENCE   10 (bases 1 to 10747)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY064081.1 and AC093668.4.
            
            On Nov 23, 2018 this sequence version replaced NM_001126340.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.403215.1,
                                           SRR3476690.1076128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream ORF predicted to
                                                inhibit translation from
                                                upstream AUG
            MANE Ensembl match               :: ENST00000495936.7/
                                                ENSP00000420178.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               HY064081.1         47-497
            452-10747           AC093668.4         60480-70775
FEATURES             Location/Qualifiers
     source          1..10747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..10747
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /note="ORAI calcium release-activated calcium modulator 2"
                     /db_xref="GeneID:80228"
                     /db_xref="HGNC:HGNC:21667"
                     /db_xref="MIM:610929"
     exon            1..87
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /inference="alignment:Splign:2.1.0"
     exon            88..196
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /inference="alignment:Splign:2.1.0"
     exon            197..434
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /inference="alignment:Splign:2.1.0"
     CDS             210..974
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /note="isoform a is encoded by transcript variant 1;
                     CAP-binding protein complex interacting protein 2;
                     H_NH0514P08.8; transmembrane protein 142B; putative
                     protein ORAI2-2; protein orai-2"
                     /codon_start=1
                     /product="protein orai-2 isoform a"
                     /protein_id="NP_001119812.1"
                     /db_xref="CCDS:CCDS5722.1"
                     /db_xref="GeneID:80228"
                     /db_xref="HGNC:HGNC:21667"
                     /db_xref="MIM:610929"
                     /translation="MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHS
                     VQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTT
                     VLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILL
                     FLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHF
                     YRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL"
     exon            435..10747
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5514..5519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /note="hexamer: AATAAA"
     polyA_site      5531
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /note="major polyA site"
     regulatory      10724..10729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
                     /note="hexamer: AATAAA"
     polyA_site      10747
                     /gene="ORAI2"
                     /gene_synonym="C7orf19; CBCIP2; MEM142B; TMEM142B"
ORIGIN      
        1 ggcgccccgg ccgggccact gggccacagg ccacgcggcc acgcagtccg agcgggagcc
       61 gagccgggcg gggcgagggc agctccggga aggaacgtcc cagggatgga agtgcttgga
      121 tgcggtgctg ctggctgcgg atgtgcgcaa ggagatggga tggagagcct gagttggcat
      181 tcgtataaat gacctgcctg gctcccacca tgagtgctga gcttaacgtg cctatcgacc
      241 cctctgctcc tgcctgccct gagcccggcc ataagggcat ggattaccgg gactgggtcc
      301 gccgcagcta cctggaactg gtcacctcta accaccactc ggtacaggcc ctgtcgtggc
      361 ggaagctcta cctgagcagg gccaagctga aggcctccag caggacctcc gccctcctct
      421 ccggctttgc catggtggcc atggtggagg tgcagctgga gacgcagtac cagtacccgc
      481 ggccgctgct gattgccttc agcgcctgca ccacggtgct ggtggccgtg cacctgttcg
      541 ccctcctcat cagcacctgc atcctgccca atgtggaggc cgtgagcaac atccacaacc
      601 tgaactccat cagcgagtcc ccgcatgagc gcatgcaccc ctacatcgag ctggcctggg
      661 gcttctccac cgtgcttggc atcctactct tcctggccga ggtggtgctg ctctgctgga
      721 tcaagttcct ccccgtggat gcccggcgcc agcctggccc cccacctggc cctgggagtc
      781 acacgggctg gcaggccgcc ctggtgtcca ccatcatcat ggtgcccgtg ggcctcatct
      841 tcgtggtctt caccatccac ttctaccgct ccctggtgcg ccacaaaacg gagcgccaca
      901 accgcgagat cgaggagctc cacaagctca aggtccagct ggacgggcat gagcgcagcc
      961 tgcaggtctt gtgaggggcc gagggccggg gctgggagcg gccctgtgcc cgggagtccg
     1021 cagaggcggg gatttgtcag atgcagacat tttgcaaggc tgccgggtag ttcaagacca
     1081 aagttttcct cttgtcttaa taccataagg actggatgac ttctcctgag atagaaccgt
     1141 ttggttcaat gagggactgt gttgctaaga gcgttggggg caaagccagg ctggttcctt
     1201 ggcctcgggg tttcctgggt cggggacacg gtgaagaggc tccagcggga cctgcccatc
     1261 agtcctgggc caggaggggc tccaagcagc acccagcggt ccgggggagt ctcagacccg
     1321 gcatgcgtgg ctggcagacc tgggagagcc agggcagggt tttgcgttca gagaaggatt
     1381 gccccagaga cccgtggtgg acttcatggg tgctgagtgg cccgtgtgac agtgatgaca
     1441 cgaaggcttc ggcgtttgag tgggtgcagg tgcacgccag ggcttggtgc ttccctgcct
     1501 ggccctggag ggagctgggt ggcctggctt caggggaaga caggagccag gacacacgtc
     1561 agcccagcag gtgtgggggg tgctgcagcc ctcggcagtg gggtcaggcc ctgggggatg
     1621 tttccaatgg tgggcagcct ggccaggccg gagaagacat gttcacgggc atctatcaga
     1681 tgcccccttg aggaggctga gttatttgag ggctgctgca aagtacgcta ggctcaaatt
     1741 ctcttttccc agccagagcc ctggccacac ggactcagag gggccaccgg ggtggggaaa
     1801 ggacccctcc cccacccccc gcagccactg gcctccagct ctcggccaca gaatggcctc
     1861 taaggctgac tcagccactc ccttgggctg tggcagcagg aggcgggggc tctggctcag
     1921 gccccggagc ctgtgcagct tgcccatggc cctaggcagc gaggggacag cctgggggac
     1981 ttcctgccta ggcaaggtca ttggccgggc ctggcctgtg gatagtgggg ccaggggccg
     2041 gcccaggcca aatgagtgcc ctccttgtta tgacaccaag tgactacaag ggaggcaaga
     2101 cccctccagg cctctcagcc gacactgggt cccaccacac acagtgactg tgccgtgcag
     2161 tgcaggttct ggccttttcc ttgaaggcat ctggtagacc cgaagccacg ctctcgggcc
     2221 gcacatgcac gccgcagcac cagctgccct gagctgcttg tacaaccaaa cacctttccc
     2281 ctcttctcca gctgtaacct ggagagtcag ccatgccttg tcttttgttc tcataaatag
     2341 tcactggggc cgggcgcagt gactcacgcc tgtaatccca gcactttggg aggcctaggt
     2401 gggcggatca cttgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccctgt
     2461 ctctactaaa aaaatacaga aaattagctg ggcgtggtgg cgggcgcctg tagccccagc
     2521 tacttgggag gctgaggcgg gagaatggca atggcgtgaa cccgggaggc agagcttgca
     2581 gtgagctgag atggcgccac tgcactccag cctgggcgac agagccagac tccatctcaa
     2641 aaaaaaaaaa aaaattagcc gggcgtgatg gcgggcacct gtagtcccag ctactcagga
     2701 ggctgaggca agagaatcac ttgaacccag gaggcagagg ttgcagtgag ctgagatcac
     2761 gccattgcac tacagcctgg gcaacaagag cgaaactttg tctaaaaaaa aaaaaaaatc
     2821 actgggcttc ttcatgctct gatcacatct ctcgtaaaag cttaagctct ctccggggtc
     2881 cgggttggcc gtgccgtgga attctgggtg gcctggctgg ggtctctgga aatgtggctg
     2941 cagcagagaa cagagaccct gacatgcagt tttccgtgct gaggggccct aggggagtca
     3001 caccaagggt ccccacgaga aagttgtggc atccccgggg gccggagaag agccccgtgt
     3061 cttctgaggg gttcgtcctt tgtgtcccct gcagacattt gtctgcgacc tttgccctcc
     3121 agcatgtatg tactttcctg cagcctgtag aaacgcctct tacggtttaa tatgtgttcg
     3181 ctttgctaaa gaatatcaac atcggccagg cgaggtgggg cacgcctgtc atcccagcac
     3241 tttgggaggc tgaggtggga ggatcacttg ggcccagggg tgcaagacca gcctgggcaa
     3301 catagcgaga ccccatgtct aaaaaaatta ttttaaatta gccaggccgg gtgcaatggc
     3361 tcgcgcccgt aatcttagca ctctgggagg ccgaggcagg cagatcactt gagatcagga
     3421 ctttaagacc agcctcggca acaacatggt gaaaccatct ctagcaaaaa tacaaaaaat
     3481 tagccgggta tggtggcggg tacctgtaat cccagctact caggaggctg aggcaagaga
     3541 atcgcttgaa cgcaggaggc agaggttgca gtgagctgag atcgtgccac tgcactccag
     3601 cctggacaac agagcaaaac tctgtctcaa aaaataataa ataaaaataa attagctggg
     3661 cgtggtggtg catgcctgta gttccagcta cttgggaggc tgaggtggga ggattgcttg
     3721 agcctgggaa gtagaggctg cagtgaacta taactgtgct agtggccggg cgcagtggct
     3781 cacgcctata atcccagcac tttgggaggc caaagcaggt ggatcacttg aggtcaggag
     3841 ttcgagacca gcctggccaa catggtgaaa ctctgtgtct actaaaaata caaaaaatta
     3901 gctgggtgtg gtggcgctcg cctgtagtcc cagctacttg ggaggctgag gcaggagaat
     3961 cacttgaacc cagaaggcag aggtagcagt gagccaagat ggtgccactg cactccagcc
     4021 tgggcgacag agggtgactc ctcaaaaaaa agaaaaatag ctaaaatatg attgtaccac
     4081 tgcactccag cctgggtgac agagtgagac cctgtctcta aaaaaaaaaa aaagaaaata
     4141 aagaaaaaag aatgtcagca tgtcagcgtt cctccaagga gtggctttgg gtcaagaaga
     4201 caggctggct ctcctaaaca aacggctccc cacggctggg agaggcagca ggcccttact
     4261 ctggcctgag tcttttggga ggggccctgc tgggccttct cctgccacct accttcctgg
     4321 accatctgtg cccctgccca cgcagtacca cactccccag actgtggaac gcatctccag
     4381 tgccatctgg gggccagtta ctgtacctgg tccccaggca gagctcttgg cctggcagca
     4441 tccaggcagg tattaagtgc ccagtgatgg tggcacatgg gtggggacgg agccacatcc
     4501 aagtctagcc ctctgattag gaggatgaca gtcttggaat ttcttgttct ctttctccta
     4561 gggttctcgt tctcccagct ccagcctttc tagtttcgag gcatgaggca aaccattgct
     4621 gtgggaatag cagtgaccat tggtagggcc atggtggccg ggagaggaaa cctcagggtc
     4681 accccagagc ctgtggggag acggagggtg agctgttgtt ggagctgcag aaacgccttg
     4741 aagggcagca tgggcgatga ggaatgccat tgcagcctag aaattcggtt tctggaggtt
     4801 tagcctgatt ttgaagagta tttaagaaca gagggctcca gaccaggtgt ggtggctcac
     4861 atctgtaatc ccagcacttt gggaggcaga ggtgggcgga tcgcctgaga tcaggagttc
     4921 gagaccagcc tggcccacat ggtgaaaccc tgtctctact aaaaatacaa aaattagccg
     4981 ggcgtagtga cacacgcctg taatcccagc tgctcgggag gcagaggcag gagaatggcg
     5041 tgaacccggg aggcggaggt tgcagtgagc cgagatcacg ccactgcact ccagcctggg
     5101 taacagagca agactctgtc tcaaaaaaaa aaaaaaaaga acaggggcct ctgcctcagt
     5161 ttgcccggga gccagccagg gcccatccta atttggagca cagtcttcct ggtgcctaga
     5221 catgccaagg cccctcccac gtggtacacc ctctccgttt agtacctgac cacctgtttc
     5281 aaaacgcagg tgtttctggt ttagaaactt ggaaggcgga atgtgttttc gtgtcttcta
     5341 ggaagggtct gctgaggacc agaccacgta agcctgagtg gatcctgact cagctgcagc
     5401 ccttacctgc ctcgtgctga tgatctatgc atggcgttat gtagatcacg tgcggcagag
     5461 acagccactg tcctgtgtgc gggtttttaa aacagctgcc ctggatgaaa cggaataaac
     5521 cagtgatgct attcaaagtc tttctgttct tgggggatgc tgtgggcaga ggggataaat
     5581 tgcagcccct ggccctcccg tggcatctgc tgactggggg acccacatcg tggcctgaaa
     5641 aactcctgga gcgccctctg gcctcctgtc gctggtcact ggccagtgtc ctcccaggct
     5701 gccccggcaa gggggcgtgg acatctctag aatggaggca gggtactcat gtccagacac
     5761 gccgccatgg ggctccgccc cgagagcgca gggtgcctct gcctggcgct tcccctccca
     5821 gacagggccc tctctttcca gaaacaaaag aaggggcagc cccagagggt ggctgagcga
     5881 caacagagcc cacctggaca gggtcagctt ggcgttcccc ccagtccctt gaggagagga
     5941 gctaccagag cactggtcac ctcaggacat tctccagccc caagtccctg tggggcagca
     6001 ggaacaggtg ggtccctcct gcgggctggt ggcactgcta aggaagcacc agacagcctt
     6061 tttttttttt ttgagacaga gtcgctctgt cacccaagct ggaatgcggt ggcatgatct
     6121 tggctcactg caacctcctc ctcccaggtt caagcgatct tgtgcctcag cctcccaagt
     6181 agctgggatt acaggcacgc accaccatgc ttggctaatt tttgtatttt tagtagagac
     6241 gggggtttca ccatgttggc caggctggtc tccaactcat gacctcgtga tctgcccacc
     6301 tcggcctccc aaagtgctgg gattacaggt gtgagccagc ttgcccagct tatgtttata
     6361 gatttatttt agagacaggg ttgggctcta ttgcccaggc cagagctgga gtgcagtggt
     6421 gcaatcatag ctctctgcag gctccagctt ctgggcgcaa gcaatcctcc cacctcagtc
     6481 tcccaagtag ctacacttgg gagactacgg gcgcacacta ccatgcccag ctaatgtttt
     6541 ttttgtagag atgggatctt gctatgttgc ccagtctggt cttgaacttc tggcctcaag
     6601 cgaccctcct gccttggcct cccaaagtgc tgggattaca ggtgcgagcc accatgcctg
     6661 gcccattctg ttttttgtcg gccactgagg tagaggccct cttctaggaa agaatttctg
     6721 tttgttttgt tttgttttgt tttgtttttt tgaaacagtc tctctctgtc tcccaggctg
     6781 gagtgcagtg gcgtgatctc agctcgctgc aacctccact tcccaggttc aagcaattct
     6841 tctgccaagc tgggactaca ggcatgcacc accaccatgc cctgctaatt tttgttgttg
     6901 tcgttggttt ttgagataga gtttcgctct tgttgcccag gctggagtgc agtggcacga
     6961 tctcagctca ccgcaacctc cgcctcccag gttcaagcaa ttatcttgcc tcagcctccc
     7021 aagtagctgg gattacaggc atgcgccacc acacctggct tatttttgta tttttagtag
     7081 agatggggtt tctccatgtt agccaagctg gtctcgaact cccgacctca gatgatccgc
     7141 ctgcctcagc ctcccaaagt gctggggtta caggtgtgag ccaccacacc cagcctttct
     7201 ttttgcattt ttaatagaga ctgagtttca tcacactggc caggctggtt tcgaactcct
     7261 ggcctcaagt gatccgctgg cctcagcctc ctaaagtgct ggattacagg catgagccac
     7321 cgtgccaggc cttgttaata tttttaactc tggcacttca ccctagaggc tgctaggaat
     7381 caggtgtgcc aagcaactgg caccactcca tggaaagcgt ctagggcagt gccttggttc
     7441 tgccaatcct gagaagccag gctgcccctt gggctgggca gtggcctcag taccgagccc
     7501 caggccagca agcccacaag cctcgagaaa gactgcactt ccggtggagg ctgcagtttc
     7561 cttaaaggga aaatctgccc cacccctgtc aagggcagga cacaagtcac tggcattgaa
     7621 ggacccactc cacacccagc agatcatcga cgcagacttt ttttttccca gatagagtct
     7681 cactctgtcg tccaggctgg actgcaatgg tgtgatcttg gctcactgta acctccgcct
     7741 cccgggctca agtgattctc ctgcctcagc ctcctgagta gctaggatta caggcgccca
     7801 ccatcacgcc tggctaattt ttgtattttt agtagagacg gggttttgcc atgttggcca
     7861 ggctggtctt gaactcctga cctcaagtga tcctcctgcc tcagcctccc aaagtgctgg
     7921 gattataggc gtgagccacc tcgtccggcc caagactttt tgcctcagat gctgcagagc
     7981 cctggtgggg cccaggaggg caaggcccac acaggagccg aaacccatgt agaacctgcc
     8041 aacctgtagc tcacacctat aatcccagca ctttgggagg ctgaggtggg cggatcgctt
     8101 gagccaagga gttcgagacc agcctgggca acattacgag accctgtctc tacaaaaata
     8161 caaaaattac ccgggcttgg tggctcgtgc ctatagtccc agctactggg gaggctgagg
     8221 tgggagaatc atctgagccc agggaggttg agactgcagt gagccaagat tgtgccactg
     8281 cactccagcc tgggtaaaat gagtgagacc acgtctcaac ccctttcaca gcccgtctgc
     8341 ggcccaccca cccatgggta ctgtgggatg ggggacaggc tggcttaaca caaatcgagg
     8401 caggaataac cccagagaat gggctttgca tggagcttgg ctcctgtccc tgcctgtgag
     8461 ggaggaccag actcggcctc accacctgcc actctgagca aacaggcaac ggtgtttcct
     8521 gaacatcttt ctgaagcggc tgagggatgt cagctgagcc cccgctgggc ctgctctgga
     8581 gcgggatgtc tccagaagcc gcccttggag cgggcacttc cctatttggg cgtgtcccag
     8641 tcccatgcct caccatcccc ttgcttgaag ctccaagagc atgagagtgg gcagcctggt
     8701 ctgctgagga aagtgtctga tggatgcgga aatggccacc ccaaacaccg gtaagcagat
     8761 gttaccctgc aggcggtggc tcctggggcc cagccctgca gaaacacatg gggcaggctg
     8821 ggcagagggg ctcacacccg ttattcccag cgctttggga ggctgaggcg ggaggatcgc
     8881 ttgagcccag gagtttgaga ccagcctggg caacatagca agactctatc tccactaaaa
     8941 atcaaaacaa aacaattagc tgggtatggt ggcacacgcc tgtagttcca gctactgggg
     9001 aggctgaggg ggaggatcac ttgagcccag gagttcaagg ctgcagtgag ccatgattgc
     9061 gccactgcac tccagcctgg gcaacagagc aagaccctgc cccgccgcct gaaagaaaga
     9121 aaaaagaaag agaaaggaag agaaagaaag gaaaagaaaa aggaaacata cgaggctatg
     9181 gggccgtgta cgggggccag gctgtggcag aagcatcctg gcgtggcctt ctccagcccc
     9241 atcctggttg ggtaaggtgt cgccgtgggt cttcgtgtca cagcttcaag gacagaccca
     9301 actctggtat cacaaactta acaggtaatg gagtttccta aagtgtgctc tgcaggagtg
     9361 ctggaagggc cagcatggaa ggaccccagg gagggagatt tctttgctcc acagcatccc
     9421 caagcctcac gaggcctctc ccctccaagt ctctatgtgc atcgttctcc agatgttgga
     9481 gcatcctgca ggggccagcc cagcctgtca ggggcagaga ccctgcactg gccccctcga
     9541 gagtggaccc ctgggctggc ttatctgctc cagtgcagtg aggatcagct ggagctccga
     9601 cctgactcac atctggatgc gcagtgaggg gcccgttggg gccgtgatac tgggaggaag
     9661 ccgggctctg tgctcttgct ccaagtgagt tgaccaggga gccgaagtta aggtggcctg
     9721 ggagccacgt cctcccacct agcggctggg ctctcacagc cactagaaac ccatcagcct
     9781 ttcccctggg tctatgcggg gctcttcagc cctcctggga gctcagtggc tgggatgctg
     9841 ctttacagac agtgcacggc tctgccatct gacagctccc agagggttct gggggtgact
     9901 gtaaagagtg gtgctggccc cgaacctttc ctgttcccct ggatttagtt cccagcaggt
     9961 ggtgaggaac tgaacatttt gtcccatagt ggtgggagag agggctggcc acatgggtcc
    10021 aggccacccc ctcagcctcc acagcctgcc ccgcacccag ccacaggaac agcagagcag
    10081 ctcccccatc caggtaagcg cccccaccac agccccatca caaaggaata gcctcctggt
    10141 gtagtgggag gtgaggagct ttttttgttt tccttttatt tattttaggg acagggtctt
    10201 gctctgttgc caagttaagt gcagtggtat gatcatgagc tcactgcagc cttgacatgg
    10261 tggtaaagcc atcctcccgc ctcagccttt cgagtagctg ggactacagg tgtgtgccac
    10321 catgcccaga cgcccagcta atgtttgtat tttttgtaga gatgggggtc tcactatgtt
    10381 gcccaggctg gcctcaagca atcctcccac ctgagccccg caaagtactc ggattacagg
    10441 tgtgagtcac cgcgcctggc cgggagcttt aatttttcct acttgttaac agcgttatgg
    10501 ggctggaagg aggctctcag atttccctgc cctcctcaca tcccccaacc ctccctgggc
    10561 gtgggggtgt caagcatgag tcaggctgag cctgactctg aagctgttcc cagctcttta
    10621 gtctaaactt caaatcttca accctgttcc ctaatccaac acattcccca aatgaaggga
    10681 ctggacagtg agatatcggg aaaccccatg aaaatagatg cataataaag gtgaaaatca
    10741 tttaaaa
//
