LOCUS       NM_001002905            5055 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 8 subfamily G member 1
            (OR8G1), transcript variant 1, coding, mRNA.
ACCESSION   NM_001002905
VERSION     NM_001002905.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5055)
  AUTHORS   Young,J.M., Endicott,R.M., Parghi,S.S., Walker,M., Kidd,J.M. and
            Trask,B.J.
  TITLE     Extensive copy-number variation of the human olfactory receptor
            gene family
  JOURNAL   Am J Hum Genet 83 (2), 228-242 (2008)
   PUBMED   18674749
REFERENCE   2  (bases 1 to 5055)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 5055)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   4  (bases 1 to 5055)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Specific repertoire of olfactory receptor genes in the male germ
            cells of several mammalian species
  JOURNAL   Genomics 39 (3), 239-246 (1997)
   PUBMED   9119360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FO680687.2 and AP002965.3.
            
            On Oct 10, 2020 this sequence version replaced NM_001002905.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This family member represents a
            polymorphic pseudogene, whereby some individuals have a functional
            allele that encodes a full-length protein, while others have a
            non-functional allele due to the presence of an early stop codon
            and a 3' end deletion. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1, coding) represents the longer
            transcript and encodes the supported protein. It represents the
            functional allele, as described in PMID: 18674749 and found in the
            GRCh38 reference genome assembly.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence because no single transcript was available for the
            full length of the gene. This RefSeq is supported by partial
            transcript and paralogous alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA2148093
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641972.1/ ENSP00000493289.1
            polymorphic pseudogene :: PMID: 18674749
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               FO680687.2         25603-25872
            271-350             FO680687.2         32309-32388
            351-4081            FO680687.2         34168-37898
            4082-5055           AP002965.3         37361-38334
FEATURES             Location/Qualifiers
     source          1..5055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..5055
                     /gene="OR8G1"
                     /gene_synonym="HSTPCR25; OR8G1P; TPCR25"
                     /note="olfactory receptor family 8 subfamily G member 1"
                     /db_xref="GeneID:26494"
                     /db_xref="HGNC:HGNC:8484"
     exon            1..270
                     /gene="OR8G1"
                     /gene_synonym="HSTPCR25; OR8G1P; TPCR25"
                     /inference="alignment:Splign:2.1.0"
     exon            271..350
                     /gene="OR8G1"
                     /gene_synonym="HSTPCR25; OR8G1P; TPCR25"
                     /inference="alignment:Splign:2.1.0"
     exon            351..5055
                     /gene="OR8G1"
                     /gene_synonym="HSTPCR25; OR8G1P; TPCR25"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..1302
                     /gene="OR8G1"
                     /gene_synonym="HSTPCR25; OR8G1P; TPCR25"
                     /note="olfactory receptor, family 8, subfamily G, member 1
                     pseudogene; olfactory receptor TPCR25; olfactory receptor
                     OR11-281"
                     /codon_start=1
                     /product="olfactory receptor 8G1"
                     /protein_id="NP_001002905.1"
                     /db_xref="CCDS:CCDS73407.1"
                     /db_xref="GeneID:26494"
                     /db_xref="HGNC:HGNC:8484"
                     /translation="MSGENNSSVTEFILAGLSEQPELQLPLFLLFLGIYVVTVVGNLG
                     MTTLIWLSSHLHTPMYYFLSSLSFIDFCHSTVITPKMLVNFVTEKNIISYPECMTQLY
                     FFLVFAIAECHMLAAMAYDRYMAICSPLLYSVIISNKACFSLILGVYIIGLVCASVHT
                     GCMFRVQFCKFDLINHYFCDLLPLLKLSCSSIYVNKLLILCVGAFNILVPSLTILCSY
                     IFIIASILHIRSTEGRSKAFSTCSSHMLAVVIFFGSAAFMYLQPSSISSMDQGKVSSV
                     FYTIIVPMLNPLIYSLRNKDVHVSLKKMLQRRTLL"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR8G1"
                     /gene_synonym="HSTPCR25; OR8G1P; TPCR25"
                     /note="hexamer: ATTAAA"
     polyA_site      2301
                     /gene="OR8G1"
                     /gene_synonym="HSTPCR25; OR8G1P; TPCR25"
                     /note="major polyA site"
ORIGIN      
        1 ttgccaccct gaagctggag aaacaaaaac tgcaaagtca taattagaaa tactgacctg
       61 tgatgcagac cagcttcaaa gtgactctga gactgagggc tgggccctgc cctctcaaca
      121 ctaaagattc cagaatgctg ggtgtctatg actctcaaca ccaacattaa tgccatgtca
      181 ggaagagaac attccaagcc aacattctcc atgtcaggaa gaggaaattg caagtaaaat
      241 caagcattga agtttttagg cagtggaaag tttggggctc ttatgaataa ggctgtcatg
      301 aacatttttg tataaatctt catgtagaca aacgtttaca tttttcttgg aaactgactg
      361 gaggagatgt caggagaaaa taattcctca gtgactgagt tcattctggc tgggctctca
      421 gaacagccag agctccagct gcccctcttc ctcctgttct taggaatcta tgtggtcaca
      481 gtggtgggca acctgggcat gaccacactg atttggctca gttctcacct gcacacccct
      541 atgtactatt tcctcagcag tctgtccttc attgacttct gccattccac tgtcattacc
      601 cctaagatgc tggtgaactt tgtgacagag aagaacatca tctcctaccc tgaatgcatg
      661 actcagctct acttcttcct cgtttttgct attgcagagt gtcacatgtt ggctgcaatg
      721 gcgtatgacc gttacatggc catctgtagc cccttgctgt acagtgtcat catatccaat
      781 aaggcttgct tttctctgat tttaggggtg tatataatag gcctggtttg tgcatcagtt
      841 catacaggct gtatgtttag ggttcaattc tgcaaatttg atttgattaa ccattatttc
      901 tgtgatcttc ttcccctcct aaagctctct tgctctagta tctatgtcaa caaactactt
      961 attctatgtg ttggtgcatt taacatcctt gtccccagcc tgaccatcct ttgctcttac
     1021 atctttatta ttgccagcat cctccacatt cgctccactg agggcaggtc caaagccttc
     1081 agcacttgta gctcccacat gttggcggtt gtaatctttt ttggatctgc agcattcatg
     1141 tacttgcagc catcttcaat cagctccatg gaccagggga aagtatcctc tgtgttttat
     1201 actattattg tgcccatgtt gaaccctctg atttatagcc tgaggaataa agatgtccat
     1261 gtttccctga agaaaatgct acagagaaga acattattgt aaacagtaat aataagaaga
     1321 tgatatatta atcctaagta gtggactgtt acattgtatg aatggatgtc tttcacttta
     1381 atgcatctgt caataatttt taccatttgg tgagattata ttaccattat tttttcattt
     1441 catgaccctt tgatgtcatt tcccatgtgg ggttttaact catatgtatc aatgagacac
     1501 aaattaatat aaatactaaa atcgacatga gtacatagac tcattaatgc cagccccatg
     1561 ttcttacctc ttttctttta cacaattgat aaaattcagc tcagttctca accataatga
     1621 aaataccatc ttccaaaagt gataccaatc tcccttattc tgtcttttca ataacaacat
     1681 aaattattgc aatatgatag ctgtaatttt agcctgcagc aatctctttt ctgccttatt
     1741 catctattta cctcatttgt ctgctgtatt tcttctttag caacataatc aaaatttcag
     1801 aatataagtt acatatccgt gtatgtgtta taattgtgca atccaatata tcatctgctt
     1861 tgcattttcc tattctagtt tgtacttgcc ttcaacctac actggacttc agtcttcatg
     1921 aagattcccc cgtacatgtg gtttattgcc acgtctccag cgtctatcat agttcttgcc
     1981 accttaggtc cttgaaagct tttttattat ttcctcattt aagctaagta taggaaagcc
     2041 atatgtatgt catacttact ttatctattt atctctcgaa gagctacata tgtttttaaa
     2101 tctaatctaa tttaatttat atttcaagtt gattaaaatt tactttagaa ggttcttcaa
     2161 gaatctataa tataactggt aacattctga cctattctat gctaagatgt atgtgtattt
     2221 gttctgtgaa aaatcccaat gcagatatga taacttgtta acacctgatt ttttaagtca
     2281 ttaaaccctc tcaacaacca aggagtccct aaagcaatac ttattttttc tttcttttca
     2341 aacatgtggc acaggaaggt taaaaaatat gtttgatgcc tgatgggtaa acatagcaaa
     2401 tctggtgata gagttggaac ctgaatagca tggtctaaac tacccttaat tctctatgcc
     2461 tagagcagaa cataatttta cctgtgctgg taatgagaaa attccttgct atgtagatat
     2521 ttagtgaatt ttatgatata taaaatatac ttcaataaaa ttgctttaaa atgaaagtga
     2581 gggtgctacg tgatcaaata caataagcta tgtttctata accagaagaa atatttcact
     2641 tgtctatatt tggatggggc tggttaagtt gctttgatca gattccaggt aatgcagctt
     2701 actctgttta tatatattta atcacaggct cctggatatc gaaactatag tttgtccatc
     2761 cttttagttg aagggagtgt aggtgaatga gccataggtt aataggacta tttcccggga
     2821 actctaaaaa catggcatgt ataaaattga gcataccaag tagatttgga tcttcttgcc
     2881 tgagaaaatt ctcaatcaat catggactct attaacctga gtctgggaag attcaactgt
     2941 taatctattt cttccatgtg gagccaagtt aaatgatttc tttaagctta tttacttatt
     3001 acttatttgc tattactagt gtatctaagt ataactagtg aaaaaattgc caggatccga
     3061 cttagaaaaa aatatatttc taaaagctaa ggggacttaa agttatttcc tcagaaaact
     3121 catctctgaa actcaatctg cattactttt ccatatcatc cttatgttct ctttcagaaa
     3181 aactatctct ttttcttctt agcttgcatt gcttgtggta attttatgat catttgaacg
     3241 tctactctgt acatttccct tgcttcaatg gactataagc tcgagtagag aatacacact
     3301 caaatattta ttaatgatta taccaaacac ccttggtttc tcatgccaca ttctttcaga
     3361 ctacctcctg tttctcattt cagcagactt gaggcacatt tattagctgt gtgcaagctg
     3421 agagttaact tgcattgaag gtgttacact tcaaatttcc agcaagtgct ttgcactttc
     3481 actctggaaa cttctccaca atttcagatg ctcatttggc ttatgtacag tcagctcaaa
     3541 gaattcttgc tcttggggtc acctttaccc agtaacagtg aaaattgtgt gtaatgccac
     3601 atcatcctgt cacacaggac agccatcttg ggaaacatca tatgcacttc tgaggaagtg
     3661 ctggtaaaat tgaaccacca ttgctcatac cagcttttca ataacatact ccaatattag
     3721 cttttccttc ttcgcatttt gactcaaatt tgtaaacatt actaaaaaat taacagctta
     3781 aatgaagata aaacaataat ttaaagtccg ttagaaaact atttatgttt gctgagtgca
     3841 gtggctcatg cctgtagtcc cagcactttg gggagctgag gtgggtgaat cacttctgtt
     3901 caggagtttg agaccagcct gggcaacaag gagaaacctc atttctgcag aaaatacaaa
     3961 aattagctgg gcatggtggt gtgtgcctga agttccagct acttgggagg ctgaggcagg
     4021 agtattgctt gggtccagga agttggggct gcagtgagcc ttgattgtgc cactgtacgt
     4081 cagcctgggc gacagagaga gattgtcccc caaactacca ccaccaccaa tgaacaaaca
     4141 aacaaaaact ttgacaactt ttaatggtca aaaaatattg tatatattat tgtgtacaag
     4201 ttattttgaa tgtgtgtgtg tgtgtatagc gaaatgccta aattgagcta gttaacatat
     4261 atattaccta acatatttat ttgtgtgtgt gtggtgagaa cactaatcca atagattttt
     4321 attactatag ttaccattta tacaatagtt tttaacttat tccttctatc taattaaaat
     4381 attatatcct ttgaccaaca tctcctccca cacgcccagc tgcagataaa cacaattcta
     4441 ctgtctacct ctgtgagttc agcattttta gattccacat gtatgtgaga tcatgtagta
     4501 tttgtctttc tgtgcctggc ttatttcatg taatataatg tcctacaggt tcatctgtat
     4561 tgttgcaaat ttttaaatct aaatattatt ccattgtgca catataccac attttgttta
     4621 tccattcttc ctaagcgatg gacacctagg ttaatctata tcttggctat tgtgaataat
     4681 gctacaataa acatgggagt gcagatattt ctttgacgtg ctgattgtat tttttgaata
     4741 tatacccgat agtggtattg ctaggtcata tggtagttca atttttaatt ttttgaggaa
     4801 gctttatgct gttttccata atgactgtac taatttacat tcccataaac agcatgtaat
     4861 ggttcacttt cctccacatc ctctccaaca gttatccgtt ctctttttga tagtaactat
     4921 cctaacaagt atgaggtgat atctcactgt agtttctctg caatttgatg atttgtaatt
     4981 ttgaacactt tttcatatac ctgttgacca tttttatgtc ttcttttgag aaatgtctat
     5041 ttagatgctt tgcct
//
