LOCUS       NM_012378               3914 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 8 subfamily B member 8
            (OR8B8), mRNA.
ACCESSION   NM_012378
VERSION     NM_012378.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3914)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   2  (bases 1 to 3914)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   3  (bases 1 to 3914)
  AUTHORS   Gaudin,J.C., Breuils,L. and Haertle,T.
  TITLE     New GPCRs from a human lingual cDNA library
  JOURNAL   Chem Senses 26 (9), 1157-1166 (2001)
   PUBMED   11705801
REFERENCE   4  (bases 1 to 3914)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Specific repertoire of olfactory receptor genes in the male germ
            cells of several mammalian species
  JOURNAL   Genomics 39 (3), 239-246 (1997)
   PUBMED   9119360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000916.6.
            
            On Aug 10, 2020 this sequence version replaced NM_012378.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000642064.1/
                                                ENSP00000493014.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AP000916.6         31034-31154         c
            122-257             AP000916.6         26946-27081         c
            258-3914            AP000916.6         22903-26559         c
FEATURES             Location/Qualifiers
     source          1..3914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..3914
                     /gene="OR8B8"
                     /gene_synonym="TPCR85"
                     /note="olfactory receptor family 8 subfamily B member 8"
                     /db_xref="GeneID:26493"
                     /db_xref="HGNC:HGNC:8477"
     exon            1..121
                     /gene="OR8B8"
                     /gene_synonym="TPCR85"
                     /inference="alignment:Splign:2.1.0"
     exon            122..257
                     /gene="OR8B8"
                     /gene_synonym="TPCR85"
                     /inference="alignment:Splign:2.1.0"
     exon            258..3914
                     /gene="OR8B8"
                     /gene_synonym="TPCR85"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1209
                     /gene="OR8B8"
                     /gene_synonym="TPCR85"
                     /note="olfactory-like receptor JCG8; olfactory receptor
                     OR11-316; olfactory receptor TPCR85"
                     /codon_start=1
                     /product="olfactory receptor 8B8"
                     /protein_id="NP_036510.1"
                     /db_xref="CCDS:CCDS8446.1"
                     /db_xref="GeneID:26493"
                     /db_xref="HGNC:HGNC:8477"
                     /translation="MAAENSSFVTQFILAGLTDQPGVQIPLFFLFLGFYVVTVVGNLG
                     LITLIRLNSHLHTPMYFFLYNLSFIDFCYSSVITPKMLMSFVLKKNSISYAGCMTQLF
                     FFLFFVVSESFILSAMAYDRYVAICNPLLYMVTMSPQVCFLLLLGVYGMGFAGAMAHT
                     ACMMGVTFCANNLVNHYMCDILPLLECACTSTYVNELVVFVVVGIDIGVPTVTIFISY
                     ALILSSIFHIDSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPFSLLAMNQGKVSSL
                     FYTTVVPMLNPLIYSLRNKDVKVALKKILNKNAFS"
ORIGIN      
        1 ggtttctcat aatcactgag ggagtggcag atttctaggt ataagagtta cacttgaggc
       61 atcttgtttc tgagcagtga ctaaaataca ttccacatgt ggcagaggag caagctctga
      121 gctccgcagc caatctgtct gaacaagtga agataagagc tggacctaaa ggcacatcac
      181 tgaaactctg ggctgaagag gatgagaggc tgaatccgga tgagcagtcc gaacttttcc
      241 cgagtcccca gtctcagaat gccttaaatg acaatggctg ctgagaattc ctccttcgtg
      301 acacagttta tcctcgcagg cttaactgac caaccgggag tccagatccc cctcttcttc
      361 ctgtttctag gcttctacgt ggtcactgtg gtggggaacc tgggcttgat aaccctgata
      421 aggctcaact ctcacttgca cacccctatg tacttcttcc tctataactt gtccttcata
      481 gatttctgct attccagtgt tatcactccc aaaatgctga tgagctttgt cttaaagaag
      541 aacagcatct cctacgcagg gtgtatgact cagctcttct tctttctttt ctttgttgtc
      601 tctgagtcct tcatcctgtc agcaatggcg tatgaccgct atgtggccat ctgtaaccca
      661 ctgttgtaca tggtcaccat gtctccccag gtgtgttttc tccttttgtt gggtgtctat
      721 gggatggggt ttgctggggc catggcccac acagcgtgca tgatgggtgt gaccttctgt
      781 gccaataacc ttgtcaacca ctacatgtgt gacatccttc cccttcttga gtgtgcttgc
      841 accagcacct atgtgaatga gcttgtagtg tttgttgttg tgggcattga tattggtgtg
      901 cccacagtca ccatcttcat ttcctatgct ctcattctct ccagcatctt ccacattgat
      961 tccacggagg gcaggtccaa agccttcagc acctgcagct cccacataat tgcagtttct
     1021 ctgttctttg ggtcaggagc attcatgtac ctcaaaccct tttctctttt agctatgaac
     1081 cagggcaagg tgtcttccct attctatacc actgtggtgc ccatgctcaa cccattaatt
     1141 tatagcctga ggaataagga cgtcaaagtt gctctaaaga aaatcttgaa caaaaatgca
     1201 ttctcctgag aaaagggcaa tgctcaggaa agaaacactg tttctcccat aagtgatttg
     1261 gactccactg gttacatgga agaaatataa tttttcctca aacaggttca tcatccccat
     1321 tttaagggtt ctttaattta caaacattct taagagcttt gaatactcac acagtaagtc
     1381 ttgaggatca tttcactcag ttccccgcta tttctgagga tagactcaag cttatgtacc
     1441 ttccccgagg tcgctcagct gctcagcagt ggaactgcga ctaaaatcca ggctctttat
     1501 ttccagtact ggctgctttt cattatggct cactttcttc ctccctcagc ctctggaaga
     1561 tttcatttca aatgtgagct ggcctaggat gttaaaatct gattctgtcc tcagaaatta
     1621 catgcaactt ttcaaaggct aattttaaat gtcgcatttt tgcaagtagg taggaagtat
     1681 atagaatttt ttgttgagat ggccttggcc aaatgaccag ggaaattctt gaagcatttt
     1741 gaagaaggtg caggggaagt gtgttaggac ccagggagca gcatgtatgg tacctcttaa
     1801 gacagtgggg tggagcttca gggacttgga cttgaagggt tttagtgatg ctgggtggaa
     1861 gaacttatag aaaatgtcaa ggttatgaag aacagaattt gggaattatt tcacatgcaa
     1921 tcacatacaa tcattgccct gttttcaaaa gtcaagatgg ggaccaaatg cagtggctca
     1981 tgcatgtact ctcagctact caggagactg agggaggaaa atcgcttgaa cccaggaggt
     2041 ggaggttgca gcgagccaag atcatgccac tgcactccag cctgggcaat ggagcaagac
     2101 tccatctaaa caacaacaac aacaaaaaaa cttcaagatg gagaagtcca ccgcctaggg
     2161 tggtcagtta tggatctgga gaatatttca gaaccacaga gagccttgtg ttacaagtca
     2221 gtagtcaggt gagatccaca cagcagtcag tcagtggagg gaatgaccac tgaatggtat
     2281 aatgctgcat gcagcagaaa ccatgtgggg tactttttgc atggtttcac agatcaactt
     2341 tctgcccctt ggcgcctcac gccgaatcct gggaggtatt ccttaactgg tccccttgcc
     2401 ctctggtttc agttgggtta gaccaatggc aacatcagca gaggaaatca gagggtagga
     2461 ggagtgtgat attatgctat ttatttccct gacttcctcc tagctgggca acagtggcag
     2521 taactgaatg cctcatttct tactgggtta taataactgc cccctccctc gtctcttcat
     2581 gccaaggagt gataatgtct ccctgctgtt gctaacccag agagcttgac catctctttg
     2641 tggtttctct caaccacttt tgcttaaaca aatgcagata gtttctttat tgtattttca
     2701 attactgtat ttatgtggat catctgattt ttgcagaaac cctgactgct gcaccttcca
     2761 ataaagggtg ggagaaatga tatggctcag gtttataagc ccacagccta atggtactgt
     2821 ataaaggaag gtagagtagc ttttcagttt aaaaagatta taaatagtag atttctttgt
     2881 gaaacaatga tatgtgaaat gctgtgaaaa tgtgttgact tacgagtctc tctttaggaa
     2941 gattctcttc tatttagaaa aagtaaagtt tggatggatg tagagtgttg ccctttggga
     3001 tggtgcagat taataagggt gaattcaaaa gaatgaggga ttgtgtcttg gacagcatgg
     3061 actagataaa caacacagaa tttagctgac tatgggattg agaggggcag agcagcataa
     3121 agactcaaaa agagcagagc ccagagagtt ggatggtaga atcaaatttg aacctgagct
     3181 tctcctcagc tgtgttgcct ttagcattac atgatgtctc tgaacatcaa tttcttcatc
     3241 tttaaaaacg tttttctcag aggtattaag tgaattagat gccagattct cggtaaattt
     3301 gtttctgtcc ctgccagatc cttttccttt taatatcagc acttgcacta atttattatg
     3361 tgaccttggg acaattgctt catttttctg ggtctatgct tgcttatatg aaaatgatca
     3421 tgttctatca gattatttct acattccatt tacaagatat atttatttat atattgacca
     3481 gataatacat ttgctatagg ctgaacactt gtgtcccctc agaatcagat tttgaaatga
     3541 cggatgttga aaggaggtgg ggtctttggg aggtgattag gtaatgaggg tggggccctc
     3601 atgaatgagg ttagtgtcct tataaaagag tcctgaggct gggtgcggtg gctcacgcct
     3661 gtaatcccag cacgcacgca cgcgcgcgcg cacacacaca cacacacaca cacacacaca
     3721 cacacacaca caaagtctga gagagacctc ccccacctct tctaccatgt aagaacaaaa
     3781 caagaaggct ctgtctatga ggcagaaagc gggctctcac cagacacgga atctgctgct
     3841 gccttaatct tggacttctc agcctctgga accatgagaa ataaattcct gctgtttaaa
     3901 agccacctgg tgtg
//
