LOCUS       NM_001005196             930 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 8 subfamily B member 4
            (OR8B4), mRNA.
ACCESSION   NM_001005196 XM_210186
VERSION     NM_001005196.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   4  (bases 1 to 930)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB065831.1.
            
            On Sep 22, 2004 this sequence version replaced XM_210186.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jul 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be functional according to the Classifier for
            Olfactory Receptor Pseudogenes.
            
            CCDS Note: This olfactory receptor gene is a segregating pseudogene
            (PMID:22908908), where some individuals have an allele that encodes
            a functional olfactory receptor, while other individuals have an
            allele that is predicted to be non-functional. This CCDS is being
            retained because the Classifier for Olfactory Receptor Pseudogenes
            (CORP) predicts the reference genome allele to be functional.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC136865.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356130.7/ ENSP00000348449.3
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..930
                     /gene="OR8B4"
                     /gene_synonym="OR11-315; OR8B4P"
                     /note="olfactory receptor family 8 subfamily B member 4"
                     /db_xref="GeneID:283162"
                     /db_xref="HGNC:HGNC:8473"
     CDS             1..930
                     /gene="OR8B4"
                     /gene_synonym="OR11-315; OR8B4P"
                     /note="olfactory receptor, family 8, subfamily B, member 4
                     pseudogene; olfactory receptor OR11-315"
                     /codon_start=1
                     /product="olfactory receptor 8B4"
                     /protein_id="NP_001005196.1"
                     /db_xref="CCDS:CCDS31710.1"
                     /db_xref="GeneID:283162"
                     /db_xref="HGNC:HGNC:8473"
                     /translation="MTLRNSSSVTEFILVGLSEQPELQLPLFLLFLGIYVFTVVGNLG
                     LITLIGINPSLHTPMYFFLFNLSFIDLCYSCVFTPKMLNDFVSESIISYVGCMTQLFF
                     FCFFVNSECYVLVSMAYDRYVAICNPLLYMVTMSPRVCFLLMFGSYVVGFAGAMAHTG
                     SMLRLTFCDSNVIDHYLCDVLPLLQLSCTSTHVSELVFFIVVGVITMLSSISIVISYA
                     LILSNILCIPSAEGRSKAFSTWGSHIIAVALFFGSGTFTYLTTSFPGSMNHGRFASVF
                     YTNVVPMLNPSIYSLRNKDDKLALGKTLKRVLF"
     exon            1..930
                     /gene="OR8B4"
                     /gene_synonym="OR11-315; OR8B4P"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgactctga gaaacagctc ctcagtgact gagtttatcc ttgtgggatt atcagaacag
       61 ccagagctcc agctccctct tttccttcta ttcttaggga tctatgtgtt cactgtggtg
      121 ggcaacttgg gcttgatcac cttaattggg ataaatccta gccttcacac ccccatgtac
      181 tttttcctct tcaacttgtc ctttatagat ctctgttatt cctgtgtgtt tacccccaaa
      241 atgctgaatg actttgtttc agaaagtatc atctcttatg tgggatgtat gactcagcta
      301 tttttcttct gtttctttgt caattctgag tgctatgtgt tggtatcaat ggcctatgat
      361 cgctatgtgg ccatctgcaa ccccctgctc tacatggtca ccatgtcccc aagggtctgc
      421 tttctgctga tgtttggttc ctatgtggta gggtttgctg gggccatggc ccacactgga
      481 agcatgctgc gactgacctt ctgtgattcc aacgtcattg accattatct gtgtgacgtt
      541 ctccccctct tgcagctctc ctgcaccagc acccatgtca gtgagctggt atttttcatt
      601 gttgttggag taatcaccat gctatccagc ataagcatcg tcatctctta cgctttgata
      661 ctctccaaca tcctctgtat tccttctgca gagggcagat ccaaagcctt tagcacatgg
      721 ggctcccaca taattgctgt tgctctgttt tttgggtcag ggacattcac ctacttaaca
      781 acatcttttc ctggctctat gaaccatggc agatttgcct cagtctttta caccaatgtg
      841 gttcccatgc ttaacccttc gatctacagt ttgaggaata aggatgataa acttgccctg
      901 ggcaaaaccc tgaagagagt gctcttctaa
//
