LOCUS       NM_001005194            1378 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 8 subfamily A member 1
            (OR8A1), mRNA.
ACCESSION   NM_001005194 XM_372443
VERSION     NM_001005194.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1378)
  AUTHORS   Otowa,T., Maher,B.S., Aggen,S.H., McClay,J.L., van den Oord,E.J.
            and Hettema,J.M.
  TITLE     Genome-wide and gene-based association studies of anxiety disorders
            in European and African American samples
  JOURNAL   PLoS One 9 (11), e112559 (2014)
   PUBMED   25390645
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1378)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 1378)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC137197.1 and BI093413.1.
            
            On Nov 7, 2018 this sequence version replaced NM_001005194.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC137197.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000284287.6/
                                                ENSP00000284287.4
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1146              BC137197.1         1-1146
            1147-1378           BI093413.1         262-493
FEATURES             Location/Qualifiers
     source          1..1378
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..1378
                     /gene="OR8A1"
                     /gene_synonym="OR11-318; OST025"
                     /note="olfactory receptor family 8 subfamily A member 1"
                     /db_xref="GeneID:390275"
                     /db_xref="HGNC:HGNC:8469"
     exon            1..1378
                     /gene="OR8A1"
                     /gene_synonym="OR11-318; OST025"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1053
                     /gene="OR8A1"
                     /gene_synonym="OR11-318; OST025"
                     /note="olfactory receptor OR11-318"
                     /codon_start=1
                     /product="olfactory receptor 8A1"
                     /protein_id="NP_001005194.2"
                     /db_xref="CCDS:CCDS31712.2"
                     /db_xref="GeneID:390275"
                     /db_xref="HGNC:HGNC:8469"
                     /translation="MAAGNHSTVTEFILKGLTKRADLQLPLFLLFLGIYLVTIVGNLG
                     MITLICLNSQLHTPMYYFLSNLSLMDLCYSSVITPKMLVNFVSEKNIISYAGCMSQLY
                     FFLVFVIAECYMLTVMAYDRYVAICHPLLYNIIMSHHTCLLLVAVVYAIGLIGSTIET
                     GLMLKLPYCEHLISHYFCDILPLMKLSCSSTYDVEMTVFFSAGFNIIVTSLTVLVSYT
                     FILSSILGISTTEGRSKAFSTCSSHLAAVGMFYGSTAFMYLKPSTISSLTQENVASVF
                     YTTVIPMLNPLIYSLRNKEVKAAVQKTLRGKLF"
     regulatory      1352..1357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR8A1"
                     /gene_synonym="OR11-318; OST025"
                     /note="hexamer: AATAAA"
     polyA_site      1378
                     /gene="OR8A1"
                     /gene_synonym="OR11-318; OST025"
                     /note="major polyA site"
ORIGIN      
        1 catcagcaga gagcccagga tgtttcacta gcaccaaagg ctcaagacta gccgtccaag
       61 attagccttt taatggggtt cttgtctccc atgcatccct gcaggcctcc cacccagagg
      121 agaatggctg caggaaatca ctctacagtg acagagttca ttctcaaggg tttaacgaag
      181 agagcagacc tccagctccc cctctttctc ctcttcctcg ggatctactt ggtcaccatc
      241 gtggggaacc tgggcatgat cactctaatt tgtctgaact ctcagctgca cacccccatg
      301 tactactttc tcagcaatct gtcactcatg gatctctgct actcctccgt cattacccct
      361 aagatgctgg tgaactttgt gtcagagaaa aacatcatct cctacgcagg gtgcatgtca
      421 cagctctact tcttccttgt ttttgtcatt gctgagtgtt acatgctgac agtgatggcc
      481 tacgaccgct atgttgccat ctgccaccct ttgctttaca acatcattat gtctcatcac
      541 acctgcctgc tgctggtggc tgtggtctac gccatcggac tcattggctc cacaatagaa
      601 actggcctca tgttaaaact gccctattgt gagcacctca tcagtcacta cttctgtgac
      661 atcctccctc tcatgaagct gtcctgctct agcacctatg atgttgagat gacagtcttc
      721 ttttcggctg gattcaacat catagtcacg agcttaacag ttcttgtttc ttacaccttc
      781 attctctcca gcatcctcgg catcagcacc acagagggga gatccaaagc cttcagcacc
      841 tgcagctccc accttgcagc cgtgggaatg ttctatggat caactgcatt catgtactta
      901 aaaccctcca caatcagttc cttgacccag gagaatgtgg cctctgtgtt ctacaccacg
      961 gtaatcccca tgttgaatcc cctaatctac agcctgagga acaaggaagt aaaggctgcc
     1021 gtgcagaaaa cgctgagggg taaactgttt tgatgcaaat gttattgttc cttttcaatt
     1081 tagtggtaat tgttataaat accagagtga cagcttctga atgctggcca gctgtggatg
     1141 gaaaataatc acttctccac atggctgggt gaatgggcat ttttccttct ttcctcttcc
     1201 ttccctcttc ctttcctctt ccttcctctt ccttccttcc tcttctttcc tcttccttcc
     1261 ctccctcttt tttcacttct ctttgaagcc agccaacttc aggttcaggt tttctttcac
     1321 ttgagatcca tccctctacc ccaagccctt taataaatgt ttcctatctt aattgtaa
//
