LOCUS       NM_001005191            4965 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 7 subfamily D member 4
            (OR7D4), mRNA.
ACCESSION   NM_001005191 XM_064879
VERSION     NM_001005191.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4965)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4965)
  AUTHORS   Hornung,J., Noack,H., Thomas,M., Farger,G., Nieratschker,V.,
            Freiherr,J. and Derntl,B.
  TITLE     Bayesian informed evidence against modulation of
            androstadienone-effects by genotypic receptor variants and
            participant sex: A study assessing Stroop interference control,
            mood and olfaction
  JOURNAL   Horm Behav 98, 45-54 (2018)
   PUBMED   29246659
  REMARK    GeneRIF: Impact of genotypic variations of the androstadienone
            (AND)-receptor OR7D4, as well as the influence of participant sex
            and concomitant hormonal fluctuations on AND-action during
            emotional interference processing, olfactory performance and mood
            assessments.
REFERENCE   3  (bases 1 to 4965)
  AUTHORS   Hoover,K.C., Gokcumen,O., Qureshy,Z., Bruguera,E., Savangsuksa,A.,
            Cobb,M. and Matsunami,H.
  TITLE     Global Survey of Variation in a Human Olfactory Receptor Gene
            Reveals Signatures of Non-Neutral Evolution
  JOURNAL   Chem Senses 40 (7), 481-488 (2015)
   PUBMED   26072518
  REMARK    GeneRIF: results suggest non-neutral evolution for an olfactory
            receptor gene
REFERENCE   4  (bases 1 to 4965)
  AUTHORS   Choquette,A.C., Bouchard,L., Drapeau,V., Lemieux,S., Tremblay,A.,
            Bouchard,C., Vohl,M.C. and Perusse,L.
  TITLE     Association between olfactory receptor genes, eating behavior
            traits and adiposity: results from the Quebec Family Study
  JOURNAL   Physiol Behav 105 (3), 772-776 (2012)
   PUBMED   22044667
  REMARK    GeneRIF: This study suggested that OR7D4 sequence variant
            (rs2878329 G>A) showed evidence of association with reduced levels
            of adiposity (p=0.03), cognitive dietary restraint (p=0.05) and
            susceptibility to hunger (p=0.008).
REFERENCE   5  (bases 1 to 4965)
  AUTHORS   Lunde,K., Egelandsdal,B., Skuterud,E., Mainland,J.D., Lea,T.,
            Hersleth,M. and Matsunami,H.
  TITLE     Genetic variation of an odorant receptor OR7D4 and sensory
            perception of cooked meat containing androstenone
  JOURNAL   PLoS One 7 (5), e35259 (2012)
   PUBMED   22567099
  REMARK    GeneRIF: Data is consistent with the idea that OR7D4 genotype
            predicts the sensory perception of meat containing androstenone and
            that genetic variation in an odorant receptor can alter food
            preferences.
REFERENCE   6  (bases 1 to 4965)
  AUTHORS   Sookoian,S., Burgueno,A., Gianotti,T.F., Marillet,G. and
            Pirola,C.J.
  TITLE     Odor perception between heterosexual partners: its association with
            depression, anxiety, and genetic variation in odorant receptor
            OR7D4
  JOURNAL   Biol Psychol 86 (3), 153-157 (2011)
   PUBMED   21093532
  REMARK    GeneRIF: The results suggested that odor perception between
            heterosexual partners may have an impact on the development of
            depression and anxiety, and that it might be influenced by genetic
            variation in OR7D4.
REFERENCE   7  (bases 1 to 4965)
  AUTHORS   Keller,A., Zhuang,H., Chi,Q., Vosshall,L.B. and Matsunami,H.
  TITLE     Genetic variation in a human odorant receptor alters odour
            perception
  JOURNAL   Nature 449 (7161), 468-472 (2007)
   PUBMED   17873857
  REMARK    GeneRIF: Genotypic variation in OR7D4 accounts for a significant
            proportion of the valence (pleasantness or unpleasantness) and
            intensity variance in perception of these steroidal odours
REFERENCE   8  (bases 1 to 4965)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   9  (bases 1 to 4965)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011464.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 6, 2020 this sequence version replaced NM_001005191.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641669.1/ ENSP00000493383.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               AC011464.5         6385-6774
            391-4965            AC011464.5         11124-15698
FEATURES             Location/Qualifiers
     source          1..4965
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4965
                     /gene="OR7D4"
                     /gene_synonym="hg105; OR19-7; OR19-B; OR19B; OR7D4P"
                     /note="olfactory receptor family 7 subfamily D member 4"
                     /db_xref="GeneID:125958"
                     /db_xref="HGNC:HGNC:8380"
                     /db_xref="MIM:611538"
     exon            1..390
                     /gene="OR7D4"
                     /gene_synonym="hg105; OR19-7; OR19-B; OR19B; OR7D4P"
                     /inference="alignment:Splign:2.1.0"
     exon            391..4965
                     /gene="OR7D4"
                     /gene_synonym="hg105; OR19-7; OR19-B; OR19B; OR7D4P"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1342
                     /gene="OR7D4"
                     /gene_synonym="hg105; OR19-7; OR19-B; OR19B; OR7D4P"
                     /note="olfactory receptor, family 7, subfamily D, member 4
                     pseudogene; olfactory receptor OR19-7; odorant receptor
                     family 7 subfamily D member 4 RT"
                     /codon_start=1
                     /product="olfactory receptor 7D4"
                     /protein_id="NP_001005191.1"
                     /db_xref="CCDS:CCDS32901.1"
                     /db_xref="GeneID:125958"
                     /db_xref="HGNC:HGNC:8380"
                     /db_xref="MIM:611538"
                     /translation="MEAENLTELSKFLLLGLSDDPELQPVLFGLFLSMYLVTVLGNLL
                     IILAVSSDSHLHTPMYFFLSNLSFVDICFISTTVPKMLVSIQARSKDISYMGCLTQVY
                     FLMMFAGMDTFLLAVMAYDRFVAICHPLHYTVIMNPCLCGLLVLASWFIIFWFSLVHI
                     LLMKRLTFSTGTEIPHFFCEPAQVLKVACSNTLLNNIVLYVATALLGVFPVAGILFSY
                     SQIVSSLMGMSSTKGKYKAFSTCGSHLCVVSLFYGTGLGVYLSSAVTHSSQSSSTASV
                     MYAMVTPMLNPFIYSLRNKDVKGALERLLSRADSCP"
ORIGIN      
        1 gcttcctagg aacagatcgt gtagaagaga aaacttcagt gataaccatc agagttagtg
       61 tgacccagtg agggctggtg gggtaagaag gaaaagagga gagagaataa gtactagcct
      121 tcacagtaat gagcctggaa agtcccatac ttattgagtc tatgaaggtg aagtccctgt
      181 actttgatgg tactttagtt ttcacagaaa ccagtgtctc ccaccttctg ttctcactcc
      241 ttggaatcca gggcccgtct ttaataagtt attttccgaa cagtctctaa ctctcctgca
      301 ctctttccta taaactttag tctcctgttg aatttcgtac atccagttac ttattcatta
      361 actactcacg gaagatctac tatgctcaag acacaacagc tacatggaag cagaaaacct
      421 tacagaatta tcaaaatttc tcctcctggg actctcagat gatcctgaac tgcagcccgt
      481 cctctttggg ctgttcctgt ccatgtacct ggtcacggtg ctggggaacc tgctcatcat
      541 tctggccgtc agctctgact cccacctcca cacccccatg tacttcttcc tctccaacct
      601 gtcctttgtt gacatctgtt tcatctccac cacagtcccc aagatgctag tgagcatcca
      661 ggcacggagc aaagacatct cctacatggg gtgcctcact caggtgtatt ttttaatgat
      721 gtttgctgga atggatactt tcctactggc cgtgatggcc tatgaccggt ttgtggccat
      781 ctgccaccca ctgcactaca cggtcatcat gaacccctgc ctctgtggcc tcctggttct
      841 ggcatcttgg ttcatcattt tctggttctc cctggttcat attctactga tgaagaggtt
      901 gaccttctcc acaggcactg agattccgca tttcttctgt gaaccggctc aggtcctcaa
      961 ggtggcctgc tctaacaccc tcctcaataa cattgtcttg tatgtggcca cggcactgct
     1021 gggtgtgttt cctgtagctg ggatcctctt ctcctactct cagattgtct cctccttaat
     1081 gggaatgtcc tccaccaagg gcaagtacaa agccttttcc acctgtggat ctcacctctg
     1141 tgtggtctcc ttgttctatg gaacaggact tggggtctat ctgagttctg ctgtgaccca
     1201 ttcttcccag agcagctcca ccgcctcagt gatgtacgcc atggtcaccc ccatgctgaa
     1261 ccccttcatc tacagcctga ggaacaagga tgtgaagggg gccctggaaa gactcctcag
     1321 cagggccgac tcttgtccat gacaaatcag ggcctcagaa ctaagaggac acactgcgta
     1381 cccctaaggc aaatgttgtg ggtttaaata tccggctctt tttctctttt aaaaaatgtg
     1441 cttgatgtgg gatttttggt tgttgttatt gggttgtttg ttgttgttat tgttattgtt
     1501 tttgagacag agtctggctc tgtcgcccag gctagagtgc agtggtgcaa tcttggctca
     1561 ctgcaacctc tacctcccag gttgaagcgg ttctcctgcc tcagcctctc aagtagctga
     1621 gattacaggt gtgtgccacc acagccagct aatttttgta tttttagtag agacagggtt
     1681 ccaccatact gttcaggctg gtctggaact cctgacctca tgatctgcct gcctcagcct
     1741 cccaaagtgc taggattaca agcgtgagcc accgtgcctg gccaatgtgt ttctttcttt
     1801 tctttttttt tttaatcaaa aacaactatg attttgcttt tgtttttgtg ttagtttctc
     1861 ctaaaaactc cctctgtaag ccctttttga cttttcttcc ctagatgttt cccataaagt
     1921 tccatctttg atcagttttc ttaccactct ttctgagact tctaatttga tgtgtatggc
     1981 actcccaata tcaagtgctg acctggtttc ctcaaaaatt atcctgttga atgttgatgt
     2041 tcctcacctt agtatagttt tttcttgtcc tctggatagg aaataaaatg aaaaccatag
     2101 attagtcgta taaaatgttt acaatatcag gacagtgctt gttgctttac atgtctgatg
     2161 ttattcaatc ctgaaaacat ttcgtgagaa attttgtctc attcactgca tttctcaaag
     2221 gaggagactg agatggaggt agagtatatc ctaacaatct gacactttgc ccacacttct
     2281 aactttgcca tcctactttc cataaaaaca gtgatataaa attttcgggg cacagtggct
     2341 cacacctgtc ttcccagcta cttggagggc tgaggcagga gaatcactgg agcctaggag
     2401 tttgaggctg tagtgagctg tgatcgtggc actgcaatcc agcctgggtg acagagcaag
     2461 accctgtctc aaaccaaaaa caaacacaaa agcaaagaat gataatgtga ttttcaactt
     2521 caaattatga ctctatattt gaaagctggt tgggtcaaat ggttcctagt aatatactgg
     2581 ccagaatgag tctgacatgc tatccctttg aaatacaagc cctataagcc cacagaaatc
     2641 agagccgtgg aatctgggag cacaaacccc ttaggtgtct cactacaggt gatgttaggc
     2701 agggccaatc ttgttccaac tcttgatttc cgggccattg tattctatat cataaagata
     2761 ttatcatttt gatggtatca aaagatatta tcatttttca ctgatttgga atgcatacta
     2821 atcctaattt gcatcctgca aatttggtag ccagtatttt ctgtttattc aaatacctgc
     2881 aataaatatt tgtctttgaa ataaaactca ggtggcagag gttgcagtga gctgagattg
     2941 tgccactgca ctccagcctg ggcgacagag caagactctg tctaaaacat aaaacaaaat
     3001 aaataaataa aacaaaataa cttagaaagt ataattgcat tgtttgtaac tctaaagata
     3061 aatagttgag ggatgaatac ctcattctcc acgatgtggt tatttcacat tgcattcctg
     3121 tatcaaaacg tttcatctac cccataaata tatacagcta ctatctacgc acaaaaatta
     3181 aaaatgtttt aaaacatttt taaagaaaaa taaaagtaga agaggagaaa agtgaatgac
     3241 cattgaagga acagggcttc ctcttctcat taaaacctct tctgtcctct gagttcccac
     3301 caccaagttt cagagacagt gacaaaccac atcagatttt tttttaattt taaaatgaaa
     3361 tgggagtcat atctgcaaat ccattgaatg aaccatgtaa ataaagaaga agcaggcctt
     3421 ccatgagaag aatatgttgc accttttttt tttttttttt ttttttgaga tggagtcttg
     3481 ctctgtcgcc caggctagag cacagtggcg ctgggattac aggcgcacgc caccatgccc
     3541 ggctaatctt ttgtattttt agtagagatg gggtttcacc atgctggcca ggctggtctc
     3601 aaactcctga cctcgtgatc cacccgcctc ggcctcccaa agtgctggga ttacaggcat
     3661 gacccaccac acccagccac tactttcatt cttgaagttc agatttatgt ttctaaggag
     3721 gactttctat tttactttct atactccttg cctgtaattt gagattttat gcattggtaa
     3781 tttatgtttt tgctaagttg gataagaccc taattctttc tgtctgattg atctatgttg
     3841 gcatgttaga aactgctgat ctttgcagcc taacttggta actttatata ttgcttaagc
     3901 atttccccat atctaacaag actgcaatca gatgtcagcc agggttgcag tcatctcgtg
     3961 gactgactgg agaggatctg ctgtgaagct cactcacatg gctgtttgta gggtttaggt
     4021 tcttgcagga caatggccta aggcccctca gtttgttgcc acaagggact ctcatggggc
     4081 agctcacata tgccagctga gttctgtcag tgcagggaag caagggacag agcaacagag
     4141 gccaggccta tccttctacc aggacatggg tctctaagca cccaagacca tggagatttc
     4201 cctctgcctt ccggtagagt tcctcaccat tcaagacatt gtactgtcag aaaaattcca
     4261 tgctgtagaa ctggcacatg gacatgtcgc cctttcctct gcactggata tttctacaga
     4321 cttaacaatg ttctcctgga ccttcagaca aaataagcca ccctggttct ccttcgccac
     4381 aagctctcag cccaacatca caataagctg ctgcaattct gcacctaaat tcagcaagtg
     4441 ttcccagcag cttctgattg ttgctcatca agaaagagct catctcactt caggcggaga
     4501 actccctagt gtagactctg tgttgtgtgt gttgtgtgtg tgtgtgtgtg tgtgagatca
     4561 cctagtaaat tctttaatga aatgtacttt cttttggcct gtctttattc aagtagataa
     4621 aataggttgt atggaagtta tggagttttt gttttgtttt gttttgagat gtcttgctct
     4681 gttgcccaag ctgcagtgaa gcggctcagt catagctcac tgcagccttg aattcctggc
     4741 ctcaagtaat cctcctgcgc caccatgtcc aggtaattta ttttatttta tttttttgta
     4801 gagatggagt cttgctatgt tgcccaggct ggtcttgaac ttctggtctc aagtgaccct
     4861 cctgcttcag cctcccaaag tggtgagatt gtaggtacag accaccatgc ccagccagat
     4921 attatggttc tttataaact ttcacattcc acccatggct cagag
//
