LOCUS       NM_175883               3286 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 7 subfamily D member 2
            (OR7D2), transcript variant 1, mRNA.
ACCESSION   NM_175883 XM_375563
VERSION     NM_175883.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3286)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3286)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3286)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   4  (bases 1 to 3286)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   5  (bases 1 to 3286)
  AUTHORS   Wilanowski,T., Tuckfield,A., Cerruti,L., O'Connell,S., Saint,R.,
            Parekh,V., Tao,J., Cunningham,J.M. and Jane,S.M.
  TITLE     A highly conserved novel family of mammalian developmental
            transcription factors related to Drosophila grainyhead
  JOURNAL   Mech Dev 114 (1-2), 37-50 (2002)
   PUBMED   12175488
REFERENCE   6  (bases 1 to 3286)
  AUTHORS   Parmentier,M., Libert,F., Schurmans,S., Schiffmann,S., Lefort,A.,
            Eggerickx,D., Ledent,C., Mollereau,C., Gerard,C., Perret,J. et al.
  TITLE     Expression of members of the putative olfactory receptor gene
            family in mammalian germ cells
  JOURNAL   Nature 355 (6359), 453-455 (1992)
   PUBMED   1370859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011464.5.
            
            On Aug 7, 2020 this sequence version replaced NM_175883.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641288.2/ ENSP00000493200.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC011464.5         46851-46995         c
            146-236             AC011464.5         45186-45276         c
            237-3286            AC011464.5         37156-40205         c
FEATURES             Location/Qualifiers
     source          1..3286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3286
                     /gene="OR7D2"
                     /gene_synonym="HTPCRH03; OR19-10; OR19-4"
                     /note="olfactory receptor family 7 subfamily D member 2"
                     /db_xref="GeneID:162998"
                     /db_xref="HGNC:HGNC:8378"
     exon            1..145
                     /gene="OR7D2"
                     /gene_synonym="HTPCRH03; OR19-10; OR19-4"
                     /inference="alignment:Splign:2.1.0"
     exon            146..236
                     /gene="OR7D2"
                     /gene_synonym="HTPCRH03; OR19-10; OR19-4"
                     /inference="alignment:Splign:2.1.0"
     exon            237..3286
                     /gene="OR7D2"
                     /gene_synonym="HTPCRH03; OR19-10; OR19-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1188
                     /gene="OR7D2"
                     /gene_synonym="HTPCRH03; OR19-10; OR19-4"
                     /note="olfactory receptor OR19-10; olfactory receptor
                     19-4"
                     /codon_start=1
                     /product="olfactory receptor 7D2"
                     /protein_id="NP_787079.1"
                     /db_xref="CCDS:CCDS32900.1"
                     /db_xref="GeneID:162998"
                     /db_xref="HGNC:HGNC:8378"
                     /translation="MEAGNQTGFLEFILLGLSEDPELQPFIFGLFLSMYLVTVLGNLL
                     IILAISSDSHLHTPMYFFLSNLSWVDICFSTCIVPKMLVNIQTENKAISYMDCLTQVY
                     FSMFFPILDTLLLTVMAYDRFVAVCHPLHYMIIMNPHLCGLLVFVTWLIGVMTSLLHI
                     SLMMHLIFCKDFEIPHFFCELTYILQLACSDTFLNSTLIYFMTGVLGVFPLLGIIFSY
                     SRIASSIRKMSSSGGKQKALSTCGSHLSVVSLFYGTGIGVHFTSAVTHSSQKISVASV
                     MYTVVTPMLNPFIYSLRNKDVKGALGSLLSRAASCL"
     regulatory      3264..3269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR7D2"
                     /gene_synonym="HTPCRH03; OR19-10; OR19-4"
                     /note="hexamer: ATTAAA"
     polyA_site      3286
                     /gene="OR7D2"
                     /gene_synonym="HTPCRH03; OR19-10; OR19-4"
                     /note="major polyA site"
ORIGIN      
        1 ccacactcat gcatcttaga gaggagagtt aggatgactt catgacaagt tccatctccc
       61 cgcctttccc tgctagattc tgtcttcagc attcaacagt caggggagga agacgtcata
      121 ccagcatttt tttttttcaa gcaatctttc catgatgagt acaaagcctt ggggaatatc
      181 tggataaagt aaaattttct agaatgtgat ctggacttgc cacaaagaaa cttcagatac
      241 atcagctaca tggaagcagg aaaccaaaca ggatttttag agtttatcct tctcggactc
      301 tctgaggatc cagaactaca gccgttcata tttgggctgt tcctgtccat gtacctggtg
      361 acggtgctgg gaaacctgct catcatcctg gccatcagct ctgactccca cctccacacc
      421 cccatgtact tcttcctctc caacctgtcc tgggttgaca tctgtttcag cacttgcatc
      481 gtccccaaga tgctggtgaa catccagacc gagaacaaag ccatctccta catggactgc
      541 ctcacacagg tctatttctc catgtttttt cctattctgg acacgctact cctgaccgtg
      601 atggcctatg accggtttgt ggctgtctgc caccctctgc actatatgat catcatgaac
      661 ccccacctct gtggcctcct ggtttttgtc acctggctca ttggtgtcat gacatccctc
      721 ctccatattt ctctgatgat gcatctaatc ttctgtaaag attttgaaat tccacatttt
      781 ttctgcgaac tgacgtacat cctccagctg gcctgctctg ataccttcct gaacagcacg
      841 ttgatatact ttatgacggg tgtgctgggc gtttttcccc tccttgggat cattttctct
      901 tattcacgaa ttgcttcatc cataaggaag atgtcctcat ctgggggaaa acaaaaagca
      961 ctttccacct gtgggtctca cctctccgtc gtttctttat tttatgggac aggcattggg
     1021 gtccacttca cttctgcggt gactcactct tcccagaaaa tctccgtggc ctcggtgatg
     1081 tacactgtgg tcacccccat gttgaacccc ttcatctaca gcctgaggaa caaggatgtg
     1141 aagggagccc tggggagtct cctcagcagg gcagcctctt gtttgtgatg gatcccttgg
     1201 ccccaggact aagaagtttt gtgagcacca atggcaaaaa tgttttattt tgaaattctt
     1261 actctttaaa attaaaaaca tttttttata ctttgagagt acaaatgcag atttcttaac
     1321 atgcatttgc ataagggtga agtctgagct tttggcgtac caattacctg aatagtgaac
     1381 ataaggcact tttttttctt ttttgagacg gagtctcact ctgtctccca ggctggagtg
     1441 cagtggagtg atctcggctc actgcaacct ccgcctcccg ggttcaagtg attcttctgt
     1501 ctcagcctcc tgagtagctg agattacagg tgtgtgccac ccatgccttt tagtagagac
     1561 ggggtttcac catcttggcc aggctggtct cgaactcctg accttgtgat ccacctgcct
     1621 tggcctctca aagtgctggg attacaggtg tgagccacca cgcccggcca aggcagtttt
     1681 taaactctca ctcccctctc accttttgca gtctccagtg tccattattc tgttataatg
     1741 cccatgcgta tacattgttt agctcccaat tataagtgag atcatgcagc atttgacttt
     1801 gtttctttac taccttactt aagagaatgg cttccagtcc catcgatgtt gctgcaaaag
     1861 acatgatttc atcctttttt atggctgagt agtactccat tgtatatatc ctcgatatct
     1921 atatagatat agacatatgt agatacatac catgttttct ttttttaaaa aaatttattt
     1981 ttatgtcagt agtttttggg gtacatgtgg tttttcatta cacggatgag ttctttagtg
     2041 gtgacttctg agtttttagt gtacccgtca cccaagtggt agtagtctct tattcctcac
     2101 ccccctccca acctttctcc cttcaagtca ccaaagttca ttatattgtt catatccctt
     2161 tgtgtcctca tagcttagct cccacttata actgagaaca tacgatatgt tcatatggat
     2221 cttatgtatg ttggttgaac atacaaacaa gtccaggttt ttcattcctg agttacttca
     2281 cctagagtaa tgacctccag ttccatccaa gttgctacaa aagacattat ttggttcctt
     2341 tttatggata agtagtattc catgctgtac atataccaca atctttatca ctcattggtt
     2401 gatgggcact taggttggtt ccatgccttt gtaattgcta attatgttgc tataaacatg
     2461 caggtgtatg tgtctttttc acataatgac tttgtttcct ttgggtagat acccagtagt
     2521 ggaactgctg gactgaaagg tagttctact tttagttctt ttttttgttt tttttttaag
     2581 acagagtctc actctgttgc ccaggctgga gtgcagtggc gcgatctcat ctcactgcaa
     2641 cctccacctc ccaggttcaa gcgattctcc tgcctcaacc tcctgagtag ctgggactac
     2701 aggcacctgc caccccaccc agctaattct tctattttta gtagagacag ggtttcacca
     2761 tgttggccag gctggtcttg aactcctgac ctcaggtgat acgcccacct cggcctccca
     2821 aagtgctggg attacaggtg tgagccactg tgcctggcct tctagttctt taagatacca
     2881 ctttaaaaaa agtccagtcc tccattgatg gacacgtagg ttgattccat atctttgcta
     2941 atgtgaatag tgccgtgata aacatggggg tgtaagttaa caattaatct ccaagtaatt
     3001 tccttgatgg cacttctgtc ctatgtgcta ttcaaaaatt gtgtccttga tcatcgttct
     3061 taattctcca ttagtgagtt ctgaacttgg gtttgaagca tttgctatag ctttgttatc
     3121 tcaagtggtg gcacagagtt cttaagctat tgattgttca ctgactttat ttctatgtgt
     3181 ttgcatgtgg gtttttgttg tttgtgtgtt cgatcatgaa cagatcaaca gtgtttattt
     3241 gttttcctac tggatgaagt atgattaaaa tacgtattta aatata
//
