LOCUS       NM_001370485            2356 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 7 subfamily C member 1
            (OR7C1), transcript variant 1, mRNA.
ACCESSION   NM_001370485 XM_011527915
VERSION     NM_001370485.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Molecular cloning and chromosomal mapping of olfactory receptor
            genes expressed in the male germ line: evidence for their wide
            distribution in the human genome
  JOURNAL   Biochem Biophys Res Commun 237 (2), 283-287 (1997)
   PUBMED   9268701
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Specific repertoire of olfactory receptor genes in the male germ
            cells of several mammalian species
  JOURNAL   Genomics 39 (3), 239-246 (1997)
   PUBMED   9119360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005255.1.
            
            On Jun 26, 2021 this sequence version replaced NM_001370485.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.187905.1,
                                           SRR1803614.115946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000641666.2/
                                                ENSP00000493429.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC005255.1         48544-48655         c
            113-300             AC005255.1         23276-23463         c
            301-532             AC005255.1         14003-14234         c
            533-721             AC005255.1         13726-13914         c
            722-2356            AC005255.1         11985-13619         c
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2356
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /note="olfactory receptor family 7 subfamily C member 1"
                     /db_xref="GeneID:26664"
                     /db_xref="HGNC:HGNC:8373"
     exon            1..112
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /inference="alignment:Splign:2.1.0"
     exon            113..300
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /inference="alignment:Splign:2.1.0"
     exon            301..532
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /inference="alignment:Splign:2.1.0"
     exon            533..721
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /inference="alignment:Splign:2.1.0"
     exon            722..2356
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /inference="alignment:Splign:2.1.0"
     CDS             735..1697
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /note="olfactory receptor, family 7, subfamily C, member
                     4; olfactory receptor OR19-16; olfactory receptor 7C4;
                     olfactory receptor TPCR86"
                     /codon_start=1
                     /product="olfactory receptor 7C1"
                     /protein_id="NP_001357414.2"
                     /db_xref="CCDS:CCDS12317.1"
                     /db_xref="GeneID:26664"
                     /db_xref="HGNC:HGNC:8373"
                     /translation="METGNQTHAQEFLLLGFSATSEIQFILFGLFLSMYLVTFTGNLL
                     IILAICSDSHLHTPMYFFLSNLSFADLCFTSTTVPKMLLNILTQNKFITYAGCLSQIF
                     FFTSFGCLDNLLLTVMAYDRFVAVCHPLHYTVIMNPQLCGLLVLGSWCISVMGSLLET
                     LTVLRLSFCTEMEIPHFFCDLLEVLKLACSDTFINNVVIYFATGVLGVISFTGIFFSY
                     YKIVFSILRISSAGRKHKAFSTCGSHLSVVTLFYGTGFGVYLSSAATPSSRTSLVASV
                     MYTMVTPMLNPFIYSLRNTDMKRALGRLLSRATFFNGDITAGLS"
     regulatory      2333..2338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /note="hexamer: ATTAAA"
     polyA_site      2356
                     /gene="OR7C1"
                     /gene_synonym="CIT-HSP-146E8; HSTPCR86P; OR19-5; OR7C4;
                     TPCR86"
                     /note="major polyA site"
ORIGIN      
        1 actctttcct gctgcctagt ctgctgagca gagcttcagt ctccaccatc aatcatccag
       61 tgaggaattt gcacttacac aaggaactct tcctcggaga gatcccctcc tgaacccacc
      121 tgcagttcac cagccccaga ccaagagcac cttctctatg cctctctgaa atgtccatcc
      181 actccagaga accagcccct gacacccacc cccttgccct gcctgcaccg attgtgcaag
      241 gagggaaggt caacagagcc aagtccattg agggatatca agagaagcca gagtaaaccc
      301 ttgatctgcg ccatcttgtc tgctcgtggc tgacaaagag aagggaagat ggagccacca
      361 tcttgaaaac ttctagtcct tagttcctgc cggcattcac ccgtgcaagc tcccagcttg
      421 tttgtgtctg cagctcgcct ttacaggatg ctctttgtta gaaaatgatt tggggctgct
      481 tttcattaaa aagaaaagcc tcactgagga ctcccataac cttactatct gcgtctgacc
      541 agggattctg catttaaaga aactcttgtt gatcttgttg gttcatggac aacactttga
      601 gaagccaggc tatagagggt acaagtatta tggaactaac actacatttc cagatcccga
      661 tggtagcaaa gaaaaggatg gaagaatttc agatgcccca gaaaaagaca gcaagaaaaa
      721 gttattttat ccccatggaa acaggaaatc aaacacatgc ccaagaattt ctcctcctgg
      781 gattttcagc aacgtcagag attcagttca ttctctttgg gctgttcctc tccatgtacc
      841 tagtcacttt caccgggaac ctgctcatca tcctggccat atgctcagac tcccacctcc
      901 acacccccat gtacttcttc ctctccaacc tgtcttttgc tgacctctgt tttacctcca
      961 cgactgtccc aaagatgtta ctgaatatac tgacacagaa caaattcata acatatgcag
     1021 gctgtctcag tcagattttt tttttcactt catttggatg cctggacaat ttactcttga
     1081 ccgtgatggc ctatgaccgc ttcgtggccg tctgtcaccc cctgcactat acggtcatca
     1141 tgaaccccca gctctgtgga ctgctggttc tggggtcctg gtgcatcagt gtcatgggtt
     1201 ccctgctcga gaccttgact gttttgaggc tgtccttctg caccgaaatg gaaattccac
     1261 actttttttg tgatctactt gaagtcctga agctcgcctg ttctgacacc ttcattaata
     1321 acgtggtgat atactttgca actggcgtcc tgggtgtgat ttccttcact ggaatatttt
     1381 tctcttacta taaaattgtt ttctctatac tgaggatttc ctcagctggg agaaagcaca
     1441 aagcgttttc cacctgtggt tcccacctct cagtggtcac cttgttctat ggcacgggct
     1501 ttggggtcta tctcagttct gcagccacac catcttctag gacaagtctg gtggcctcag
     1561 tgatgtacac catggtcacc cccatgctga accccttcat ctacagcctg aggaacacgg
     1621 acatgaagag ggccctgggg agactcctca gtagggcaac attttttaat ggtgacatca
     1681 ctgcaggact ttcataagta gcaaggcttg gaccattggg aggcactttt ggtggttctt
     1741 gaatgtatcc aaacatcaat gtattctctt ttagttctgg aattaccata tcttatcgtg
     1801 tctttgatac aggagctaga aagaaattat ttaggtagat agggagggcc acagagtcct
     1861 tggcaaggtt tccccgttaa caaaaagcag ccctcaaaat catttctttt ctaacaaaga
     1921 acagcctgaa aaatcgagct gcagacatag ataagcaagc tggaagcttg catgagtgaa
     1981 tgccggctgc tgcgccaata gaaaagggct agctggggac cagtcatgtt caacatggag
     2041 gctccctctt ccttttcttt gtcaaccatg tgtacagcaa aggaacaggc aacatggggc
     2101 tgcccaggta aagaacccat ctgtataata aaagattagg gtggggcagc cagcttctcc
     2161 acatgctatg caaatggcac acctgatcca accaatcttt tatggcctat gtaaatcaga
     2221 caacacctcc tcaagctagt ttataaaacc ctgtgcattt caccatggaa ctggcaaccc
     2281 attttctctg ggacccctct ctgcacatag agctcttctc tttctctcac ctattaaact
     2341 tctgctctta acctca
//
