LOCUS       NM_017506               2126 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 7 subfamily A member 5
            (OR7A5), transcript variant 1, mRNA.
ACCESSION   NM_017506 XM_017026583
VERSION     NM_017506.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   2  (bases 1 to 2126)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 2126)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   4  (bases 1 to 2126)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Molecular cloning and chromosomal mapping of olfactory receptor
            genes expressed in the male germ line: evidence for their wide
            distribution in the human genome
  JOURNAL   Biochem Biophys Res Commun 237 (2), 283-287 (1997)
   PUBMED   9268701
REFERENCE   5  (bases 1 to 2126)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Specific repertoire of olfactory receptor genes in the male germ
            cells of several mammalian species
  JOURNAL   Genomics 39 (3), 239-246 (1997)
   PUBMED   9119360
REFERENCE   6  (bases 1 to 2126)
  AUTHORS   Parmentier,M., Libert,F., Schurmans,S., Schiffmann,S., Lefort,A.,
            Eggerickx,D., Ledent,C., Mollereau,C., Gerard,C., Perret,J. et al.
  TITLE     Expression of members of the putative olfactory receptor gene
            family in mammalian germ cells
  JOURNAL   Nature 355 (6359), 453-455 (1992)
   PUBMED   1370859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA444957.1, AK312475.1 and AC005255.1.
            
            On or before May 8, 2019 this sequence version replaced
            XM_017026583.2, NM_017506.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.127960.1,
                                           SRR1803612.505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322301.5/ ENSP00000316955.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DA444957.1         192-228
            38-562              AK312475.1         2-526
            563-563             AC005255.1         41274-41274         c
            564-1085            AK312475.1         528-1049
            1086-2126           AC005255.1         39711-40751         c
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2126
                     /gene="OR7A5"
                     /gene_synonym="HTPCR2"
                     /note="olfactory receptor family 7 subfamily A member 5"
                     /db_xref="GeneID:26659"
                     /db_xref="HGNC:HGNC:8368"
     exon            1..112
                     /gene="OR7A5"
                     /gene_synonym="HTPCR2"
                     /inference="alignment:Splign:2.1.0"
     exon            113..2126
                     /gene="OR7A5"
                     /gene_synonym="HTPCR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1085
                     /gene="OR7A5"
                     /gene_synonym="HTPCR2"
                     /note="olfactory receptor, family 7, subfamily A, member 5
                     pseudogene; olfactory receptor OR19-17; olfactory receptor
                     TPCR92"
                     /codon_start=1
                     /product="olfactory receptor 7A5"
                     /protein_id="NP_059976.1"
                     /db_xref="CCDS:CCDS12318.1"
                     /db_xref="GeneID:26659"
                     /db_xref="HGNC:HGNC:8368"
                     /translation="MEPGNDTQISEFLLLGFSQEPGLQPFLFGLFLSMYLVTVLGNLL
                     IILATISDSHLHTPMYFFLSNLSFADICVTSTTIPKMLMNIQTQNKVITYIACLMQMY
                     FFILFAGFENFLLSVMAYDRFVAICHPLHYMVIMNPHLCGLLVLASWTMSALYSLLQI
                     LMVVRLSFCTALEIPHFFCELNQVIQLACSDSFLNHMVIYFTVALLGGGPLTGILYSY
                     SKIISSIHAISSAQGKYKAFSTCASHLSVVSLFYGAILGVYLSSAATRNSHSSATASV
                     MYTVVTPMLNPFIYSLRNKDIKRALGIHLLWGTMKGQFFKKCP"
     regulatory      2018..2023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR7A5"
                     /gene_synonym="HTPCR2"
                     /note="hexamer: ATTAAA"
     polyA_site      2043
                     /gene="OR7A5"
                     /gene_synonym="HTPCR2"
                     /note="major polyA site"
     regulatory      2104..2109
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR7A5"
                     /gene_synonym="HTPCR2"
                     /note="hexamer: ATTAAA"
     polyA_site      2126
                     /gene="OR7A5"
                     /gene_synonym="HTPCR2"
                     /note="major polyA site"
ORIGIN      
        1 actctttcct gctgcctagt ctgctgagca gagcttcagt ctccaccatc aatcatccag
       61 tgaggaattt gcacttacac aaggaactct tcctcggaga gatcccctcc tgtcacttca
      121 atcaaatgga accaggaaat gatacacaaa tttcagaatt tcttcttctg ggattttcac
      181 aagaacctgg actgcaaccc ttcctctttg ggctgttcct gtccatgtac ctggtcactg
      241 tgctcgggaa cctgctcatc atcctggcca caatctcaga ctcccacctc cacaccccca
      301 tgtacttctt cctctccaac ctgtcctttg ctgacatttg tgttacttcc accaccattc
      361 caaaaatgct gatgaacatc cagacacaga acaaagtcat cacctacata gcctgcctca
      421 tgcagatgta ttttttcata ctctttgctg gatttgaaaa cttcctcctg tccgtgatgg
      481 cctatgaccg gtttgtggcc atctgtcacc ccctgcacta catggtcatt atgaaccctc
      541 acctctgtgg actgctggtt ctagcatcct ggaccatgag tgctctgtat tccttgctac
      601 aaatcttaat ggtagtacgg ctgtccttct gcacagcctt agaaatcccc cactttttct
      661 gtgaacttaa tcaggtcatc caacttgctt gttctgatag ctttcttaat cacatggtga
      721 tatattttac agttgcgctg ctgggtggag gtcccctgac tgggatcctt tactcttact
      781 ctaagataat ttcttccata catgcaatct catcagctca ggggaagtac aaggcatttt
      841 ccacctgtgc atctcacctc tcagttgtct ccttatttta tggtgcaatc ctaggggtgt
      901 accttagttc tgctgccacc cgcaactcac actcaagtgc aacagcctca gtgatgtaca
      961 ctgtggtcac ccccatgctg aaccccttta tctatagtct gaggaataaa gacataaaga
     1021 gggctctggg aatacatttg ttgtggggaa caatgaaagg gcaatttttc aagaagtgcc
     1081 catgattgca gggctctaag cttcagaggt agtaactgtc attcttcaat cagatagtgg
     1141 aaatagaact tgctccttct attaatactt attatatttc tgggagtttc aatttgttgt
     1201 gatttcaact ggtcttgtag aatttaagca actcctttta ttaagctttc tgctctctga
     1261 tatccaacag ttttttctct ttgttgtttt cctactttct caaggttatt tccgactttg
     1321 gatcagaaac actttggaga tttccatttg tctcatacag ggaagagttg tatgtctcct
     1381 gtggcataga ctacacttgg caattggggt aattgatgta aatttatagt ggaatatgac
     1441 ctgagaccac aatttgttca cttttgtatt cttcagtcct atgtctgtct ctaccttcaa
     1501 tgctcctcct gataatgtag acctgaacat acttgtgtat tttgcagctg gtcatgagat
     1561 tgtgttgtcc tcattaggac atcatgtctt tgtcagtgcc atgtccacag tatctgccat
     1621 actccctggc atagtacggt aaggcaaaaa ttgtttatca aaaatatgtt ccgagtgcaa
     1681 tgcccactga aagacaaact tgcatatgtt gattaactta atatggactt acagtcagag
     1741 atgaccttaa atatgatgga gtaaaattgt caatcataca ttgaattgct atggaagact
     1801 tgtttttatg atgtgcatgg actcattgaa gtatggaagc ttagtgccca tatataagtt
     1861 tatttattgg agtgatggat ttggtgccat ggtctataat gtttcatgca tccatacttc
     1921 tgtttttgct tcaaaatttt tagtgctccc tacaaatacg aatccttcta tcccactaac
     1981 caaaatacct ccttcattat aaaattttgt cgtaaacatt aaagtgcagg tcagtgaaca
     2041 atattcaatg tatcatcaat ttattcatct cttttatgct ctaaattctc ttaaatactc
     2101 atgattaaag aatgactcac acaaaa
//
