LOCUS       NM_001005286            1762 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 6 subfamily F member 1
            (OR6F1), mRNA.
ACCESSION   NM_001005286
VERSION     NM_001005286.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   2  (bases 1 to 1762)
  AUTHORS   Gilad,Y., Bustamante,C.D., Lancet,D. and Paabo,S.
  TITLE     Natural selection on the olfactory receptor gene family in humans
            and chimpanzees
  JOURNAL   Am J Hum Genet 73 (3), 489-501 (2003)
   PUBMED   12908129
REFERENCE   3  (bases 1 to 1762)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC118470.2.
            
            On Jul 29, 2020 this sequence version replaced NM_001005286.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641470.1/ ENSP00000493342.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               AC118470.2         19442-19757         c
            317-380             AC118470.2         17002-17065         c
            381-1762            AC118470.2         14547-15928         c
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..1762
                     /gene="OR6F1"
                     /gene_synonym="OR1-34; OR1-38; OST731"
                     /note="olfactory receptor family 6 subfamily F member 1"
                     /db_xref="GeneID:343169"
                     /db_xref="HGNC:HGNC:15027"
     exon            1..316
                     /gene="OR6F1"
                     /gene_synonym="OR1-34; OR1-38; OST731"
                     /inference="alignment:Splign:2.1.0"
     exon            317..380
                     /gene="OR6F1"
                     /gene_synonym="OR1-34; OR1-38; OST731"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1762
                     /gene="OR6F1"
                     /gene_synonym="OR1-34; OR1-38; OST731"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..1369
                     /gene="OR6F1"
                     /gene_synonym="OR1-34; OR1-38; OST731"
                     /note="olfactory receptor OR1-34 pseudogene; olfactory
                     receptor OR1-38"
                     /codon_start=1
                     /product="olfactory receptor 6F1"
                     /protein_id="NP_001005286.1"
                     /db_xref="CCDS:CCDS31095.1"
                     /db_xref="GeneID:343169"
                     /db_xref="HGNC:HGNC:15027"
                     /translation="MDTGNKTLPQDFLLLGFPGSQTLQLSLFMLFLVMYILTVSGNVA
                     ILMLVSTSHQLHTPMYFFLSNLSFLEIWYTTAAVPKALAILLGRSQTISFTSCLLQMY
                     FVFSLGCTEYFLLAAMAYDRCLAICYPLHYGAIMSSLLSAQLALGSWVCGFVAIAVPT
                     ALISGLSFCGPRAINHFFCDIAPWIALACTNTQAVELVAFVIAVVVILSSCLITFVSY
                     VYIISTILRIPSASGRSKAFSTCSSHLTVVLIWYGSTVFLHVRTSIKDALDLIKAVHV
                     LNTVVTPVLNPFIYTLRNKEVRETLLKKWKGK"
     regulatory      1640..1645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR6F1"
                     /gene_synonym="OR1-34; OR1-38; OST731"
                     /note="hexamer: AATAAA"
     polyA_site      1665
                     /gene="OR6F1"
                     /gene_synonym="OR1-34; OR1-38; OST731"
                     /note="major polyA site"
ORIGIN      
        1 aaaacaacaa aagggaagtg gaatggaact aggacagaat ggggtcagag cataagaaca
       61 aaaggaaaca gaaaaagact gagctctaat ttcaaagatt atgaaagttt gagttaataa
      121 aggagtaatg gatgtcaacc gaaggaagca cactattaaa cagcaagata atcaaagaaa
      181 aacagagata tagagggaat aattgcaatc aaaatatatt atttttaaat aaagaaaatc
      241 atggaataaa aaatgagtaa aagtaaggtc aagagacaaa gcttttggag tttatggcag
      301 aaagaatttc aactgggtga ttcatgtgcc cattagagct tgagaagcac tgcttggaag
      361 ccccttctgc catcaatgag gactgtgtga ttgggttaaa gggctcagtg cggggactct
      421 gttttctggt ttcagtacca caatggacac aggcaacaaa actctgcccc aggactttct
      481 cttactgggc tttcctggtt ctcaaactct tcagctctct ctctttatgc tttttctggt
      541 gatgtacatc ctcacagtta gtggtaatgt ggctatcttg atgttggtga gcacctccca
      601 tcagttgcat acccccatgt acttctttct gagcaacctc tccttcctgg agatttggta
      661 taccacagca gcagtgccca aagcactggc catcctactg gggagaagtc agaccatatc
      721 atttacaagc tgtcttttgc agatgtactt tgttttctca ttaggctgca cagagtactt
      781 cctcctggca gccatggctt atgaccgctg tcttgccatc tgctatcctt tacactacgg
      841 agccatcatg agtagcctgc tctcagcgca gctggccctg ggctcctggg tgtgtggttt
      901 cgtggccatt gcagtgccca cagccctcat cagtggcctg tccttctgtg gcccccgtgc
      961 catcaaccac ttcttctgtg acattgcacc ctggattgcc ctggcctgca ccaacacaca
     1021 ggcagtagag cttgtggcct ttgtgattgc tgttgtggtt atcctgagtt catgcctcat
     1081 cacctttgtc tcctatgtgt acatcatcag caccatcctc aggatcccct ctgccagtgg
     1141 ccggagcaaa gccttctcca cgtgctcctc gcatctcacc gtggtgctca tttggtatgg
     1201 gtccacagtt ttccttcacg tccgcacctc tatcaaagat gccttggatc tgatcaaagc
     1261 tgtccacgtc ctgaacactg tggtgactcc agttttaaac cccttcatct atacgcttcg
     1321 taataaggaa gtaagagaga ctctgctgaa gaaatggaag ggaaaataaa tctcctctac
     1381 cacaacagat gtcctgtaaa tggtctctgc atctatacag aggttccaag taagaatgtg
     1441 gaggaatagg gcaaatcttt cttggtacac agagaaaaaa caaacaaaca aaacaagcaa
     1501 tactgtattt tctatacatt atcatgtatg ataaaaatgg gagtttttga cataagcaaa
     1561 tgggattttt aagcaaaaaa taattataca ttgaattagg tttgctctgg actttggttt
     1621 ataaattaga gacatctgca ataaaaagag tgctttggta tatcagctct aaattcttgt
     1681 ttctttttaa agattagcaa aattgtctta gtataaaata ttgagaacta catttgtgga
     1741 acacgaggga agagaaatag gc
//
