LOCUS       NM_001005490            9556 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 6 subfamily C member 74
            (OR6C74), transcript variant 1, mRNA.
ACCESSION   NM_001005490
VERSION     NM_001005490.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9556)
  AUTHORS   Goodbourn,P.T., Bosten,J.M., Bargary,G., Hogg,R.E.,
            Lawrance-Owen,A.J. and Mollon,J.D.
  TITLE     Variants in the 1q21 risk region are associated with a visual
            endophenotype of autism and schizophrenia
  JOURNAL   Genes Brain Behav 13 (2), 144-151 (2014)
   PUBMED   24152035
REFERENCE   2  (bases 1 to 9556)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122684.3.
            
            On Dec 16, 2020 this sequence version replaced NM_001005490.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343399.5/ ENSP00000368987.2
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC122684.3         93024-93232         c
            210-9556            AC122684.3         81216-90562         c
FEATURES             Location/Qualifiers
     source          1..9556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..9556
                     /gene="OR6C74"
                     /note="olfactory receptor family 6 subfamily C member 74"
                     /db_xref="GeneID:254783"
                     /db_xref="HGNC:HGNC:31303"
     exon            1..209
                     /gene="OR6C74"
                     /inference="alignment:Splign:2.1.0"
     exon            210..9556
                     /gene="OR6C74"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1157
                     /gene="OR6C74"
                     /codon_start=1
                     /product="olfactory receptor 6C74"
                     /protein_id="NP_001005490.1"
                     /db_xref="CCDS:CCDS31816.1"
                     /db_xref="GeneID:254783"
                     /db_xref="HGNC:HGNC:31303"
                     /translation="MRNHTTVANFILLGLTDDPQLQVIIFLLLFFTYMLSITGNLTII
                     TLTLLDLHLKTPMYFFLRNFSFLEVSFTTVYIPKFLVSMATGDKTISYNDCAAQLFFT
                     ILLGATEFFLLAAMSYERYVAICKPLHYTTIMSSRVCSLLVFASWMAGFLIIFPPLLM
                     GLQLDFCAANTVDHFFCDVSPILQLSCTDTDIIELMMLLSAILTLLVTLVLVILSYTN
                     IIRTILKIPSSQQRKKAFSTCSSHMVVVSISYGSCIFMYVKPSAKERVSLNKGIALLS
                     TSVAPMLNPFIYTLRNKQVKDVFKHTVKKIELFSMK"
ORIGIN      
        1 ctcgtataga ctagaaacac ctcagcgtga acaacaagct agaaaccttc tctttgttct
       61 tcttctctct agattatata tacacatata tgtatatata gaagagatat gataaacata
      121 gaggtagata tatgctccaa atttaattta atacaacata aatcagagaa catcttatta
      181 ataaaaatca tgagaagaaa tgaacctaga aatcaactat gagaaaccat acaacagtag
      241 caaactttat tcttcttgga ctgacagatg atccacaatt acaggtgatt atttttcttc
      301 tccttttttt cacctacatg ttgagcatca ctgggaatct aaccatcatc actctcaccc
      361 tactggattt gcatctcaag acacccatgt atttcttcct ccgaaatttc tcatttttag
      421 aagtctcatt cacaactgtc tacattccca aatttcttgt tagtatggca acaggtgata
      481 agaccatttc ttacaacgat tgtgcagcac agctgttttt cactattctc ttgggggcaa
      541 ctgaattttt tcttctggct gccatgtcct atgagcgcta tgtggccatc tgcaaacccc
      601 tgcattacac caccatcatg agcagcagag tttgcagctt gctggtcttt gcttcatgga
      661 tggctggctt cctaataatt tttccgccac tcctgatggg tctccagctt gatttctgtg
      721 cagccaacac tgtagatcat ttcttctgtg atgtttctcc tatactgcag ctctcttgca
      781 cagacactga cataatagaa ttaatgatgc ttctctcagc cattttgacg ctcctggtta
      841 cactggtatt agtgattctc tcctacacaa atattatcag gactattctg aaaatacctt
      901 cttctcaaca gagaaaaaaa gcattttcta catgttcttc ccacatggtg gtcgtgtcca
      961 tttcttatgg cagctgcatc ttcatgtatg tgaaaccctc agcaaaagaa agagtgtcat
     1021 taaataaagg gatagctctg ctcagcactt ctgttgcccc catgttgaat ccctttattt
     1081 atacactgag aaacaaacaa gtaaaagatg tttttaagca cacagtcaaa aagattgaac
     1141 ttttctcaat gaaatgaatc actttaacga tattattaag gttattagta aaataaaaca
     1201 agaagagtgg agtatgtgca aagtttttca atgtttgtat tcaataatat tacctctttt
     1261 ttgacttata attttcatta tggccttcct aatctccaaa gcctaacctt cactgccatt
     1321 tctccctcat gctgagatca catagaaaag atatttcttg gttttggtca aaatcatttg
     1381 cctgttattt attgcctctt ttatttcctc tcaaaattct ctcagaggaa gacaaagtga
     1441 gacttcagtt tttccatgct cttttccact cttctggaat tcaaggaccc aatttgtcat
     1501 atattctaca tagagttcag tagactacct aggtttgatc acttaacgcg tgcattattg
     1561 gtggatacaa aagtgaaatc tgctttcttt cttagtgttt agtagaatct cgaagcaaat
     1621 caatttaatg gcatttcttt aattacacag tttaatagct tcaatttttt ttaaccaggc
     1681 ttagagatat agtatactct cagaaataaa tgaaagaaac ttcagagagg ttaaagcatt
     1741 actgctattg cagctatcat atagaactta cagctagcat ttattgattg cttacaatgt
     1801 gccagatgtt attaaattta ttagttccat cttcaaaact ctgtaagaca ggtatttata
     1861 tgctccattt atggattaaa aatataagtc ataaggatta aataatttgt tgatgacaac
     1921 aaaaataaat acccaaggat gacaaaaatg atgccttcat gtccactcac cgcttacaca
     1981 tttttagcaa aacgaagtga aaatctctct ctgctcttaa gtcacttaga atgcaaaaga
     2041 acagtaagac ctttgtagaa cattctatag atttatggat gtcatagata aaattaagac
     2101 cttacagctc cacagagtac cttatttttc aaattaagtg gtttgaacat taaaattaga
     2161 tataatgact gatcatgtgc agagtattta aaaacttttc ctttcaatag taccctatct
     2221 cagtgttata agacaagaaa actttttctg aaagactaat gtcagtttcc tcaagaaata
     2281 tttgtctatg atttagtttc cacataaggt aactgataac cttatgaata attctgactg
     2341 gaaggattta tttttctgac ttataaaatt attatataca ttttatctta atgtatttcc
     2401 aagtgtatat aactttgtca tatccccagg ctagcaagaa attttatttg aattttacaa
     2461 gcattagtga gaagctttaa atatatatat atctaaataa atattaacag ggcactgaga
     2521 agctgagaag attcaaatag acttttcaat agtggtcatg tatgtgtaaa tggtttttat
     2581 aatactgcaa tactttaaga acattttatt tgaaaataga aaataaatat ctagggagta
     2641 ttctttaact ttcactattt ggctttcttt gcatcaggaa tttaagtttt tttttattat
     2701 tatactttaa gttctagggt acatgtgcac aacgtgcagg tttgttaaca tatgtataca
     2761 tgtgccatgt tggtgtgctg cacccattaa cttgtcattt acattaggta tatctcctaa
     2821 tgctatccct cccctctccc cccacctcac agcaggcccc ggtgtgtgat gttcgccttc
     2881 ctgtgtccag gtgttcttat tgttcaattc ccacctatga gtgacaacat gcggtgtttg
     2941 gttttttgtc cttgcgatag cttgctgaga atgatggttt atacacaaat aattatactt
     3001 tatagataat aacgacactc aagaaaagtt gactcaaaat gtttggaatc tgacaaaaag
     3061 tctgatctgg aatatctcag attttcttct gaacactctt ctccacaatt taagttgttg
     3121 ccaaatgcaa atatgtaaca tatttatttt atatttctaa gtattacatt gcttactttt
     3181 aaaacttatt ctttatacat gaactctaag ctcagctctt tttaaagtct aatatatagg
     3241 taaatccata aatcattgaa tgtatattaa aaactttttc tccccttttt taatccaaaa
     3301 atgaattatt gacaattttg tgaaattcag aaatatactt agtagactta actacttaga
     3361 atagatggat ttttttctat ttctaggttg tttgtaagta gataacagaa aaagcaaaag
     3421 gaaagaaacc ctaggcctaa gttacgatgg gaaaagatta gtgaagatca ttttttactt
     3481 aatttgaaat aaatcactag caatctgatt tattgtgtaa ataccagaga tcagggtcca
     3541 ttataggcac ttaaaatttt taaattgtgc taggattcta aaaaatatta aaatctcatt
     3601 tgttcacctg tttaactcat ttctaatatt catttttctg gaagtgaaaa ggaaaaaaat
     3661 aaccaactgt ttttcaccag tattaggttg gcgcaaaagg aattgcagtt tcaccattaa
     3721 aagtaattaa aatttcacca ttaaaattta atttcaccac taaaagtaat ggtgaaatca
     3781 caattccttt tgtaccaacc taatatatac tgagtaagta ttaagacaag ctagactcaa
     3841 ggtatgtcaa ttgtctatta catagccttc ctgcctttga tctctaactc atcctccaca
     3901 ttgctagtag gatactttct aaaatacaaa tcagtcatgc caccactcta ctaatacatt
     3961 attgatggtt ctccgttgcc tgcaaaataa tgacaaaatt ccccaaatat ttgcataacc
     4021 tggcctgtcc agtttggttt cttatctctt ccaactagta cttctatgat gtaaccacac
     4081 taaacaacta agtatattgc aaaacttgtg tgctgtcacg tatattgaat gcctgcccat
     4141 tgcccaaatc tctgttagct tgcaaaactt caatcagtta aagttaatta acatggagac
     4201 ttctgtggaa ggctggtcga caagtatatg ttagtcactt catactcaaa ttttgtagtg
     4261 tttgtagtca actctagatg gtgcttatca tagcacatgt aattaactat atttatttct
     4321 tgcaacgaac tctaaatctc atagttttct acattctctt catccaagcc ggtgcctagt
     4381 aaggaataaa taaaataaat aaggcagcaa atgacaggag atgagtgaag ttaatatgtt
     4441 catctataaa ataagattaa aatgtggcat ttgatagggc ttaatataaa aatgtaagcc
     4501 tagattaagg atgtctacta taaaataatt aatagattgg acttgatgac aggcaatatg
     4561 aaaaaaaaat taggtgttag aaaactacaa gtttactata aatatggagt gtttatgagc
     4621 attgaagaga taattcaatt gtatgataca ataaagtccc attgtatcat acatatctca
     4681 aaaattctgt ttagttttat cctttaaaaa tcttttgaag taaaagaata gtcaatatta
     4741 tcataaattt agaaattatg tcatatgaga aaatatttag ggtactaatg acatggagct
     4801 tgagaaaaaa ttgcttataa gaaaaataaa tgctaccttc aaatattaag attactgtgt
     4861 tctcaaaaat tatggacttg cttttctttt tataagtgta agtgtgcaac tggtgtttat
     4921 caaacattca attagtaaat atatgtatat ttttcatggt acatgcacat ttatcagttt
     4981 ataatttata tataaacaat agtataaaat attttgaaat tttaatagaa aaataggaat
     5041 taataaagga aattatacaa aatgatcaat atattttaat aatataactt tacagtataa
     5101 cttttaattt tacttatggt acaaatatta gtttcatttt aattcagcat actttattat
     5161 acttgcaaat acttatgtaa ttattgtgtg aaatgaactg caagtcttat tacagtttat
     5221 tttaccttgt acttagttat gtgggttgtt gtagtgcaaa gttaatgctt cacaataatg
     5281 tggatccatt ttaaatgaac tggaaatcac aataattatt cttcaatccc attcaaatat
     5341 gctttttttt ttgaaattga ctacattaat gttaatcagc tgtcttgatt ttgcattttt
     5401 atgtaatttt ctaaaagcac acaaatgttt taaaatatta aaatgattat gttttcaagt
     5461 tttctaatga gtagatgagt atttttatat ttaatgagtt taaataattt ccagtaacaa
     5521 aaatcgtgga aagaatttca aacagtcaat ttccaaattt ctcttttaat tcaactttct
     5581 tttgataatg ggttactttt tcccatattt ttaaaacacc atctgttttg gaacagagta
     5641 agggggtgat atcttcaaga aaacatatta ctgatggaga cctgttgtca tagggaaggg
     5701 aaaactaggc tatgtctact tataaaataa aattccataa ttctcttcaa tgtgtctttt
     5761 aaaatacttt acataagaaa ttctgattct gtatctgata caagttttta aattattact
     5821 tagcatatca tcatacattt ctgatttgct tctcttcctt ttttttcttc tccacctccc
     5881 cttccttctc ctttctcttc taacaaccct ttaaaaatgt aaaatacatc tcaggatctc
     5941 aggtggaagt ctgtaccaaa acaatccttg gcctgtgggc tatggtttgc tggcctgtgg
     6001 aataaatgat ggcaaagggc tagagtacaa aggtatacca ttttatttgc aggttgtgcc
     6061 aataaattct tgtattatct attaatccat aaacattcat tcccaaaatc aataactgga
     6121 tatttagtgc cagaattatt tttgatttat tctagtaaat gggccataac tgaaaagaca
     6181 gttgcaattg aatttactac ctaatttaac ttatgggttc attatcatct gctaaaattt
     6241 atctgtgtta ggagaggcag acagttgagt tcaatgggta tgtggattaa gtcaccactc
     6301 ctgcatcttt gttttttaag tctttgatgg tggcactagc tttgaagctt ttccaaggat
     6361 ataatgatgc tgtctgttta ttatctctta gtgagggaga ccatatggtt ttccacttgg
     6421 ccctgaatat atgtgtttta actgtatgca caggacaact ttgcacatgc actaggttca
     6481 ctgtaaaaca gactagcaca taatcataac ttatcaggaa aatgtctctg actccaattt
     6541 cttccactct tataagtaaa cacactggca ttttatagtc attgtaatta agcttagctc
     6601 agaaatgagg tggaataacc tctgaaaaat ccatgtttca ttgatttcac tgtacgattt
     6661 tcttgggaaa ggaccacata tctattgaag gacactagcg gaagatttgg atattaatat
     6721 gcatgacagt tttgcaaaga caactttctt catgggttct ggttctatga aaggattgaa
     6781 gtctgtaatt gaataaggag ctttaactcc attatgatgg ctaattcatt cttcctttca
     6841 cttatcctag agttctttca attatatgga ccagttagaa acctaatgag ctgcctgttt
     6901 attttagtcc taggaacttc ataatctgtt gttcactact aaagtgcatc atgcaatatt
     6961 gataactact tcggccatac tgaccaataa gtaaccacac tgaatatgct catatcagtt
     7021 aagtgctatt acatagcctc tgactttcca tgatccatca tgtccactga aatcagggag
     7081 ttcattttaa caaaagcatc ttccatcttc atttcaaacc agtggttaca atacttttta
     7141 aagctgctag caaataccct tgtgaatatt ttaatatctt gccaaaagat tttcctctgg
     7201 gtattctcca gttacatagc taaggggtat gtaagtaaat tgcatacaat aaagctgttc
     7261 catattgcaa ttcctctaag ttttagattt atatttacat atatgaaata catacacaca
     7321 tatatgtaat tcccagttgg gatcctttca gatttccaat caattaactt tcacaaaaga
     7381 tatctgggaa ggatgtaaat ttaaccaata ttgctgtata ataaactgcg agatcagagc
     7441 ctacctttgt tttcagcacc aagtgacatg aggatttaag agataaattt atttaggaca
     7501 gtcatgggaa cttcatgatt tgctgattat tgtataattc aagataataa ttaaaggata
     7561 caaccttgta attttctttc tttaagatcc tcaatatgga tcttaccatg ttatagcctt
     7621 atagcatgtg cagtacttgt atttcacatg cttagcacag tgctctttac cttatacatc
     7681 tactttgaga aagctcagcc ttaaatataa gcttctttcc aagtgataat atttgatgcc
     7741 atagacttgt aatattccat tttcttatgg ttgcagcact tctcagacct ttcaagatga
     7801 tattaactaa ttataaatta cccttcttaa ggatctattt catgcaacca cttgtagtac
     7861 caaatatatc agttatcact gttaggttgc aattctccat ggcatttcta cacatttaat
     7921 attatgcttg gtctggattt ttttttacaa agttgtttta atatcattca gccttgaaag
     7981 atcgaaataa tacctccctc cagggcagaa gggagatttg cttcctgact aggattataa
     8041 aatagatgtc tcccagggtg gccaggttgg gcaggttttc tagctatctc tttaaaatag
     8101 tgggggttcc ctaagttcag gatttcacag ttgtgttaca gactgattgt gtctgctcta
     8161 cccatggagc cccctctgca ttgcaccccc tggggactgg gaggcaaagg gaacgaggaa
     8221 acaacagatg ttggtgagga tgtggagaag taggaacact tttacactgt tggtgggagt
     8281 ataaattagt tcaaccattg tggaagacag tgtggtgatt cctcaaggat ctagaactag
     8341 aaataccatt tgacccagca atcccattac tgggtatata cccaaaggat tataaatcat
     8401 tctactataa agacacatgc acacatatgt ttattgtggc actattagca atagcaaaga
     8461 cttggaacca acccaaatgc ccatcaatga taggttggat aaagaaaatg tggtacatat
     8521 acaccatgga acactataaa atatacatcc ataaaaaacg atgagttcat atcctttgca
     8581 gggacatgga tgatgctgga aactatcatt ctcagcaaac taacacaaga acagaaaacc
     8641 aaacaccgca tgttctcact cataagtggg agttgaacaa tgacagagaa gaattttaaa
     8701 tgcatatttc tcaatgaaac taggcagact taaaaggcta taaattattt aatttcattt
     8761 atataatatt ctggtagaga taaatttata gagaaagtaa catatcagtg gttgccagga
     8821 ctttgttgga gtaaggatta aacgaggaag catagggaat ctttggttag ggtagtaaaa
     8881 ttattctata tagtaatgta aagatgaata cataatgtag ggagaccccc tgaaactatt
     8941 gctatggaat aaaaggtgaa atgctcctga ttattgtaaa tacaaaattg catgcaggat
     9001 tgtgtaaaga caatgccagg ttggactgcc agaatgagcc aacagcacat gatgtgcttc
     9061 cccctgcaga gagcctacga acggacatgc agtcagggag gtttcacatc accaagattc
     9121 ctgtcccaga aaagcagatg ttcatagctc tgggaatgga atgggaccct tgtgtagagc
     9181 ctataaatgg acgcattggg ggggcacctg ttcatatgga taagataggg ctataaacgc
     9241 cctcatcttg ccacagctct tctaggcctc tttgggggta aggcatactc ccttctgata
     9301 ttttccggtc taaccggttg tctagcttca cctcctgttt ctatggattg tttgtaacca
     9361 gcttttgctg caactgttac tgctgattaa taacttgcta atcataggtt atggaaagac
     9421 tgtgtttctg ttttaaggct ctgttagaaa ttactgatgc acacactata ttgtaaactc
     9481 ttatctctgt atactgtact tctgcataca gatgttatgt taaagaacta cttcatcccc
     9541 atgtgaccat ctcacc
//
