LOCUS       NM_001005494            5141 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 6 subfamily C member 4
            (OR6C4), transcript variant 1, mRNA.
ACCESSION   NM_001005494
VERSION     NM_001005494.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5141)
  AUTHORS   Goodbourn,P.T., Bosten,J.M., Bargary,G., Hogg,R.E.,
            Lawrance-Owen,A.J. and Mollon,J.D.
  TITLE     Variants in the 1q21 risk region are associated with a visual
            endophenotype of autism and schizophrenia
  JOURNAL   Genes Brain Behav 13 (2), 144-151 (2014)
   PUBMED   24152035
REFERENCE   2  (bases 1 to 5141)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 5141)
  AUTHORS   Youngblood,K., Fruchter,L., Ding,G., Lopez,J., Bonagura,V. and
            Davidson,A.
  TITLE     Rheumatoid factors from the peripheral blood of two patients with
            rheumatoid arthritis are genetically heterogeneous and somatically
            mutated
  JOURNAL   J Clin Invest 93 (2), 852-861 (1994)
   PUBMED   7509350
REFERENCE   4  (bases 1 to 5141)
  AUTHORS   Lauzurica,P., Bragado,R., Lopez,D., Galocha,B. and Lopez de
            Castro,J.A.
  TITLE     Asymmetric selection of T cell antigen receptor alpha- and
            beta-chains in HLA-B27 alloreactivity
  JOURNAL   J Immunol 148 (11), 3624-3630 (1992)
   PUBMED   1316921
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009779.18.
            
            On Jul 31, 2020 this sequence version replaced NM_001005494.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641569.1/ ENSP00000493181.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-517               AC009779.18        187080-187596       c
            518-5141            AC009779.18        181366-185989       c
FEATURES             Location/Qualifiers
     source          1..5141
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..5141
                     /gene="OR6C4"
                     /gene_synonym="OR12-10"
                     /note="olfactory receptor family 6 subfamily C member 4"
                     /db_xref="GeneID:341418"
                     /db_xref="HGNC:HGNC:19632"
     exon            1..517
                     /gene="OR6C4"
                     /gene_synonym="OR12-10"
                     /inference="alignment:Splign:2.1.0"
     exon            518..5141
                     /gene="OR6C4"
                     /gene_synonym="OR12-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             536..1465
                     /gene="OR6C4"
                     /gene_synonym="OR12-10"
                     /note="olfactory receptor OR12-10"
                     /codon_start=1
                     /product="olfactory receptor 6C4"
                     /protein_id="NP_001005494.1"
                     /db_xref="CCDS:CCDS31827.1"
                     /db_xref="GeneID:341418"
                     /db_xref="HGNC:HGNC:19632"
                     /translation="MKNRTMFGEFILLGLTNQPELQVMIFIFLFLTYMLSILGNLTII
                     TLTLLDPHLQTPMYFFLRNFSFLEISFTSIFIPRFLTSMTTGNKVISFAGCLTQYFFA
                     IFLGATEFYLLASMSYDRYVAICKPLHYLTIMSSRVCIQLVFCSWLGGFLAILPPIIL
                     MTQVDFCVSNILNHYYCDYGPLVELACSDTSLLELMVILLAVVTLMVTLVLVTLSYTY
                     IIRTILRIPSAQQRTKAFSTCSSHMIVISLSYGSCMFMYINPSAKEGGAFNKGIAVLI
                     TSVTPLLNPFIYTLRNQQVKQAFKDSVKKIVKL"
ORIGIN      
        1 agatgcccat cctctgccat ctaagaactt caacataatc tctcttagaa cataaatttt
       61 cagaaatttt ctgtctctca aagtattttc ttccaattca ataactgcta tgggctttgt
      121 ttttattttt tattacctat gtgaagttct ctgtctctca ggaactatga tttgattctg
      181 gattggattc ttagaatgga aaataatatg ctcttttttc tggttaagtt ccataagttt
      241 ggatacttct attaagagaa aggtaaaatg tggatggaag ccaatagaaa acatgttaaa
      301 gtatatacta ctcaaagatt cacgtggcac atctcatctt tgatttacct cttaggaaca
      361 acaaggtaaa cagtatacta tagtcattca ggttgtcaaa ggtatgagca acatatgttt
      421 ttaaagtcac tgattttatc attctataaa tgtggatcat gaaatgaatc aactgtgaaa
      481 atctggaaga aaatgcagta cttgccaaag accacaggtt ttccgaaggt caacaatgaa
      541 aaacagaacc atgtttggtg agtttattct actgggcctt acaaatcaac ctgaactcca
      601 agtgatgata ttcatctttc tgttcctcac ctacatgcta agtatcctag gaaatctgac
      661 tattatcacc ctcaccttac tagaccccca cctccagacc cccatgtatt tcttcctccg
      721 gaatttctcc ttcttagaaa tttccttcac atccattttt attcccagat ttctgaccag
      781 catgacaaca ggaaataaag ttatcagctt tgctggctgc ttgactcagt atttttttgc
      841 tatatttctt ggagctaccg agttttacct cctggcctcc atgtcttatg atcgttatgt
      901 ggccatctgc aaacccttgc attacctgac tattatgagc agcagagtct gcatacaact
      961 agtgttctgc tcctggttgg ggggattcct agcaatctta ccaccaatca tcctgatgac
     1021 ccaggtagat ttctgtgtct ccaacattct gaatcactat tactgtgact atgggcctct
     1081 cgtggagctt gcctgctcag acacaagcct cttagaactg atggtcatcc tcttggccgt
     1141 tgtgactctc atggttactc tggtgctggt gacactttct tacacataca ttatcaggac
     1201 tattctgagg atcccttctg cccagcaaag gacaaaggcc ttttccactt gttcctccca
     1261 catgattgtc atctccctct cttatggcag ctgcatgttt atgtacatta atccttctgc
     1321 aaaagaagga ggtgctttca acaaaggaat agctgtactc attacttcgg ttactccctt
     1381 actgaatccc ttcatatata ctttaagaaa tcagcaagtg aaacaagctt tcaaggactc
     1441 agtcaaaaag attgtgaaac tttaaaaaag gagattacac ttcaaaatac attttcactt
     1501 aacaaatatg cattgaatgt ctatatttca agtgctaaat tggcccttga agattaaaat
     1561 aggaaaagta tatgtcttaa tttcaagaaa actatagtct agaatcaagg aaagatatat
     1621 aaatggtaaa tttatgtaat aaatttacaa aaaacaaaat aatattttaa ttgttattag
     1681 agaagagtga atggggatct gaaaaggaac agttggaaag aattagttct gttttccata
     1741 aattatttga aatttaagaa gcaaaacaga ttgtttattt agaagagtag gaggataaga
     1801 atttagagtg aaaaaggaaa ccagatcata aaagtaagta attacaacta ctgagttagc
     1861 tgggtttcat gagtcaagaa attttcagaa ttgttttgag gagaatgtag tatcagcatt
     1921 gttcttcagc atggagccct ggagactatg tttccatcga ggagtgaata atttttcttc
     1981 tcctccattt tttcatctat atttcaaatg taaccattgc aacttccctc ctttcataag
     2041 aggaaaatga aagaatatat atttagtcta cttttctcca aatgaggaga aaatttttaa
     2101 gatttttgtc aacttaatat gtccattttc tagtttatgg ttaaaacagg tttctagaga
     2161 caagtttaga aggctttcat tctcctagac aaaatctatt gtttcttttc ttaggtgaca
     2221 ttttaagtta atggcatgag atctgttttc tctctctttg atagtttctg gtaatttttt
     2281 ccttcctatc atgattttat tttcatcctt ttgtttcact ttattagata ttagaaaaga
     2341 aaattctgtt atctggctct acttctttaa ctttccccca gatttttgct ttcgtttgta
     2401 acataaacca tggatgacca ttttataaag taaaaagaat ataaagtgtc aatgcaatct
     2461 tatatctaga atgttccaaa ttatgagtct tgaaaaacaa ctagaaatag actatcctac
     2521 caaaaacttt acacatggat tcaaggcaat gacaacttga atttgaatag gtagtggtag
     2581 tgtccaattt caatggaagt aagcactttt ttttaatctg agcatttgta cacagtttaa
     2641 taatatctta aaaaattgca ggagctttgt tactatttgg ggtaaaagtg gaacacaatc
     2701 tggtattttc acatgcttta tatgtggtaa tatgttgagt aaaatgaggt acttctcaag
     2761 catttaagga acaagctgga ttgaactgat tatgagagca aattatcaga gccacagaag
     2821 gtattggaga atgtataata tttttgaaaa agtattttat gtaaagctgt tgctattctg
     2881 agtatcttgt tttctttggt tgctagctag agattagtga taatattcaa tatattccaa
     2941 atttaatgca ctacaagaac aagaagtgtt cttgaatagc cacatctaaa tcattaagtt
     3001 cccctacacc cacatttcta ctaaaaccta tggtacagtg ggagcaatgt catatagtgg
     3061 cttaaaacat aggctttagt tcaaatccca gattttcaac tttctaccaa agttacctgg
     3121 ggatagttac ttgatctctc taaggctcac ctctgtcaac tctaaaatgt ttacaataat
     3181 agtgtctatc ttatagtttt gagcattcac tgagaaaata gatgtaaaat attaaaagac
     3241 agccagtatt tattgtgttt aataaatgac atctattata actatattat aaacaatata
     3301 tttttcaagg aactggagct taactagaaa gaaggcatta aattggttgg tttaatatag
     3361 cagggacagt aaaaatgttg gccattgtac ttgaaatcca tctgcacaag gccagcatat
     3421 ttctactctc cacacatcca gctgcatgct gggtagctgg gtcagcaaag atcttaccta
     3481 ctcttcagat aaagccatca aaatacttgg cagcaggtta taagaactgg gctagcatca
     3541 acttcattgc cctagatatc tatgggagag acaggatgta ttaacatgct gagacaagga
     3601 aggaaggtac tttgtgtaag ttaatgttta agatcactag gcaagagttc actcagcatt
     3661 ctttatataa gcatttggaa atgaacatgg aaaagaatgt atcaccttct aaatgagctt
     3721 gtcaaaaaaa aaaaagcaag tcatattctt ctaaagctgt tcatctagtc tggctgtatg
     3781 ttaattcata cttggaatgt aatccaagtc atagataagc aaaaggaatg acttcacaga
     3841 gtctggtgct gagctaccag aatattcagt atctaaatat ataaaatggt gagtttgatt
     3901 cctcatgtca ccaaagtgga caagaattaa aagaaacagc tttagctgcc taacattctc
     3961 agaatcatat tataccagtg ctagggtgag gagactatga aaatgagtaa aagccaatct
     4021 gctacatttg ggcattcatt cttctattgc ctctctttaa agctgccaga gcttgtggat
     4081 atatggatta caattctaaa caggtagtct tccagcatca tttcttgcaa agagttttaa
     4141 ataaaattca aaacaataaa atatattttt taattttttt tatttcagcc aggatcagtg
     4201 actcacactt ctaatcccag ctctttggga ggctgaggca ggcggatcac ttgaggtcag
     4261 gagttcaaga acagcctggc caacacagtg aaaccccgtt tctactatta cattgataga
     4321 aaagtaattg tggtttttgc tactaaaagt aatggcaaaa actgcaatta cttttgcacc
     4381 aaccaaataa aaatacaaaa atcagccagg catggtgatg cgtgcctgta attccagcta
     4441 ctgggaaggc tgaagcacaa gaatcacttg gagtacaagt ggccttttgt tacatcagtg
     4501 aattaaatag tggtgaattc tgggatttta gtgcacctgt cacccaagta gtatacattg
     4561 gacctaagct gtagtttttt tatccctagc cccctcccat cattcccctt ctgagtctct
     4621 aaagttcatt ataccactct gtgtgccttt gcatactcat agcttagctc ccacttacga
     4681 gtgagaacat acttataagt gagaacatag tttttggttt tccactcccg tattacttca
     4741 cttagaataa cgacttccag ctccatccaa actgctgcaa aatacattct tttgttcctt
     4801 tccaggccag gtgcagtggc tcttgcctgt aatcccagaa atttgggagg ctgaggaggg
     4861 tggatcactt gagttcagga gttcgagacc agcctggcca acatggtgaa accctgtctc
     4921 tatcaaaaat acaaaaatta gcctggtgtg gtggcacgtg cctgtagttc cagctacttg
     4981 ggaggctaag gtacaagaat cacttgaacc agggaggcag aggttgtagt gagctgagtt
     5041 tatgccactg tactccaggc tgggcaacac agcaagactc tgtctcaaaa aaacataaaa
     5101 taaaataata aaaaatgttg cttcttttca tggctgagta g
//
