LOCUS       NM_173351               1698 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 6 subfamily B member 3
            (OR6B3), mRNA.
ACCESSION   NM_173351 XM_371606
VERSION     NM_173351.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1698)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013469.8.
            
            On Aug 5, 2020 this sequence version replaced NM_173351.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.4295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000641019.2/
                                                ENSP00000493035.1
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC013469.8         89757-89818
            63-171              AC013469.8         96218-96326
            172-1698            AC013469.8         97181-98707
FEATURES             Location/Qualifiers
     source          1..1698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..1698
                     /gene="OR6B3"
                     /gene_synonym="OR6B3P; OR6B3Q"
                     /note="olfactory receptor family 6 subfamily B member 3"
                     /db_xref="GeneID:150681"
                     /db_xref="HGNC:HGNC:15042"
     exon            1..62
                     /gene="OR6B3"
                     /gene_synonym="OR6B3P; OR6B3Q"
                     /inference="alignment:Splign:2.1.0"
     exon            63..171
                     /gene="OR6B3"
                     /gene_synonym="OR6B3P; OR6B3Q"
                     /inference="alignment:Splign:2.1.0"
     exon            172..1698
                     /gene="OR6B3"
                     /gene_synonym="OR6B3P; OR6B3Q"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1192
                     /gene="OR6B3"
                     /gene_synonym="OR6B3P; OR6B3Q"
                     /note="olfactory receptor, family 6, subfamily B, member 3
                     pseudogene; olfactory receptor OR2-2"
                     /codon_start=1
                     /product="olfactory receptor 6B3"
                     /protein_id="NP_775486.1"
                     /db_xref="CCDS:CCDS42837.1"
                     /db_xref="GeneID:150681"
                     /db_xref="HGNC:HGNC:15042"
                     /translation="MSGENVTRVGTFILVGFPTAPGLQYLLFLLFLLTYLFVLVENLA
                     IILTVWSSTSLHRPMYYFLSSMSFLEIWYVSDITPKMLEGFLLQQKRISFVGCMTQLY
                     FFSSLVCTECVLLASMAYDRYVAICHPLRYHVLVTPGLCLQLVGFSFVSGFTISMIKV
                     CFISSVTFCGSNVLNHFFCDISPILKLACTDFSTAELVDFILAFIILVFPLLATMLSY
                     AHITLAVLRIPSATGCWRAFFTCASHLTVVTVFYTALLFMYVRPQAIDSRSSNKLISV
                     LYTVITPILNPLIYCLRNKEFKNALKKAFGLTSCAVEGRLSSLLELHLQIHSQPL"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR6B3"
                     /gene_synonym="OR6B3P; OR6B3Q"
                     /note="hexamer: AATAAA"
     polyA_site      1698
                     /gene="OR6B3"
                     /gene_synonym="OR6B3P; OR6B3Q"
                     /note="major polyA site"
ORIGIN      
        1 tctgagtagg agcagagaca catcattgcc tgcctcgcgc cctgccctgc agctgcaatc
       61 agcctatgtc cacatgggtt cactgcttct gttgtggaaa ccgcattgga agggcagcgg
      121 ccttggtgtt agaagattcc agtctgtgtc ctggtgctgc cccggccctg ggcctgcagc
      181 tcccaagcac agaggcatga gtggggagaa tgtcaccagg gtcggcacct tcatcctggt
      241 gggcttcccc acggccccag ggctgcagta cctgctcttc ctcctcttcc tgctcaccta
      301 cctctttgtc ctggtggaga acctggccat catcctcacc gtctggagca gcacctccct
      361 ccacaggccc atgtactact ttctgagctc catgtctttc ctagagatct ggtacgtgtc
      421 tgacatcacc cccaagatgc tggagggctt cctcctccag cagaaacgca tctctttcgt
      481 cgggtgcatg acgcagctct acttcttcag ctccctggtg tgcaccgagt gtgtgcttct
      541 ggcctccatg gcctacgacc gctacgtggc catctgccac ccgctgcgct accacgtcct
      601 tgtgaccccg gggctgtgcc tccagctggt gggcttctcc tttgtgagtg gcttcaccat
      661 ctccatgatc aaggtctgtt ttatctccag cgtcacgttc tgtggctcca acgtcttgaa
      721 ccacttcttc tgtgacattt cccccatcct caagctggcc tgcacggact tctccactgc
      781 agagctggtg gatttcattc tggccttcat catcctggtg tttccactcc tggccaccat
      841 gctgtcatat gcgcacatca ccctggctgt cctgcgcatc ccctcggcca ccggctgctg
      901 gagagccttc ttcacctgcg cctctcacct caccgtggtc accgtcttct atacagcctt
      961 gcttttcatg tatgtccggc cccaggccat tgattcccgg agctccaaca agctcatctc
     1021 tgttttgtac acagttatca cccccatctt gaaccccttg atatactgcc tgaggaataa
     1081 ggaatttaag aatgccttga aaaaagcctt cggcttgacg agctgcgccg tagaggggag
     1141 gctttctagt cttctggaac ttcatctcca aatacacagc cagcctctct gaggaggcca
     1201 tttgactgtt tgcattattg tagtaccgca tttatttaaa aattacttcc aaatctattt
     1261 ttctccttca ggaaaaaaac tgaggttgag gttaatagca taggtattgt tgttggtgtt
     1321 gtaataccag tactttcttg tttttgtaga tgagcaaagc tgtagttagt aaagcttaat
     1381 gaattttcct cgcctttaaa attaccatgc acatttcaga aagcagcaaa acatgccaga
     1441 tcatctgaga ttttaaagtc cccaataaat tgcggtgtgt taaagtacta aatatttaac
     1501 catgtggcaa aatgagctcc aggtgtccct gaagcaaaat gtgtctggga aaagtaaggg
     1561 catgtagcct tctgttttat acccaacgaa tgttctctga ttgtcttggg tggatgcccc
     1621 ctctgccttt ttcctaaata aacccctact gcatgcccag tcagctgctg agaaaataaa
     1681 aattgtttta ttattgca
//
