LOCUS       NM_003696               4295 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 6 subfamily A member 2
            (OR6A2), mRNA.
ACCESSION   NM_003696
VERSION     NM_003696.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4295)
  AUTHORS   Wang,C. and Andreasson,K.I.
  TITLE     Odorant receptors in macrophages: potential targets for
            atherosclerosis
  JOURNAL   Trends Immunol 43 (4), 262-264 (2022)
   PUBMED   35283015
  REMARK    GeneRIF: Odorant receptors in macrophages: potential targets for
            atherosclerosis.
REFERENCE   2  (bases 1 to 4295)
  AUTHORS   Orecchioni,M., Kobiyama,K., Winkels,H., Ghosheh,Y., McArdle,S.,
            Mikulski,Z., Kiosses,W.B., Fan,Z., Wen,L., Jung,Y., Roy,P.,
            Ali,A.J., Miyamoto,Y., Mangan,M., Makings,J., Wang,Z., Denn,A.,
            Vallejo,J., Owens,M., Durant,C.P., Braumann,S., Mader,N., Li,L.,
            Matsunami,H., Eckmann,L., Latz,E., Wang,Z., Hazen,S.L. and Ley,K.
  TITLE     Olfactory receptor 2 in vascular macrophages drives atherosclerosis
            by NLRP3-dependent IL-1 production
  JOURNAL   Science 375 (6577), 214-221 (2022)
   PUBMED   35025664
  REMARK    GeneRIF: Olfactory receptor 2 in vascular macrophages drives
            atherosclerosis by NLRP3-dependent IL-1 production.
REFERENCE   3  (bases 1 to 4295)
  AUTHORS   Kurland,M.D., Newcomer,M.B., Peterlin,Z., Ryan,K., Firestein,S. and
            Batista,V.S.
  TITLE     Discrimination of saturated aldehydes by the rat I7 olfactory
            receptor
  JOURNAL   Biochemistry 49 (30), 6302-6304 (2010)
   PUBMED   20608641
  REMARK    GeneRIF: I7 olfactory receptor
REFERENCE   4  (bases 1 to 4295)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (bases 1 to 4295)
  AUTHORS   Lane,R.P., Cutforth,T., Young,J., Athanasiou,M., Friedman,C.,
            Rowen,L., Evans,G., Axel,R., Hood,L. and Trask,B.J.
  TITLE     Genomic analysis of orthologous mouse and human olfactory receptor
            loci
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7390-7395 (2001)
   PUBMED   11416212
REFERENCE   6  (bases 1 to 4295)
  AUTHORS   Buettner,J.A., Glusman,G., Ben-Arie,N., Ramos,P., Lancet,D. and
            Evans,G.A.
  TITLE     Organization and evolution of olfactory receptor genes on human
            chromosome 11
  JOURNAL   Genomics 53 (1), 56-68 (1998)
   PUBMED   9787077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087280.11.
            
            On Aug 7, 2020 this sequence version replaced NM_003696.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641196.1/ ENSP00000492990.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC087280.11        30037-30182         c
            147-4295            AC087280.11        22229-26377         c
FEATURES             Location/Qualifiers
     source          1..4295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4295
                     /gene="OR6A2"
                     /gene_synonym="I7; OR11-55; OR6A1; OR6A2P"
                     /note="olfactory receptor family 6 subfamily A member 2"
                     /db_xref="GeneID:8590"
                     /db_xref="HGNC:HGNC:15301"
                     /db_xref="MIM:608495"
     exon            1..146
                     /gene="OR6A2"
                     /gene_synonym="I7; OR11-55; OR6A1; OR6A2P"
                     /inference="alignment:Splign:2.1.0"
     exon            147..4295
                     /gene="OR6A2"
                     /gene_synonym="I7; OR11-55; OR6A1; OR6A2P"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..1306
                     /gene="OR6A2"
                     /gene_synonym="I7; OR11-55; OR6A1; OR6A2P"
                     /note="olfactory receptor, family 6, subfamily A, member 2
                     pseudogene; olfactory receptor, family 6, subfamily A,
                     member 1; hI7 olfactory receptor; seven transmembrane
                     helix receptor; olfactory receptor OR11-83; hP2 olfactory
                     receptor; olfactory receptor 6A1; olfactory receptor
                     11-55"
                     /codon_start=1
                     /product="olfactory receptor 6A2"
                     /protein_id="NP_003687.2"
                     /db_xref="CCDS:CCDS7772.1"
                     /db_xref="GeneID:8590"
                     /db_xref="HGNC:HGNC:15301"
                     /db_xref="MIM:608495"
                     /translation="MEWRNHSGRVSEFVLLGFPAPAPLQVLLFALLLLAYVLVLTENT
                     LIIMAIRNHSTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFVGSKQDHGQLISFEGC
                     MTQLYFFLGLGCTECVLLAVMAYDRYMAICYPLHYPVIVSGRLCVQMAAGSWAGGFGI
                     SMVKVFLISGLSYCGPNIINHFFCDVSPLLNLSCTDMSTAELTDFILAIFILLGPLSV
                     TGASYVAITGAVMHIPSAAGRYKAFSTCASHLTVVIIFYAASIFIYARPKALSAFDTN
                     KLVSVLYAVIVPLLNPIIYCLRNQEVKRALCCTLHLYQHQDPDPKKASRNV"
     regulatory      2712..2717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR6A2"
                     /gene_synonym="I7; OR11-55; OR6A1; OR6A2P"
                     /note="hexamer: AATAAA"
     polyA_site      2730
                     /gene="OR6A2"
                     /gene_synonym="I7; OR11-55; OR6A1; OR6A2P"
                     /note="major polyA site"
     regulatory      2857..2862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR6A2"
                     /gene_synonym="I7; OR11-55; OR6A1; OR6A2P"
                     /note="hexamer: TATAAA"
     polyA_site      2878
                     /gene="OR6A2"
                     /gene_synonym="I7; OR11-55; OR6A1; OR6A2P"
ORIGIN      
        1 atctatggga ggaagagaaa gtggaatctc tgtatcatct ttcttagtcc cgatgactca
       61 actttttttg catacatttt aaatcctctc ctaaccaacc cagccatctc aggaggacct
      121 tgatgagtca gtgacatctg aataaactca tttccagatt aaagaagaga gcagtggcct
      181 cagctcagtg attaattaca tgaactcctt acgtggtatt cgaccaatat aagcccatta
      241 agagaaaggc tgggttcttg ttgtggccta ctgaagactc tctactctca tctcctgaag
      301 agcagtaaga gagaccaatg acatggagtg gcggaaccat agtgggagag tgagtgagtt
      361 tgtgttgctg ggcttccctg ctcctgcgcc actacaggta ctattgtttg cccttttgct
      421 gctggcctat gtgttggtgc tgactgagaa cacactcatc attatggcaa ttaggaacca
      481 ttctaccctc cacaaaccca tgtacttttt tctagctaat atgtcctttc tggagatctg
      541 gtatgtcact gtcactattc ccaagatgct tgctggcttt gttggatcca aacaggatca
      601 tggacagcta atctcctttg agggatgcat gacacagctc tactttttcc ttggcttggg
      661 ctgcactgag tgtgtccttc tcgctgttat ggcctatgat cgctatatgg ccatctgcta
      721 tcctctccac tacccagtca ttgtcagtgg ccggctgtgt gtgcagatgg ctgctggctc
      781 ttgggctgga ggttttggca tctccatggt caaagttttt cttatttctg gcctctctta
      841 ctgtggcccc aacatcatca accacttttt ctgtgatgtc tctccattgc tcaacctctc
      901 atgcactgat atgtccacag cagagcttac agatttcatc ctggccattt ttattcttct
      961 agggccactc tctgtcactg gggcctccta tgtggccatt actggtgctg tgatgcacat
     1021 tccttcggct gctggacgct ataaggcctt ttccacctgt gcctctcatc tcactgttgt
     1081 gataatcttc tatgcagcca gtatcttcat ctatgctcgg ccaaaggcac tctcagcttt
     1141 tgacaccaac aagttggtct ctgtactgta tgctgtcatt gtaccattgc tcaatcccat
     1201 catttactgc ctgcgcaatc aagaggtcaa gagagcccta tgctgtactc tgcacctgta
     1261 ccagcaccag gatcctgacc ccaagaaagc tagcagaaat gtatagaagg gatgtgtgaa
     1321 atctgataaa atgctattaa acttgggatc aatgtgttct atgaagtcca gtggagttct
     1381 tagggcctaa attgggggcc agagtttcaa aggcatcact atggaactag gaatactttc
     1441 tttaactagt ccaagaggag agagaggaat aggttgcaag ctagaaaatg gatttctgca
     1501 ggacagggcc ataaaataca ggatagagct gggtccacta ttgtctgtcc ctttgtaatt
     1561 tgcatagaca aggttccaat caaggaagca caggcttcat tacggaaaag caacacaaga
     1621 ctttttgata agatctctat taggtagcag aggcccagga gatatcattc tagcgtgtgt
     1681 tacaaggcaa ggagataaga aactaggaat ttttgttttg ggaacatatc acctatcaaa
     1741 acataatggt ttctaggttt attttcaaat ttactgtggt cagtgtccac attgaactag
     1801 tggctgagtg cagttgtttc atcaatactc tgtctccctg attagactat aagcaccatg
     1861 gtgacaggat cagattttct tttacatcct tttattacca tgggcaggaa cagtatctag
     1921 tgcatgatgg ctatgaatat gtataatgaa tgaatatagt ttggaaccat gtaggcaagg
     1981 catgtgtgtc atgcctatat gtggggttgg caggtgcagg aagtaaaccc ctcatacttt
     2041 actagtatgc agagagatac aaattggctc agccttgcca gaaaaaaatt ttgaaaatat
     2101 gtattacaaa tcctaaaaat attgcaacca ttctgattcg gaaagatttg tgcagataga
     2161 cacttttact tataaataca gaaacaagga aaggaaataa gcaaaatatg ctcaactttc
     2221 gcaaacaggg cactggtcaa ataaattgta gctcatatgt tacatggaaa actatgcaga
     2281 aattgaaata aagtgatcta aatagagtta atgaaagaaa aaatatttct aacttaataa
     2341 aaatattatg ttatataaca gtatcaaaaa tatcagccat atttgcttgt ttaaacaaga
     2401 ctagaaggaa tatgactaaa atgctggcta gataatgctg gactgcttac acctgtaaat
     2461 tgcattctgt ggctaagcat tgccatcaat atatttattt aaatgctttt tttcttagcc
     2521 catattatat ataactttat ttatctggac agggagatgg atacagggta tgtcagtatg
     2581 attttcagaa atttagctcc ctactgtcac ccgacaacca gaactctgaa gacagtgaag
     2641 attctatctc cagatatgga tccaactgtt gctcaagatg tgggatctaa ctttattgct
     2701 gtatgttact taataaaatt tacaaaagga tattaccaag gatatcatgc attatttgct
     2761 agcccatact tattaaaagt tttaatataa tgtgcatatc tatttgtgcc taaacagtat
     2821 aagtatcttg ttgtaataat tttttaaatg actggatata aagttcatca aaaatctact
     2881 gtcgaagtgt ccccgtagaa gaagtttctg aaatggggtt gtgatcaggg atgggagagt
     2941 cctcctctag gcattgttat tacaactctt ttataaactc ttttataagt taactcgagt
     3001 taataggaag taaaagcata atgttgaatt tcttcattgt gcttttcttt tattttccaa
     3061 tgctttaaaa cacctctaat tctgatttca agtattggaa tagggtttag cacagtattc
     3121 ctcacatact cacctttcaa taaaccacga atgagtttga gtcccatgta ctatggtgag
     3181 attgacacct ctccagacgg ggactgaatt tttagtgaac atatgaccct caggactcat
     3241 attgaaattg aggtcacaaa actttgtaaa ctttttcatg tgaagtattg attatcagat
     3301 taagtatccc ccatcctcca tttatgtaac tgatttttcc cataaacgta gatgtagaac
     3361 tttattttat ccttgttcca tttgatcctg tttgttttcg accatctttg taatctgccg
     3421 gtctttcaaa gtattgctta gataatataa gtcttttata attccccttt gctaatacag
     3481 tatctggaga agcttctagt ctcttgcatc agtacaagag gtgggagtac tggatctacc
     3541 cgggttattc agagtggcca gaggcaacta acaactacag gcaagtgagg attaatataa
     3601 atgacttctg tgctccaggt gtctagtggt ttccaatgtt gagtaaactc cagatttctc
     3661 agtctgcctt ttaagtttct tcacagcaca ttcttaattt tcctttttgt ccttatttta
     3721 attttttgtc cactacaaac cttgtacagg tgaattctag attgtgatta acaattttta
     3781 tttgagacta ataagccagt gtatttcact gtttgctaaa acatcacatt gaccaggatc
     3841 aggaaacaaa aatccttctt gataaacagc attttaaaaa taacaattgt tctgcagctc
     3901 tgtaaaccct atttcccttc attaaaaaac ccttacagtt atgaacaagt aaagactgag
     3961 aaatatcaga tcaaagcttg tcaaagagac aagataccta tatggagtac ggtatattgg
     4021 attggaccct ggaacataaa gtaatactaa cagaaaagat aataaaatct gaataaaatg
     4081 gcaaaatctg aatagtttaa cagtgatgta tcaattttgg tttcttattt tgacaagtat
     4141 gtatgctaat gaaggatgaa tatattagaa gaaacaaact gagagatggg tgtgtgaaaa
     4201 actctcttta gcatctttgc aatttttctg taagcctaat attgttccaa aatttagaag
     4261 tttattttaa aaagaaacac gttgttagtt tttcc
//
