LOCUS       NM_030876               2763 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 5 subfamily V member 1
            (OR5V1), mRNA.
ACCESSION   NM_030876
VERSION     NM_030876.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2763)
  AUTHORS   St Pourcain,B., Whitehouse,A.J., Ang,W.Q., Warrington,N.M.,
            Glessner,J.T., Wang,K., Timpson,N.J., Evans,D.M., Kemp,J.P.,
            Ring,S.M., McArdle,W.L., Golding,J., Hakonarson,H., Pennell,C.E.
            and Smith,G.D.
  TITLE     Common variation contributes to the genetic architecture of social
            communication traits
  JOURNAL   Mol Autism 4 (1), 34 (2013)
   PUBMED   24047820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2763)
  AUTHORS   Pelak,K., Goldstein,D.B., Walley,N.M., Fellay,J., Ge,D.,
            Shianna,K.V., Gumbs,C., Gao,X., Maia,J.M., Cronin,K.D.,
            Hussain,S.K., Carrington,M., Michael,N.L. and Weintrob,A.C.
  CONSRTM   Infectious Disease Clinical Research Program HIV Working Group;
            National Institute of Allergy and Infectious Diseases Center for
            HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Host determinants of HIV-1 control in African Americans
  JOURNAL   J Infect Dis 201 (8), 1141-1149 (2010)
   PUBMED   20205591
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[J Infect Dis. 2010 Aug 15;202(3):501]
REFERENCE   3  (bases 1 to 2763)
  AUTHORS   Thompson,E.E., Haller,G., Pinto,J.M., Sun,Y., Zelano,B., Jacob,S.,
            McClintock,M.K., Nicolae,D.L. and Ober,C.
  TITLE     Sequence variations at the human leukocyte antigen-linked olfactory
            receptor cluster do not influence female preferences for male odors
  JOURNAL   Hum Immunol 71 (1), 100-103 (2010)
   PUBMED   19833159
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 2763)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2763)
  AUTHORS   Franke,A., Hampe,J., Rosenstiel,P., Becker,C., Wagner,F.,
            Hasler,R., Little,R.D., Huse,K., Ruether,A., Balschun,T.,
            Wittig,M., Elsharawy,A., Mayr,G., Albrecht,M., Prescott,N.J.,
            Onnie,C.M., Fournier,H., Keith,T., Radelof,U., Platzer,M.,
            Mathew,C.G., Stoll,M., Krawczak,M., Nurnberg,P. and Schreiber,S.
  TITLE     Systematic association mapping identifies NELL1 as a novel IBD
            disease gene
  JOURNAL   PLoS One 2 (8), e691 (2007)
   PUBMED   17684544
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2763)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   7  (bases 1 to 2763)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 2763)
  AUTHORS   Volz,A., Ehlers,A., Younger,R., Forbes,S., Trowsdale,J.,
            Schnorr,D., Beck,S. and Ziegler,A.
  TITLE     Complex transcription and splicing of odorant receptor genes
  JOURNAL   J Biol Chem 278 (22), 19691-19701 (2003)
   PUBMED   12637542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662781.4.
            
            On Jul 21, 2020 this sequence version replaced NM_030876.5.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript was available for the full length
            of the gene. The extent of this transcript is supported by
            transcript alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641768.1/ ENSP00000493269.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AL662781.4         82529-82762         c
            235-2763            AL662781.4         67646-70174         c
FEATURES             Location/Qualifiers
     source          1..2763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..2763
                     /gene="OR5V1"
                     /gene_synonym="6M1-21; hs6M1-21"
                     /note="olfactory receptor family 5 subfamily V member 1"
                     /db_xref="GeneID:81696"
                     /db_xref="HGNC:HGNC:13972"
     exon            1..234
                     /gene="OR5V1"
                     /gene_synonym="6M1-21; hs6M1-21"
                     /inference="alignment:Splign:2.1.0"
     exon            235..2763
                     /gene="OR5V1"
                     /gene_synonym="6M1-21; hs6M1-21"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..1282
                     /gene="OR5V1"
                     /gene_synonym="6M1-21; hs6M1-21"
                     /note="olfactory receptor OR6-26"
                     /codon_start=1
                     /product="olfactory receptor 5V1"
                     /protein_id="NP_110503.3"
                     /db_xref="CCDS:CCDS4657.1"
                     /db_xref="GeneID:81696"
                     /db_xref="HGNC:HGNC:13972"
                     /translation="MERKNQTAITEFIILGFSNLNELQFLLFTIFFLTYFCTLGGNIL
                     IILTTVTDPHLHTPMYYFLGNLAFIDICYTTSNVPQMMVHLLSKKKSISYVGCVVQLF
                     AFVFFVGSECLLLAAMAYDRYIAICNPLRYSVILSKVLCNQLAASCWAAGFLNSVVHT
                     VLTFCLPFCGNNQINYFFCDIPPLLILSCGNTSVNELALLSTGVFIGWTPFLCIVLSY
                     ICIISTILRIQSSEGRRKAFSTCASHLAIVFLFYGSAIFTYVRPISTYSLKKDRLVSV
                     LYSVVTPMLNPIIYTLRNKDIKEAVKTIGSKWQPPISSLDSKLTY"
ORIGIN      
        1 ggatcttctt aatccaaagg gcattttcct tactcactcc agtcccatgc actggccttc
       61 agggactgag tagagtcttg gcactcacct agaaaaccca tcactcagaa gtttatcagc
      121 acagactctg tagggaacat tattttgtgt tacttcgttg tattcttaaa aacagcccca
      181 tatcagtctc tcagagtctg aatggtaatc tctgctcaat atctccaatc acaggtcatg
      241 ctattgcagc atatgattca tttttataat ctggtcttct ctttgcccaa ttcctgaaag
      301 gaaaccaggc gacatcatgg aaagaaagaa tcaaacagct ataactgaat tcatcatctt
      361 gggattctcc aacctaaatg aattgcagtt tttactattc accatcttct ttctgactta
      421 tttctgtact ttgggaggaa atatattaat tatcttgacg actgtgactg atccacacct
      481 gcatacacct atgtattatt ttctagggaa cttggccttt attgacatct gctacaccac
      541 cagcaatgtc ccccagatga tggtgcacct cctctcaaag aaaaaaagca tttcttatgt
      601 ggggtgtgtg gttcaacttt ttgcatttgt tttctttgta ggatcagagt gtctcctact
      661 ggcagcaatg gcatatgatc gttacattgc aatctgcaat cctttaaggt attcagttat
      721 tctgagcaag gttctatgca atcaattagc agcctcatgc tgggctgctg gtttccttaa
      781 ctcagtggtg catacagtgt tgacattctg cctgcccttc tgtggcaaca atcagattaa
      841 ttacttcttc tgtgacatcc cccctttgct gatcttgtct tgtggaaaca cttctgtcaa
      901 tgagttggca ctgctatcca ctggggtctt cattggttgg actcctttcc tttgtatcgt
      961 actttcctac atttgcataa tctccaccat cttgaggatc cagtcctcag agggaagacg
     1021 aaaagccttc tctacatgtg cctcccacct ggccattgtc tttctctttt atggcagcgc
     1081 catctttaca tatgtacggc ccatctcaac ttactcatta aagaaagata ggttggtttc
     1141 agtgttgtac agtgttgtta cccccatgct aaaccctata atttacacat tgaggaataa
     1201 ggacatcaaa gaagctgtca aaactatagg gagcaagtgg cagccaccaa tttcctcttt
     1261 ggatagtaaa ctcacttatt gaacctcaca ggttcaataa tcttatacta caaaattaac
     1321 tttttcacca gtcagctgtt tttattgaaa gtttaaaaga taattgcaat gttgggacag
     1381 atattgaaga gttgatacac tccagtctaa gtgtacttat tcttgagctt tagttagttc
     1441 tatgagagat atcaatgttg ctctctttag atattatctt cttatttatt tttccattcc
     1501 tgaattttgc attcaaagac tgtttccctc tttcatgaga tatttgttta atggacttca
     1561 tcacttgaaa atttccctgc tttttcatat tgctttctgt atattaaata atgtgaaata
     1621 tttttcttca cattcctcat atgtgtgtca tatttttctg ttcttactac ttaagccatg
     1681 cttttgacct ttctttcttt agtaggccct tcttaataaa acatcatcac caatagatta
     1741 agaaatgtaa acacagtaaa gtgatgtttt acctccagat ctgttggtag ctaattttaa
     1801 ttttatcacc tgctgcatgg gccaaggcca atttatcttc acattggaat gaagacagtc
     1861 ataattttca atcccatttg acatgcattc tttattctat tcaaaaggca gaatttcctg
     1921 agggattttt ctaaaactaa gtccccaaaa catattacta ttttatagag tatcttaaat
     1981 ttgggaaact tttttcgcta aaaatttaga aaacagaatc agataaaaca tacagaaaaa
     2041 acaagggttt tttgatgggg aataaaaagt cttagttata taatgactaa atttagaaaa
     2101 aaaagtagaa attactaatg ttaaaagtaa aagtacttaa ttactatttt ctatgtgtta
     2161 ttaccatgta aagtacagtt atgaagtcaa gacaaatggg aaggaagact aagtggtgga
     2221 agagagaaat aaatacagac actggagaga aaatttaaaa gataaagaga cttagagata
     2281 ccaagaaggg aaaataaata acatacaatg taagagccta agagattgaa agagagatag
     2341 aaaaaggctt atagatcagg tagatacaag ttgtctagtg tctttcttca ctattctctc
     2401 aggaccgtct tctttttctt cccataccta ctgatgcctc ccttgattaa gtcttgactt
     2461 cccagcccct cttttgtgta atgttgtcat agtgttctag tggagtgcct tgtctccatt
     2521 cctattctgt ttaatgtacc ctgcacatca tttctgagtt aactttctta acatggtgtt
     2581 atgtacagtc tcctatactg tttttgtttt aataaactct actggcttac tggcacactc
     2641 ttcatttaac taaatatatt tgtaaccact gtctataaaa tctaagtact acctactttg
     2701 taactcatct cctgcaggaa ccctaaataa ttcttctcca ggtatggctt gatctttcct
     2761 gac
//
