LOCUS       NM_001005482            1566 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 5 subfamily H member 2
            (OR5H2), mRNA.
ACCESSION   NM_001005482
VERSION     NM_001005482.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1566)
  AUTHORS   Shibel,R., Sarfstein,R., Nagaraj,K., Lapkina-Gendler,L., Laron,Z.,
            Dixit,M., Yakar,S. and Werner,H.
  TITLE     The Olfactory Receptor Gene Product, OR5H2, Modulates Endometrial
            Cancer Cells Proliferation via Interaction with the IGF1 Signaling
            Pathway
  JOURNAL   Cells 10 (6), 1483 (2021)
   PUBMED   34204736
  REMARK    GeneRIF: The Olfactory Receptor Gene Product, OR5H2, Modulates
            Endometrial Cancer Cells Proliferation via Interaction with the
            IGF1 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1566)
  AUTHORS   Daly,A.K., Donaldson,P.T., Bhatnagar,P., Shen,Y., Pe'er,I.,
            Floratos,A., Daly,M.J., Goldstein,D.B., John,S., Nelson,M.R.,
            Graham,J., Park,B.K., Dillon,J.F., Bernal,W., Cordell,H.J.,
            Pirmohamed,M., Aithal,G.P. and Day,C.P.
  CONSRTM   DILIGEN Study; International SAE Consortium
  TITLE     HLA-B*5701 genotype is a major determinant of drug-induced liver
            injury due to flucloxacillin
  JOURNAL   Nat Genet 41 (7), 816-819 (2009)
   PUBMED   19483685
REFERENCE   3  (bases 1 to 1566)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117473.3.
            
            On Nov 19, 2020 this sequence version replaced NM_001005482.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000355273.3/
                                                ENSP00000347418.3
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1566              AC117473.3         96308-97873
FEATURES             Location/Qualifiers
     source          1..1566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q11.2"
     gene            1..1566
                     /gene="OR5H2"
                     /gene_synonym="OR3-10"
                     /note="olfactory receptor family 5 subfamily H member 2"
                     /db_xref="GeneID:79310"
                     /db_xref="HGNC:HGNC:14752"
     exon            1..1566
                     /gene="OR5H2"
                     /gene_synonym="OR3-10"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..1328
                     /gene="OR5H2"
                     /gene_synonym="OR3-10"
                     /note="olfactory receptor OR3-10"
                     /codon_start=1
                     /product="olfactory receptor 5H2"
                     /protein_id="NP_001005482.2"
                     /db_xref="CCDS:CCDS33801.2"
                     /db_xref="GeneID:79310"
                     /db_xref="HGNC:HGNC:14752"
                     /translation="MEQDNTTLLTEFVLTGLTYQPEWKMPLFLVFLVIYLITIVWNLG
                     LIALIWNDPQLHIPMYFFLGSLAFVDAWISSTVTPKMLVNFLAKNRMISLSECMIQFF
                     SFAFGGTTECFLLATMAYDRYVAICKPLLYPVIMNNSLCIRLLAFSFLGGFLHALIHE
                     VLIFRLTFCNSNIIHHFYCDIIPLFMISCTDPSINFLMVFILSGSIQVFTIVTVLNSY
                     TFALFTILKKKSVRGVRKAFSTCGAHLLSVSLYYGPLIFMYLRPASPQADDQDMIDSV
                     FYTIIIPLLNPIIYSLRNKQVIDSFTKMVKRNV"
ORIGIN      
        1 tgtttctggt cttggccaga ggcatgcttc ccagcacact tgatggccac cttgcaggct
       61 gtaacccctt ataagaaata agtcttctct ccttttctaa atttacaaat agtgattttc
      121 ttaagttaac acacattaca tgcatttcta tcatctgcat tttaaaagta gattatttga
      181 tcacattttt agaattaaaa taattgcatt tattttgatt tcttatattt cccaaaacag
      241 tttccatcta ttacaggaat atgaaagaaa attaaaaggg tattgtaata agagtatgtt
      301 tttctatcaa cttccctccc ccagtatttg ctgtataagt cttagtgaat gctcttttac
      361 atttactgca tttcatttca gggatgtcga atgaggacat ggaacaggat aatacaacat
      421 tgctgacaga gtttgttctc acaggactta catatcagcc agagtggaaa atgcccctgt
      481 tcttggtgtt cttggtgatc tatctcatca ctattgtgtg gaaccttggt ctgattgctc
      541 ttatctggaa tgacccacaa cttcacatcc ccatgtactt ttttcttggg agtttagcct
      601 ttgttgatgc ttggatatct tccacagtaa ctcccaaaat gttggttaat ttcttggcca
      661 aaaacaggat gatatctctg tctgaatgca tgattcaatt tttttccttt gcatttggtg
      721 gaactacaga atgttttctc ttggcaacaa tggcatatga tcgctatgta gccatatgca
      781 aacctttact atatccagtg attatgaaca attcactatg catacggctg ttagccttct
      841 catttttagg tggcttcctc catgccttaa ttcatgaagt ccttatattc agattaacct
      901 tctgcaattc taacataata catcattttt actgtgatat tataccactg tttatgattt
      961 cctgtactga cccttctatt aattttctaa tggtttttat tttgtctggc tcaattcagg
     1021 tattcaccat tgtgacagtt cttaattctt acacatttgc tcttttcaca atcctaaaaa
     1081 agaagtctgt tagaggcgta aggaaagcct tttccacctg tggagcccat ctcttatctg
     1141 tctctttata ttatggccca cttatcttca tgtatttgcg ccctgcatct ccacaagcag
     1201 atgaccaaga tatgatagac tctgtctttt atacaatcat aattcctttg ctaaatccca
     1261 ttatctacag tctgagaaat aaacaagtaa tagattcatt cacaaaaatg gtaaaaagaa
     1321 atgtttagat ttcatagtga tatctctcat tttcagtaaa aagaattttg cagttagata
     1381 aggtgttttg ctaagtgttc aaagttattg taaatataat tgttttagca ttttaatgac
     1441 ttagggtttt atacctaata aactccttaa aatatttata tatgttattc aaaagcatcc
     1501 aaggaatttt aacctggtgt tcatgttata ttagataatt aaagcagaaa acaaatgaaa
     1561 acattt
//
