LOCUS       NM_001005566            2210 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 5 subfamily B member 2
            (OR5B2), mRNA.
ACCESSION   NM_001005566 XM_497298
VERSION     NM_001005566.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2210)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   2  (bases 1 to 2210)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002345.4 and KC877418.1.
            
            On Aug 7, 2020 this sequence version replaced NM_001005566.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2467150
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641342.2/ ENSP00000493419.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AP002345.4         68412-68514         c
            104-158             AP002345.4         67015-67069         c
            159-346             KC877418.1         1-188               c
            347-2210            AP002345.4         61631-63494         c
FEATURES             Location/Qualifiers
     source          1..2210
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..2210
                     /gene="OR5B2"
                     /gene_synonym="OR11-240; OST073"
                     /note="olfactory receptor family 5 subfamily B member 2"
                     /db_xref="GeneID:390190"
                     /db_xref="HGNC:HGNC:8323"
     exon            1..103
                     /gene="OR5B2"
                     /gene_synonym="OR11-240; OST073"
                     /inference="alignment:Splign:2.1.0"
     exon            104..158
                     /gene="OR5B2"
                     /gene_synonym="OR11-240; OST073"
                     /inference="alignment:Splign:2.1.0"
     exon            159..2210
                     /gene="OR5B2"
                     /gene_synonym="OR11-240; OST073"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1116
                     /gene="OR5B2"
                     /gene_synonym="OR11-240; OST073"
                     /note="olfactory receptor OR11-240"
                     /codon_start=1
                     /product="olfactory receptor 5B2"
                     /protein_id="NP_001005566.1"
                     /db_xref="CCDS:CCDS31550.1"
                     /db_xref="GeneID:390190"
                     /db_xref="HGNC:HGNC:8323"
                     /translation="MENCTEVTKFILLGLTSVPELQIPLFILFTFIYLLTLCGNLGMM
                     LLILMDSCLHTPMYFFLSNLSLVDFGYSSAVTPKVMAGFLRGDKVISYNACAVQMFFF
                     VALATVENYLLASMAYDRYAAVCKPLHYTTTMTASVGACLALGSYVCGFLNASFHIGG
                     IFSLSFCKSNLVHHFFCDVPAVMALSCSDKHTSEVILVFMSSFNIFFVLLVIFISYLF
                     IFITILKMHSAKGHQKALSTCASHFTAVSVFYGTVIFIYLQPSSSHSMDTDKMASVFY
                     AMIIPMLNPVVYSLRNREVQNAFKKVLRRQKFL"
     regulatory      2192..2197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR5B2"
                     /gene_synonym="OR11-240; OST073"
                     /note="hexamer: AATAAA"
     polyA_site      2210
                     /gene="OR5B2"
                     /gene_synonym="OR11-240; OST073"
                     /note="major polyA site"
ORIGIN      
        1 gtcttgtcct gcaaggtgga ttcccaattc cattgtccac agctgaagcc catgctattc
       61 ttgcctctcc attctggcca tgtggattcc tcctccaatc aaggacttgc aatttgaaga
      121 taccaactga aagtgtgtca tcttccttga agagcaaggt catcttaagt ttctcagata
      181 atactgatgg agaattgtac ggaagtgaca aagttcattc ttctaggact aaccagtgtc
      241 ccagaactac agatccccct ctttatcttg ttcaccttca tctacctcct cactctgtgt
      301 gggaacctgg ggatgatgtt gctgatcctg atggactctt gtctccacac ccccatgtac
      361 tttttcctca gtaacctgtc tctggtggac tttggatact cctcagctgt cactcccaag
      421 gtcatggctg ggttccttag aggagacaag gtcatctcct acaatgcatg tgctgttcag
      481 atgttcttct ttgtagcctt ggccacggtg gaaaattact tgttggcctc aatggcctat
      541 gaccgctatg cagcagtgtg caaaccccta cactacacca ccaccatgac ggccagtgta
      601 ggtgcctgtc tggccctagg ctcatatgtc tgtggcttcc taaatgcctc attccacatt
      661 gggggcatat tcagtctctc tttctgtaaa tccaatctgg tacatcactt tttctgtgat
      721 gttccagcag tcatggctct gtcttgctct gataaacaca ctagtgaggt gattctggtt
      781 tttatgtcaa gctttaatat cttttttgtt cttctagtta tctttatctc ctacttgttc
      841 atattcatca ccatcttgaa gatgcattca gctaagggac accaaaaagc attgtccacc
      901 tgtgcctctc acttcactgc agtctccgtc ttctatggga cagtaatctt catctacttg
      961 cagcccagct ccagccactc catggacaca gacaaaatgg catctgtgtt ctatgctatg
     1021 atcatcccca tgctgaaccc tgtggtctac agcctgagga acagagaagt ccagaatgca
     1081 ttcaagaaag tgttgagaag gcaaaaattt ctataagttt ggaattttaa cattgttgta
     1141 tacacaaaaa tgttgtttcc ctcatctcag actttcctca tgcaatgagt tacatttgaa
     1201 accccacaat acatttaagt tcatgaggtg atattcttac ctctttagaa gtcaattttt
     1261 taataaaaat aaaatattat cagaaatgta atacctgaat gaggaaggct aaatggaaat
     1321 gttagaattt ttggaacttg ctggtcaaaa cttactaatg acattcggtt tactcacttg
     1381 ttccccttgc attttttcta ccacattcca gtgcaaacat acttgttaaa cagggacacc
     1441 aacaagccca caaaaaagta catgtttatg cctcttgtgg gcacataggc attagaagga
     1501 gaaatttact cagaagtaaa tggagtgtgg ctagttttta tataaaggat gtaagtaatt
     1561 aatttagtat tatagtataa atttattttt gaatagactt taagaacagt tttatgttca
     1621 cagcaaaatg gagaggtaag tacagagatt tcccatatac cttctgcccc cacatacata
     1681 taccctccct cattgtcaat atcctccaac agagtgctac attttttaca attgatgaac
     1741 ctacattgac acatcattat catctcaaga ccataattta cattaggatt cactcttgct
     1801 gttgtccctt ctatggattt gaataaatgt ataatgacat ctatttatca ttatagtatc
     1861 atattgagta gtttcactgc tctaaagctc ttctatgctc tacttactca ttcttccttc
     1921 ttccctaacc cctgacaact actgatcttt ttctgtctcc acagttttgc tttctccaga
     1981 atgtcatata gttaaaatca tatggtatgt aacctttcca tattggctta tttcacatag
     2041 taatatgcat ctgttttctc cataactttt cgtggcttga tagctcattt cattttagca
     2101 ctgaatattg tctattgtca agtggtatca cactttattc atgtacctac tgaaggatat
     2161 tttggttgct tccctagtgt tggcagttat gaataaagcc gctataaaca
//
