LOCUS       NM_001004733            1368 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 5 subfamily B member 12
            (OR5B12), mRNA.
ACCESSION   NM_001004733 XM_372409
VERSION     NM_001004733.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002345.4.
            
            On Jul 27, 2020 this sequence version replaced NM_001004733.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641921.2/ ENSP00000493263.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AP002345.4         82439-82629         c
            192-1368            AP002345.4         79387-80563         c
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1368
                     /gene="OR5B12"
                     /gene_synonym="OR11-241; OR5B12P; OR5B16; OST743"
                     /note="olfactory receptor family 5 subfamily B member 12"
                     /db_xref="GeneID:390191"
                     /db_xref="HGNC:HGNC:15432"
     exon            1..191
                     /gene="OR5B12"
                     /gene_synonym="OR11-241; OR5B12P; OR5B16; OST743"
                     /inference="alignment:Splign:2.1.0"
     exon            192..1368
                     /gene="OR5B12"
                     /gene_synonym="OR11-241; OR5B12P; OR5B16; OST743"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1155
                     /gene="OR5B12"
                     /gene_synonym="OR11-241; OR5B12P; OR5B16; OST743"
                     /note="olfactory receptor, family 5, subfamily B, member
                     12 pseudogene; olfactory receptor, family 5, subfamily B,
                     member 16; olfactory receptor OR11-241; olfactory receptor
                     5B16"
                     /codon_start=1
                     /product="olfactory receptor 5B12"
                     /protein_id="NP_001004733.1"
                     /db_xref="CCDS:CCDS31551.1"
                     /db_xref="GeneID:390191"
                     /db_xref="HGNC:HGNC:15432"
                     /translation="MENNTEVTEFILVGLTDDPELQIPLFIVFLFIYLITLVGNLGMI
                     ELILLDSCLHTPMYFFLSNLSLVDFGYSSAVTPKVMVGFLTGDKFILYNACATQFFFF
                     VAFITAESFLLASMAYDRYAALCKPLHYTTTMTTNVCACLAIGSYICGFLNASIHTGN
                     TFRLSFCRSNVVEHFFCDAPPLLTLSCSDNYISEMVIFFVVGFNDLFSILVILISYLF
                     IFITIMKMRSPEGRQKAFSTCASHLTAVSIFYGTGIFMYLRPNSSHFMGTDKMASVFY
                     AIVIPMLNPLVYSLRNKEVKSAFKKTVGKAKASIGFIF"
     regulatory      1341..1346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR5B12"
                     /gene_synonym="OR11-241; OR5B12P; OR5B16; OST743"
                     /note="hexamer: AATAAA"
     polyA_site      1368
                     /gene="OR5B12"
                     /gene_synonym="OR11-241; OR5B12P; OR5B16; OST743"
                     /note="major polyA site"
ORIGIN      
        1 tgattccaaa gccaatagca tttttctttc aatttccccc tgcctctaaa gaactttaag
       61 ccttttggcc aaacgctaaa gaacagtctc caaaaagttg ttttccttct ttaaaggact
      121 taatttctga tgtgacattc acttatatat gaaagtgctg gacctgaatt ttgtatttct
      181 cagggagaaa gggcagctac ataattccca atggagaaca acacagaggt gactgaattc
      241 atccttgtgg ggttaactga tgacccagaa ctgcagatcc cactcttcat agtcttcctt
      301 ttcatctacc tcatcactct ggttgggaac ctggggatga ttgaattgat tctactggac
      361 tcctgtctcc acacccccat gtacttcttc ctcagtaacc tctccctggt ggactttggt
      421 tattcctcag ctgtcactcc caaggtgatg gtggggtttc tcacaggaga caaattcata
      481 ttatataatg cttgtgccac acaattcttc ttctttgtag cctttatcac tgcagaaagt
      541 ttcctcctgg catcaatggc ctatgaccgc tatgcagcat tgtgtaaacc cctgcattac
      601 accaccacca tgacaacaaa tgtatgtgct tgcctggcca taggctccta catctgtggt
      661 ttcctgaatg catccattca tactgggaac actttcaggc tctccttctg tagatccaat
      721 gtagttgaac actttttctg tgatgctcct cctctcttga ctctctcatg ttcagacaac
      781 tacatcagtg agatggttat tttttttgtg gtgggattca atgacctctt ttctatcctg
      841 gtaatcttga tctcctactt atttatattt atcaccatca tgaagatgcg ctcacctgaa
      901 ggacgccaga aggccttttc tacttgtgct tcccacctta ctgcagtttc catcttttat
      961 gggacaggaa tctttatgta cttacgacct aactccagcc atttcatggg cacagacaaa
     1021 atggcatctg tgttctatgc catagtcatt cccatgttga atccactggt ctacagcctg
     1081 aggaacaaag aggttaagag tgcctttaaa aagactgtag ggaaggcaaa ggcctctata
     1141 ggattcatat tttaattata aagaattcac aataagataa ttttttccac ctcatattaa
     1201 tctttgtcta ccaagcccaa tatttgggct tcctcatgga cagtttctat tgactgtttt
     1261 cttaaacata tgaattggcc atactttctt cattctttaa gtgacacttt ttttgttgtt
     1321 aaaatctgga cattttaaat aataaaaaat agcatattct aaaaatca
//
