LOCUS       NM_001004729            7647 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 5 subfamily AN member 1
            (OR5AN1), mRNA.
ACCESSION   NM_001004729 XM_372411
VERSION     NM_001004729.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7647)
  AUTHORS   Sato-Akuhara,N., Trimmer,C., Keller,A., Niimura,Y., Shirasu,M.,
            Mainland,J.D. and Touhara,K.
  TITLE     Genetic variation in the human olfactory receptor OR5AN1 associates
            with the perception of musks
  JOURNAL   Chem Senses 48 (2023)
   PUBMED   36625229
  REMARK    GeneRIF: Genetic variation in the human olfactory receptor OR5AN1
            associates with the perception of musks.
REFERENCE   2  (bases 1 to 7647)
  AUTHORS   Ben Khemis,I., Sagaama,A., Issaoui,N. and Ben Lamine,A.
  TITLE     Steric and energetic characterizations of mouse and human musk
            receptors activated by nitro musk smelling compounds at molecular
            level: Statistical physics treatment and molecular docking analysis
  JOURNAL   Int J Biol Macromol 188, 333-342 (2021)
   PUBMED   34389381
  REMARK    GeneRIF: Steric and energetic characterizations of mouse and human
            musk receptors activated by nitro musk smelling compounds at
            molecular level: Statistical physics treatment and molecular
            docking analysis.
REFERENCE   3  (bases 1 to 7647)
  AUTHORS   Ahmed,L., Zhang,Y., Block,E., Buehl,M., Corr,M.J., Cormanich,R.A.,
            Gundala,S., Matsunami,H., O'Hagan,D., Ozbil,M., Pan,Y.,
            Sekharan,S., Ten,N., Wang,M., Yang,M., Zhang,Q., Zhang,R.,
            Batista,V.S. and Zhuang,H.
  TITLE     Molecular mechanism of activation of human musk receptors OR5AN1
            and OR1A1 by (R)-muscone and diverse other musk-smelling compounds
  JOURNAL   Proc Natl Acad Sci U S A 115 (17), E3950-E3958 (2018)
   PUBMED   29632183
  REMARK    GeneRIF: Molecular mechanism of activation of human musk receptors
            OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling
            compounds.
REFERENCE   4  (bases 1 to 7647)
  AUTHORS   Sato-Akuhara,N., Horio,N., Kato-Namba,A., Yoshikawa,K., Niimura,Y.,
            Ihara,S., Shirasu,M. and Touhara,K.
  TITLE     Ligand Specificity and Evolution of Mammalian Musk Odor Receptors:
            Effect of Single Receptor Deletion on Odor Detection
  JOURNAL   J Neurosci 36 (16), 4482-4491 (2016)
   PUBMED   27098692
REFERENCE   5  (bases 1 to 7647)
  AUTHORS   Block,E., Jang,S., Matsunami,H., Sekharan,S., Dethier,B.,
            Ertem,M.Z., Gundala,S., Pan,Y., Li,S., Li,Z., Lodge,S.N., Ozbil,M.,
            Jiang,H., Penalba,S.F., Batista,V.S. and Zhuang,H.
  TITLE     Implausibility of the vibrational theory of olfaction
  JOURNAL   Proc Natl Acad Sci U S A 112 (21), E2766-E2774 (2015)
   PUBMED   25901328
REFERENCE   6  (bases 1 to 7647)
  AUTHORS   McClintock,T.S., Adipietro,K., Titlow,W.B., Breheny,P., Walz,A.,
            Mombaerts,P. and Matsunami,H.
  TITLE     In vivo identification of eugenol-responsive and muscone-responsive
            mouse odorant receptors
  JOURNAL   J Neurosci 34 (47), 15669-15678 (2014)
   PUBMED   25411495
  REMARK    GeneRIF: OR5AN1 is an odorant receptor that responds to macrocyclic
            ketone and lactone musk odor molecules such as exaltone and
            muscone, and is the ortholog of mouse odorant receptors responsive
            to muscone.
REFERENCE   7  (bases 1 to 7647)
  AUTHORS   Shirasu,M., Yoshikawa,K., Takai,Y., Nakashima,A., Takeuchi,H.,
            Sakano,H. and Touhara,K.
  TITLE     Olfactory receptor and neural pathway responsible for highly
            selective sensing of musk odors
  JOURNAL   Neuron 81 (1), 165-178 (2014)
   PUBMED   24361078
  REMARK    GeneRIF: This study identifed that OR5AN1 was a specific muscone
            receptor expressed by neurons innervating the muscone-responsive
            anteromedial glomeruli.
REFERENCE   8  (bases 1 to 7647)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002780.3.
            
            On Jul 22, 2020 this sequence version replaced NM_001004729.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641998.1/ ENSP00000493250.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AP002780.3         1042-1419
            379-7647            AP002780.3         6593-13861
FEATURES             Location/Qualifiers
     source          1..7647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..7647
                     /gene="OR5AN1"
                     /gene_synonym="OR11-244"
                     /note="olfactory receptor family 5 subfamily AN member 1"
                     /db_xref="GeneID:390195"
                     /db_xref="HGNC:HGNC:15255"
                     /db_xref="MIM:615702"
     exon            1..378
                     /gene="OR5AN1"
                     /gene_synonym="OR11-244"
                     /inference="alignment:Splign:2.1.0"
     exon            379..7647
                     /gene="OR5AN1"
                     /gene_synonym="OR11-244"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1327
                     /gene="OR5AN1"
                     /gene_synonym="OR11-244"
                     /note="olfactory receptor OR11-244; muscone receptor"
                     /codon_start=1
                     /product="olfactory receptor 5AN1"
                     /protein_id="NP_001004729.1"
                     /db_xref="CCDS:CCDS31559.1"
                     /db_xref="GeneID:390195"
                     /db_xref="HGNC:HGNC:15255"
                     /db_xref="MIM:615702"
                     /translation="MTGGGNITEITYFILLGFSDFPRIIKVLFTIFLVIYITSLAWNL
                     SLIVLIRMDSHLHTPMYFFLSNLSFIDVCYISSTVPKMLSNLLQEQQTITFVGCIIQY
                     FIFSTMGLSESCLMTAMAYDRYAAICNPLLYSSIMSPTLCVWMVLGAYMTGLTASLFQ
                     IGALLQLHFCGSNVIRHFFCDMPQLLILSCTDTFFVQVMTAILTMFFGIASALVIMIS
                     YGYIGISIMKITSAKGRSKAFNTCASHLTAVSLFYTSGIFVYLSSSSGGSSSFDRFAS
                     VFYTVVIPMLNPLIYSLRNKEIKDALKRLQKRKCC"
ORIGIN      
        1 atctctcttg ctgtgagtgg acagccaatt ttgtggtcaa acatgcccat cttggagtgt
       61 gatacgccca cctgaaaaat tccattggaa aagaaataag caatttcaac ctttggcaag
      121 aaccctgtct tcttggagga cctgggtaaa ggtcacagga caagacttag aacagtggat
      181 tctgtaccgt ctcaatatcc atgtaattct tccagtaagg atacacatgg aacagagttt
      241 atggtcctca gtctctctca ttcttcaact cttcccactt cctcacttcc acattctgta
      301 cctaaagctc ttcgttggat tctcttactc cttactcaac cttctgtaaa aagaaaaacc
      361 tcaaacataa aatttcagga gcactgagcc aatgactggg ggaggaaata ttacagaaat
      421 cacctatttc atcctgctgg gattctcaga ttttcccagg atcataaaag tgctcttcac
      481 tatattcctg gtgatctaca ttacatctct ggcctggaac ctctccctca ttgttttaat
      541 aaggatggat tcccacctcc atacacccat gtatttcttc ctcagtaacc tgtccttcat
      601 agatgtctgc tatatcagct ccacagtccc caagatgctc tccaacctct tacaggaaca
      661 gcaaactatc acttttgttg gttgtattat tcagtacttt atcttttcaa cgatgggact
      721 gagtgagtct tgtctcatga cagccatggc ttatgatcgt tatgctgcca tttgtaaccc
      781 cctgctctat tcatccatca tgtcacccac cctctgtgtt tggatggtac tgggagccta
      841 catgactggc ctcactgctt ctttattcca aattggtgct ttgcttcaac tccacttctg
      901 tgggtctaat gtcatcagac atttcttctg tgacatgccc caactgttaa tcttgtcctg
      961 tactgacact ttctttgtac aggtcatgac tgctatatta accatgttct ttgggatagc
     1021 aagtgcccta gttatcatga tatcctatgg ctatattggc atctccatca tgaagatcac
     1081 ttcagctaaa ggcaggtcca aggcattcaa cacctgtgct tctcatctaa cagctgtttc
     1141 cctcttctat acatcaggaa tctttgtcta tttgagttcc agctctggag gttcttcaag
     1201 ctttgacaga tttgcatctg ttttctacac tgtggtcatt cccatgttaa atcccttgat
     1261 ttacagtttg aggaacaaag aaattaaaga tgccttaaag aggttgcaaa agagaaagtg
     1321 ctgctgagtt tacagattct gagatttctg ccagatatgg cccatcagaa tctccctaac
     1381 ccacaaaata tgataatgaa tggactataa caaaattcat gctgcctact gcctttggac
     1441 aaagaaggct tgatttgatg cacaaaatat gccaatatgg accaacagat gactcaatgc
     1501 cacagacatc aggatcttta ggtcctggag gttcattatt tttatcctac atcaggataa
     1561 ataatgtggc ctcatcattt atgaatttgt ccaaaattat ttgtgaaaca acaagattta
     1621 gaaatctttt gtttcctgtg gcttctcaga tcaaagatgg ctcaatgtta ggactttgcc
     1681 actacagaaa tgaggcctgg cacagacccc caggagttca gaaacatcat ctcccatata
     1741 tgctgataca gcataataaa gacatggtgg taaccattgt ttattctgtg tttctggatg
     1801 ggaaagaata aacagacaga ggggttctgc cattggaaag ggaaaaaaaa gcaatatatt
     1861 ggcctggttg tgtctttaag aaagagcaac atgagatagc tgcagtttgc ctaagacctc
     1921 tctcagctaa tcatctaata catttttggc aatttccttg cctacaccag ctgtagcata
     1981 agaaagaagg aggtgatttt aatcatgaag tgggatagaa acaaggatat ggttcctgca
     2041 atcatattta cttatgagtc tgatgatttg atttcttgta tctagagtct agtgggaaat
     2101 tataatggag atgatattca aagttcacag ccaatagcaa catctgatac tgtgggactc
     2161 aaactttctt tttctccccc attaaattta gaaaatttac tcttgtttga ctgggtaact
     2221 attgaatcca ggagaggatg aaagaaacat gggtcaaata tatttcagtc aagctcaacc
     2281 tagacaagct aacctgcagt catgttcaga gaagtcatgc atttaagcct actctacatc
     2341 agccagtccc agctgatctc cagatgatct gaggatatgt gagtgataat aaatgaatgt
     2401 tgcagtcagc actggatttt gcagtttgtt atacagcagt agttaaccaa tatacttcat
     2461 aatttaaaat taaaaatttt ctccttgtcc aaactgcctg gcgtaaaatt caggctctgc
     2521 cacccccaag gtgtgtgatg ctgggcaagc cacacaatct tttgtgcctc agttttctca
     2581 tttgtaaaat tgagatatta tatatctatt ttggagttgt ttaggattat tgagctgata
     2641 cttattcaaa actcagaata gggaccccag catataataa acgctatacg tgaatcatgt
     2701 attattattt attaagtgct ttctatgttc aaagaattta aatggtttca gttgagctaa
     2761 gttttactgt tataccaact tcacagatga ataaacttag gccagagaaa ttcagaaaca
     2821 cagctagtaa gtgaaggggt gggaatccaa actaacattg cagatatcaa agcctcctcc
     2881 cttcttcaat accccttaat gtataaggtg ccaaattgct tattaatata caaggtacat
     2941 atgaataaaa taaagcaata tttatgagat gtagccaaag ctaaaatcag aagtaacaat
     3001 cttttgaaaa gaaatacaat aaagtaacaa agctgtgaat cagaaaaaaa ttgaaaaaag
     3061 aatgccaatt caaaccttaa gaaaactaga ggagaagtgg aggagtgggc aagatggctg
     3121 accagaagca gctagtgtgt gtggctgtca tggaaaggaa cagaaggggt gagcattagg
     3181 tctttgcaac cctcaagtca ggagatctcc ttgtgaaccc actccaccag ggctttcagt
     3241 cttcagtcta atacacagag ctatgtggag tcttggcaga gcagccactc aggccagcat
     3301 ggagtcctcg aaggcttaga tacttgggtt ttctggtaaa agtagctgca gccccagcaa
     3361 agttggaggt tagactcctg tatataaccc taggaaagag gctgaatcca ggggtgttaa
     3421 cagcaacaac ccacaggccc cacttccatg ccacctcaca agataagatc cactggcttg
     3481 gaattccaga cagctaccag tagtggcatt gtacctccct aagaaggagc tcaaagggaa
     3541 gagctgggct gtcatctttg ctgttcagat gccttagctg ttccggcctt tgggctttga
     3601 agaatctgag ctgacccagg gtggaagaga acccccagcc tagcacaaca cagctgctct
     3661 acccaaacat agccagacta tgctttaggt gggtgtccaa tcccattcct cttcactggg
     3721 caggacctcc caactggggc ctgcagccac ccccaccaag ctctccaggt gacaaagatt
     3781 tgaattatcc ctgagatggc actcacagag ggagaagtgg gttaccatct ttgctgtttt
     3841 aatgacttag caactccagc ctttgggctt tgaagtatct gagacgactg aggactgaag
     3901 tagaccccca acacagcaca gctgttctac caaaacgtgg ccagactgct ttttcaagtg
     3961 gttcctaatc ctgttcctcc tcactgggtg gaacctctca actaggctct ccagccactt
     4021 cctacagctg ctttgggcca ccaaaactgc atacctccct gggacaaagc tctcagagga
     4081 agggacaagc cactgtcttt gctgtttcac agccttcact ggtgacacct ccaggttctg
     4141 ggaaatctga ggtgaccagg tactggagca gcccccaagc ataaaacagc agccctatgg
     4201 aaaagtggcc agagtgtttc gtgggtttcc attcccatat cttctcacca ggaagatctt
     4261 caggcctggg cttccagcca ccaccagcca gaactatcaa gccagtatca aatcaccaac
     4321 tccctagaca gagcttccga ggtcaacaga aagtttctat gccactgcct ctgcagtgga
     4381 actgcccttg acacgctcca actaatgaat gagcaaagac actaagtgct ttatccacac
     4441 ctctaataat ctgtagtcaa cccaaggaga agaggctggt ctgtctccca cgggtcccac
     4501 acacccccca ccactcatca ccagacaaag aacccctggc ttgggcccac aacacatacc
     4561 ctctatcttg ggctggctgc actgagcgat tgctgacctg catctctctg gggtggagcc
     4621 cccaggagtc aaacaaatga cccttagcca caaccattac gaagatctct tccactgctg
     4681 tctctaagct ggggaaggaa cgtaaacaca aagatctccc cagagctgca gcaggcagcc
     4741 caggagtgct gaatcaggaa ctacaggcag cactcagggg gagaggaaac cacacgttct
     4801 gagcactgag agggaacaca gctgcaaatg tgaggaaaca taggggagcc acacaacaga
     4861 acaagagtct tccagctgtc ctgtaagcct aggtatcacc tactgaatca cacctcaaaa
     4921 cttcaacacc aaaaatatct cactaatata tccccctctg aaacaagaga taagaagtga
     4981 gcatcaaaca cagaccctac acaaagcctt ggcccagtga aaacatccag aaaataagtt
     5041 gattgactat actcaaacta ctctgcagtt aaagaaacac ccacatgcag agatgagaaa
     5101 aaaaaaacaa tgtaagaact ctggtaactc aaatggccaa aatatcatat gtcctccaaa
     5161 tgatcacacc agttctccag caaaggtcct taaccaggcc aaactggcta gaatgacaga
     5221 aatagaattc agaatatgga tagaaaaaaa aagatcatgg aaattcagga ggatggcaaa
     5281 atccaatcca agaaaaataa gaatcacaat aaagtgacac agaagctgaa agaaaaatag
     5341 ccagtataaa aaagcactta gtgggtctga cagagctgaa tagcgcaata caagaattcc
     5401 acaatgcaat caaaagtatt aagagcagaa taaaccaagc tgaggaaaca atctcagaac
     5461 ttgatgctgg ttctctgaaa taagacagtc agacacaaat aaagaaaaaa aaagaaataa
     5521 acaaagcctc caagaagtat gggttatgta aacaggccaa atctacaagt aattgacatc
     5581 actgaaaggg aggggaagga agaaaacaac ttggaaaata tatttcagaa tattgtccat
     5641 gaaaatatcc ccaaccttgc tagagaggac aacagtcaaa ttcagtaaat acagagaagt
     5701 ccttcaagat tctacacaag aagataatca ccaagacaca taatcattat gttttccaag
     5761 gtcaaaataa aagaatgtta aaggcagcta taaggaaagg gtgagtcatc tacaaaggga
     5821 tccccgtcag gctaacagca gacctctcca ctggtaccct acaagccaga agagtttggg
     5881 gttttgtctt ccacatcctt aaagaaaata gtcttcaacc aagaatttca tatctagcca
     5941 aactaagctc ctaagtgaag gaataataca atccttctca gataagcaaa tgttgaggga
     6001 cttcattacc accagacctg ccttacaaga gatcttgaaa ggagcagtaa atatagaaag
     6061 gaaaaactgc taccagctaa tacaaaaaca cagttaaaca cagaaaccaa tgtcactatg
     6121 aagcaaccac acaaacaagt aaacataata accagctgac agcacaatga cagaatcaaa
     6181 tgcacacata tcagtattaa ccttgaatgt aaatgggcta aatgccccac taaaaaggca
     6241 cagagtggca agcaggataa aaaaggaaga cccaatggta tgctgtcttc aagagacccg
     6301 tctcacatgt aagacacaca caggctcaaa ataaagggaa ggagaaactt ccatggctga
     6361 tttgttactg ttgctgccaa atgtcacaga ctgaaagaat caaaattgta aaaatttcta
     6421 ttctaaccaa ttaatgtatg aattatgtga aataccaatc aaaatcacaa catgcttgtg
     6481 gaaactaaaa gttgattatg aaattaatac agaaaagagc aaagtatatc caagatattc
     6541 ttgcccttac aaatatcaat gtattcagaa gctatataag tgacataagc aagatgggga
     6601 gtcagggatc tcagccctca tcacccacag aaaacaactg gacagctatc tgtgcatgaa
     6661 aattgctata ggaaggctct gcagtccagt taaggagctg cagcaacaca gtgaagacaa
     6721 gtgaatgaac gtgttagtca gagttctcca gagagacaaa accaatagga tacatcagag
     6781 gagttcctga actccttaaa attgttggaa aaatattctg tatatataca tcttttttga
     6841 tcaaagcttt acatcatttg gattcacaag aaggaccatg agataacctc tgtgatagct
     6901 ctaggctgtt atcttgtagg ctttttcttt tcacatgtcc atgtgttatc tacacacaat
     6961 tgggttcttt tgctttaata tttgtgtgta tgtggagtat tcctttttct tttaaacaaa
     7021 ggtaagacta gactttctct gaatatgcta tttggcaact tggttttttt ttttccacta
     7081 aagatagcct tccaggtcag cacataaaga taaacatttt taatgtttgc atagtgtccc
     7141 tgcttaatat tacatagagt agctgggtca taattattta atcagtactc aaaaacatag
     7201 tatgagtgca aaaatgttca ctgatttgga gagaaagatt gtgttatggc aagttagaag
     7261 aaacagaata tgtgaaggtg aggaattcag aggaacctct ataggtcacc accttaggga
     7321 aaaaaaaaga caaaataagg attggaaaac tgcagaatgt ttaaatttgt taccaccaaa
     7381 gctgaaagca caatttgtgc agaaggagtt acggtacagc taaggctaac ctgcatctat
     7441 gctccagctt ccaggactcc tccctatgcc agagacatta taataacaga gaaaacaaca
     7501 acaacaacaa cttacaaata aaggatgtaa aatgaattat aatacaaggc aaggccacat
     7561 gtagtctagc taagcccatc ttgagggaag gtccagggac aaatttggaa aaaattatag
     7621 gataggcaac agataaaggt atgaagt
//
