LOCUS       NM_001005171            5456 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 52 subfamily K member 1
            (OR52K1), transcript variant 1, mRNA.
ACCESSION   NM_001005171 XM_372347
VERSION     NM_001005171.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5456)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 5456)
  AUTHORS   Kwee,L.C., Liu,Y., Haynes,C., Gibson,J.R., Stone,A.,
            Schichman,S.A., Kamel,F., Nelson,L.M., Topol,B., Van den
            Eeden,S.K., Tanner,C.M., Cudkowicz,M.E., Grasso,D.L., Lawson,R.,
            Muralidhar,S., Oddone,E.Z., Schmidt,S. and Hauser,M.A.
  TITLE     A high-density genome-wide association screen of sporadic ALS in US
            veterans
  JOURNAL   PLoS One 7 (3), e32768 (2012)
   PUBMED   22470424
REFERENCE   3  (bases 1 to 5456)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010930.9.
            
            On Jul 24, 2020 this sequence version replaced NM_001005171.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641528.1/ ENSP00000493011.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               AC010930.9         43010-43540
            532-5456            AC010930.9         48937-53861
FEATURES             Location/Qualifiers
     source          1..5456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..5456
                     /gene="OR52K1"
                     /gene_synonym="OR11-8"
                     /note="olfactory receptor family 52 subfamily K member 1"
                     /db_xref="GeneID:390036"
                     /db_xref="HGNC:HGNC:15222"
     exon            1..531
                     /gene="OR52K1"
                     /gene_synonym="OR11-8"
                     /inference="alignment:Splign:2.1.0"
     exon            532..5456
                     /gene="OR52K1"
                     /gene_synonym="OR11-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             860..1804
                     /gene="OR52K1"
                     /gene_synonym="OR11-8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     olfactory receptor 52K1; olfactory receptor OR11-8"
                     /codon_start=1
                     /product="olfactory receptor 52K1 isoform 1"
                     /protein_id="NP_001005171.2"
                     /db_xref="CCDS:CCDS31352.1"
                     /db_xref="GeneID:390036"
                     /db_xref="HGNC:HGNC:15222"
                     /translation="MLPSNITSTHPAVFLLVGIPGLEHLHAWISIPFCFAYTLALLGN
                     CTLLFIIQADAALHEPMYLFLAMLATIDLVLSSTTLPKMLAIFWFRDQEINFFACLVQ
                     MFFLHSFSIMESAVLLAMAFDRYVAICKPLHYTTVLTGSLITKIGMAAVARAVTLMTP
                     LPFLLRRFHYCRGPVIAHCYCEHMAVVRLACGDTSFNNIYGIAVAMFIVVLDLLFVIL
                     SYVFILQAVLQLASQEARYKAFGTCVSHIGAILSTYTPVVISSVMHRVARHAAPRVHI
                     LLAIFYLLFPPMVNPIIYGVKTKQIREYVLSLFQRKNM"
ORIGIN      
        1 cttagactga aagaggaagg cggcactggt gctgcatgaa gctaatgaaa agggcccagg
       61 attgtaagtc agactgagga ctgtggatac agctgcaact tagggaaata gaaaacaagt
      121 gatgttattg gggtgagcag gaaggtggga gtgagctgga aggtgggggc actgtcaatt
      181 tcttcccata gccattcctg atcttaggca tcagctctcc aaccctgtta ttgcttctac
      241 tctggtcctt caatagaggg aacagaagtc tcgatagtcc cacccaactg tttggtacac
      301 aaactccaga tgctctcccc accacagagg atgcctgctt ccgtcctatg ccaaacactg
      361 tgggccatct ccaagaagtc ttagttgatt attccagttt ggatctgtca cttctcacct
      421 cctgtcattg ctttttctaa cccctggcaa atgccccatc ccagttaaag ggcttctgca
      481 ttagtcaaga ggaagaaaac gaggcctgaa ctagaaagat ggcagggaaa ggtattcatg
      541 acatcaccaa gaacacagaa aacactacat atactccatt cctttatgaa agttgtctta
      601 gaatattaaa tatccataga attgatatcc catctactca atgagattca aatttctttg
      661 agggtagaaa atatggatta tacttctcca tgtctatgaa ggctgctagg ttattttgtt
      721 taaagtctag caatggaaac aagaggtaat ctttgcaggt gggatagcac aggttgaact
      781 ctaatcatat atactgtaga aggtatatat agaaggtgaa gaagccctgt aaaaattgac
      841 aaggagattt ccaggagcca tgcttccctc taatatcacc tcaacacatc cagctgtctt
      901 tttgttggta ggaattcctg gtttggaaca cctgcatgcc tggatctcca tccccttctg
      961 ctttgcttat actctggccc tgctaggcaa ctgtaccctt ctcttcatta tccaggctga
     1021 tgcagccctc catgaaccca tgtacctctt tctggccatg ttggcaacca ttgacttggt
     1081 tctttcttct acaacgctgc ccaaaatgct tgccatattc tggttcaggg atcaggagat
     1141 caacttcttt gcctgtctgg tccagatgtt cttccttcac tccttctcca tcatggagtc
     1201 agcagtgctg ctggccatgg cctttgaccg ctatgtggcc atctgcaagc cattgcacta
     1261 cacgacggtc ctgactgggt ccctcatcac caagattggc atggctgctg tggcccgggc
     1321 tgtgacacta atgactccac tccccttcct gctcagacgc ttccactact gccgaggccc
     1381 agtgattgcc cattgctact gtgaacacat ggctgtggta aggctggcgt gtggggacac
     1441 tagcttcaac aatatctatg gcattgctgt ggccatgttt attgtggtgt tggacctgct
     1501 ctttgttatc ctgtcttatg tcttcatcct tcaggcagtt ctccagcttg cctctcagga
     1561 ggcccgctac aaggcatttg ggacatgtgt gtctcacata ggtgccatcc tgtccaccta
     1621 cactccagta gtcatctctt cagtcatgca ccgtgtagcc cgccatgctg cccctcgtgt
     1681 ccacatactc cttgctattt tctatctcct tttcccaccc atggtcaatc ctatcatata
     1741 tggagtcaag accaagcaga ttcgtgagta tgtgctcagt ctattccaga gaaagaacat
     1801 gtagatggat agttctcttt ttttatccca cttgccaagt aatgagaatg ctggattggg
     1861 gttgagggga aaaatctaaa taggaaaatt gcagagtatc tttgacaatt ctctagtatg
     1921 ataaggaaaa tgaggtttca ttcctcacag atctacgagt caggtcaaac caggagtgca
     1981 cctatagtct ggtctgatag tagaggtttg accttcccat tgtcatagac tcatcacatg
     2041 gctaaggaag acaaacctct caaagtggta ttgtaatctg ggtgaaagac agtaggacct
     2101 ttattggctg agattggccc aaacagctga gtcacccaaa caggtgactt ctttatccag
     2161 gtatgagtga ggaaatgtac ctcaaatttt gtgaccccaa aaccattatt ccttttagta
     2221 ctgaaattac ccccatgtct tttctgacaa gtaccctcca ccctttgcca ctctttatag
     2281 cctactatct cccaatttta tttctacagt tagacagctc catttataag tagatctatt
     2341 tcttccatta agtcaattcc tcttttactt ccttcctgat agacatggcc aattccttta
     2401 gtgaacattt atcaaaagag tcctccgatg ttccttttta tcaatttata tcatgtatct
     2461 agcttttcac tgcatgtctt ttgcctccaa aatacttagt aatatttatt aaatgaacgg
     2521 atagaagagc tgaatactat ctttgaacta tgaaccatga aaagagaaat aacacccttc
     2581 cctcttgaag ctgagatttc tgaaaataag aaaatacaat actgtcacac actgcataat
     2641 gaagttttgg tcagtaatgg atcacctata tgatggtgat tgcataacat tatagtaccg
     2701 tatatttact gtatgttttt taacttttaa gttacatgta caggtttgtt atctaggtaa
     2761 agccatgtta tgggggtttt gttgtacaga ttatttcatc acccaagtat taagcctagt
     2821 attcattagc tatttttctg tttaaataca caaatactta ttgtgttaca attgcctaca
     2881 atattgggtt tgtagcctag gagcaacagg ctataccata tagcttaggt gtatagcaag
     2941 cgataccatc taggtttgtg taaatacact ctatgatgtt cacaggttga taaaatcacc
     3001 tgaggacaca tttctcagaa tgtatcccca tcattaagca atgcatgact agttagacat
     3061 gattgtagtt gtgatagact gtattactgt ccaccaatat ttagtctcct gtccttctat
     3121 catgggtagg gtatttcctt cactccacga attttaaact ttgctgtatg acttgatttg
     3181 gccaatgaaa tttgagtagc cctgaaatgt acttcgagaa tcagaaagtt tattaaaaaa
     3241 aacagatgct agtgaggttg tagagaaaag gaaacactta tatactgctg gtaggagtgt
     3301 aaattatttc acccattatg gaaagcagta ggtgattcct caaagaccta aaaacagaaa
     3361 taccatttga ctgagtgatc ctttagtggg tatgtaccca aaggaaccta agttgttcta
     3421 ccataaagat aacatgtatg tgtacattca ctgcagcact attcacaata gcaaagacac
     3481 ggaatcaacc taaaggccta tcaacagttg actggataaa gaaaatgtga tacatatgca
     3541 ccatggaata ctatgcagcc gtcaaaaaga ataagatcat gtcctttgca ggaacatgga
     3601 tggagctaga ggccattatt ctttgcaaac taaaagggga atagaaaaat aaaataccac
     3661 atgttctcac ttataagtgg gaactaaaca atgagaacac atggacacaa agaggagcag
     3721 gagacactgg ggcctattta aggtaggagg gagaggatca ggaaaaataa ctatcaggta
     3781 ctacgcctag tacctaggtg attaaagaac ttgtacaaca aactcccgtg acacaagttt
     3841 atttatataa cacacctgca catgtacctc taacctaaaa taaaagttaa aaaggacact
     3901 atgatattgg tgcaaagatc gaatggaaag gaacagaaag acaagaagtt gcctggtcca
     3961 tatagacacg tgttattgca gaggtgtgtg atacatatgc accatggaat actatacagc
     4021 catcaaaaag aaataagatc acgtcctttg tgggaacatg gatggagcta gaggccatta
     4081 ttctttgcaa attaaagtgt gcattaactt tcctgctttc tttcccctct gctgcaaaac
     4141 ccagcaaagt tccagttaga ggctgtgaca aagccaaagt ccacccacaa tgagtaagaa
     4201 gtgtaaatga gaaattgtgt ttgagctgct aaaaaaaaaa aataaacttt aaaatatggc
     4261 tggaaagctt atctttcatt ctttccctct accagaagaa taagcgtatc acagcctaga
     4321 ctcatgatga agatccatgg agcagatgtg aatctgactc actgcctgta gcatagtcat
     4381 aactgaccca cagtgttcat ataacatgaa caaggatgat tttgttgttt ttgtagtgaa
     4441 ccactgaaat ttgggagttg tttgtttcac agccttaccc aaggagcacc aattgctgga
     4501 gttgtgagtt ctatcttgca tttcaactca tgacagctca agactgaata tttaaaggaa
     4561 atacagtctt cttacagcat atcataaaat tatttcactt atctctgctt ttgtctttca
     4621 aactctcata atgaacactt cttcagtcag ttctacaaaa agaagctccc atacatactt
     4681 ttacatgatc tacttatact gtagggacca gccctacagg gtctgtgagt ttttcccctt
     4741 gtgtgcagag atgagagatc atagaaataa agacaaaaga taaagagaag aaaagacagc
     4801 tgggcctggg ggaccagtac caccaagatg cagagaccgg tagtggcccc gaatgcctgg
     4861 ctgcactgtt atttattgga tacaaggcaa aaggggcagg gtaaagagtg tgagtcatct
     4921 ccaatggttg ataaggtcac ataagtcacg tgtccactgg acagggggcc cttccctgtt
     4981 tggcagccaa gaaggagaga gagagaggac agcttacacc attatttctt ctatgcattt
     5041 caaagacttt tagtactttc acttattctg ctactgctat ctggaaggca gagccaggtg
     5101 tacagggtgg aacgtgaaag tgaaacagga gcgtgactgc tgaagcacag catcacaggg
     5161 atgctggatg ctgtggcctc cagatggctg tgggtgggcc tgactaatgt caggccttcc
     5221 acaagaggtg gtgaaacaga gtcttctcta actcccccag ggaaagggag actccctttc
     5281 tgggtctgtt agtaacgggt gtcttcccta ggaactgact actactagac cacagtccac
     5341 taggtaatgg gtgccttccc aggcactggc attaccgcta gaccaaggag ccctctagtg
     5401 gccctgtccg ggcgtgacag aggctcacac ttgtcttctg gtcacttctc accgcg
//
