LOCUS       NM_001005161            1124 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 52 subfamily B member 4
            (OR52B4), transcript variant 1, coding, mRNA.
ACCESSION   NM_001005161 XM_089858
VERSION     NM_001005161.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1124)
  AUTHORS   Riaz,M., Lores-Motta,L., Richardson,A.J., Lu,Y., Montgomery,G.,
            Omar,A., Koenekoop,R.K., Chen,J., Muether,P., Altay,L., Schick,T.,
            Fauser,S., Smailhodzic,D., van Asten,F., de Jong,E.K., Hoyng,C.B.,
            Burdon,K.P., MacGregor,S., Guymer,R.H., den Hollander,A.I. and
            Baird,P.N.
  TITLE     GWAS study using DNA pooling strategy identifies association of
            variant rs4910623 in OR52B4 gene with anti-VEGF treatment response
            in age-related macular degeneration
  JOURNAL   Sci Rep 6, 37924 (2016)
   PUBMED   27892514
  REMARK    GeneRIF: The association of variant rs4910623 in OR52B4 gene with
            anti-VEGF treatment response in age-related macular degeneration.
            OR52B4 single nucleotide polynorphism rs4910623 allele frequency in
            age-related macular degeneration patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1124)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1124)
  AUTHORS   Swaminathan,S., Huentelman,M.J., Corneveaux,J.J., Myers,A.J.,
            Faber,K.M., Foroud,T., Mayeux,R., Shen,L., Kim,S., Turk,M.,
            Hardy,J., Reiman,E.M. and Saykin,A.J.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative  and  NIA-LOAD/NCRAD
            Family Study Group
  TITLE     Analysis of copy number variation in Alzheimer's disease in a
            cohort of clinically characterized and neuropathologically verified
            individuals
  JOURNAL   PLoS One 7 (12), e50640 (2012)
   PUBMED   23227193
REFERENCE   4  (bases 1 to 1124)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1124)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1124)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009758.8.
            
            On Jan 20, 2010 this sequence version replaced NM_001005161.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Transcript Variant: This variant (1, coding) represents the
            protein-coding allele encoded by the GRCh38 reference genome.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC140928.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000624801.3/ ENSP00000485530.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1124              AC009758.8         136595-137718
FEATURES             Location/Qualifiers
     source          1..1124
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1124
                     /gene="OR52B4"
                     /gene_synonym="OR11-3"
                     /note="olfactory receptor family 52 subfamily B member 4"
                     /db_xref="GeneID:143496"
                     /db_xref="HGNC:HGNC:15209"
     exon            1..1124
                     /gene="OR52B4"
                     /gene_synonym="OR11-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1036
                     /gene="OR52B4"
                     /gene_synonym="OR11-3"
                     /note="olfactory receptor OR11-3"
                     /codon_start=1
                     /product="olfactory receptor 52B4"
                     /protein_id="NP_001005161.2"
                     /db_xref="GeneID:143496"
                     /db_xref="HGNC:HGNC:15209"
                     /translation="MPTVNHSGTSHTVFHLLGIPGLQDQHMWISIPFFISYVTALLGN
                     SLLIFIILTKRSLHEPMYLFLCMLAGADIVLSTCTIPQALAIFWFRAGDISLDRCITQ
                     LFFIHSTFISESGILLVMAFDHYIAICYPLRYTTILTNALIKKICVTVSLRSYGTIFP
                     IIFLLKRLTFCQNNIIPHTFCEHIGLAKYACNDIRINIWYGFSILMSTVVLDVVLIFI
                     SYMLILHAVFHMPSPDACHKALNTFGSHVCIIILFYGSGIFTILTQRFGRHIPPCIHI
                     PLANVCILAPPMLNPIIYGIKTKQIQEQVVQFLFIKQK"
ORIGIN      
        1 agctcctggt gacatcgcaa agaatgttgc agattttatc ttcttctacc tctgtgagta
       61 ggaggtgagg ttctgaaagt tctccccagc tatgcctact gtaaaccaca gtggcactag
      121 ccacacagtc ttccacttgc tgggcatccc tggcctacag gaccagcaca tgtggatttc
      181 tatcccattc ttcatttcct atgtcaccgc ccttcttggg aacagcctgc tcatcttcat
      241 tatcctcaca aagcgcagcc tccatgaacc catgtacctc ttcctctgca tgctggctgg
      301 agcagacatt gtcctctcca cgtgcaccat tcctcaggcc ttagctatct tctggttccg
      361 tgctggggac atctccctgg atcgttgcat cactcagctc ttcttcatcc attccacctt
      421 catctctgag tcagggatct tgctggtgat ggcctttgac cactatattg ccatatgcta
      481 cccactgagg tacaccacca ttcttacaaa tgctctgatc aagaaaattt gtgtgactgt
      541 ctctctgaga agttatggta caattttccc tatcatattt cttttaaaaa gattgacttt
      601 ctgccagaat aatattattc cacacacctt ttgtgaacac attggcctag ccaaatatgc
      661 atgtaatgac attcgaataa acatttggta tgggttttcc attctaatgt cgacggtggt
      721 cttagatgtt gtactaattt ttatttccta tatgctgatt ctccatgctg tcttccacat
      781 gccttctcca gatgcttgcc acaaagctct caacacattt ggctcccatg tctgcatcat
      841 catcctcttt tatgggtctg gcatcttcac aatccttacc cagaggtttg gacgccacat
      901 tccaccttgt atccacatcc cgttggctaa tgtctgcatt ctggctccac ctatgctgaa
      961 tcccattatt tatgggatca aaaccaagca aatccaggaa caggtggttc agtttttgtt
     1021 tataaaacag aaataacttt ggtttaagaa ctgagttttc agaatctcta gctatctggt
     1081 aagtgggtat gaaagtggta gatgggagag gtcagctgat accg
//
