LOCUS       NM_012375               6178 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 52 subfamily A member 1
            (OR52A1), mRNA.
ACCESSION   NM_012375
VERSION     NM_012375.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6178)
  AUTHORS   Joslyn,G., Ravindranathan,A., Brush,G., Schuckit,M. and White,R.L.
  TITLE     Human variation in alcohol response is influenced by variation in
            neuronal signaling genes
  JOURNAL   Alcohol Clin Exp Res 34 (5), 800-812 (2010)
   PUBMED   20201926
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   2  (bases 1 to 6178)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 6178)
  AUTHORS   Bulger,M., Bender,M.A., van Doorninck,J.H., Wertman,B.,
            Farrell,C.M., Felsenfeld,G., Groudine,M. and Hardison,R.
  TITLE     Comparative structural and functional analysis of the olfactory
            receptor genes flanking the human and mouse beta-globin gene
            clusters
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14560-14565 (2000)
   PUBMED   11121057
REFERENCE   4  (bases 1 to 6178)
  AUTHORS   Feingold,E.A., Penny,L.A., Nienhuis,A.W. and Forget,B.G.
  TITLE     An olfactory receptor gene is located in the extended human
            beta-globin gene cluster and is expressed in erythroid cells
  JOURNAL   Genomics 61 (1), 15-23 (1999)
   PUBMED   10512676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129505.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2020 this sequence version replaced NM_012375.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380367.3/ ENSP00000369725.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               AC129505.8         28047-28357         c
            312-6178            AC129505.8         20424-26290         c
FEATURES             Location/Qualifiers
     source          1..6178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..6178
                     /gene="OR52A1"
                     /gene_synonym="HPFH1OR"
                     /note="olfactory receptor family 52 subfamily A member 1"
                     /db_xref="GeneID:23538"
                     /db_xref="HGNC:HGNC:8318"
     exon            1..311
                     /gene="OR52A1"
                     /gene_synonym="HPFH1OR"
                     /inference="alignment:Splign:2.1.0"
     exon            312..6178
                     /gene="OR52A1"
                     /gene_synonym="HPFH1OR"
                     /inference="alignment:Splign:2.1.0"
     CDS             633..1571
                     /gene="OR52A1"
                     /gene_synonym="HPFH1OR"
                     /note="olfactory receptor OR11-319; odorant receptor
                     HOR3'beta4"
                     /codon_start=1
                     /product="olfactory receptor 52A1"
                     /protein_id="NP_036507.2"
                     /db_xref="CCDS:CCDS31374.1"
                     /db_xref="GeneID:23538"
                     /db_xref="HGNC:HGNC:8318"
                     /translation="MSISNITVYMPSVLTLVGIPGLESVQCWIGIPFCAIYLIAMIGN
                     SLLLSIIKSERSLHEPLYIFLGMLGATDIALASSIMPKMLGIFWFNVPEIYFDSCLLQ
                     MWFIHTLQGIESGILVAMALDRYVAICYPLRHANIFTHQLVIQIGTMVVLRAAILVAP
                     CLVLIKCRFQFYHTTVISHSYCEHMAIVKLAAANVQVNKIYGLFVAFTVAGFDLTFIT
                     LSYIQIFITVFRLPQKEARFKAFNTCIAHICVFLQFYLLAFFSFFTHRFGSHISPYIH
                     ILFSSIYLLVPPFLNPLVYGAKTTQIRIHVVKMFCS"
ORIGIN      
        1 aattcatccc gtgtttcaga atgctacaga cctcactatg agttttactg ggggatgagc
       61 acacaaagat ggtctgagac agacttccag aagaagaaga agatgtccgt gttagagata
      121 aatgaaaagt gtaaaaagtc atctgcaaaa tgtccacagt atattatatt ggcacatatc
      181 ctggcaccaa acagagtaaa atttatgaca ttagctggat gctgttacac agagtgcaga
      241 cagaaagtag agccatcaca gaacccacaa cttaagggaa tgaagctgga atccttggag
      301 aagaaaaatt ggtctggaaa gaaataacag actggccagt agtccaatcc cctgtccagg
      361 tgattttgct ggttctaatg tatttggatt gccatgcaca taacatccta ttatggcaca
      421 gtgcctgtga atgccccacc tgaaaacagt gatgtatctc catgaatcca tcttttcctt
      481 tcaaaactgt gaataagatg gatgatttta gagttatacc caaatcagac agactcaata
      541 taatgagttt ggagaaaatc agaaagcaga agaggaacag taacactgac tgagaaactt
      601 cttttgtttg catcaggaga cccaacgaca ctatgtccat ttccaacatc acagtctaca
      661 tgccctctgt gttgacacta gtagggatcc caggcctaga atctgtgcag tgctggattg
      721 ggattccatt ctgtgccatt tatctcattg ctatgattgg aaattccttg cttctgagca
      781 tcatcaaatc tgagcgcagt ctccatgagc ccttgtacat tttcttaggc atgctaggag
      841 ccacagacat tgcacttgct agcagcatta tgccaaagat gcttggaata ttctggttta
      901 atgtgcctga aatctatttt gattcctgct tgcttcaaat gtggttcatc cacacattgc
      961 agggtataga gtcaggcatc cttgtggcca tggccctgga ccgttatgtg gccatctgtt
     1021 atccactaag acatgccaac atcttcaccc accagcttgt cattcagata ggaactatgg
     1081 tcgtactcag ggctgctatt cttgtagccc catgcctagt actgataaag tgccggtttc
     1141 aattttatca cacaacagtc atctcccact cctactgtga gcatatggcc attgtgaaac
     1201 tagcagcagc aaatgttcaa gtcaacaaaa tctatggttt gtttgtggcc ttcactgtag
     1261 caggatttga cctcacattc atcacattgt cctacatcca gatatttatc acagtttttc
     1321 gtttgcccca gaaggaggct aggtttaaag cattcaatac ctgcattgct cacatctgtg
     1381 tcttcctcca gttctacctc cttgccttct tctccttctt cacacatagg tttgggtctc
     1441 acatctcccc ttatatccat attctctttt ctagcattta cttgctggtc cctccatttc
     1501 tcaatccact tgtctatggt gcaaagacca cacagattcg cattcatgtg gtaaaaatgt
     1561 tctgttcata aaatccacct taattaatgc ctacatgctt ttttcttttg cagtagtaac
     1621 catatcaaaa caaaacaaaa aacatattat ttgagatgct gggtttgtga aatctgccag
     1681 cacaatagct ggttttagat catcatggct catatcaatc agtgggattg tgaattctac
     1741 gtgactaatg aaagtgagaa gtgtgaaatg agtgaagtag tgaatatata ttattttttc
     1801 tcttttattc tttagcccct ggttgagtta ttcttctaag aatatttctc caggaggatt
     1861 tataaattat gcctttgtca ctgaatttaa atgcacctaa ggctcgttgt tctgaaacat
     1921 ccagggactc aatgaaaaca agttgttgac tctcattttc ttgatcatcc ctgccttaaa
     1981 aaaaaaaatc aaaggaagta catgttaact gtgttcttgt caaagaaaat cttatgaata
     2041 tcaagagaca ataaagccta aaaatttaaa tacattttca gagtcataca aggaattaca
     2101 ggcacaaaaa ttagaaccag gtgttgcatt tgacacatca atgttgttgt tttttttttt
     2161 gctaacctca aaatttactt ctttattaat tcatcatttt atcaaaaacc tgcaatatta
     2221 aaaatactat actacagaat cgtgacataa tagtaaatct ggcacagtga ataattctca
     2281 tgagtttgta cctatgtaat tctggaaaag agagactgaa aggaagagag gtggggaatg
     2341 ggcaggcaag ggaaagaaga gagaaataac aagtgtacac ataggatgtg gagttcagag
     2401 agaatgaagc attgaaatct aaccaaagca ggggagttgc atttattgta ttttgttttt
     2461 tggttaggta gttacctctg attcttgagg aatgatggat gagtagccaa ggaagtaaga
     2521 acacatcatg ccaggtagat agtagaggag atttaaacta gataatgtag tttaaggtaa
     2581 ctctagtttt ttcaatatgg tatgagtgca aggtagaact tggggagaca aggaaaatat
     2641 gaatatcaaa aatggctatt aatgttgtgc agagttgctg gactttattc caaaagctat
     2701 aatgtgccat tggagagtat tcatttgttt gcttgtgttc tacaagtaag acgtgtgtgt
     2761 gtgtgtgtgt gtgtgtgtgt gtgtgtgtct gcttgggcat gtggcagcat accacacagc
     2821 aaatataaat aagtctaggg ctattgtgtt agtgaagagg aggactatat tgtctaaaat
     2881 tagtggcata agaatttacg gctagtcaat tgttcttgaa aaacctcagg tcatagatca
     2941 tttttttcaa ggttatggaa aatattcaca tatgggcaga tgtccatact ttgatttacc
     3001 agattaaaac cactgcaaat ataagaaata ttggattgct tgtcatacac ccacctggtg
     3061 gatcctctgg cttcacggat taggacttag cagatatcca tggctgttga gaatgattat
     3121 agaggctatc ttaagggatc ttttgagact gtttcaagtt tcaatatcta ctagagctaa
     3181 ttttattgga ttaccaatag ggatggtttt tcttaagtaa cataattttc tcaaaaataa
     3241 aatagcctct gatgttattt cttaatattt tagccagaat tcagcaaact tttacataaa
     3301 tggccaaata atatatagct aaggctttat ggaaaaagag gcaaattcaa gaatatcatg
     3361 taggcattaa tataacaaga tagaaaaatg tatgtccaca aataattttt atgaaattca
     3421 aacaatatta acaataataa ttgcattgtc tttaattaaa gaaggtctac taattaaaat
     3481 aatagaatcc attttttttt tctacagagt aacaaagtgt agctgaaagt tagagtttcc
     3541 ccatcaccaa attgattaca aatattcatc tgtaaaaatc attcttaact agtggactat
     3601 agaaaacagg aagtaggcca ggtttgggat gtttaacaat gaccacttta agcagcacca
     3661 ccaaaaatat gtggtaatat aggtccaaca aagagacaca atgtgaaact acaacatatt
     3721 tgcaccatct ccgaatttta atatctcata aaatatgtag tccagagttc atattgttta
     3781 attactgtag tcttcaaatt tcaggatcag tcccaagctg agacttacta atagaaaaca
     3841 gaagaaacaa ataggtcatt acaaggaaaa gaggataacc aggaccctct aacctcccac
     3901 acacttggac ggggacaatt attgaaaaaa aatctttaac ataaaattgc ttgaaagata
     3961 ataatatttt ttgtaaggat aattttcaag aaaggtttct agaaatcata aaattaactt
     4021 ccaggagatt acatcaattt caacaatgac taaaataatg tttgcctaaa ttcttaacaa
     4081 cactagttat taccgatatt tacctttgac agtttgatag gtgaaatatg attcccttta
     4141 taattagcat ttaacaaaga aatatttgtg ctgctatctt cttttccgtt tgtacattct
     4201 ttatgtgaag tacttcattg tttcctttgt tcatttttct aatttgtgtc catttatttt
     4261 cttcttgagt ttaaaatttg atgagtaaat attgaattat ttccaagggc tttattgctc
     4321 aggactttac cagaggattt ccaataggct attggcattt tctagtagaa gtgacttcag
     4381 gcataaagaa gaaaagaaaa agtaaaaagt cttaacattg gagacctttg acctattagg
     4441 agcagaacgc ttggtgaaaa aaaaaaaatg ctttcaggcc gggtgcggtg gctcacgcct
     4501 gtaatcccag cactttggga gacggaggtg ggtggatcat gaggtcagga gttcaagacc
     4561 agcctggcca agatggtgaa accccatctc taccaaaaat acaaaaaatt agatgggcgt
     4621 gttggggggg tgcctgtaat cccagctact cgggaggctg aggcaggaga attgcttgaa
     4681 ctcggagggc ggaggttgcg gtgacccgag atggtgccac tgcactccag cctgggtgac
     4741 atagtgagac accgtctcaa aaaaaaaaaa aaaagatttc aggaactgaa ccttctagct
     4801 ttttgcagcc cttcatttaa atgttcaatt tgggaaaaat aacttacaac atttggctca
     4861 tttccaccct tcttggtaga gaactgtcct ttggcaacaa gccttctatg ctgatattcc
     4921 taagcggtct ccatttcaat gtgagaatac atcaatatta ccctcaattt attgttaaat
     4981 ggacgacctt ttgagatttg gttagcaggc ctatttggct ttaatactaa gctgtatgcc
     5041 tgtatttaaa cagtattaaa aatgcaagtg attcctagct actcctgagg ctaaggcagg
     5101 agaatcgctt gaacccggga ggcagaagtt gcggtgagtc gagatgtctc cactgcactc
     5161 cagcctgggc gacagagcaa gactctgtct ccgaaaaaaa aaaaaaaata caggtaatat
     5221 tttgtcctac cacatctatt tataatttct aaaattgctc agaatttgta ttaataagga
     5281 ttcttcacag tacaaaacca ataggttatg catacatata tgtatataca catatatgca
     5341 gatatgtata cctatacata tatatctgta tctatgtatc tatatgagat agattaattt
     5401 taagaacctg actcacacag ttatgaaggc tggcaaatcc aaaatctgca gggagagcct
     5461 ataggctgga gactcaggga agagccagtg ttgtaattta agtccaaagg cagtctcctg
     5521 gcagaattct ctcttgattg gggcaagtca gtcttttgtt ctatccaggc cttcaactgc
     5581 ttggaaggca cattataaag gtcaatatgc tttactcaaa gtttattaat ttaaatgcca
     5641 gtctcatcca gaaataccca cacagaaaca tccagaataa tatctgacca gaatctgggc
     5701 attgtgcccc aatcaaattg acacatacaa ctattcagtg tgaaaaaacc aaggcagaga
     5761 gcaggtaagt acagcacctc cccacaccag agactcaaca tcatggttta caagttacta
     5821 aagaataata ttgggacaaa ataaagcttg taggaattca tccacgttca accattgatg
     5881 tgctgatctc agtgttgtaa agatatcaat tctccttaaa tttaatctag aaatgtagag
     5941 taatcttaag cagaatgctg tcagactttt ctggcataag tgcaaatgct ttaaaaaaat
     6001 atttaattaa agaagtaaaa actgaaagtg aaatgtatga tagagttctg ataaatacct
     6061 ctgccctata ttctaagatt tcagatttag atgatgactc tctaaagagt cgaggatggg
     6121 aacagaggac agtaactgtg gtcgcctcca tgcaaggtct gagactaaca tacacaat
//
