LOCUS       NM_001004754            3302 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 51 subfamily I member 2
            (OR51I2), transcript variant 1, coding, mRNA.
ACCESSION   NM_001004754 XM_372357
VERSION     NM_001004754.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3302)
  AUTHORS   Milton,J.N., Rooks,H., Drasar,E., McCabe,E.L., Baldwin,C.T.,
            Melista,E., Gordeuk,V.R., Nouraie,M., Kato,G.R., Minniti,C.,
            Taylor,J., Campbell,A., Luchtman-Jones,L., Rana,S., Castro,O.,
            Zhang,Y., Thein,S.L., Sebastiani,P., Gladwin,M.T. and
            Steinberg,M.H.
  CONSRTM   Walk-PHAAST Investigators
  TITLE     Genetic determinants of haemolysis in sickle cell anaemia
  JOURNAL   Br J Haematol 161 (2), 270-278 (2013)
   PUBMED   23406172
  REMARK    Erratum:[Br J Haematol. 2014 Aug;166(3):468. Kato, Gregory R
            [corrected to Kata, Gregory J]]
REFERENCE   2  (bases 1 to 3302)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 3302)
  AUTHORS   Bulger,M., Bender,M.A., van Doorninck,J.H., Wertman,B.,
            Farrell,C.M., Felsenfeld,G., Groudine,M. and Hardison,R.
  TITLE     Comparative structural and functional analysis of the olfactory
            receptor genes flanking the human and mouse beta-globin gene
            clusters
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14560-14565 (2000)
   PUBMED   11121057
REFERENCE   4  (bases 1 to 3302)
  AUTHORS   Bulger,M., van Doorninck,J.H., Saitoh,N., Telling,A., Farrell,C.,
            Bender,M.A., Felsenfeld,G., Axel,R. and Groudine,M.
  TITLE     Conservation of sequence and structure flanking the mouse and human
            beta-globin loci: the beta-globin genes are embedded within an
            array of odorant receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 5129-5134 (1999)
   PUBMED   10220430
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Jul 6;96(14):8307. von
            Doorninck JH [corrected to van Doorninck JH]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087380.3.
            
            On Aug 11, 2020 this sequence version replaced NM_001004754.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1, coding) represents the
            protein-coding allele encoded by the GRCh38 reference genome.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641930.1/ ENSP00000493016.1
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC087380.3         95067-95108
            43-3302             AC087380.3         99003-102262
FEATURES             Location/Qualifiers
     source          1..3302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..3302
                     /gene="OR51I2"
                     /gene_synonym="OR11-38"
                     /note="olfactory receptor family 51 subfamily I member 2"
                     /db_xref="GeneID:390064"
                     /db_xref="HGNC:HGNC:15201"
     exon            1..42
                     /gene="OR51I2"
                     /gene_synonym="OR11-38"
                     /inference="alignment:Splign:2.1.0"
     exon            43..3302
                     /gene="OR51I2"
                     /gene_synonym="OR11-38"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1211
                     /gene="OR51I2"
                     /gene_synonym="OR11-38"
                     /note="olfactory receptor OR11-38; HOR5'Beta12; odorant
                     receptor HOR5'beta12"
                     /codon_start=1
                     /product="olfactory receptor 51I2"
                     /protein_id="NP_001004754.1"
                     /db_xref="CCDS:CCDS31383.1"
                     /db_xref="GeneID:390064"
                     /db_xref="HGNC:HGNC:15201"
                     /translation="MGLFNVTHPAFFLLTGIPGLESSHSWLSGPLCVMYAVALGGNTV
                     ILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMF
                     LIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLP
                     FLIKRLPICRSNVLSHSYCLHPDMMRLACADISINSIYGLFVLVSTFGMDLFFIFLSY
                     VLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPCYIHVLM
                     SNVYLFVPPVLNPLIYSAKTKEIRRAIFRMFHHIKI"
ORIGIN      
        1 ggaagaactt gttctgtggg tgtctcatca gtctctcttc tgagggaaat attagctcag
       61 cctgcaggct gatcatcata aaatatgaag aaaaggagtt tgcctgcatc atctcaaaag
      121 cagtgatttc atgaatgcgt cagtttccat ttatgtcaac atcatcgctt tgtctcttat
      181 ctcctgattt cttgtcctcc agcaagtgca actgttagaa ttctccaagt cagaagatct
      241 gactctgaaa agtaccctaa gtttgttttg ctatggggtt gttcaatgtc actcaccctg
      301 cattcttcct cctgactggt atccctggtc tggagagctc tcactcctgg ctgtcagggc
      361 ccctctgcgt gatgtatgct gtggcccttg ggggaaatac agtgatcctg caggctgtgc
      421 gagtggagcc cagcctccat gagcccatgt actacttcct gtccatgttg tccttcagtg
      481 atgtggccat atccatggcc acactgccca ctgtactccg aaccttctgc ctcaatgccc
      541 gcaacatcac ttttgatgcc tgtctaattc agatgtttct tattcacttc ttctccatga
      601 tggaatcagg tattctgctg gccatgagtt ttgaccgcta tgtggccatt tgtgacccct
      661 tgcgctatgc aactgtgctc accactgaag tcattgctgc aatgggttta ggtgcagctg
      721 ctcgaagctt catcaccctt ttccctcttc cctttcttat taagaggctg cctatctgca
      781 gatccaatgt tctttctcac tcctactgcc tgcacccaga catgatgagg cttgcctgtg
      841 ctgatatcag tatcaacagc atctatggac tctttgttct tgtatccacc tttggcatgg
      901 acctgttttt tatcttcctc tcctatgtgc tcattctgcg ttctgtcatg gccactgctt
      961 cccgtgagga acgcctcaaa gctctcaaca catgtgtgtc acatatcctg gctgtacttg
     1021 cattttatgt gccaatgatt ggggtctcca cagtgcaccg ctttgggaag catgtcccat
     1081 gctacataca tgtcctcatg tcaaatgtgt acctatttgt gcctcctgtg ctcaaccctc
     1141 tcatttatag cgccaagaca aaggaaatcc gccgagccat tttccgcatg tttcaccaca
     1201 tcaaaatatg actttcacac ttggctttag aatctgttat tttggccata ggctctcatc
     1261 agtagcatcg tcatcatcat catcaaagta taagatagat tgtgtgctgc gggaaaagta
     1321 ggccaggaga tggtgatgca aaacttataa cacaaaacaa ggagttccaa atgaatagta
     1381 cattcactaa ataccaacag tattcttaga aagataaata ttgggggcaa ttgagtaatt
     1441 agacaagttt tacagaggaa gactaattta agctaggaat tattttctat aataatgaat
     1501 attactaata taataattaa caaacttagt cctaaaatgt atcaagtact attataaatt
     1561 atttgtgtgt attaattcac ttaatattca tacaaatcct ctaagacaca gagaattaag
     1621 ttaattcttc agcctaacac agataatatg tggtccagtt gacattcaac actaatctct
     1681 ctctagtgtc agtgcagcac ccaaccggta taaatatggc ctgacggtca aattggcatc
     1741 atttaacatt accattgctg cctttgcttt ccccaccact gtcattctca aacactcata
     1801 cattgcttta acttcacaaa gtgaaatcag cttaactatt agaactcacc ataaaatgta
     1861 tgaacaaatg tgatccaggt aaactgatag atattgccat ttaggaaaat ctccagattc
     1921 ttctttactt cttttatctg cccaccactc aatccttacc aacagaaaac aatgttcaat
     1981 atctgaaata tctgactcat agaattttgg gggaaagggg gaattgtggt aggggcacaa
     2041 tttctatttc tctttccttc ttgagatttt aactgtcttc cacaaaatga catgttaaga
     2101 gatgttagaa attaagtcag tctaggattt ccagttgcaa aaaaaaaaag cctaggatag
     2161 acagactaga gcacttatgg tttagatacc agaaaataat tctttcagac cttctcatac
     2221 gcttcccttg ataccagagg taggatatag taagaaattc cttggtgcta attttggtgc
     2281 tgtcatacta agtttagatc tacttgtaga tcaaaagaga gcgagggatt gggggagaaa
     2341 gaagggggga gagagagaga gaaagagaaa gagagaaaga gaaaaagaga aagagaaaga
     2401 gagaaagaga gagagagaga tgcactaggt agtctaactt aactcaccat ggaaactcat
     2461 ccagaaacca cgtagtagca aagcatattg ttatctagag gttttttctc tttgtattga
     2521 ggaaatacca acaagagaga gagtcagaaa gagggagcta ttttaaaaat gagataatgt
     2581 aagtacttgg gattcagatt tttttcaaaa atgtctacag gtacaataag acaccaataa
     2641 tatatgtgtc ctggcccact aaatagattg cttttagaag aatgtttgga tagcataact
     2701 tagtatgatt tccaatggaa aattattaga atatttagtg gtttaaagta tggtcttcag
     2761 tcaatttaaa taataacttt tctgattcat attagaagct cctatttcaa catgaaataa
     2821 taattttaat gctttgatat tttagtttca aatatataca acaaatacat aaatgcaaag
     2881 gcaaggctta gggaagccgc caaatgaaag taaactctca ctgattccta cctcagaagc
     2941 agcgagggat acattctttt gaccataggc cttacttaga aacccaatgg tgtaacatag
     3001 aaagggcaag gaacaagaaa atatgagcct cccaaaaagc ctctggctcc tttgtacctt
     3061 aatttcacct tccttttttc agcattaatt aaaagagcta ctgattttca ggttctaatg
     3121 gaaaatgcac atttatattt ttccctccct catgagacag atgccataag aaaaatgtag
     3181 ggccactcct gcagctctaa tcctaaaaag gtctaagcta agccctgttt ttgttttttt
     3241 gaccttgggt taaaaactct ttaacttctt tttatttaac ataatctttt ttgaactcaa
     3301 ca
//
