LOCUS       NM_030774               2792 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 51 subfamily E member 2
            (OR51E2), mRNA.
ACCESSION   NM_030774
VERSION     NM_030774.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2792)
  AUTHORS   Billesbolle,C.B., de March,C.A., van der Velden,W.J.C., Ma,N.,
            Tewari,J., Del Torrent,C.L., Li,L., Faust,B., Vaidehi,N.,
            Matsunami,H. and Manglik,A.
  TITLE     Structural basis of odorant recognition by a human odorant receptor
  JOURNAL   Nature 615 (7953), 742-749 (2023)
   PUBMED   36922591
  REMARK    GeneRIF: Structural basis of odorant recognition by a human odorant
            receptor.
REFERENCE   2  (bases 1 to 2792)
  AUTHORS   Li,Y., Li,Q., Li,D., Gu,J., Qian,D., Qin,X. and Chen,Y.
  TITLE     Exosome carrying PSGR promotes stemness and epithelial-mesenchymal
            transition of low aggressive prostate cancer cells
  JOURNAL   Life Sci 264, 118638 (2021)
   PUBMED   33164833
  REMARK    GeneRIF: Exosome carrying PSGR promotes stemness and
            epithelial-mesenchymal transition of low aggressive prostate cancer
            cells.
REFERENCE   3  (bases 1 to 2792)
  AUTHORS   Pronin,A. and Slepak,V.
  TITLE     Ectopically expressed olfactory receptors OR51E1 and OR51E2
            suppress proliferation and promote cell death in a prostate cancer
            cell line
  JOURNAL   J Biol Chem 296, 100475 (2021)
   PUBMED   33640452
  REMARK    GeneRIF: Ectopically expressed olfactory receptors OR51E1 and
            OR51E2 suppress proliferation and promote cell death in a prostate
            cancer cell line.
REFERENCE   4  (bases 1 to 2792)
  AUTHORS   Kerslake,R., Hall,M., Randeva,H.S., Spandidos,D.A., Chatha,K.,
            Kyrou,I. and Karteris,E.
  TITLE     Co-expression of peripheral olfactory receptors with SARS-CoV-2
            infection mediators: Potential implications beyond loss of smell as
            a COVID-19 symptom
  JOURNAL   Int J Mol Med 46 (3), 949-956 (2020)
   PUBMED   32705281
  REMARK    GeneRIF: Coexpression of peripheral olfactory receptors with
            SARSCoV2 infection mediators: Potential implications beyond loss of
            smell as a COVID19 symptom.
REFERENCE   5  (bases 1 to 2792)
  AUTHORS   Abaffy,T., Bain,J.R., Muehlbauer,M.J., Spasojevic,I., Lodha,S.,
            Bruguera,E., O'Neal,S.K., Kim,S.Y. and Matsunami,H.
  TITLE     A Testosterone Metabolite 19-Hydroxyandrostenedione Induces
            Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via
            an Ectopic Olfactory Receptor
  JOURNAL   Front Oncol 8, 162 (2018)
   PUBMED   29892571
  REMARK    GeneRIF: Olfactory receptor OR51E2, also known as a Prostate
            Specific G-Protein Receptor, is highly expressed in prostate
            cancer.  We identified 24 agonists and 1 antagonist for this
            receptor. We detected that agonist 19-hydroxyandrostenedione, a
            product of the aromatase reaction, is endogenously produced upon
            receptor activation and contributes to neuroendocrine
            transdifferentiation of prostate cancer LNCaP cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2792)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   7  (bases 1 to 2792)
  AUTHORS   Yuan,T.T., Toy,P., McClary,J.A., Lin,R.J., Miyamoto,N.G. and
            Kretschmer,P.J.
  TITLE     Cloning and genetic characterization of an evolutionarily conserved
            human olfactory receptor that is differentially expressed across
            species
  JOURNAL   Gene 278 (1-2), 41-51 (2001)
   PUBMED   11707321
REFERENCE   8  (bases 1 to 2792)
  AUTHORS   Xia,C., Ma,W., Wang,F., Hua,Sb. and Liu,M.
  TITLE     Identification of a prostate-specific G-protein coupled receptor in
            prostate cancer
  JOURNAL   Oncogene 20 (41), 5903-5907 (2001)
   PUBMED   11593396
REFERENCE   9  (bases 1 to 2792)
  AUTHORS   Xu,L.L., Stackhouse,B.G., Florence,K., Zhang,W., Shanmugam,N.,
            Sesterhenn,I.A., Zou,Z., Srikantan,V., Augustus,M., Roschke,V.,
            Carter,K., McLeod,D.G., Moul,J.W., Soppett,D. and Srivastava,S.
  TITLE     PSGR, a novel prostate-specific gene with homology to a G
            protein-coupled receptor, is overexpressed in prostate cancer
  JOURNAL   Cancer Res 60 (23), 6568-6572 (2000)
   PUBMED   11118034
REFERENCE   10 (bases 1 to 2792)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090719.8 and AK314051.1.
            
            On May 17, 2019 this sequence version replaced NM_030774.3.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY033942.1, SRR1803616.125178.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155984 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396950.4/ ENSP00000380153.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC090719.8         10983-10989
            8-337               AK314051.1         1-330
            338-2792            AC090719.8         26211-28665
FEATURES             Location/Qualifiers
     source          1..2792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2792
                     /gene="OR51E2"
                     /gene_synonym="HPRAJ; OR51E3P; OR52A2; PSGR"
                     /note="olfactory receptor family 51 subfamily E member 2"
                     /db_xref="GeneID:81285"
                     /db_xref="HGNC:HGNC:15195"
                     /db_xref="MIM:611268"
     exon            1..201
                     /gene="OR51E2"
                     /gene_synonym="HPRAJ; OR51E3P; OR52A2; PSGR"
                     /inference="alignment:Splign:2.1.0"
     exon            202..2792
                     /gene="OR51E2"
                     /gene_synonym="HPRAJ; OR51E3P; OR52A2; PSGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..1214
                     /gene="OR51E2"
                     /gene_synonym="HPRAJ; OR51E3P; OR52A2; PSGR"
                     /note="olfactory receptor, family 51, subfamily E, member
                     3 pseudogene; olfactory receptor, family 52, subfamily A,
                     member 2; olfactory receptor OR11-16; prostate-specific
                     G-protein coupled receptor"
                     /codon_start=1
                     /product="olfactory receptor 51E2"
                     /protein_id="NP_110401.1"
                     /db_xref="CCDS:CCDS7751.1"
                     /db_xref="GeneID:81285"
                     /db_xref="HGNC:HGNC:15195"
                     /db_xref="MIM:611268"
                     /translation="MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIV
                     VFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFF
                     IHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPL
                     LIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYF
                     LIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMG
                     DIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK"
     regulatory      2770..2775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR51E2"
                     /gene_synonym="HPRAJ; OR51E3P; OR52A2; PSGR"
                     /note="hexamer: AATAAA"
     polyA_site      2792
                     /gene="OR51E2"
                     /gene_synonym="HPRAJ; OR51E3P; OR52A2; PSGR"
                     /note="major polyA site"
ORIGIN      
        1 cttctgggaa tctccacacc ctgaagacac agtgagttag caccaccacc aggaattggc
       61 ctttcagctc tgtgcctgtc tccagtcagg ctggaataag tctcctcata tttgcaagct
      121 cggccctccc ctggaatcta aagcctcctc agccttctga gtcagcctga aaggaacagg
      181 ccgaactgct gtatgggctc tactgccagt gtgacctcac cctctccagt cacccctcct
      241 cagttccagc tatgagttcc tgcaacttca cacatgccac ctttgtgctt attggtatcc
      301 caggattaga gaaagcccat ttctgggttg gcttccccct cctttccatg tatgtagtgg
      361 caatgtttgg aaactgcatc gtggtcttca tcgtaaggac ggaacgcagc ctgcacgctc
      421 cgatgtacct ctttctctgc atgcttgcag ccattgacct ggccttatcc acatccacca
      481 tgcctaagat ccttgccctt ttctggtttg attcccgaga gattagcttt gaggcctgtc
      541 ttacccagat gttctttatt catgccctct cagccattga atccaccatc ctgctggcca
      601 tggcctttga ccgttatgtg gccatctgcc acccactgcg ccatgctgca gtgctcaaca
      661 atacagtaac agcccagatt ggcatcgtgg ctgtggtccg cggatccctc ttttttttcc
      721 cactgcctct gctgatcaag cggctggcct tctgccactc caatgtcctc tcgcactcct
      781 attgtgtcca ccaggatgta atgaagttgg cctatgcaga cactttgccc aatgtggtat
      841 atggtcttac tgccattctg ctggtcatgg gcgtggacgt aatgttcatc tccttgtcct
      901 attttctgat aatacgaacg gttctgcaac tgccttccaa gtcagagcgg gccaaggcct
      961 ttggaacctg tgtgtcacac attggtgtgg tactcgcctt ctatgtgcca cttattggcc
     1021 tctcagtggt acaccgcttt ggaaacagcc ttcatcccat tgtgcgtgtt gtcatgggtg
     1081 acatctacct gctgctgcct cctgtcatca atcccatcat ctatggtgcc aaaaccaaac
     1141 agatcagaac acgggtgctg gctatgttca agatcagctg tgacaaggac ttgcaggctg
     1201 tgggaggcaa gtgaccctta acactacact tctccttatc tttattggct tgataaacat
     1261 aattatttct aacactagct tatttccagt tgcccataag cacatcagta cttttctctg
     1321 gctggaatag taaactaaag tatggtacat ctacctaaag gactattatg tggaataata
     1381 catactaatg aagtattaca tgatttaaag actacaataa aaccaaacat gcttataaca
     1441 ttaagaaaaa caataaagat acatgattga aaccaagttg aaaaatagca tatgccttgg
     1501 aggaaatgtg ctcaaattac taatgattta gtgttgtccc tactttctct ctcttttttc
     1561 tttctttttt ttttattatg gttagctgtc acatacaact tttttttttt ttgagatggg
     1621 gtctcgctct gtcaccaggc tggagtgcag tggcgcgatc tcggctcact gcaacctcca
     1681 catcccatgt tgaagtaatt cttctgcctc agcctcccga gtagctggga ctagaggaac
     1741 gtgccaccat gactggctaa ttttctgtat tttttagtag agacagagtt tcaccatgtt
     1801 ggccaggatg gtctcgatct cctgaccttg tgatccaccc gcctcagcct cccaaagtgt
     1861 tgggattaca ggtgtgaacc actgtgcccg gcctgtgtac aactttttaa atagggaata
     1921 tgatagcttc gcatggtggt gtgcacctat agcccccact gcctggaaag ctgaggtggg
     1981 agaatcgctt gagtccagga gtttgaggtt acagtgatcc acgatcgtac cactacactc
     2041 cagcctgggc aacagagcaa gaccctgtct caaagcataa aatggaataa catatcaaat
     2101 gaaacaggga aaatgaagct gacaatttat ggaagccagg gcttgtcaca gtctctactg
     2161 ttattatgca ttacctggga atttatataa gcccttaata ataatgccaa tgaacatctc
     2221 atgtgtgctc acaatgttct ggcactatta taagtgcttc acaggtttta tgtgttcttc
     2281 gtaactttat ggagtaggta ccatttgtgt ctctttatta taagtgagag aaatgaagtt
     2341 tatattatca aggggactaa agtcacacgg cttgtgggca ctgtgccaag atttaaaatt
     2401 aaatttgatg gttgaataca gttacttaat gaccatgtta tattgcttcc tgtgtaacat
     2461 ctgccattta tttcctcagc tgtacaaatc ctctgttttc tctctgttac acactaacat
     2521 caatggcttt gtacttgtga tgagagataa ccttgcccta gttgtgggca acacatgcag
     2581 aataatcctg ttttacagct gcctttcgtg atcttattgc ttgctttttt ccagattcag
     2641 ggagaatgtt gttgtctatt tgtctcttac atctccttga tcatgtcttc attttttaat
     2701 gtgctctgta cctgtcaaaa attttgaatg tacaccacat gctattgtct gaacttgagt
     2761 ataagataaa ataaaatttt attttaaatt tt
//
