LOCUS       NM_001395252             939 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 51 subfamily B member 5
            (OR51B5), mRNA.
ACCESSION   NM_001395252
VERSION     NM_001395252.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Sera,T., Sakuma,T., Maruo,K., Tsujio,G., Yamamoto,Y., Sugimoto,A.,
            Kushiyama,S., Togano,S., Kuroda,K., Kasashima,H., Ohira,M. and
            Maeda,K.
  TITLE     Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the Development
            of Scirrhous-type Gastric Cancer
  JOURNAL   Anticancer Res 42 (11), 5195-5203 (2022)
   PUBMED   36288877
  REMARK    GeneRIF: Candidate Oncogenes, ARHGAP4, NOS3, and OR51B5, for the
            Development of Scirrhous-type Gastric Cancer.
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Son,B., Kang,W., Park,S., Choi,D. and Park,T.
  TITLE     Dermal Olfactory Receptor OR51B5 Is Essential for Survival and
            Collagen Synthesis in Human Dermal Fibroblast (Hs68 Cells)
  JOURNAL   Int J Mol Sci 22 (17), 9273 (2021)
   PUBMED   34502185
  REMARK    GeneRIF: Dermal Olfactory Receptor OR51B5 Is Essential for Survival
            and Collagen Synthesis in Human Dermal Fibroblast (Hs68 Cells).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Tsai,T., Veitinger,S., Peek,I., Busse,D., Eckardt,J.,
            Vladimirova,D., Jovancevic,N., Wojcik,S., Gisselmann,G.,
            Altmuller,J., Stander,S., Luger,T., Paus,R., Cheret,J. and Hatt,H.
  TITLE     Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect
            epidermal proliferation and differentiation
  JOURNAL   Exp Dermatol 26 (1), 58-65 (2017)
   PUBMED   27315375
  REMARK    GeneRIF: OR51B5 and ISO play important roles in HaCaT and
            keratinocyte migration, thereby influencing wound healing.
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Solovieff,N., Milton,J.N., Hartley,S.W., Sherva,R., Sebastiani,P.,
            Dworkis,D.A., Klings,E.S., Farrer,L.A., Garrett,M.E.,
            Ashley-Koch,A., Telen,M.J., Fucharoen,S., Ha,S.Y., Li,C.K.,
            Chui,D.H., Baldwin,C.T. and Steinberg,M.H.
  TITLE     Fetal hemoglobin in sickle cell anemia: genome-wide association
            studies suggest a regulatory region in the 5' olfactory receptor
            gene cluster
  JOURNAL   Blood 115 (9), 1815-1822 (2010)
   PUBMED   20018918
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Bulger,M., Bender,M.A., van Doorninck,J.H., Wertman,B.,
            Farrell,C.M., Felsenfeld,G., Groudine,M. and Hardison,R.
  TITLE     Comparative structural and functional analysis of the olfactory
            receptor genes flanking the human and mouse beta-globin gene
            clusters
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14560-14565 (2000)
   PUBMED   11121057
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Bulger,M., van Doorninck,J.H., Saitoh,N., Telling,A., Farrell,C.,
            Bender,M.A., Felsenfeld,G., Axel,R. and Groudine,M.
  TITLE     Conservation of sequence and structure flanking the mouse and human
            beta-globin loci: the beta-globin genes are embedded within an
            array of odorant receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 5129-5134 (1999)
   PUBMED   10220430
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Jul 6;96(14):8307. von
            Doorninck JH [corrected to van Doorninck JH]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104389.8.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC136708.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300773.3/ ENSP00000300773.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               AC104389.8         144926-145864       c
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..939
                     /gene="OR51B5"
                     /gene_synonym="HOR5'Beta5; OR11-37"
                     /note="olfactory receptor family 51 subfamily B member 5"
                     /db_xref="GeneID:282763"
                     /db_xref="HGNC:HGNC:19599"
     CDS             1..939
                     /gene="OR51B5"
                     /gene_synonym="HOR5'Beta5; OR11-37"
                     /note="olfactory receptor OR11-37; odorant receptor
                     HOR5'beta5"
                     /codon_start=1
                     /product="olfactory receptor 51B5"
                     /protein_id="NP_001382181.1"
                     /db_xref="CCDS:CCDS31378.1"
                     /db_xref="GeneID:282763"
                     /db_xref="HGNC:HGNC:19599"
                     /translation="MSSSGSSHPFLLTGFPGLEEAHHWISVFFLFMYISILFGNGTLL
                     LLIKEDHNLHEPMYFFLAMLAATDLGLALTTMPTVLGVLWLDHREIGSAACFSQAYFI
                     HSLSFLESGILLAMAYDRFIAICNPLRYTSVLTNTRVVKIGLGVLMRGFVSVVPPIRP
                     LYFFLYCHSHVLSHAFCLHQDVIKLACADTTFNRLYPAVLVVFIFVLDYLIIFISYVL
                     ILKTVLSIASREERAKALITCVSHICCVLVFYVTVIGLSLIHRFGKQVPHIVHLIMSY
                     AYFLFPPLMNPITYSVKTKQIQNAILHLFTTHRIGT"
     exon            1..939
                     /gene="OR51B5"
                     /gene_synonym="HOR5'Beta5; OR11-37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcgtcca gcggcagctc ccatcccttc ctattgactg gttttccagg cttggaggaa
       61 gctcatcact ggatttccgt atttttcttg ttcatgtata tatccatcct ttttggcaat
      121 ggcaccctcc ttcttctcat taaggaagat cacaatcttc atgagcccat gtacttcttt
      181 ctggccatgc tggctgccac agacctgggg ctggccctga ccacaatgcc cacggtgctg
      241 ggagtcctct ggctggatca cagggagatt ggaagtgcgg cctgcttttc ccaggcctac
      301 tttatacact cactttcctt tctcgagtct ggcattctgc ttgccatggc ctatgaccgt
      361 tttattgcca tctgcaaccc tcttagatat acctctgtac ttactaatac tcgagtagtg
      421 aagattgggc tgggagttct gatgagggga tttgtatccg ttgttccccc aatcaggccc
      481 ctctattttt ttctgtattg tcactcccat gttctttcac atgcattctg ccttcaccag
      541 gatgtcatta aactcgcctg tgctgatacc accttcaacc gactgtaccc agctgtgctt
      601 gtagtcttta tatttgtgct ggattatctg attatcttca tctcctatgt gttgatactc
      661 aagactgtcc tgagcattgc ctccagagag gagagggcca aggctctcat tacctgtgtc
      721 tcccatatct gctgtgtcct ggttttttat gtcacagtga ttggattgtc tctgattcat
      781 cgttttggaa agcaggttcc acatattgtt cacctcatta tgagctatgc ctattttctg
      841 ttccctccac taatgaatcc tataacatat agtgtcaaga ccaagcagat tcagaatgcc
      901 attcttcacc tttttactac ccatagaatt ggaacctga
//
