LOCUS       NM_033180                939 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 51 subfamily B member 2
            (OR51B2), mRNA.
ACCESSION   NM_033180
VERSION     NM_033180.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Li,B., Kamarck,M.L., Peng,Q., Lim,F.L., Keller,A., Smeets,M.A.M.,
            Mainland,J.D. and Wang,S.
  TITLE     From musk to body odor: Decoding olfaction through genetic
            variation
  JOURNAL   PLoS Genet 18 (2), e1009564 (2022)
   PUBMED   35113854
  REMARK    GeneRIF: From musk to body odor: Decoding olfaction through genetic
            variation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Bulger,M., Bender,M.A., van Doorninck,J.H., Wertman,B.,
            Farrell,C.M., Felsenfeld,G., Groudine,M. and Hardison,R.
  TITLE     Comparative structural and functional analysis of the olfactory
            receptor genes flanking the human and mouse beta-globin gene
            clusters
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14560-14565 (2000)
   PUBMED   11121057
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Bulger,M., van Doorninck,J.H., Saitoh,N., Telling,A., Farrell,C.,
            Bender,M.A., Felsenfeld,G., Axel,R. and Groudine,M.
  TITLE     Conservation of sequence and structure flanking the mouse and human
            beta-globin loci: the beta-globin genes are embedded within an
            array of odorant receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 96 (9), 5129-5134 (1999)
   PUBMED   10220430
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Jul 6;96(14):8307. von
            Doorninck JH [corrected to van Doorninck JH]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104389.8.
            
            On Nov 18, 2020 this sequence version replaced NM_033180.4.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be non-functional as an olfactory receptor
            according to the Classifier for Olfactory Receptor Pseudogenes.
            This RefSeq record was created from transcript and genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC117461.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000624187.1/ ENSP00000485407.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               AC104389.8         125699-126637       c
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..939
                     /gene="OR51B2"
                     /gene_synonym="HOR5'Beta3; OR51B1P"
                     /note="olfactory receptor family 51 subfamily B member 2"
                     /db_xref="GeneID:79345"
                     /db_xref="HGNC:HGNC:14703"
     CDS             1..939
                     /gene="OR51B2"
                     /gene_synonym="HOR5'Beta3; OR51B1P"
                     /note="olfactory receptor 51B1; odorant receptor
                     HOR5'beta3"
                     /codon_start=1
                     /product="olfactory receptor 51B2"
                     /protein_id="NP_149420.4"
                     /db_xref="GeneID:79345"
                     /db_xref="HGNC:HGNC:14703"
                     /translation="MWPNITAAPFLLTGFPGLEAAHHWISIPFFAVYVCILLGNGMLL
                     YLIKHDHSLHEPMYYFLTMLAGTDLMVTLTTMPTVMGILWVNHREISSVGCFLQAYFI
                     HSLSVVESGSLLAMAYDCFIAIRNPLRYASILTNTRVIALGVGVFLRGFVSILPVILR
                     LFSFSYCKSHVITRAFCLHQEIMRLACADITFNRLYPVILISLTIFLDCLIILFSYIL
                     ILNTVIGIASGEERAKALNTCISHISCVLIFYVTVMGLTFIYRFGKNVPEVVHIIMSY
                     IYFLFPPLMNPVIYSIKTKQIQYGIIRLLSKHRFSS"
     exon            1..939
                     /gene="OR51B2"
                     /gene_synonym="HOR5'Beta3; OR51B1P"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtggccca atattactgc agcccctttt ttgctgactg gctttccagg gctggaggca
       61 gctcatcact ggatctccat ccccttcttt gctgtttatg tgtgcatcct tctgggcaat
      121 ggcatgctcc tctacctcat caagcatgac cacagtcttc atgagcccat gtactacttc
      181 ctcaccatgc tggcaggcac agacctcatg gtgacattga ccacgatgcc tactgtaatg
      241 ggcatcctat gggtgaatca cagggagatt agcagtgtgg gctgcttcct acaggcttac
      301 tttattcact ccctttctgt tgtggaatca ggttccctcc tggcaatggc atatgattgt
      361 ttcattgcca tccgcaatcc tttgagatat gcttccattc tcaccaatac tagagtcata
      421 gcgttaggag tgggagtgtt tctaaggggt tttgtatcca tcctgcctgt aattttgcgt
      481 cttttttcat tttcatattg caaatctcat gttatcacac gtgctttctg cctccaccaa
      541 gaaatcatga gactggcttg tgctgacata actttcaata gactttaccc tgtaattttg
      601 atctctttaa caatcttcct agactgtctg atcatcctct tctcctatat tctaattctt
      661 aatactgtca taggcattgc ttctggtgaa gagagagcca aagccctcaa tacctgtatc
      721 tcccacatta gttgtgttct tatcttctat gttacagtga tgggtttgac attcatttac
      781 agatttggga agaatgtgcc agaggttgtc cacattatca tgagttacat ctacttcctc
      841 tttcctcctt taatgaaccc tgtcatctac agcatcaaaa ccaagcaaat acaatatggc
      901 attatccgcc ttttatctaa acataggttt agtagttaa
//
