LOCUS       NM_001004726             918 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 4 subfamily X member 1
            (OR4X1), mRNA.
ACCESSION   NM_001004726 XM_372376
VERSION     NM_001004726.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Ryu,C.S., Sakong,J.H., Ahn,E.H., Kim,J.O., Ko,D., Kim,J.H.,
            Lee,W.S. and Kim,N.K.
  TITLE     Association study of the three functional polymorphisms
            (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss
  JOURNAL   Genes Genomics 41 (1), 61-70 (2019)
   PUBMED   30203366
  REMARK    GeneRIF: OR4X1A>T (rs10838851) is not associated with recurrent
            pregnancy loss in Korean women.
REFERENCE   2  (bases 1 to 918)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 918)
  AUTHORS   Takabatake,N., Toriyama,S., Takeishi,Y., Shibata,Y., Konta,T.,
            Inoue,S., Abe,S., Igarashi,A., Tokairin,Y., Ishii,M., Koyano,S.,
            Emi,M., Kato,T., Kawata,S. and Kubota,I.
  TITLE     A nonfunctioning single nucleotide polymorphism in olfactory
            receptor gene family is associated with the forced expiratory
            volume in the first second/the forced vital capacity values of
            pulmonary function test in a Japanese population
  JOURNAL   Biochem Biophys Res Commun 364 (3), 662-667 (2007)
   PUBMED   17964544
  REMARK    GeneRIF: study identified novel nSNP in OR4X1 gene (rs10838851,
            Tyr273Ter*), which is significantly associated with FEV1.0/FVC
            value in pulmonary function test in a Japanese population
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 918)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 918)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC026975.5.
            
            On Sep 19, 2004 this sequence version replaced XM_372376.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jul 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be functional according to the Classifier for
            Olfactory Receptor Pseudogenes.
            
            CCDS Note: This olfactory receptor gene is a segregating pseudogene
            (PMID:22908908), where some individuals have an allele that encodes
            a functional olfactory receptor, while other individuals have an
            allele that is predicted to be non-functional. This CCDS is being
            retained because the Classifier for Olfactory Receptor Pseudogenes
            (CORP) predicts the reference genome allele to be functional.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320048.1/ ENSP00000321506.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-918               AC026975.5         194878-195795
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..918
                     /gene="OR4X1"
                     /gene_synonym="OR11-104"
                     /note="olfactory receptor family 4 subfamily X member 1"
                     /db_xref="GeneID:390113"
                     /db_xref="HGNC:HGNC:14854"
     CDS             1..918
                     /gene="OR4X1"
                     /gene_synonym="OR11-104"
                     /note="olfactory receptor OR11-104"
                     /codon_start=1
                     /product="olfactory receptor 4X1"
                     /protein_id="NP_001004726.1"
                     /db_xref="CCDS:CCDS31487.1"
                     /db_xref="GeneID:390113"
                     /db_xref="HGNC:HGNC:14854"
                     /translation="MVATNNVTEIIFVGFSQNWSEQRVISVMFLLMYTAVVLGNGLIV
                     VTILASKVLTSPMYFFLSYLSFVEICYCSVMAPKLIFDSFIKRKVISLKGCLTQMFSL
                     HFFGGTEAFLLMVMAYDRYVAICKPLHYMAIMNQRMCGLLVRIAWGGGLLHSVGQTFL
                     IFQLPFCGPNIMDHYFCDVHPVLELACADTFFISLLIITNGGSISVVSFFVLMASYLI
                     ILHFLRSHNLEGQHKALSTCASHVTVVDLFFIPCSLVYIRPCVTLPADKIVAVFYTVV
                     TPLLNPVIYSFRNAEVKNAMRRFIGGKVI"
     exon            1..918
                     /gene="OR4X1"
                     /gene_synonym="OR11-104"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggttgcta caaacaatgt gactgaaata attttcgtgg gattttccca gaattggagt
       61 gagcagaggg tcatttctgt gatgtttctc ctcatgtaca cagctgttgt gctgggcaat
      121 ggcctcattg tggtgaccat cctggccagc aaagtgctca cctcccccat gtatttcttt
      181 ctcagctact tatcctttgt ggagatctgc tactgttctg tcatggcccc caagcttatc
      241 tttgactcct ttatcaagag gaaagtcatt tctctcaagg gctgcctcac acagatgttt
      301 tccctccatt tctttggtgg cactgaggcc tttctcctga tggtgatggc ctatgaccgc
      361 tatgtggcca tctgcaagcc cttgcactac atggccatca tgaaccagcg aatgtgtggt
      421 ctcctcgtga ggatagcatg gggcgggggc ctgctgcatt ctgttgggca aaccttcctg
      481 attttccagc tcccgttctg tggccccaac atcatggacc actacttctg tgatgtccac
      541 ccagtgctgg agctggcctg cgcagacacc ttcttcatta gcctgctgat catcaccaat
      601 ggcggctcca tctccgtagt cagtttcttc gtgctgatgg cttcctacct gatcatcctg
      661 cacttcctga gaagccacaa cttggagggg cagcacaagg ccctctccac ctgtgcctct
      721 catgtcacag ttgtcgacct gttcttcata ccttgctcct tggtctatat taggccctgt
      781 gtcaccctcc ctgcagacaa gatagttgct gtattttata cagtggtcac acctctctta
      841 aaccctgtga tttactcctt caggaatgct gaagtgaaaa atgccatgag gagatttatt
      901 gggggaaaag taatttga
//
