LOCUS       NM_001005500            3493 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 4 subfamily M member 1
            (OR4M1), mRNA.
ACCESSION   NM_001005500 XM_497391
VERSION     NM_001005500.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3493)
  AUTHORS   Ovali,M.A. and Bozgeyik,I.
  TITLE     Asprosin, a C-Terminal Cleavage Product of Fibrillin 1 Encoded by
            the FBN1 Gene, in Health and Disease
  JOURNAL   Mol Syndromol 13 (3), 175-183 (2022)
   PUBMED   35707591
  REMARK    GeneRIF: Asprosin is a key regulatory factor for preserving the
            homeostasis of energy metabolism. Asprosin promotes hepatic glucose
            release in the liver and appetite stimulation in the hypothalamus
            through activation of the cAMP signaling circuitry through
            interacting with its G protein-coupled receptor, called OR4M1. In
            this review, we discuss the current literature on asprosin and its
            receptor, OR4M1.
            Review article
REFERENCE   2  (bases 1 to 3493)
  AUTHORS   Li,E., Shan,H., Chen,L., Long,A., Zhang,Y., Liu,Y., Jia,L., Wei,F.,
            Han,J., Li,T., Liu,X., Deng,H. and Wang,Y.
  TITLE     OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin
  JOURNAL   Cell Metab 30 (2), 319-328 (2019)
   PUBMED   31230984
REFERENCE   3  (bases 1 to 3493)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512310.4.
            
            On Aug 13, 2020 this sequence version replaced NM_001005500.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641200.1/ ENSP00000492985.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AL512310.4         23726-23815         c
            91-3493             AL512310.4         13623-17025         c
FEATURES             Location/Qualifiers
     source          1..3493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3493
                     /gene="OR4M1"
                     /gene_synonym="OLFR734; OR14-7"
                     /note="olfactory receptor family 4 subfamily M member 1"
                     /db_xref="GeneID:441670"
                     /db_xref="HGNC:HGNC:14735"
                     /db_xref="MIM:619939"
     exon            1..90
                     /gene="OR4M1"
                     /gene_synonym="OLFR734; OR14-7"
                     /inference="alignment:Splign:2.1.0"
     exon            91..3493
                     /gene="OR4M1"
                     /gene_synonym="OLFR734; OR14-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1061
                     /gene="OR4M1"
                     /gene_synonym="OLFR734; OR14-7"
                     /note="olfactory receptor OR14-7"
                     /codon_start=1
                     /product="olfactory receptor 4M1"
                     /protein_id="NP_001005500.1"
                     /db_xref="CCDS:CCDS32021.1"
                     /db_xref="GeneID:441670"
                     /db_xref="HGNC:HGNC:14735"
                     /db_xref="MIM:619939"
                     /translation="METANYTKVTEFVLTGLSQTREVQLVLFVIFLSFYLFILPGNIL
                     IICTIRLDPHLTSPMYFLLANLALLDIWYSSITAPKMLIDFFVERKIISFGGCIAQLF
                     FLHFVGASEMFLLTVMAYDRYAAICRPLHYATIMNRRLCCILVALSWMGGFIHSIIQV
                     ALIVRLPFCGPNELDSYFCDITQVVRIACANTFPEELVMICSSGLISVVCFIALLMSY
                     AFLLALLKKHSGSGENTNRAMSTCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVF
                     HTVIFPLLNPIIYTLRNKEVKAAMRKVVTKYILCEEK"
ORIGIN      
        1 ggataaagtc ctccactgtg ggtggtggaa gaggcttctt ctacctcctc cccatagttc
       61 ctgaaggcac caagactgtc acagtaattg ttatattatg aaaagagtaa attgaagaaa
      121 tggaaactgc aaattacacc aaggtgacag aatttgttct cactggccta tcccagactc
      181 gggaggtcca actagtccta tttgttatat ttctatcctt ctatttgttc atcctaccag
      241 gaaatatcct tatcatttgc accatcaggc tagaccctca tctgacttct cctatgtatt
      301 tcctgttggc taatctggcc ctccttgata tttggtactc ttccattaca gcccctaaaa
      361 tgctcataga cttctttgtg gagaggaaga taatttcctt tggtggatgc attgcacagc
      421 tcttcttctt acactttgtt ggggcttcgg agatgttctt gctcacagtg atggcctatg
      481 accgctatgc tgctatctgc cgacccctcc actatgctac catcatgaat cgacgtctct
      541 gctgtatcct ggtggctctc tcctggatgg ggggcttcat tcattctata atacaggtgg
      601 ctctcattgt tcgacttcct ttctgtgggc ccaatgagtt agacagttac ttctgtgaca
      661 tcacacaggt tgtccggatt gcctgtgcca acaccttccc agaggagtta gtgatgatct
      721 gtagtagtgg tctgatctct gtggtgtgtt tcattgctct gttaatgtcc tatgccttcc
      781 ttctggcctt gctcaagaaa cattcaggct caggtgagaa taccaacagg gccatgtcca
      841 cctgctattc ccacattacc attgtggtgc taatgtttgg gccatccatc tacatttatg
      901 ctcgcccatt tgactcattt tccctagata aagtggtgtc tgtgtttcat actgtaatat
      961 tccctttact taatcccatt atttacacat tgagaaacaa ggaagtaaag gcagccatga
     1021 ggaaggtggt caccaaatat attttgtgtg aagagaagtg aaagataaat tatacatttt
     1081 atagtcctcc tgaggatcat tgtcctaaag caggaagtat ttgcagtaat aatgctgcat
     1141 tcacttcctc cgttcatttg tgttcttaaa attttactat aatttttctc tattaattcc
     1201 tctttatatt gaaaaaatag aggcattaag atgaaaataa atttactcac acctaccctg
     1261 aaattccagg cagatcatta ttagaatttg agatataata ataatctgct aaagtacatt
     1321 ttaactaatt gtttattgag taactactct gcagaggctc tggctttgag gggaacatgt
     1381 tgataaaaat aaataagaca tggagacgtg tccattacaa atatgaagta aatggcaagc
     1441 atatggatgc agctagcttc aagttagcaa ataaatattg tcaagtttca gtgttggctc
     1501 agtggaatgg tatctggtaa acatcttgct gggtctggaa aaacagatta tttgtccttt
     1561 atctcctctt atttccagag ttgatggaaa atgaggattc atttatagaa ggtatttcag
     1621 tttatatttc aggtggtgtc cattcaacag ttggagacag aactcaaaat tttatcacat
     1681 tatgaaaaca aattttatga attcaaagca gagtataatt tggctgatac atgagattca
     1741 tgtcattcca gatgaagcct ccaggcaact agcaattttt atagccagtc cctacttaca
     1801 tccttcagag tgaaagcagg cttggggaga aagcttctag gttgactgga attggtagac
     1861 atctagccgt gtagtttttt tctaaactat catctccttt gccacttttg tatgttttcc
     1921 gtaattgcta atcctgcctc tcatgttaaa cttaaattgg ttaggtgctg tttttgttag
     1981 cgcttaattc agagttattt cccattgaga gacctggatg tgttggttcc catgatccct
     2041 tagagaatta ttagggactg atttcctatt ttcaagcact aaaaactcac tctccaagct
     2101 tctgaatgta agaggtagat tagaacattt gattttatag gttatgtttt ttacttaaat
     2161 ttattagttt ttcatttcaa aactaggaaa tattttcatt gaagggcaag aatgcattgg
     2221 gtgtattaag ctttagtctt cttttttaaa tttgataatg taatatggac taaattttaa
     2281 gtgaattaga tccttgtcaa cattaggaat gaatatataa aaataaatcg tataactatt
     2341 cctagagtta ctatttattt acagagattt atttattaat tgaggaggta atttatgcca
     2401 gacccagtgt acctcggatg cacaggatgg aatggtggta cacaaagctt gttttttgct
     2461 ttgggaattt ttccttatgg tgaccttctt cgatcttcaa tgctacgtta cttctcttct
     2521 aggaacccaa aggcatggat tgatgttatg agtcctgatt tttgagttga cttctcatca
     2581 cctggaagtg aataaagcag tagacttctc taacattttg taacacagca tgaaaaaata
     2641 taaagtacaa aagatatata tatataatat gataaaatga tgagttatgt ttctaaatct
     2701 tttatcatct tactgtcatt tctctgtatt tgatctagcc agacttctat tcattttgtc
     2761 acttatcttt catcaaacta gggctgatgt tctttggaaa gggaccactg atttgatatg
     2821 ctcttcaaac accagcacac tgtactacag aaggatattt actgaaaata ctgaagctag
     2881 taatacaaag gaaaaaggca taaaaacagt agtgtgataa ctaattgctt acttgggaat
     2941 attatctgaa attagaaact aatatcaatg aagaaaaagg ggaacttttg gcaaactcta
     3001 gtaagtaata actgagcctg attcatggag gacataattg gaataaggac tgagagcaat
     3061 ttcacccctt ggaggacatt tggaagtgcc cagagacatt tgtggtggtc acaactgagg
     3121 acgtatattg gcatcttgta ctatttagac atcttacaat gcacaggaca gcccccagcc
     3181 cctgactccc acatgaatta tctggcccaa aatgtcaata gtgccgagaa tgaagaactc
     3241 catcaggttg agaaactctg acttaaataa tgggcaggga taaggcaggt tagtgtagaa
     3301 gaaataggtg ttaacctcat atgcaatgtt gtgtcattga atattgtttc caaatagctc
     3361 agtatcctca gcaatcacat acaaaatatg cctcaggact ccttttccct atataactcc
     3421 tacattttct ttcagttact tttaaatgtc ttttaatctc tttttttctt tcagtctctc
     3481 ctagtcctcc ttc
//
