LOCUS       NM_001317107            3796 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 4 subfamily E member 1
            (OR4E1), transcript variant 1, coding, mRNA.
ACCESSION   NM_001317107
VERSION     NM_001317107.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Menashe,I., Abaffy,T., Hasin,Y., Goshen,S., Yahalom,V., Luetje,C.W.
            and Lancet,D.
  TITLE     Genetic elucidation of human hyperosmia to isovaleric acid
  JOURNAL   PLoS Biol 5 (11), e284 (2007)
   PUBMED   17973576
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   Boysen,C., Simon,M.I. and Hood,L.
  TITLE     Analysis of the 1.1-Mb human alpha/delta T-cell receptor locus with
            bacterial artificial chromosome clones
  JOURNAL   Genome Res 7 (4), 330-338 (1997)
   PUBMED   9110172
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Koop,B.F., Rowen,L., Wang,K., Kuo,C.L., Seto,D., Lenstra,J.A.,
            Howard,S., Shan,W., Deshpande,P. and Hood,L.
  TITLE     The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region:
            organization, sequence, and evolution of 97.6 kb of DNA
  JOURNAL   Genomics 19 (3), 478-493 (1994)
   PUBMED   8188290
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC243972.3.
            
            On Aug 3, 2020 this sequence version replaced NM_001317107.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1, coding) represents the
            protein-coding allele encoded by the GRCh38 reference genome.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151119
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641792.2/ ENSP00000493111.1
            polymorphic pseudogene :: based on alignments, homology
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-729               AC243972.3         93959-94687
            730-3796            AC243972.3         96825-99891
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3796
                     /gene="OR4E1"
                     /gene_synonym="OR4E1P"
                     /note="olfactory receptor family 4 subfamily E member 1"
                     /db_xref="GeneID:26687"
                     /db_xref="HGNC:HGNC:8296"
     exon            1..729
                     /gene="OR4E1"
                     /gene_synonym="OR4E1P"
                     /inference="alignment:Splign:2.1.0"
     exon            730..3796
                     /gene="OR4E1"
                     /gene_synonym="OR4E1P"
                     /inference="alignment:Splign:2.1.0"
     CDS             747..1694
                     /gene="OR4E1"
                     /gene_synonym="OR4E1P"
                     /note="olfactory receptor, family 4, subfamily E, member 1
                     pseudogene; olfactory receptor OR14-43"
                     /codon_start=1
                     /product="olfactory receptor 4E1"
                     /protein_id="NP_001304036.1"
                     /db_xref="CCDS:CCDS86370.1"
                     /db_xref="GeneID:26687"
                     /db_xref="HGNC:HGNC:8296"
                     /translation="MEEAILLNQTSLVTYFRLRGLSVNHKARIAMFSMFLIFYVLTLI
                     GNVLIVITIIYDHRLHTPMYFFLSNLSFIDVCHSTVTVPKMLRDVWSEEKLISFDACV
                     TQMFFLHLFACTEIFLLTVMAYDRYVAICKPLQYMIVMNWKVCVLLAVALWTGGTIHS
                     IALTSLTIKLPYCGPDEIDNFFCDVPQVIKLACIDTHVIEILIVSNSGLISVVCFVVL
                     VVSYAVILVSLRQQISKGKRKALSTCAAHLTVVTLFLGHCIFIYSRPSTSLPEDKVVS
                     VFFTAVTPLLNPIIYTLRNEEMKSALNKLVGRKERKEEK"
     regulatory      3776..3781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR4E1"
                     /gene_synonym="OR4E1P"
                     /note="hexamer: AATAAA"
     polyA_site      3796
                     /gene="OR4E1"
                     /gene_synonym="OR4E1P"
                     /note="major polyA site"
ORIGIN      
        1 tctttctcta cagattcccc ttcagtactt gaaggtggaa taatccacct gaaactggca
       61 atacaaaact tgcacctaaa cagtgtgctg caaaggaaat aggatgcttc tgccgcactg
      121 gttttctgaa taattagatc aagttttgtg ttagaagtgt cctaataaac ctgaagggcc
      181 tgcaaaagtg gctgactctt tttttttttt tttttttttg gacagggtcg ttgtgttgct
      241 caggatggag tgcagtggta aaatcacggc tcactgcagc cttgacctcc tgggttcaag
      301 aaatcctcct gcctcagcct cctgagcagc tggaaccaca ggtataagcc aacatgccca
      361 gctaattttt tgtatttttt gtagagacgg ggtttcgcca tgttgcccgg gcttgactgt
      421 ggcttttaat ctcctctact caccactaca atctggaaaa gtgaaaacat atatattatt
      481 tctgtactac attttctgtt aactggaaac caatcctaga aaatcttggt gcagaattac
      541 atattttgac atattgaaaa atatgataat aatatagcta caaaggtgtg atttttacag
      601 acagcctgaa atagtacctt ttaccagaaa atatcgccaa atacatctac tgtgacatca
      661 ccaaaactgt gaacaagacc taaggaggga acttcaaggg ctctcacctt tcttattgga
      721 gaaagcaagg ttgtctaaca aagagaatgg aagaggccat cctactcaat caaacttctt
      781 tagtgacata ttttcggctt agaggtttat ctgtaaatca taaggcacgg atagctatgt
      841 tttccatgtt cctcattttt tatgtcctga cactgattgg gaatgttctc attgtcataa
      901 ctattatcta tgaccaccgg ctccatactc ccatgtattt cttcctcagc aacctgtcct
      961 ttattgatgt ctgccactcc actgtcactg tccccaagat gctgagagac gtgtggtcag
     1021 aggaaaagct catctctttt gatgcctgtg tgacccagat gttcttcctg cacctctttg
     1081 cctgcacaga gatcttcctc ctcaccgtca tggcctatga tcggtatgtg gccatctgta
     1141 aacccctgca gtacatgata gtgatgaact ggaaggtatg tgtgctgctg gctgtggccc
     1201 tctggacagg agggaccatc cactccatag ccctcacctc ccttaccatc aagctgccct
     1261 actgtggtcc tgatgagatt gacaacttct tctgtgatgt acctcaggtg atcaagctgg
     1321 cctgcattga cacccacgtc attgagatcc tcattgtctc caacagtgga ttgatctccg
     1381 tggtctgttt tgtggtcctg gtggtgtcct acgcagtcat cctggtgagt ctgaggcagc
     1441 agatctccaa gggcaagcgg aaggccctgt ccacctgtgc agcccatctc actgtagtta
     1501 cactgttcct gggacactgc atcttcatct attcccgccc atccaccagc ctcccagagg
     1561 acaaggtagt atctgtgttt ttcactgcag tcacccccct gctgaacccc attatctata
     1621 cccttaggaa tgaagaaatg aagagtgcct taaacaagtt agtggggaga aaagagagaa
     1681 aagaagaaaa atgaaaatgt ctacgtcctt aggatacgtg gtgctccaaa ttaaagaagc
     1741 gccttgcaaa gaataagtta cataccatat ttatcagact atgtgactta taaaactatc
     1801 cttggtccaa tatctgacag tcatagcaat cgttatggtt attaatatct tctctgtgct
     1861 ggaaattatt ctaggcactg tgcatttact taattctcac aactttgaaa ggtagatatt
     1921 atgatgcttg tttgtacatg aagaaactaa agctcgagga gagtaaataa catgcccaaa
     1981 gtcactcagc tagaaaacaa tgaaggcagc atgtgaatcc aagtggatca acagaaactc
     2041 aagctctttt cacaacatat gctgcctctt tctgcttttc tgttggagtg ataaccaagg
     2101 tctaaacaaa ccttcagatt tctgggcagc ccttgcctgc atcattcact cagatgctta
     2161 tgtaaacagc ttagcaaaca ctagtgaagc agataaagtg agtttccaca tgactttggt
     2221 gacagagaaa gaagactttg aacaggtgaa gttactgaca ctctcaagta tccaggcaaa
     2281 atctgccatc agagcaatga aatggggata tcttactatt cattcatttg acaaatattt
     2341 actgagcact tattatgtac cagatactag gtttatagcc ataaataaga catacatgta
     2401 gtccttcctt catggagttt agggtctagt gaaaatagaa aacaaaaata tgaacaaata
     2461 aattttaact acagattgtg ataaatgcta taaaacagca gggtgctgtt agagagtatg
     2521 gaagagactt gctttagtgg tcaaggatgg cctctctgag gaagttacat ttaagattaa
     2581 aaggagccag ccataagaga ggtgatggac attctagaca ggggaaatgg ccggtgcaaa
     2641 gatctatgct gggaaagacc ttggcttgtt caaggaagta aatgatcagt gtgattacag
     2701 cttagactat aaggcagaga gtggcaagag agtgatatca gagagctaaa aagaatcttt
     2761 ccatattctc tcaagaagtt tagaatcttt tccagtacaa taagaagcca ccagaatgat
     2821 ttaagcacag gtgtggcatg aaataattta tgttttaata aaattatttt agttattatg
     2881 tagagaattc actcaactaa gcaacagcat ccaatattgt tcttagagca atggatgact
     2941 gttaagtact tagtcataaa tacttagaaa acaacttggt agaaacttgg tagaaaacac
     3001 caagttggat aaaccattgt ctataaacca acatcttaaa tctcactgtg gcggcacata
     3061 gtgtagcaga atggaatgtg gtgaatcaac tgggatatga agaggatatc ccagataacg
     3121 gcatctcata ttcatgttta caaaagagca tgacacattg gaaatcatca gtttgttctc
     3181 acatcatcgc taaaaaaggc atgcttaaat gcagctggga tttcctaggc actcagtgag
     3241 tgtatgatca ataaacctgt gagccacaag gtctacatca tgatttttag gaggaaaatt
     3301 tttatttgct aggaaatgtg ttaggaagga tattcaagtg acacaagaat tataaaattt
     3361 atgtaaaata aatgcccttt tattataggc aatggcagac aataaggaga aatatctaaa
     3421 tatctttcca atgagcccaa atggaactgc ttgtgcagga atcagccata cagaggaaca
     3481 cgtgcaaaat tgtcatattg tctgtcaaca acacaatgct tcaacgtagc cattaagatt
     3541 gtagctggta aaactataac ggaacaacgt tgtgatgttt gcttattttt ttcatagcag
     3601 caagcaaaat ttctgacact acccgttttt agtcacacta atttttcaac tctctgggga
     3661 cgtaaaaata aaacattttg tctccgtttt acagaaaaaa gcttttcaga ctcagagaca
     3721 agataaaaat gtatttaatt actcactaaa taaatagaga gtcttaaaga acaaaaataa
     3781 aagatcttga tgcttg
//
