LOCUS       NM_001386095            5127 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 4 subfamily D member 1
            (OR4D1), transcript variant 1, mRNA.
ACCESSION   NM_001386095
VERSION     NM_001386095.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5127)
  AUTHORS   Barnes,I.H.A., Ibarra-Soria,X., Fitzgerald,S., Gonzalez,J.M.,
            Davidson,C., Hardy,M.P., Manthravadi,D., Van Gerven,L.,
            Jorissen,M., Zeng,Z., Khan,M., Mombaerts,P., Harrow,J., Logan,D.W.
            and Frankish,A.
  TITLE     Expert curation of the human and mouse olfactory receptor gene
            repertoires identifies conserved coding regions split across two
            exons
  JOURNAL   BMC Genomics 21 (1), 196 (2020)
   PUBMED   32126975
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5127)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 5127)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   4  (bases 1 to 5127)
  AUTHORS   Vanderhaeghen,P., Schurmans,S., Vassart,G. and Parmentier,M.
  TITLE     Specific repertoire of olfactory receptor genes in the male germ
            cells of several mammalian species
  JOURNAL   Genomics 39 (3), 239-246 (1997)
   PUBMED   9119360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005962.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2151119 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000268912.6/ ENSP00000365451.3
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC005962.1         70006-70206
            202-569             AC005962.1         71051-71418
            570-676             AC005962.1         75479-75585
            677-5127            AC005962.1         76757-81207
FEATURES             Location/Qualifiers
     source          1..5127
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..5127
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /note="olfactory receptor family 4 subfamily D member 1"
                     /db_xref="GeneID:26689"
                     /db_xref="HGNC:HGNC:8293"
     exon            1..201
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /inference="alignment:Splign:2.1.0"
     exon            202..569
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /inference="alignment:Splign:2.1.0"
     exon            570..676
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /inference="alignment:Splign:2.1.0"
     exon            677..5127
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /inference="alignment:Splign:2.1.0"
     CDS             696..1628
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /note="olfactory receptor, family 4, subfamily D, member
                     3; olfactory receptor OR17-23 pseudogene; olfactory
                     receptor, family 4, subfamily D, member 4 pseudogene;
                     seven transmembrane helix receptor; olfactory receptor
                     4D3; olfactory receptor TPCR16"
                     /codon_start=1
                     /product="olfactory receptor 4D1"
                     /protein_id="NP_001373024.1"
                     /db_xref="CCDS:CCDS42365.1"
                     /db_xref="GeneID:26689"
                     /db_xref="HGNC:HGNC:8293"
                     /translation="MEPQNTTQVSMFVLLGFSQTQELQKFLFLLFLLVYVTTIVGNLL
                     IMVTVTFDCRLHTPMYFLLRNLALIDLCYSTVTSPKMLVDFLHETKTISYQGCMAQIF
                     FFHLLGGGTVFFLSVMAYDRYIAISQPLRYVTIMNTQLCVGLVVAAWVGGFVHSIVQL
                     ALILPLPFCGPNILDNFYCDVPQVLRLACTDTSLLEFLMISNSGLLVIIWFLLLLISY
                     TVILVMLRSHSGKARRKAASTCTTHIIVVSMIFIPCIYIYTWPFTPFLMDKAVSISYT
                     VMTPMLNPMIYTLRNQDMKAAMRRLGKCLVICRE"
     regulatory      3623..3628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /note="hexamer: AATATA"
     polyA_site      3646
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
     regulatory      5105..5110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /note="hexamer: AATAAA"
     polyA_site      5127
                     /gene="OR4D1"
                     /gene_synonym="OR17-23; OR4D3; OR4D4P; TPCR16"
                     /note="major polyA site"
ORIGIN      
        1 actccccaag gaatttccct ttccttaagg ccaatcccat atgtgttcct tgtctgagag
       61 aggccaggag aagaatggag ctacaggaga agagtgacct gggagatggg aggctctaag
      121 tcctcttggc cactgtgggc tggaggaagg tgatggcctc attgtccttc ccatggacaa
      181 atcagcacga caaagcctat cctctcacgg cagtctggcc catcccagca ccctgtcctc
      241 cattaagcaa tcacacattc ttttgggaac caactatgag aaagggtctg tgtgtaccac
      301 gtactgtgta atacttaaca tattggattt gcactgaaat tacaacacat gtgaggaaca
      361 gagccatcct catgaaaaaa taccaaggca tagcaacatt atggaagagc taattactct
      421 tgaaccttga aggaagggta gaattcagac aggtgaacag gacagaaaag caattcagat
      481 gcggcactga ctggatgaag gcactgagac ctgagggacc gaagaagaga taagtttggc
      541 tgaagctgaa tcttcttaga ggagagcaga gataagatca gctggagtgc agtggccata
      601 atagctcact gcagccttga tctcctgggc tcaagcaatc cttccacctc agcctcctga
      661 ataactgaga ctacaggaac gtgggggaag atcctatgga accacagaac accacacagg
      721 tatcaatgtt tgtcctctta gggttttcac agacccaaga gctccagaaa ttcctgttcc
      781 ttctgttcct gttagtctat gttaccacca ttgtgggaaa cctccttatc atggtcacag
      841 tgacttttga ctgccggctc cacacaccca tgtattttct gctccgaaat ctagctctca
      901 tagacctctg ctattccaca gtcacctctc caaagatgct ggtggacttc ctccatgaga
      961 ccaagacgat ctcctaccag ggctgcatgg cccagatctt cttcttccac cttttgggag
     1021 gtgggactgt cttttttctc tcagtcatgg cctatgaccg ctacatagcc atctcccagc
     1081 ccctccggta tgtcaccatc atgaacactc aattgtgtgt gggcctggta gtagccgcct
     1141 gggtgggggg ctttgtccac tccattgtcc aactggctct gatacttcca ctgcccttct
     1201 gtggccccaa tatcctagat aacttctact gtgatgttcc ccaagtactg agacttgcct
     1261 gcactgatac ctccctcctg gagttcctca tgatctccaa cagtgggctg ctagttatca
     1321 tctggttcct cctccttctg atctcttata ctgtcatcct ggtgatgctg aggtcccact
     1381 cgggaaaggc aaggaggaag gcagcttcca cctgcaccac ccacatcatc gtggtgtcca
     1441 tgatcttcat tccctgtatc tatatctata cctggccctt caccccattc ctcatggaca
     1501 aggctgtgtc catcagctac acagtcatga cccccatgct caaccccatg atctacaccc
     1561 tgagaaacca ggacatgaaa gcagccatga ggagattagg caagtgccta gtaatttgca
     1621 gggagtaaac tttaagtaag ttgactttaa atgacaaatt tctctggatt tttattttcc
     1681 cacatgaaaa atggaggaaa gtctttataa agcataacaa atcagattac acttatattt
     1741 cttgaggacc tagtgctgtg tcaagtactg tgttaagcac ttccacgctt tttttctttt
     1801 tttttttttt tagatggagc cttgctctgt cacccaggct ggagtgcagt ggtgcagtct
     1861 aggctcactg caacctccac ctcccgggtt caatgattct cctgcctcag cctcccgcgc
     1921 agctgggatt acaggcaccc accaccacgc ccggctaatt tttgtattct tagtagagat
     1981 ggggtttcac tacaatgacc aggctggtct cgaactcctg acctaggtga tccacccgcc
     2041 ttggcctccc aaagtgctgg gattacaggc gtgagccaca gcgcccggcc taacacttcc
     2101 acagttttat ctcattactt ttcatgaaac cgacagtaga tatattatta ttgttgttaa
     2161 acagttttac aaatgagaaa acgcagagag aagtgacttg ctcaaaggtg aacagtaagt
     2221 gagtggcaga gcttgccctg gaacctggtt cttcttgact ccaagtttag aggcaagaaa
     2281 taggaatggg atttgaaact caagagtttc ctgcgaccac aagagaaaac ctagagaggt
     2341 cttcgtctat agagaagtat ctctgatgaa tggtcaactg cttcatctta actctgggac
     2401 agttacattc ttttctgctc cccacctccc tgcctcattc cccactgtgg aatttagaaa
     2461 gttatctcgc cctccctcct cccccacaaa aaaagtttga gtcgccgctg cgggttgcta
     2521 gcggagtcgc gcgtcgggag ctacgtaggg cagggaaggc atggcttctg ttttcgtcca
     2581 atgagaaggg gccagcggtg gcggtcgggc caggtccggg gcctggggac gccgaggcgg
     2641 ccgcggagga gcgccgcgtc aaggtctcca gcctgcccta cagtgtggat gcgctcgtgt
     2701 cggacaagaa gccgcccaag gaggcatccc cagtgccggc caaaagcgcc tcttccgggg
     2761 ccaccctgcg gctactgctg ctgccggggc acggcgctcg ggaagcgcac agccccgggc
     2821 cgctgatcaa gcccttcgag accgcctcgg tcaagtggga aaactcccta agacggagcg
     2881 gcgtggatgc aggaaccctg ctgataattc gccgccgcca agacacgtga gccctaccac
     2941 ctgcaccctg agaaaacaca agaccaatcc gaagccgcgc acagccttta ccacgtccca
     3001 gctcctcgct ctggagggca agttgctcca gaaacagtac ctctccattg cagagggtgc
     3061 ggacttctcc agctctccga acctcacgga gactcaggtc aaaatcttgt tccagaaccg
     3121 aagggccaag acgaaaagac tgcaggagtc agaactggaa aagctgaaaa tggctgcaaa
     3181 acctatgcta ccctccagct tcagtctccc tttccccatc agctcgcccc tgcaggcagc
     3241 gtccatatac gcagcatcct acccgttcca tagacctgtg cttcccatcc cgcccgtggg
     3301 actctatgcc acgccagtgg gatatggcat gtaccacctg tcctaaggaa gaccagatca
     3361 atagactcca tgatggatgt ttgtttcaaa gggtttcctc tccctctcca agaaggcagg
     3421 accagccaat actcctgttc tgcaaaccct gagtgcacca ccctaagcgg ctaggccggc
     3481 agggccacac gacacagctg aagtttgttc tttaggcgga ggcaccaagc cttgttttct
     3541 tggtgtaatc ttccaggtgc ccccttctcc tttcacaaag attggctctg atggttttta
     3601 tgtataaata tatatataat aaaatataat acatttgtat acagtagatg taaaaattca
     3661 aattatttta aaaggcaaaa tttatataca tatgtgcttt tttcctatat gtcaccttct
     3721 taaagagact gtgtaagtcc atttgttgtg ttttcttaaa gagggagaca aattatttgc
     3781 aaaacttgct aaagtcaatg attttgatgg gatgattgac ttctgcttat ggaaaacaaa
     3841 tattagaatt ggacataatg cacatagaaa gtattagata tggagaggtt tttcaaagtg
     3901 aaggggacac atcacatttc tgcattttac ttgcattaaa agaaaccttt ttatatacta
     3961 ccatatttgt tcctatctct ccccacgccc accccccccc cacacacaca tttttacagt
     4021 tttacctttt tgaagaattt tttttttgta agaccaataa ccgggatgag aagaatcctg
     4081 agaatgcctg gaggtgaggt agaaaattag aaatacttcc taattcttct caaggctgtt
     4141 gctttacttc atttcagata attggagagt aaaaagttaa agcctgttgg gaggagttga
     4201 tggtttctga gaaatactag gtactttcat cctcacagat tgcaaagatt atttgggtgg
     4261 gggggtacag taattttctg cttaaaaaat gagtaccttg taaccattac ctgtatgcta
     4321 aatattcttg aacaattggt agatccagaa agaaaaaaaa ttatgctttc tctgtgtgtg
     4381 tacctgctgt atatgctaaa cttattagaa aattttatat actttttaac atgtccaggg
     4441 cagaagataa agccatgttt tgacttggtg aaaatggagt tgccaaacag cccattaagc
     4501 tccctggtat ttcaccttcc tctccatctc tcccatccct ccagtatgcc tttacccctt
     4561 tgaaagggtg ccttgtacaa ttgtatatat tttattgaag agttattata tcttattctg
     4621 aattaaatta aacatgtttt attgcaaaaa aaagaagaga aagttatctc acttttagca
     4681 ttgtctaaat agttccccaa aaggcatttg ccctttgttt ttgttccatc tttactaaat
     4741 actctttgga taatcttcac attgtgctac ttagctgaaa tggcttaaat atggcccctt
     4801 caaaattcag gtattgaaat ttaatgttca gtgtgatggt gttaagaggc gaagccttta
     4861 agaggtgatt aggccatgag gattcctccc ttattaatgg gattaaggcc tttataaaag
     4921 agacttcatg cagcattagg ctcgctagcc ctttggtctt ctgccatatg aggacacagc
     4981 attcctcccc tctggaggat gcagcaacaa ggtgccatct tggaagcaga gaatagccct
     5041 caccagacaa ccaaacctgt tggaacctta atcttggact gtccagcctc cagaactgca
     5101 aaagaataaa tttctgttct ttacaaa
//
