LOCUS       NM_001004701             933 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 4 subfamily C member 16
            (OR4C16), mRNA.
ACCESSION   NM_001004701 XM_166868
VERSION     NM_001004701.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 933)
  AUTHORS   Ryu,C.S., Sakong,J.H., Ahn,E.H., Kim,J.O., Ko,D., Kim,J.H.,
            Lee,W.S. and Kim,N.K.
  TITLE     Association study of the three functional polymorphisms
            (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss
  JOURNAL   Genes Genomics 41 (1), 61-70 (2019)
   PUBMED   30203366
  REMARK    GeneRIF: OR4C16G>A polymorphism was associated with idiopathic
            recurrent pregnancy loss in Korean women.
REFERENCE   2  (bases 1 to 933)
  AUTHORS   Olender,T., Waszak,S.M., Viavant,M., Khen,M., Ben-Asher,E.,
            Reyes,A., Nativ,N., Wysocki,C.J., Ge,D. and Lancet,D.
  TITLE     Personal receptor repertoires: olfaction as a model
  JOURNAL   BMC Genomics 13, 414 (2012)
   PUBMED   22908908
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 933)
  AUTHORS   Menashe,I., Aloni,R. and Lancet,D.
  TITLE     A probabilistic classifier for olfactory receptor pseudogenes
  JOURNAL   BMC Bioinformatics 7, 393 (2006)
   PUBMED   16939646
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 933)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
REFERENCE   5  (bases 1 to 933)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001998.4.
            
            On Oct 24, 2006 this sequence version replaced NM_001004701.1.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. This olfactory receptor gene is a
            segregating pseudogene, where some individuals have an allele that
            encodes a functional olfactory receptor, while other individuals
            have an allele encoding a protein that is predicted to be
            non-functional. [provided by RefSeq, Jun 2015].
            
            Sequence Note: This gene is a segregating pseudogene. This RefSeq
            represents the protein encoded by the reference genome allele,
            which is predicted to be non-functional as an olfactory receptor
            according to the Classifier for Olfactory Receptor Pseudogenes.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000623907.1/ ENSP00000485295.1
            polymorphic pseudogene :: PMID: 22908908
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-933               AP001998.4         117185-118117
FEATURES             Location/Qualifiers
     source          1..933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q11"
     gene            1..933
                     /gene="OR4C16"
                     /gene_synonym="OR11-135"
                     /note="olfactory receptor family 4 subfamily C member 16"
                     /db_xref="GeneID:219428"
                     /db_xref="HGNC:HGNC:15172"
     CDS             1..933
                     /gene="OR4C16"
                     /gene_synonym="OR11-135"
                     /note="olfactory receptor OR11-135"
                     /codon_start=1
                     /product="olfactory receptor 4C16"
                     /protein_id="NP_001004701.2"
                     /db_xref="GeneID:219428"
                     /db_xref="HGNC:HGNC:15172"
                     /translation="MQLNNNVTEFILLGLTQDPFWKKIVFVIFLRLYLGTLLGNLLII
                     ISVKTSQALKNPMFFFLFYLSLSDTCLSTSITPRMIVDALLKKTTISFSECMIQVFSS
                     HVFGCLEIFILILTAVDRYVDICKPLHYMTIISQWVCGVLMAVAWVGSCVHSLVQIFL
                     ALSLPFCGPNVINHCFCDLQPLLKQACSETYVVNLLLVSNSGAICAVSYVMLIFSYVI
                     FLHSLRNHSAEVIKKALSTCVSHIIVVILFFGPCIFMYTCLATVFPMDKMIAVFYTVG
                     TSFLNPVIYTLKNTEVKSAMRKLWSKKLITDDKR"
     exon            1..933
                     /gene="OR4C16"
                     /gene_synonym="OR11-135"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcaactga ataataatgt gactgagttc attctgcttg gattgacaca ggatcctttt
       61 tggaagaaaa tagtgtttgt tatttttttg cgtctctact tgggaacact gttgggtaat
      121 ttgctaatca ttattagtgt caagaccagc caggcactta agaacccaat gttcttcttc
      181 cttttctact tatccttatc tgatacttgc ctctctactt ccataacccc tagaatgatt
      241 gtggatgccc ttttgaagaa gacaactatc tccttcagcg agtgcatgat ccaagtcttt
      301 tcatcccatg tctttggctg cctggagatc ttcatcctca tcctcacggc tgttgaccgc
      361 tatgtggaca tctgtaagcc cctgcactac atgaccatca taagccagtg ggtctgtggt
      421 gttttgatgg ctgtggcctg ggtgggatcc tgtgtgcatt ctttagttca gatttttctt
      481 gccctgagtt tgccattctg tggccccaat gtgatcaatc actgtttctg tgacttgcag
      541 cccttgttga aacaagcctg ttcagaaacc tatgtggtta acctactcct ggtttccaat
      601 agtggggcca tttgtgcagt gagttatgtc atgctaatat tctcctatgt catcttcttg
      661 cattctctga gaaaccacag tgctgaagtg ataaagaaag cactttccac atgtgtctcc
      721 cacatcattg tggtcatctt gttctttgga ccttgcatat ttatgtacac atgccttgca
      781 accgtattcc ccatggataa gatgatagct gtattttata cagttggaac atcttttctc
      841 aaccctgtga tttacacgct gaagaataca gaagtgaaaa gtgccatgag gaagctttgg
      901 agcaagaaat tgatcacaga tgacaaaaga taa
//
