LOCUS       NM_012373               3800 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 3 subfamily A member 3
            (OR3A3), transcript variant 1, mRNA.
ACCESSION   NM_012373
VERSION     NM_012373.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3800)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   2  (bases 1 to 3800)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 3800)
  AUTHORS   Gilad,Y. and Lancet,D.
  TITLE     Population differences in the human functional olfactory repertoire
  JOURNAL   Mol Biol Evol 20 (3), 307-314 (2003)
   PUBMED   12644552
REFERENCE   4  (bases 1 to 3800)
  AUTHORS   Fuchs,T., Malecova,B., Linhart,C., Sharan,R., Khen,M., Herwig,R.,
            Shmulevich,D., Elkon,R., Steinfath,M., O'Brien,J.K., Radelof,U.,
            Lehrach,H., Lancet,D. and Shamir,R.
  TITLE     DEFOG: a practical scheme for deciphering families of genes
  JOURNAL   Genomics 80 (3), 295-302 (2002)
   PUBMED   12213199
REFERENCE   5  (bases 1 to 3800)
  AUTHORS   Glusman,G., Sosinsky,A., Ben-Asher,E., Avidan,N., Sonkin,D.,
            Bahar,A., Rosenthal,A., Clifton,S., Roe,B., Ferraz,C., Demaille,J.
            and Lancet,D.
  TITLE     Sequence, structure, and evolution of a complete human olfactory
            receptor gene cluster
  JOURNAL   Genomics 63 (2), 227-245 (2000)
   PUBMED   10673334
REFERENCE   6  (bases 1 to 3800)
  AUTHORS   Rouquier,S., Taviaux,S., Trask,B.J., Brand-Arpon,V., van den
            Engh,G., Demaille,J. and Giorgi,D.
  TITLE     Distribution of olfactory receptor genes in the human genome
  JOURNAL   Nat Genet 18 (3), 243-250 (1998)
   PUBMED   9500546
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   7  (bases 1 to 3800)
  AUTHORS   Ben-Arie,N., Lancet,D., Taylor,C., Khen,M., Walker,N.,
            Ledbetter,D.H., Carrozzo,R., Patel,K., Sheer,D., Lehrach,H. et al.
  TITLE     Olfactory receptor gene cluster on human chromosome 17: possible
            duplication of an ancestral receptor repertoire
  JOURNAL   Hum Mol Genet 3 (2), 229-235 (1994)
   PUBMED   8004088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087498.8 and AC025125.15.
            
            On Aug 7, 2020 this sequence version replaced NM_012373.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000641141.1/ ENSP00000493061.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC087498.8         3047-3161           c
            116-309             AC087498.8         2360-2553           c
            310-3800            AC025125.15        124880-128370       c
FEATURES             Location/Qualifiers
     source          1..3800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..3800
                     /gene="OR3A3"
                     /gene_synonym="OR17-137; OR17-16; OR17-201; OR3A6; OR3A7;
                     OR3A8P"
                     /note="olfactory receptor family 3 subfamily A member 3"
                     /db_xref="GeneID:8392"
                     /db_xref="HGNC:HGNC:8284"
     exon            1..115
                     /gene="OR3A3"
                     /gene_synonym="OR17-137; OR17-16; OR17-201; OR3A6; OR3A7;
                     OR3A8P"
                     /inference="alignment:Splign:2.1.0"
     exon            116..309
                     /gene="OR3A3"
                     /gene_synonym="OR17-137; OR17-16; OR17-201; OR3A6; OR3A7;
                     OR3A8P"
                     /inference="alignment:Splign:2.1.0"
     exon            310..3800
                     /gene="OR3A3"
                     /gene_synonym="OR17-137; OR17-16; OR17-201; OR3A6; OR3A7;
                     OR3A8P"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1263
                     /gene="OR3A3"
                     /gene_synonym="OR17-137; OR17-16; OR17-201; OR3A6; OR3A7;
                     OR3A8P"
                     /note="olfactory receptor, family 3, subfamily A, member
                     7; olfactory receptor, family 3, subfamily A, member 6;
                     olfactory receptor, family 3, subfamily A, member 8
                     pseudogene; olfactory receptor 3A6; olfactory receptor
                     3A7; olfactory receptor 3A8; olfactory receptor 17-201;
                     olfactory receptor OR17-22"
                     /codon_start=1
                     /product="olfactory receptor 3A3"
                     /protein_id="NP_036505.3"
                     /db_xref="CCDS:CCDS11025.2"
                     /db_xref="GeneID:8392"
                     /db_xref="HGNC:HGNC:8284"
                     /translation="MEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTTGG
                     NLSILAAVLVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLS
                     QLFFFHLLAGMDCFLLTAMAYDRLLAICQPLTYSTRMSQTVQRMLVAASWACAFTNAL
                     THTVAMSTLNFCGPNEVNHFYCDLPQLFQLSCSSTQLNELLLFVAAAFMAVAPLVFIS
                     VSYAHVVAAVLQIRSAEGRKKAFSTCGSHLTVVGIFYGTGVFSYMRLGSVESSDKDKG
                     VGVFMTVINPMLNPLIYSLRNTDVQGALCQLLVGKRSLT"
ORIGIN      
        1 ccaagacaag ttcaggaatt tgcttgtctc tgctcaaatg ccctggttga tatctgagaa
       61 agaagaggca ggcggatcat gaggtcagga gactgagacc atcctggcta acatggagag
      121 ccagtttctg agtgccccag aggagaatgc tgtagtgaac acagccctgt acagagaaga
      181 cagcagcttg attcctctca tttctcagtc attagcccct cactcgctct ccgggaggat
      241 aacggggtgt gtgcagctcc tccccttctt tcctgaggaa acctcagtgg cttccgtgcc
      301 cttgccagga aactcatgga gccagaagct gggaccaata ggaccgctgt tgctgagttc
      361 attctactgg gcctagtgca aacagaagag atgcagccag ttgtctttgt gctcctcctc
      421 tttgcctatc tggtcacaac tgggggcaac ctcagcatcc tggcagccgt cttggtggag
      481 cccaaactcc acgcccccat gtacttcttc ctggggaacc tgtcagtgct ggatgtcgga
      541 tgtatcactg tcactgttcc tgcaatgttg ggtcgtctct tgtcccacaa gtccacaatt
      601 tcctatgacg cctgcctctc ccagctcttc ttcttccacc ttctggctgg gatggactgc
      661 ttcctgctga ccgccatggc ctatgaccga ctcctggcca tctgccagcc cctcacctac
      721 agcacccgca tgagtcagac agtccagagg atgttggtgg ctgcgtcctg ggcttgtgcc
      781 ttcaccaacg cactgaccca cactgtggcc atgtccacgc tcaacttctg tggccccaat
      841 gaggtcaatc acttctactg tgacctccca cagctcttcc agctctcctg ctccagcacc
      901 caactcaatg agctgctgct ctttgtagca gcagccttca tggctgtggc acccttggtc
      961 ttcatcagtg tgtcctatgc ccatgtggta gctgctgtgc tgcaaatccg ctctgctgag
     1021 ggcagaaaga aggccttctc cacatgtggc tcccacctca ctgtggtggg catcttctat
     1081 gggacaggtg tcttcagcta catgaggctg ggttcagtgg aatcttcaga caaggataag
     1141 ggggttgggg ttttcatgac tgtgatcaac cccatgctga acccacttat ctacagcctc
     1201 agaaatactg atgttcaggg cgctctgtgt cagctacttg tggggaagcg atcactgacc
     1261 tgagagatga cctcctttcc tgccttttct ggaccgagga aaatttcccg agaagatagt
     1321 aaccaacaaa ccttgtttat aaccattatt tctatctcct gatgcctgag gagtggtgtt
     1381 atgtgtttgg cctacaagga aaccctatat aattcattca tttattcatt caacaaatat
     1441 ttattaaatt acttctatga tccaaacaat cttctagggc attggtgagc aaaatggaca
     1501 aaagtctctg cactcaagca aatcacatgc tataaaggta ggctaaataa ataaataagc
     1561 atcatatata gtataccaca tggtgataca ctctatagaa aaaagctggt aagacaggaa
     1621 gacatgaagt gagcttctgc caaccaggcc tcctgggcaa gttggtacct tgctttgggc
     1681 tgtgcccgct ttctcggtag agctgaaatc ttggcagcac tttatgcctg agcagcaatg
     1741 tcctacagga aagggccact tcatcccagc ctaggtaacc aagaatatca ctgcaaagtt
     1801 tccttccaga gggatgtgag actccctcca gatcagagtg tggaaaggta ttttgaaccg
     1861 tgggcccagt gccaggaatc atttcatgct actgttcacc tttcacctcc cataaaatca
     1921 gttccctcgc tttaatacca cacgggaatc ccataggacg atcaggcaac aggtggggtc
     1981 tagagaagga aagagctact aaataaaaac tatgttaata cataagtgat ataccttaag
     2041 atcaaaaagg gaatgtccta tttccatccc ctgcggtatc tttctgtctt atttgataaa
     2101 tcatcttcct gacacatatg atactttttg aaacagtaag cgtttatgtt ccaactaggt
     2161 cctcagaatt ttattgtaga atacccaata caacattctc ctccaaagtc ttacttttct
     2221 atcccaaacc ttctagcctg aaaatacaca cccataaatg cagtccctgg gagtgacacc
     2281 tccttctaac tttaacttta tttgattaat acatcaatac tgctgcaacc cagagcattt
     2341 cctcatcttg atgtctatcc aggtttcagc ccattaattc ctgattctct ccagcccctc
     2401 taggaagact gtttactgcg tcctagcaac actactgtcc ctctgctgtt catccctaaa
     2461 actgtccatg ggtgcacctg aaccttggct tctctgtgat ttcctcttgg ggttgactgg
     2521 aaggatgggc tgagataagg ttgtgaagac aagatgtgag agtgggaggt aggaacggat
     2581 tggagcggag caatgaagat gaaatgagca tatcgagagg gatgggacag ggtgatgagc
     2641 aaaagtggta agaaggaagg atggaagtaa tgaaggaaat gatgcaatga gagaatggga
     2701 agagagaagt atgtctctta cctgatgctc ttgggtgtcc agacacttta acgttaaaga
     2761 acttgagctt cccttaaggg caaagttctt gtgaatgaaa atcacggaca cgggttgtaa
     2821 tcacatcatt cctactcatc cactgctctg tgatcttaga aagttcctta ccatggttgg
     2881 gcttgtgtcc acctgtacca taagggactg ggacaagatt ttctatccac ggttcctcac
     2941 atttaatgac ctctgatcat aatagtctga atgagctctt ccctgggtct gaacacatca
     3001 caaacatttt gagagcatta ccaccaccat ttccaccact ccatctacgc cgtgagcatc
     3061 taacgcttgt ctatgacccc caaagatccc aggccctggc actgcctcct gtgtggcatt
     3121 gccacctcct ttcctgtgtt ccacctgtcc tccaacactg aggggtttcc tgaacaagtg
     3181 agaaagatgt acttccttgg gagtttctct ctttgtgctc tcaaatataa atatacctat
     3241 ttttaaatgt ttcagaaata ttatacctga tagtggaaac attcagaaaa tattattctt
     3301 tcaaatggga aataaaaatc caattattcc ttcacctcgc caaaaacctc atcagagtta
     3361 actcctctta agaatttgat gaccaggcat ggtggctcac gcctgtcatc ccagtgcttt
     3421 gggaggccaa ggcaggtaga tcacctgagg tcaggagttc gagaccatgc tggccaacat
     3481 ggtgaaaccc catctctact aaaaatacaa aaattagccg ggcatgatgg cgggcacctg
     3541 taatcccagc tagttgggag gctgaggcag gagaatcgct tgaacccaga aggcagaagt
     3601 tgcagtgagc tgagatagcg ccactgcact cccgcctaca ctccagcctg ggcaacaaga
     3661 gcgaaatgcc atctcaaaaa aagaaaaaaa aaaaaaaaaa gaacttggtg tttaatcctc
     3721 caaagatttc ctatatatat gatatgccta cttcacatct gtagaaacat actgttctgt
     3781 gatctgcttt atgattttcc
//
