LOCUS       NM_002551               3301 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 3 subfamily A member 2
            (OR3A2), mRNA.
ACCESSION   NM_002551
VERSION     NM_002551.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3301)
  AUTHORS   Gelernter,J., Sherva,R., Koesterer,R., Almasy,L., Zhao,H.,
            Kranzler,H.R. and Farrer,L.
  TITLE     Genome-wide association study of cocaine dependence and related
            traits: FAM53B identified as a risk gene
  JOURNAL   Mol Psychiatry 19 (6), 717-723 (2014)
   PUBMED   23958962
REFERENCE   2  (bases 1 to 3301)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   3  (bases 1 to 3301)
  AUTHORS   Glusman,G., Sosinsky,A., Ben-Asher,E., Avidan,N., Sonkin,D.,
            Bahar,A., Rosenthal,A., Clifton,S., Roe,B., Ferraz,C., Demaille,J.
            and Lancet,D.
  TITLE     Sequence, structure, and evolution of a complete human olfactory
            receptor gene cluster
  JOURNAL   Genomics 63 (2), 227-245 (2000)
   PUBMED   10673334
REFERENCE   4  (bases 1 to 3301)
  AUTHORS   Rouquier,S., Taviaux,S., Trask,B.J., Brand-Arpon,V., van den
            Engh,G., Demaille,J. and Giorgi,D.
  TITLE     Distribution of olfactory receptor genes in the human genome
  JOURNAL   Nat Genet 18 (3), 243-250 (1998)
   PUBMED   9500546
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   5  (bases 1 to 3301)
  AUTHORS   Glusman,G., Clifton,S., Roe,B. and Lancet,D.
  TITLE     Sequence analysis in the olfactory receptor gene cluster on human
            chromosome 17: recombinatorial events affecting receptor diversity
  JOURNAL   Genomics 37 (2), 147-160 (1996)
   PUBMED   8921386
REFERENCE   6  (bases 1 to 3301)
  AUTHORS   Ben-Arie,N., Lancet,D., Taylor,C., Khen,M., Walker,N.,
            Ledbetter,D.H., Carrozzo,R., Patel,K., Sheer,D., Lehrach,H. et al.
  TITLE     Olfactory receptor gene cluster on human chromosome 17: possible
            duplication of an ancestral receptor repertoire
  JOURNAL   Hum Mol Genet 3 (2), 229-235 (1994)
   PUBMED   8004088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087498.8.
            
            On Jul 12, 2022 this sequence version replaced NM_002551.4.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3548694.1,
                                           SRR14038193.3587017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000573901.3/
                                                ENSP00000516654.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC087498.8         28223-28406
            185-282             AC087498.8         78405-78502
            283-476             AC087498.8         129980-130173
            477-554             AC087498.8         135378-135455
            555-3301            AC087498.8         135608-138354
FEATURES             Location/Qualifiers
     source          1..3301
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..3301
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /note="olfactory receptor family 3 subfamily A member 2"
                     /db_xref="GeneID:4995"
                     /db_xref="HGNC:HGNC:8283"
     exon            1..184
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /inference="alignment:Splign:2.1.0"
     exon            185..282
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /inference="alignment:Splign:2.1.0"
     exon            283..476
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /inference="alignment:Splign:2.1.0"
     exon            477..554
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /inference="alignment:Splign:2.1.0"
     exon            555..3301
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /inference="alignment:Splign:2.1.0"
     CDS             561..1508
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /note="olfactory receptor OR17-14; olfactory receptor
                     17-228"
                     /codon_start=1
                     /product="olfactory receptor 3A2"
                     /protein_id="NP_002542.4"
                     /db_xref="CCDS:CCDS42233.2"
                     /db_xref="GeneID:4995"
                     /db_xref="HGNC:HGNC:8283"
                     /translation="MEPEAGTNRTAVAEFILLGLVQTEEMQPVVFVLLLFAYLVTTGG
                     NLSILAAVLVEPKLHAPMYFFLGNLSVLDVGCITVTVPAMLGRLLSHKSTISYDACLS
                     QLFFFHLLAGMDCFLLTAMAYDRLLAICQPLTYSTRMSQTVQRMLVAASLACAFTNAL
                     THTVAMSTLNFCGPNEVNHFYCDLPQLFQLSCSSTQLNELLLFAVGFIMAGTPLVLII
                     TAYSHVAAAVLRIRSVEGRKKAFSTCGSHLTVVCLFFGRGIFNYMRLGSEEASDKDKG
                     VGVFNTVINPMLNPLIYSLRNPDVQGALWQIFLGRRSLT"
     regulatory      3281..3286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /note="hexamer: ATTAAA"
     polyA_site      3301
                     /gene="OR3A2"
                     /gene_synonym="OLFRA04; OR17-14; OR17-228; OR228"
                     /note="major polyA site"
ORIGIN      
        1 acgccgccgt cgggcggtcg taggacatgg ccgccaggag gtagctctcg gtgatgccca
       61 gagccacgaa gaagtacatc tcggcaaagc acgcctggaa ggatatggcc tggcccgggt
      121 ggagcaggcc ggccagcagc ctggggaccg tgacggtggt aaagcagacg tccacgaggc
      181 tcagacatgc cacaaaatgt tgaatgaaga taggcagcgt tggcaaggag agtttctgaa
      241 acttccactg gagggctctg cgtgttccgg caggaatggt ttgagagcca gtttctgagt
      301 gccccagagg agaatgctgt agtgaacaca gccctgtaca gagaagacag cagcttgatt
      361 cctctcattt ctcagtcatt agcccctcac tcgctctccg ggaggataac ggggtgtgcg
      421 cagctcctcc ccttctttcc tgaagaaacc tcagtggctt ccgtgccctt gccagggtat
      481 tctgaccttt tcagctagca gaggatgagg aggacaaggt ggtggtgtca ttgggcatgt
      541 caaccaagag caagaaactc atggagccag aagctgggac caataggacc gctgttgctg
      601 agttcattct actgggccta gtgcaaacag aagagatgca gccagttgtc tttgtgctcc
      661 tcctctttgc ctatctggtc acaactgggg gcaacctcag catcctggca gccgtcttgg
      721 tggagcccaa actccacgcc cccatgtact tcttcctggg gaacctgtca gtgctggatg
      781 tcggatgtat cactgtcact gttcctgcaa tgttgggtcg tctcttgtcc cacaagtcca
      841 caatttccta tgacgcctgc ctctcccagc tcttcttctt ccaccttctg gctgggatgg
      901 actgcttcct gctgaccgcc atggcctatg accgactcct ggccatctgc cagcccctca
      961 cctacagcac ccgcatgagt cagacagtcc agaggatgtt ggtggctgcg tccttggctt
     1021 gtgccttcac caacgcactg acccacactg tggccatgtc cacgctcaac ttctgtggcc
     1081 ccaatgaggt caatcacttc tactgtgacc tcccacagct cttccagctc tcctgctcca
     1141 gcacccaact caatgagctg ctgctctttg ctgtgggttt catcatggca ggcacacctt
     1201 tggttctcat catcactgcc tacagccacg tggcagctgc agttctacga atccgttcag
     1261 tggagggccg aaagaaggcc ttctccacgt gtggctccca cctcaccgtg gtttgtcttt
     1321 tctttggaag aggtatcttc aactacatga gactgggttc agaggaggct tcagacaagg
     1381 ataaaggggt tggagttttc aacactgtta tcaaccctat gctgaaccct cttatctaca
     1441 gcctcagaaa ccctgatgtt cagggtgctc tgtggcaaat atttttgggg aggagatcac
     1501 tgacctgaga ggtaatgggg tccctccttt cctgcctttt ctggactgag gaaaatttcc
     1561 catgaagaca gtaaccagga aaaattcagc cacaactatt tttcctatct cctgatgctt
     1621 gaagatcggt gttacatatt tgtcctacta ggaaacccta cataatttat tcattcaaca
     1681 aatacttatt agagtacctc tatgatctgg acagtcttcc aaggcattgg tggacaaaat
     1741 ggacaaaagt ctctgcactc atgcaactca catgctataa aagtagacaa agtaaataag
     1801 catcatatat accacatgat gatagtttct atagagatga acaaagatgt taatatgaag
     1861 tcaggttctg ccaagcaagc cctgtgcaag ttttaccctg tttttggctg tgcctacttt
     1921 ctggatagag ttaaagcctt gtagttctgt gtgcctggca agcagcattc tacaaagaat
     1981 gtccagtcgg tcaatcacag cctaagtgac caaaagtatt tctgcaatat ttctggtgag
     2041 gacatgagat tccctgcaga tcagaatagg ggaaaatttt ttgtttgttt ctttgttttg
     2101 ttttgttgtt gttttgttaa aaacttgtta aaaagttttt taaaaaaacc aaaaccatag
     2161 gcctagtgca atggattatt tcattcattt gtttgccttt caccttcatt ttcttctctc
     2221 cgctaccaca aaagaatcct gctggatgtt gactgggcgc agggtggctg acgcctgtaa
     2281 tcccagcact ttgggaggcc gaggcggatg gatcacgagg tcaggagatc gagaccatcc
     2341 tgactaacat agtgaaaccc cttctctact ataaatacaa aaacaaaatt agccggtgta
     2401 gtggtgggcg cctgtagtcc cagctactcg ggaggctgag gcaggagaat ggcgtgaacc
     2461 tggggggcgg agcttgcagt gagccgagat agcgccactg cactccagcc tgggcgacag
     2521 agcaagactc cgtctcaaaa aaaaaaaaaa aaagaatcct gctggatgtt tagggaacag
     2581 gaaaggtcta gagaggaaaa gagcccacta aattaaaact acgttcatac atatatgata
     2641 tatcttaagg tcataaaagg aaggtttcat ctccattccc tgccatgcct ttttctctca
     2701 tttaatgtta ccttcctcac acatatgata aagtttttga aagagtaaat gtttgtatta
     2761 caatcaggtc cttagaattt tcaatgtaga atatccaata taaccttctc ctccaaagtc
     2821 ttacttagct ctctcaaagc tccttgctta gaaaatacat acccataaat gtagttcctg
     2881 gaaaggaggg atgcatgcat gcctgtcttc cttccttccc agtgtaaata tatttatttt
     2941 aaaaattatt cagaatgtta tacctaatag tggaaacatt cagacgatat tattttgtca
     3001 agtaggaaat aaaaatccaa atgttccttc actgcaccaa aaatcacact gttcagagtt
     3061 tacgcctctg acaattgttg tgttttttcc tctagcgatt tcctgtatat atgatatgcc
     3121 cgtttcacat cagtagaacc atactgttct gtgatctgct tcctgttttt cctgcatatt
     3181 gtgccataca atcttttaca taatgaagac taacatcctg ctttatctgt tttaatggtg
     3241 gcacagtata tcattaaaca tgtaagtcac aatttctttc attaaacctc tatttctata
     3301 a
//
