LOCUS       NM_002550               1650 bp    mRNA    linear   PRI 26-OCT-2024
DEFINITION  Homo sapiens olfactory receptor family 3 subfamily A member 1
            (OR3A1), mRNA.
ACCESSION   NM_002550
VERSION     NM_002550.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Gelernter,J., Sherva,R., Koesterer,R., Almasy,L., Zhao,H.,
            Kranzler,H.R. and Farrer,L.
  TITLE     Genome-wide association study of cocaine dependence and related
            traits: FAM53B identified as a risk gene
  JOURNAL   Mol Psychiatry 19 (6), 717-723 (2014)
   PUBMED   23958962
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Marrakchi,M., Vidic,J., Jaffrezic-Renault,N., Martelet,C. and
            Pajot-Augy,E.
  TITLE     A new concept of olfactory biosensor based on interdigitated
            microelectrodes and immobilized yeasts expressing the human
            receptor OR17-40
  JOURNAL   Eur Biophys J 36 (8), 1015-1018 (2007)
   PUBMED   17579849
  REMARK    GeneRIF: This work shows the feasibility of an olfactory biosensor
            based on the immobilization of Saccharomyces cerevisiae yeast cells
            genetically modified to express the human olfactory receptor
            OR17-40
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Jacquier,V., Prummer,M., Segura,J.M., Pick,H. and Vogel,H.
  TITLE     Visualizing odorant receptor trafficking in living cells down to
            the single-molecule level
  JOURNAL   Proc Natl Acad Sci U S A 103 (39), 14325-14330 (2006)
   PUBMED   16980412
  REMARK    GeneRIF: This unique mechanism of continuous internalization and
            recycling of OR17-40 might be instrumental in allowing rapid
            recovery of odor perception.
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Malnic,B., Godfrey,P.A. and Buck,L.B.
  TITLE     The human olfactory receptor gene family
  JOURNAL   Proc Natl Acad Sci U S A 101 (8), 2584-2589 (2004)
   PUBMED   14983052
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 May 4;101(18):7205]
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Glusman,G., Sosinsky,A., Ben-Asher,E., Avidan,N., Sonkin,D.,
            Bahar,A., Rosenthal,A., Clifton,S., Roe,B., Ferraz,C., Demaille,J.
            and Lancet,D.
  TITLE     Sequence, structure, and evolution of a complete human olfactory
            receptor gene cluster
  JOURNAL   Genomics 63 (2), 227-245 (2000)
   PUBMED   10673334
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Glusman,G., Clifton,S., Roe,B. and Lancet,D.
  TITLE     Sequence analysis in the olfactory receptor gene cluster on human
            chromosome 17: recombinatorial events affecting receptor diversity
  JOURNAL   Genomics 37 (2), 147-160 (1996)
   PUBMED   8921386
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Crowe,M.L., Perry,B.N. and Connerton,I.F.
  TITLE     Olfactory receptor-encoding genes and pseudogenes are expressed in
            humans
  JOURNAL   Gene 169 (2), 247-249 (1996)
   PUBMED   8647456
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Ben-Arie,N., Lancet,D., Taylor,C., Khen,M., Walker,N.,
            Ledbetter,D.H., Carrozzo,R., Patel,K., Sheer,D., Lehrach,H. et al.
  TITLE     Olfactory receptor gene cluster on human chromosome 17: possible
            duplication of an ancestral receptor repertoire
  JOURNAL   Hum Mol Genet 3 (2), 229-235 (1994)
   PUBMED   8004088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087498.8.
            
            On Aug 6, 2020 this sequence version replaced NM_002550.2.
            
            Summary: Olfactory receptors interact with odorant molecules in the
            nose, to initiate a neuronal response that triggers the perception
            of a smell. The olfactory receptor proteins are members of a large
            family of G-protein-coupled receptors (GPCR) arising from single
            coding-exon genes. Olfactory receptors share a 7-transmembrane
            domain structure with many neurotransmitter and hormone receptors
            and are responsible for the recognition and G protein-mediated
            transduction of odorant signals. The olfactory receptor gene family
            is the largest in the genome. [provided by RefSeq, Jul 2008].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323404.2/ ENSP00000313803.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC087498.8         116171-116248
            79-1650             AC087498.8         121943-123514
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..1650
                     /gene="OR3A1"
                     /gene_synonym="OLFRA03; OR17-40; OR17-82; OR40"
                     /note="olfactory receptor family 3 subfamily A member 1"
                     /db_xref="GeneID:4994"
                     /db_xref="HGNC:HGNC:8282"
     exon            1..78
                     /gene="OR3A1"
                     /gene_synonym="OLFRA03; OR17-40; OR17-82; OR40"
                     /inference="alignment:Splign:2.1.0"
     exon            79..1650
                     /gene="OR3A1"
                     /gene_synonym="OLFRA03; OR17-40; OR17-82; OR40"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1032
                     /gene="OR3A1"
                     /gene_synonym="OLFRA03; OR17-40; OR17-82; OR40"
                     /note="olfactory receptor OR17-15; olfactory receptor
                     17-40; Olfactory receptor-like protein OR17-82"
                     /codon_start=1
                     /product="olfactory receptor 3A1"
                     /protein_id="NP_002541.2"
                     /db_xref="CCDS:CCDS11023.1"
                     /db_xref="GeneID:4994"
                     /db_xref="HGNC:HGNC:8282"
                     /translation="MQPESGANGTVIAEFILLGLLEAPGLQPVVFVLFLFAYLVTVRG
                     NLSILAAVLVEPKLHTPMYFFLGNLSVLDVGCISVTVPSMLSRLLSRKRAVPCGACLT
                     QLFFFHLFVGVDCFLLTAMAYDRFLAICRPLTYSTRMSQTVQRMLVAASWACAFTNAL
                     THTVAMSTLNFCGPNVINHFYCDLPQLFQLSCSSTQLNELLLFAVGFIMAGTPMALIV
                     ISYIHVAAAVLRIRSVEGRKKAFSTCGSHLTVVAIFYGSGIFNYMRLGSTKLSDKDKA
                     VGIFNTVINPMLNPIIYSFRNPDVQSAIWRMLTGRRSLA"
ORIGIN      
        1 atgttggagc agggatccag gatcactcaa taagggcagc ctgagcctca agctggatgc
       61 ctgagagtgg taatccagga actcatgcag ccagaatctg gggccaatgg aacagtcatt
      121 gctgagttca tcctgctggg cttgctggag gcgccagggc tgcagccagt tgtctttgtg
      181 ctcttcctct ttgcctacct ggtcacggtc aggggcaacc tcagcatcct ggcagctgtc
      241 ttggtggagc ccaaactcca cacccccatg tacttcttcc tggggaacct atcagtgctg
      301 gatgttgggt gcatcagcgt cactgttcca tcaatgttga gtcgtctcct gtcccgcaag
      361 cgtgcagttc cctgtggggc ctgccttacc cagctcttct tcttccatct gttcgttgga
      421 gtggactgct tcctgctgac cgccatggcc tatgaccgat tcctggccat ctgccggccc
      481 ctcacctaca gcacccgcat gagtcagaca gtccagagga tgttggtggc tgcgtcctgg
      541 gcttgtgctt tcaccaacgc actgacccac actgtggcca tgtccacgct caacttctgt
      601 ggccccaatg tgatcaatca cttctactgt gacctcccac agctcttcca gctctcctgc
      661 tccagcaccc aactcaatga gctgctgctt tttgctgtgg gttttataat ggcaggtacc
      721 cccatggctc tcattgtcat ctcctatatc cacgtggcag ctgcagtcct gcgaattcgc
      781 tctgtagagg gcaggaagaa agccttctcc acatgtggct cccacctcac tgtggttgcc
      841 atattctatg gttcaggtat ctttaactat atgcgactgg gttcaaccaa gctttcagac
      901 aaggataaag ctgttggaat tttcaacact gtcatcaatc ccatgctgaa cccaatcatc
      961 tacagcttca gaaaccctga tgtgcagagt gccatctgga ggatgctcac agggaggcgg
     1021 tcactggctt gaggaggtct caattgaccc tttctccctg tgtcttgtac taaaggaaaa
     1081 gtcttctaga gccagaaact aggaaaaaaa tggttcacac ctgtttctgt ttcatgggca
     1141 taagaaggac tttttgtagg gaataatagt tttcatttct gaaagcagcc ctgtccaatt
     1201 ataagcaatg agtgtatagg atctgccaag ccagcccctt agacaaattc agcttcaggc
     1261 accgtgttct ctcctttctg gctagaggtg aaacctagga agctgtgagt gctgacaggt
     1321 tcatgttcca gaaggaatga ctctttggtt ggttacagcc ttagttgcca gaagtacccc
     1381 agaaaactcc ccgccagaag tcatattttt ccctcaagtt caggtgtgct tggtctgttt
     1441 ataaaacata ggtctagaga ttaggattgt tttatttctc ccatcagaac tctaaaagca
     1501 aaaataaaac aaaaagaaac aaaaacaaaa aagtagctct ttctattccc attaaacaag
     1561 gaccccatag catagacagg ggacagaggg gaagctgtat gattatgtat tctctagtaa
     1621 ttctggagca cctgatacct gtgtgcagct
//
